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9034834 Antiviral supplement formulations  
The disclosure provides an oral antiviral supplement composition comprising a lysine, an ascorbic compound, a flavonoid glycoside, a threonine, and a pyridoxine. The disclosure also provides a...
9012413 FGF receptor-activating N-acyl octasaccharides, preparation thereof, and therapeutic use thereof  
The invention relates to FGF receptor-activating N-acyl octasaccharides having Formula (I), wherein: R1 is an O-alkyl group optionally replaced by one or more aryl or cycloalkyl groups, R2 is an...
8993737 Phospholinked dye analogs with an amino acid linker  
In various embodiments, the present invention provides fluorescent dyes that are linked to another species through an amino acid or peptide linker. In an exemplary embodiment, the dye is linked to...
8993740 Method for preparation of the tetrasaccharide lacto-N-neotetraose (LNnt) containing N-acetyllactosamine  
The present invention relates to a method for preparation of the tetrasaccharide lacto-N-neotetraose (LNnt, formula (I)) especially in large scale, as well as intermediates in the synthesis, a new...
8993738 Modified nucleosides, analogs thereof and oligomeric compounds prepared therefrom  
The present invention provides modified nucleosides, analogs thereof and oligomeric compounds prepared therefrom. More particularly, the present invention provides modified nucleosides and analogs...
8987216 Polysulfated glycosides and salts thereof  
The invention relates to polysulfated glycosides of formula (I), the pharmaceutically acceptable salts thereof, as well as the pharmaceutical compositions containing these compounds as active...
8980558 Methods, compositions and kits for the improved detection of small RNA molecules  
The present invention provides compositions, methods and kits for use in the detection of small RNA sequences, which allow for rapid and robust amplification and detection. The methods provide...
8969535 Photocleavable labeled nucleotides and nucleosides and methods for their use in DNA sequencing  
Provided are novel nucleotides, nucleoside, and their derivatives described herein, that can be used in DNA sequencing technology and other types of DNA analysis. In one embodiment, the nucleotide...
8962573 Compounds targeting the cation-independent mannose 6-phosphate receptor  
The invention relates to conjugates of products of interest including glycoproteins, nanoparticles, and imaging agents and of compounds of the general formula (1): that target the...
8962578 Fungicidal active substance combinations  
The invention relates to novel fungicidally active compound combinations of 2′-cyano-3,4-dichloroisothiazole-5-carboxanilide and active compounds listed in the disclosure.
8940879 Functional molecule, functional molecule synthesizing amidite and target substance analysis method  
To provide a functional molecule including a modified nucleotide unit having a substituent introduced to a base thereof, wherein the substituent is removably introduced to the base; a functional...
8937167 Compounds and methods for treating bacterial infections  
The present invention encompasses compounds and methods for treating urinary tract infections.
8927698 Method for the synthesis of a trisaccharide  
The present invention relates to an improved synthesis of a trisaccharide of the formula, novel intermediates used in the synthesis and the preparation of the intermediates.
8927506 Acetates of 2-deoxy monosaccharides with anticancer activity  
Novel compounds and methods of using the same to inhibit glycolysis and treat cancer and other diseases are provided herein.
8927497 Absorption enhancers for intranasal administration  
A composition including a surfactant and at least one alkyl glycoside and/or saccharide alkyl ester and a drug. The surfactant composition(s) when admixed with a drug is non-toxic and...
8921532 Phospholink nucleotides for sequencing applications  
The present invention provides labeled phospholink, nucleotides that can be used in place of naturally occurring nucleotide triphosphates or other analogs in template directed nucleic acid...
8912165 Methods of skin treatment and use of water-soluble β-(1,3) glucans as active agents for producing therapeutic skin treatment agents  
A method of treating an ulcer comprising applying to the ulcer a preparation comprising a water-soluble β-(1,3) glucan with β-(1,6) linked side-chains, where the side-chains comprise β-(1,3)...
