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7390890 |
Inhibitors of nucleoside metabolism
The present invention provides compounds having the formula:
wherein A is CH or N; B is chosen from OH, NH 2 , NHR, H or halogen; D is chosen from OH, NH 2 , NHR, H, halogen or SCH 3 ; R is an...
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7390782 |
Methods and products related to metabolic interactions in disease
The invention involves methods of regulating cell growth and division to control disease processes by manipulating mitochondrial metabolism and the expression of cell surface immune proteins. The...
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7375088 |
Polyene polyketides, processes for their production and their use as a pharmaceutical
This invention relates to a new class of polyene polyketides, their pharmaceutically acceptable salts and derivatives, and to methods for obtaining the compounds. One method of obtaining these...
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7375064 |
Functionalized polymeric surfactants based upon alkyl polyglycosides
The invention relates to a series of multifunctional polyglycosides derivatives that are made by the polymerized by the reaction of polyoxyalkylene containing crosslinking reagent and...
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7371733 |
Anti bacterial compounds
The invention relates to novel paranmycin compounds that have activity against gram positive and gram negative bacteria, preferably bacteria that are resistant to other antibiotics. Paranmycins are...
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7371732 |
Glucopyranosyloxy-substituted aromatic compounds, medicaments containing such compounds, their use and process for their manufacture
The present invention relates to glucopyranosyloxy-substituted aromatic groups of general formula
wherein
R 1 to R 6 and R 7a , R 7b , R 7c are defined as in claim 1, the tautomers, the...
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7371731 |
Methods for using glucose pentasulfate for treating amyloid associated with type II diabetes
A pharmaceutical agent for treating an amyloid disease in a patient, wherein the pharmaceutical agent comprises glucose pentasulfate or a pharmaceutically acceptable salt thereof. The agent is...
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7371730 |
Crystals of glucopyranosyloxybenzyl benzene derivative
The present invention provides crystals of 2-(4-methoxybenzyl)phenyl 6-O-ethoxycarbonyl-β-D-glucopyranoside, pharmaceutical compositions containing the same and their uses, which exhibit excellent...
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7365174 |
Azalide and azalactam derivatives and method for producing the same
Compounds represented by the general formula (1) or pharmaceutically acceptable salts thereof, effective in the prevention and/or treatment of infections with microbes: (1) (a) wherein R 1 is...
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7365055 |
Derivatives of morphine-6-glucuronide, pharmaceutical compositions containing them, their preparation method and their uses
The invention relates to novel derivatives of morphine-6-glucuronide, the preparation method thereof and the uses of same in therapy, for example, as analgesics.
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7361744 |
Oligosaccharide derivative
Compounds having the formula (I):
wherein A represents a group such as a cyclic group, R 1 and R 2 represent groups such as alkyl groups or hydroxymethyl groups, and n represents 1 or 2, or...
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7358346 |
C-glycosides, uses thereof
The present invention relates to novel C-glycoside compounds of given absolute configuration, to a process for synthesising them and to compositions containing them. The invention also relates to...
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7338941 |
Pharmaceutical compositions for lowering blood glucose and blood cholesterol levels
Methods of treating a mammal with high blood-glucose, or high blood-cholesterol, levels with isovitexin, and pharmaceutical compositions comprising the same are disclosed.
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7335627 |
Polymeric alkylpolyglycoside carboxylates
The products of the invention are polymers of carboxylated alkylpolyglycosides. The products are very mild surfactants that are useful in personal care applications.
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7321029 |
2′-arabino-fluorooligonucleotide N3′→P5′ phosphoramidates: their synthesis and use
Oligonucleotides with a novel sugar-phosphate backbone containing at least one 2′-arabino-fluoronucleoside and an internucleoside 3′-NH—P(—O)(OR)—O-5′ linkage, where R is a positively...
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7307065 |
2′-Fluoronucleosides
A class of 2′-fluoro-nucleoside compounds are disclosed which are useful in the treatment of hepatitis B infection, hepatitis C infection, HIV and abnormal cellular proliferation, including...
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7304039 |
Glucose-based compounds with affinity to P-selectin
The present invention relates to certain glucose-based compounds that have an affinity to P-selectin. Further, the invention relates to the use of these glucose-based compounds for the preparation...
