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8173608 |
Compound having cyclic structure and use thereof
The present invention relates to a compound represented by the following formula (1′) wherein R is an aldopyranose residue, R2 is a C2-18 hydrocarbon group optionally having substituent(s), R3 is a...
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8173610 |
Derivatives of epirubicin, their medicinal application and pharmaceuticaly acceptable forms of drugs
The present invention relates to novel derivatives of epirubicin, pharmaceutical composition comprising these derivatives, and uses of epirubicin and its derivative for treating HCV.
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8173607 |
Promoter for the production of hyaluronic acid containing ginsenoside compound K
There are provided a promoter containing ginsenoside compound K for the production of hyaluronic acid, and more particularly, a new efficacy of 20-O-β-D-glucopyranosyl-20(S)-protopanaxadiol ...
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8173606 |
Sulfated oligosaccharide derivatives
The invention relates to compounds which are polysulfated oligosaccharide derivatives having activity as inhibitors of heparan sulfate-binding proteins and inhibitors of the enzyme heparanase;...
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8168598 |
Optimised formulation of tobramycin for aerosolization
The invention provides a tobramycin formulation for delivery by aerosolization in the form of additive-free, isotonic solution whose pH has been optimised to ensure adequate shelf-life at room...
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8168583 |
2-fluoronucleosides
2′-Fluoro-nucleoside compounds are disclosed which are useful in the treatment of hepatitis B infection, hepatitis C infection, HIV and abnormal cellular proliferation, including tumors and c...
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8163705 |
Glycolipid and use thereof
The present invention provide a compound represented by the following formula (1) wherein each symbol is as defined in the specification, or a salt thereof. The compound of the present invention...
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8163461 |
Photoacid generator compounds and compositions
The invention provides various photoacid generator compounds and ionic components thereof. Photoresist compositions that include the ions and non-ionic photoacid generator compounds are also...
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8148503 |
Nucleotides and nucleosides and methods for their use in DNA sequencing
The present invention relates generally to labeled and unlabled cleavable terminating groups and methods for DNA sequencing and other types of DNA analysis. More particularly, the invention relates...
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8133669 |
Chemically modified nucleoside 5′-triphosphates for thermally initiated amplification of nucleic acid
Provided herein are methods and compositions for nucleic acid replication. These methods involve the use of 3′-substituted nucleoside 5′-triphosphates or 3′-substituted terminated primers in nucle...
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8129106 |
Sequence-specific detection of methylation in biomolecules
A method for detecting sequence specific methylation in a biomolecule, comprising: (a) contacting the biomolecule with an S-adenosyl-L-methionine-dependent methyltransferase in the presence of a...
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8124575 |
Polymeric surfactants based upon alkyl polyglycosides and sugars
The present invention relates to a series of polyglycoside derivatives that are (a) polymeric (that is cross linked with hydroxypropyl linkages) and (b) contain additional functional groups...
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8110380 |
Starch-based biodegradable material composition
A starch-based biodegradable material composition includes: an enzyme-hydrolyzed starch; and a biodegradable polyester selected from at least one of an aliphatic polyester of polybutylene succinate...
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8106007 |
Conjugates of a polypeptide and a pentasaccharide
The present invention relates to conjugates of a polypeptide and an oligosaccharide, wherein the polypeptide is conjugated to at least one oligosaccharide-spacer residue, the oligosaccharide being...
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8106182 |
Antisense oligonucleotides (ODN) against Smad7 and uses thereof in medical field
The invention relates to antisense oligonucleotidic sequences (ODN) against Smad7 suitably modified, and their uses in medical field as therapeutic biological agents, in particular in the treatment...
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8101746 |
Granular sucralose, and method of making it
Granular sucralose-containing particles are produced by the methods of the invention, which involve coating sucralose from solution to form granules with this coated sucralose on an outer region...
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8097706 |
Methods for preparing capecitabine and beta-anomer-rich trialkyl carbonate compound used therein
The present invention relates to a method for preparing capecitabine and a method for preparing a β-anomer-rich trialkyl carbonate compound used therein, and a highly pure capecitabine can be ...