8907070 Glycolipids of branched chain alkyl oligosaccharides for liquid crystal and related applications  
Glycolipids of branched chain alkyl oligosaccharides include a primary alcohol branched in the 2-position and an oligosaccharide, covalently bond to the alcohol in either α- or β-linkage (shown in...
8889650 Antimelancholic medicine prepared with jujube camp materials  
An antimelancholic pharmaceutical composition or health products prepared with jujuba cAMP materials and a preparative method are provided in the present invention. The present pharmaceutical...
8883746 α-galactosylceramide derivatives, pharmaceutically acceptable salts thereof, preparation method and pharmaceutical composition for the immune adjuvant containing the same as an active ingredient  
Disclosed are novel α-galactosylceramide derivatives, pharmaceutically acceptable salts thereof, preparation methods thereof, and pharmaceutical compositions for use in an immune adjuvant...
8877905 Nucleotides and nucleosides and methods for their use in DNA sequencing  
The present invention relates generally to labeled and unlabeled cleavable terminating groups and methods for DNA sequencing and other types of DNA analysis. More particularly, the invention...
8877906 Amphiphiles for protein solubilization and stabilization  
The invention provides amphiphiles for manipulating membrane proteins. The amphiphiles can feature carbohydrate-derived hydrophilic groups and branchpoints in the hydrophilic moiety and/or in a...
8853372 Saccharide siloxanes stable in aqueous environments and methods for the preparation and use of such saccharide siloxanes  
A novel saccharide siloxane copolymer has improved stability in the presence of water as compared to certain previously known saccharide siloxanes. The saccharide siloxane copolymer is useful in...
8853373 Method and reagent for gene sequence analysis  
Provided is a nucleic acid substrate which has nucleic acid substrate characteristics equivalent to those of dATP, has a low substrate specificity for luciferase, exerts no negative effect on...
8846851 Methods of ring opening polymerization and catalysts therefor  
A salt catalyst comprises an ionic complex of i) a nitrogen base comprising one or more guanidine and/or amidine functional groups, and ii) an oxoacid comprising one or more active acid groups,...
8846881 Modular nucleotide compositions and uses therefor  
Nucleic acid compositions, methods of making and using such compositions that comprise modular functional groups that can be configured to provide desired functionality to different nucleotide...
8828952 Sulfated oligosaccharide derivatives  
The invention relates to novel compounds that have utility as inhibitors of heparan sulfate-binding proteins; compositions comprising the compounds, and use of the compounds and compositions...
8828955 Glutathione production enhancer, prophylactic/therapeutic agent for diseases caused by glutathione deficiency, and food, beverage and feed  
The invention aims at finding a highly-safe natural product having glutathione production-enhancing activity, and providing a glutathione production enhancer and a prophylactic/therapeutic agent...
8808988 Compositions and methods for nucleotide sequencing  
The invention provides nucleoside and nucleotide molecules containing cleavable linkers linking a label such as a dye. The invention also provides nucleosides and nucleotide molecules containing a...
8809285 Monophosphorylated lipid A derivatives  
The present invention provides for monophosphorylated lipid A derivatives and carbohydrate derivatives that are useful as agents in the treatment of diseases and conditions, including cancers....
8796437 Tetrahydropyran nucleic acid analogs  
The present disclosure describes tetrahydropyran nucleoside analogs, oligomeric compounds prepared therefrom and methods of using the oligomeric compounds. More particularly, tetrahydropyran...
8796432 Chemically cleavable 3'-o-allyl-DNTP-allyl-fluorophore fluorescent nucleotide analogues and related methods  
This invention provides a nucleotide analogue comprising (i) a base selected from the group consisting of adenine, guanine, cytosine, thymine and uracil, (ii) a deoxyribose, (iii) an allyl moiety...
8795979 Hydrolase enzyme substrates and uses thereof  
The present invention provides novel methods for determining the presence or amount of a hydrolytic enzyme in a sample, based on novel substrates for the enzymes, and also provides compositions...