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7300921 |
Polyene polyketides and methods of production
Novel polyene polyketides, their pharmaceutically acceptable salts, prodrugs and derivatives have been found to have antibiotic activity. One method for obtaining the compounds is by cultivation of...
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7294618 |
Glucopyranosyloxypyrazole derivatives and medicinal use thereof
The present invention provides glucopyranosyloxypyrazole derivatives represented by the general formula:
wherein R 1 , R 2 and R 3 represent a hydrogen atom or a halogen atom; R 4 represents...
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7288640 |
Processes for the production of aminoalkyl glucosaminide phosphate and disaccharide immunoeffectors, and intermediates therefor
This invention relates to processes for production of alkylamino glucosaminide phosphate compounds, and of disaccharide compounds, including various novel intermediates and intermediate processes....
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7276592 |
Nucleotide analogs with six-membered rings
The present invention is related to compounds comprising six-membered rings capable of being incorporated into nucleic acids. Particularly, the six-membered ring is a derivative of cyclohexane,...
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7271153 |
Nitrogenous heterocyclic derivatives, medicinal compositions containing the same, medicinal uses thereof, and intermediates therefor
The present invention provides nitrogen-containing heterocyclic derivatives represented by the general formula:
wherein X 1 and X 3 independently represent N or CH; X 2 represents N or CR 2...
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7265245 |
Compounds useful for the treatment of diseases associated with the formation of amyloid fibrils
The present invention provides new amyloidogenesis inhibiting compounds of formula (I):
in which
R 1 is a —NR a R b group, where R a and R b , independently, are a hydrogen atom or...
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7262178 |
Treatment of sepsis and septic shock
A method and composition for the treatment of humans or animals for septic shock and sepsis using a mixture of sophorolipids.
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7259141 |
Vancomycin analogs and methods thereof
The present invention provides vancomycin analogs and methods related to synthesis of these analogs via chemoenzymatic techniques. In a preferred embodiment, the vancomycin analogs have a...
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7241875 |
Method for the production of surface active agent mixtures
An aqueous surfactant mixture comprised of an alkyl and/or alkenyl oligoglycoside ether carboxylic acid is made by a process comprising reacting in an aqueous solution an alkyl and/or alkenyl...
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7235533 |
Compounds and their uses
Compounds having a mimetic or antagonistic property of an inositol phosphoglycan, and the uses of these compounds are disclosed, together with the use, e.g. to treat a condition ameliorated by...
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7217698 |
Use of mannosamine derivatives for the stimulation of neurite growth
The present invention relates to the use of peracylated N-acyl-mannosamine derivatives for the preparation of a medicament for stimulating neurite growth.
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7217697 |
Glucopyranosyloxypyrazole derivative medicinal composition containing the same medicinal use thereof and intermediate therefor
The present invention provides glucopyranosyloxypyrazole derivatives represented by the general formula:
wherein R 1 is a hydrogen atom or a hydroxyalkyl group; one of Q and T is a group...
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7214794 |
Ceramide analogs, process for their preparation and their use as antitumor agents
The present invention is directed to ceramide analog compounds of general formula (I) the process for their preparation and use for the preparation of pharmaceutical formulations for the treatment...
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7214783 |
Universal bases for nucleic acid analyses, methods for using universal bases, and kits comprising universal bases
Compounds, methods and kits for making and analyzing primer extension products incorporating one or more universal bases are described, including methods and kits for nucleic acid sequencing and...
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7211663 |
Synthesis of oligosaccharides, reagents and methods related thereto
One aspect of the present invention relates to differentially protected glycosyl phosphates. Another aspect of the present invention relates to the preparation of glycosyl phosphates from glycal...
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7189702 |
Glucopyranosyloxypyrazole derivatives and medicinal use thereof
The present invention provides glucopyranosyloxypyrazole derivatives represented by the general formula:
wherein one of Q and T represents a group represented by the general formula:
while...
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7189683 |
Non-ionic surfactants based upon alkyl polyglucoside
The invention relates to a series of polyglycoside derivatives that contain water-soluble groups introduced into the molecule by reaction with the hydroxyl groups present in the starting...