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8088626 |
Chiral selectors for separating enantiomers of a compound
The invention relates to the use of compounds as new chiral selectors for separating the optical or enantiomeric isomers of a compound, wherein the chiral selector comprises at least one compound...
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8088904 |
Tetrahydropyran nucleic acid analogs
The present disclosure describes tetrahydropyran nucleoside analogs, oligomeric compounds prepared therefrom and methods of using the oligomeric compounds. More particularly, tetrahydropyran...
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8084590 |
Labelled nucleotides
The invention provides a nucleotide or nucleoside having a base attached to a detectable label via a cleavable linker, characterised in that the cleavable linker contains a moiety selected from the...
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8084589 |
Phosphoramidite nucleoside analogs
Described are phosphoramidite nucleoside analog monomers, precursors thereof, and oligonucleotides including one or more of the monomers. The monomers can be used during automated synthesis of...
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8080588 |
Surfactants for tertiary mineral oil extraction based on branched alcohols
Surfactants of the general formula R1—X where R1 is an aliphatic C17H35-alkyl radical and X is a hydrophilic group, and the mean degree of branching of the R1 radical is from 2.8 to 3.7. Mixtures w...
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8080539 |
Method of treating human preeclampsia employing resibufagenin
A method of treating preeclampsia including administering a therapeutically effective dose of resibufagenin to a patient having preeclampsia. Effecting the determination of the presence of...
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8076310 |
Phosphonate nucleosides useful as active ingredients in pharmaceutical compositions for the treatment of viral infections, and intermediates for their production
Disclosed herein are novel phosphonate nucleosides and thiophosphonate nucleosides comprising a phosphonalkoxy-substituted or phosphonothioalkyl-substituted five-membered, saturated or unsaturated,...
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8071758 |
Method for production of limulus-positive glycolipid, the limulus-positive glycolipid, and composition containing the limulus-positive glycolipid
It has been found that a limulus-positive glycolipid is present in xanthan gum derived from Xanthomonas, which has been commercially available and eaten for many years, and this was purified, and...
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8058414 |
Unnatural polymerase substrates that can sustain enzymatic synthesis of double stranded nucleic acids from a nucleic acid template and methods of use
Nucleotide analogs that can sustain the enzymatic synthesis of double-stranded nucleic acid from a nucleic template are described. The nucleotide analogs include: (i) a base selected from the group...
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8058031 |
Labeled nucleotide analogs and uses therefor
Labeled nucleotide analogs used in place of naturally occurring nucleoside triphosphates or other analogs in template directed nucleic acid synthesis reactions and other nucleic acid reactions, and...
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8053417 |
Hexosylceramides as adjuvants and their uses in pharmaceutical compositions
The present invention relates to new adjuvants and the uses in pharmaceutical compositions, like in vaccines. In particular, the present invention provides new compounds useful as adjuvants for...
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8048860 |
Butanol extract of Bidens pilosa
A method of treating a Th1-mediated disorder includes administering to a subject in need of the treatment an effective amount of a compound of the formula I: wherein R1 is H, alkyl, aryl, or...
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8048868 |
Method of preventing preeclampsia
A method of preventing preeclampsia including administering to a patient during an early stage of pregnancy a prophylactically-effective amount of resibufogenin. The administration of resibufogenin...
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8044194 |
Cyclic carbonyl monomers functionalized with carbohydrates, polymers derived therefrom, and methods of preparation thereof
A cyclic carbonyl monomer has the formula (7): wherein at least one W′ or Wa group comprises a protected glycoside; each Z independently represents O, S, NH or NW″; n is an integer from 0 to 6 whe...
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8030096 |
Water-soluble rhodamine dyes conjugates
The present invention provides novel, water-soluble, red-emitting fluorescent rhodamine dyes and red-emitting fluorescent energy-transfer dye pairs, as well as labeled conjugates comprising the...
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8030481 |
Stevioside polymorphic and amorphous forms, methods for their formulation, and uses
Exemplary embodiments of this invention encompass a method for purifying a substantially crude stevioside, methods for preparing polymorphic and amorphous forms of stevioside, and the polymorphic...
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8003615 |
Stable vitamin B6 derivative
A compound represented by the following general formula (I) or a salt thereof: wherein R1 represents a glycosyl group, a phosphate group, or a cyclic phosphate group bound to R2; R2 represents...