8785416 Sulphated disaccharides for the treatment of neurodegenerative and/or neurovascular diseases  
The present invention relates to the use of a series of sulphated disaccharides for the preparation of a medicament for the treatment or prevention of a neurodegenerative and/or neurovascular...
8778897 Method of treatment using α-1-adrenergic agonist compounds  
Methods for treating or preventing cardiomyopathy in a subject by administering an α1 adrenergic receptor agonist, wherein the treatment does not result in increased blood pressure are provided.
8772253 Aureolic acid derivatives, the method for preparation thereof and the uses  
Aureolic acid derivatives, process for obtaining them and uses thereof. This invention provides a bacterial strain that produces compound belonging to the family of aureolic acids useful in the...
8716469 Synthetic oligosaccharides for Moraxella vaccine  
The present invention provides synthetic Moraxella catarrhalis lipooligosaccharide (LOS)-based oligosaccharides and conjugates containing various M. catarrhalis serotype-specific oligosaccharide...
8716457 Nucleobase characterisation  
The present invention provides modified nucleobase compounds, modified nucleic acid mimetic compounds and various uses thereof. In addition, the invention provides methods for nucleobase...
8703922 Low-viscosity liquid crystal compound  
The present invention relates to a liquid crystal compound that can be used as a base for injection formulations. The present invention provides an amphipathic compound having the following...
8691797 Chlorination of carbohydrates and carbohydrate derivatives  
Disclosed is a method for chlorinating a carbohydrate or a derivative thereof to produce a polychlorinated carbohydrate or a derivative thereof, such as sucralose, the method involves (i) reacting...
8680251 Triterpenoid 2-deoxy glycosides, method of preparation thereof and use thereof as medicaments  
The invention describes novel triterpenoid 2-deoxy glycosides of general formula I, wherein at least one of the substituents X1 and R2 contains a 2-deoxy glycosidic group, method of preparation...
8648179 Enzymatic nucleic acid synthesis: compositions and methods for inhibiting pyrophosphorolysis  
Nucleotide triphosphate probes containing a molecular and/or atomic tag on a a γ and/or β phosphate group and/or a base moiety having a detectable property are disclosed, and kits and method for...
8637276 Methods, compositions and kits for the improved detection of small RNA molecules  
The present invention provides compositions, methods and kits for use in the detection of small RNA sequences, which allow for rapid and robust amplification and detection. The methods provide...
8614314 Saccharide structures and methods of making and using such structures  
Described are oligosaccharides having a protecting group at two, a plurality, a majority of, or each position in the oligosaccharide which is amenable to derivatization. Collections, libraries and...
8604004 Moenomycin analogs, methods of synthesis, and uses thereof  
The present invention provides novel moenomycin analogs as well as pharmaceutical compositions thereof, methods of synthesis, and methods of use in treating an infection by administering an...
8598130 Insecticidal combinations  
A method of controlling or preventing damage to a plant, which comprises applying on the plant or a surrounding area thereof a combination comprising (I) abamectin, and (II) cyflumetofen, in any...
8586564 Synthetic glycolipid analogues and derivatives for the treatment of pathologic disorders  
The present invention describes compositions and methods for synthetic analogues and derivatives of β-glycolipids. These analogues and derivatives may be used for the treatment, amelioration or...
8586551 18-membered macrocycles and analogs thereof  
The present invention relates generally to the 18-membered macrocyclic antimicrobial agents called Tiacumicins, specifically, OPT-80 (which is composed almost entirely of the R-Tiacumicin B),...
8575334 High-purity fractionation of anthocyanins from fruits and vegetables  
Disclosed is a method for separating anthocyanins depleted in phenolic mixture content from fruits or vegetables feedstock containing anthocyanins and phenolic mixtures. The first step is to...
8569247 Hydrolysate of crocin  
The present invention relates to a composition derived from the hydrolysate of plant containing crocin or the derivatives thereof. The composition includes a significant amount of crocetin...