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7186701 |
Dehydrating agent and method for dehydrating moist article using the agent and dehydrated article obtained by the method
The present invention has the object to dehydrate hydrous matters without denaturing or deteriorating them by using a dehydrating agent comprising an anhydrous cyclotetrasaccharide, and provides a...
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7183265 |
Powdery product comprising crystalline β-maltose monohydrate, its preparation, and uses
The object of the present invention is to provide a powdery product comprising crystalline β-maltose monohydrate which is powderized by spray method, and has a high-solubility in aqueous solvents...
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7183261 |
Galactosylceramide analogs, and β-glucocerebrosidase activators, external skin preparations and method of activating β-glucocerebrosidase using the analogs
Galactosylceramide analogues represented by the following formula (1) or (2).
(wherein X and Y each represent S or O, R 1 and R 2 each represent an alkyl group or an alkenyl group each having...
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7169762 |
Substance having physiological property, method for producing the same and uses thereof
A glucoside containing isomaltol represented by formula (I):
(wherein Sug represents a glucose residue or a sugar linkage composed of two or more glucose units) as an aglycon, a physiologically...
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7164015 |
Non-cryogenic process for forming glycosides
The present invention provides a method for making glycoside compounds including the steps of: (a) lithiating an aromatic reactant having a leaving group using a lithium reagent in a first...
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7148223 |
4′-thio-L-xylo furanosyl nucleosides, precursors thereof, preparation and use thereof
Compounds represented by the formula 1:
A is selected from the group consisting of
wherein each R individually is H or acyl, Y is X, N 3 , NH 2 , monoalkylamino, or dialkylamino; Z is...
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7148200 |
Method for treating cancer
A method for treating a cancer. The cancer excluding an adenocarcinoma and being epithelioma, glioma, sarcoma, melanoma, lymphoma or leukemia; or the cancer is an adenocarcinoma cancer excluding...
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7144995 |
Fluorescent nitrogenous base and nucleosides incorporating same
A fluorescent nitrogenous base and nucleosides including the fluorescent nitrogenous base are provided. Nucleosides including the fluorescent nitrogenous base are capable of Watson-Crick base...
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7141554 |
Method of treating irritable bowel syndrome
A nutritional composition is disclosed which comprises synergistic functional carbohydrates for preventing or treating infection by pathogenic bacteria and/or promoting gut flora balance and...
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7129220 |
Substituted indole-O-glucosides
Substituted indole-O-glucosides, compositions containing them, and methods of using them, for example for the treatment of diabetes and Syndrome X are disclosed.
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7129219 |
Immunoeffector compounds
This invention provides compounds containing a 2-deoxy-2-amino-β-D-glucopyranose (glucosamine) glycosidically linked to a cyclic aminoalkyl (aglycon) group. The invention further provides methods...
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7119079 |
Bioadhesive pharmaceutical compositions
Disclosed are compounds having the formula
wherein R 2 is hydrogen, a monomeric glycoside or an oligomeric glycoside, R 3 is hydrogen, a monomeric glycoside, an oligomeric glycoside, or a...
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7115721 |
Microorganism, its product and utilization thereof
There are provided a novel microorganism Enterobacter sp. B20 strain which produces (E)-4-(2-isocyanovinyl)phenyl α-rhamnopyranoside having a favorable effect of inhibiting melanogenesis and...
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7115575 |
Glucopyranosyloxypyrazole derivatives, medicinal compositions containing the same and intermediates in the production thereof
The present invention relates to glucopyranosyloxypyrazole derivatives represented by the general formula:
wherein R 1 represents a hydrogen atom or a lower alkyl group; one of Q 1 and T 1 ...
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7115372 |
Methods for targeting RNA molecules
Described are methods for identifying targets in RNA molecules based on differences in RNA secondary structure related to sequence variances between different allelic forms. Also described are...
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7112573 |
Isoflavone and triterpene glycosides from soybeans
The invention provides new isoflavonoid and triterpenoid compounds isolated from a soybean phytochemical concentrate. The new compounds have exhibited cytotoxic activity against selected tumor cell...
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