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8003769 |
Dye-labeled ribonucleotide triphosphates
The invention provides novel dye-labeled ribonucleotide analogs and methods for synthesizing those analogs. The compounds of the invention are especially useful for DNA sequencing by the polymerase...
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7998935 |
Quinaldine based semisquaraines and squaraine dyes, process for preparation thereof and use thereof
The present invention provides quinaldine-based semisquaraines, symmetrical and unsymmetrical squaraine dyes represented by the general formulae 1, 2 and 3 and/or pharmaceutically acceptable...
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7994141 |
Compositions comprising compounds of natural origin for damaged skin
The present invention relates to a skin-protecting composition for the damaged skin, comprising glycyrrhizin, quercetin, rosmarinic acid, madecassic acid, chamazulene, bicalein and emodin. The...
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7994140 |
Classes of compounds that interact with GPCRs
The present invention relates to a method of identifying a candidate therapeutic agent. The method comprises contacting a G-Protein Coupled Receptor (GPCR) with a compound of General Formula (I),...
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7989599 |
Activator including biosurfactant as active ingredient, mannosyl erythritol lipid, and production method thereof
The present invention includes as an active ingredient at least one biosurfactant, in particular mannosyl alditol lipid (such as MEL and MML) or triacylated mannosyl alditol lipid. This allows...
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7985856 |
Method for preparing hexose derivatives
A method for preparing hexose derivatives comprises the steps of providing a silylated hexose, treating the silylated hexose with a first carbonyl compound in the presence of a catalyst to form an...
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7973146 |
Engineered fluorescent dye labeled nucleotide analogs for DNA sequencing
Engineered nucleotide compositions, having polymerase interacting components that improve the interactivity of the polymerase and the nucleotide, particularly for nucleic acid sequencing...
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7973145 |
Sulfonated sugar compounds, pharmaceutical compositions which contain the same, and methods of treating tumors with the same
Sulfoquinovosylacyl propanediol compounds represented by formula (I): wherein R1 is an acyl residue of a fatty acid, Y is a number of 1, 2 or 3, and M represents a cation having a positive charge...
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7968522 |
Treatment and prophylaxis of sepsis and septic shock
A method and composition for the prophylaxis or treatment of humans or animals for septic shock and sepsis using a mixture of sophorolipids.
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7968735 |
Light-emitting biomarker
The invention concerns novel 1,2-dioxetane derivatives of general formula (I) as defined in the description, capable of emitting a detectable luminescent signal, their use in a method for detecting...
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7964569 |
Glycomimetic replacements for hexoses and N-acetyl hexosamines
Compounds and methods are provided for obtaining oligosaccharide mimics. More specifically, compounds and methods are described wherein oligosaccharide mimics are obtained by incorporating or...
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7960523 |
Processes for the production of aminoalkyl glucosaminide phosphate and disaccharide immunoeffectors, and intermediates therefor
This invention relates to processes for production of alkylamino glucosaminide phosphate compounds, and of disaccharide compounds, including various novel intermediates and intermediate processes....
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7960543 |
Nucleoside or nucleotide derivative and use thereof
The object of the present invention is to provide a nucleoside or nucleotide having a 5-substituted-2-oxo(1H)pyridin-3-yl group as a base, as well as a method using the same. In one embodiment, the...
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7960353 |
Novobiocin analogues as neuroprotective agents and in the treatment of autoimmune disorders
Novobiocin analogues and pharmaceutical composition containing such compounds useful for the treatment and/or prevention of neurodegenerative disorders and autoimmune disorders.
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7956171 |
Nucleotide analogs
The disclosure provides nucleotide analogs and methods of their use. Analogs of the invention comprise a reporter molecule (label) attached via the N4, N6, O4, or O6 position of the nitrogenous...
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7956039 |
Use of amygdalin analogues for the treatment of psoriasis
The compounds of formula (I), wherein n is an integer from 0 to 4; R1 is a radical selected from the group consisting of H, CH3, CH2-CH3, C(CH3)3, COOH, CONH2 and C≡CH; R2, R3, R4 and R5 are r...
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