Patents in Class 536/27.810

Matches 1 - 50 out of 182

1 2 3 4 >

Match	Document	Document Title
1	7385050	Cleavable linker for polynucleotide synthesis Functionalized supports for polynucleotide synthesis are disclosed. The supports have linker moieties that are stable to conditions used in polynucleotide synthesis, but may be cleaved to release...
2	7335765	Nucleoside and oligonucleotide analogues A compound of the formula (1): wherein R 1 and R 2 are the same or different and represent a hydrogen atom, a hydroxyl protecting group, a phosphate group, or —P(R 3 )R 4 , wherein R 3 and...
3	7307166	Oxpurine nucleosides and their congeners, and acyl, derivatives thereof, for improvement of hematopoiesis The invention relates to certain oxypurine nucleosides, congeners of such oxypurine nucleosides, and acyl derivatives thereof, and compositions which contain at least one of these compounds. The...
4	7271258	Methods of synthesizing oligonucleotides using carbonate protecting groups and alpha-effect nucleophile deprotection The invention provides methods for synthesizing oligonucleotides using nucleoside monomers having carbonate protected hydroxyl groups that are deprotected with α-effect nucleophiles. The α-effect...
5	7179896	Method of making PNA oligomers This application relates to monomers of the general formula (I) for the preparation of PNA (peptide nucleic acid) oligomers and provides method for the synthesis of both predefined sequence PNA...
6	7101993	Oligonucleotides containing 2′-O-modified purines Compounds are provided containing purine nucleotides that bear moieties X at the 2′ position thereof wherein X is R 1 —(R 2 ) n ; R 1 is C 3 -C 20 alkyl, C 4 -C 20 alkenyl or C 2 -C 20 ...
7	7101992	Nucleic acid base pair A novel artificial nucleic acid base pair which is obtained by forming a selective base pair by introducing a group having steric hindrance (preferably a group having steric hindrance and static...
8	6972330	Chemical synthesis of methoxy nucleosides Process for chemical synthesis of methoxy nucleosides.
9	6924271	3-β-D-ribofuranosylthiazolo[4-5-d]pyridimine nucleosides and uses thereof The invention is directed to 3-β-D-ribofuranosylthiazolo[4,5-d]pyridimine nucleosides and pharmaceutical compositions containing such compounds that have immunomodulatory activity. The invention...
10	6914138	Urea nucleosides as therapeutic and diagnostic agents Modified nucleosides and methods of making and using the nucleosides are disclosed. The compounds can be prepared by reacting nucleoside starting materials that contain a suitable leaving group at...
11	6914061	4′-thio-L-xylofuranosyl nucleosides, precursors thereof, preparation and use thereof Compounds represented by the formula 1: A is selected from the group consisting of wherein each R individually is H or acyl, Y is X, N 3 , NH 2 , monoalkylamino, or dialkylamino; Z...
12	6884880	Process for the preparation of 9-β-anomeric nucleoside analogs A process for substantially enhancing the regio and stereoselective synthesis of 9-β-anomeric nucleoside analogs is described. The introduction of the sugar moiety onto a 6-substituted purine base...
13	6762170	2-(purin-9-yl)-tetrahydrofuran-3,4-diol derivatives There are provided according to the invention, novel compounds of formula (I) wherein R 1 , R 2 and R 3 are as described in the specification, processes for preparing them, formulations...
14	RE38416	Cross-linking oligonucleotides This invention is directed to novel substituted nucleotide bases with a crosslinking arm which accomplish crosslinking between specific sites on adjoining strands of oligonucleotides a...
15	6677345	Cyclin dependent kinase inhibitors A range is disclosed of pyrimidine derivatives (I) which can act as inhibitors of cyclin dependent kinases (CDK's) and which thereby can provide useful therapeutic compounds for use in treatment of...
16	6646118	Solid phase synthesis The present invention relates to a support system for solid phase synthesis of oligomers, such as oligonucleotides, wherein the starting compound is bound to the support via a disiloxyl linkage....
17	6593466	Guanidinium functionalized nucleotides and precursors thereof The present invention provides oligomers which are specifically hybridizable with a selected sequence of RNA or DNA wherein at least one of the nucleoside moieties of the oligomer is modified to...
18	6579976	Process for producing 2′,3′-diethyl substituted nucleoside derivatives There can be provided an excellent industrial process for producing compounds having sugar-moiety hydroxyl groups or halogen atoms reduced in nucleic acids or in derivatives thereof by allowing...
19	6555676	Biologically active phosphotriester-type compounds Compounds of formula RS—P(═O)(QR)—Nu where: R is a radical —(CH 2 )n—W—X; X is a radical —C(═Z)(Y) or —S—U; Z is O or S; W is O or S; Q is O or S; Y and U are an alkyl, aryl or...
20	RE38090	3′-substituted nucleoside derivative The invention relates to a 3′-substituted nucleoside derivative represented by the following general formula (1): wherein B means a nucleic acid base which may have a substituent, Z represents...
21	6534486	2-(purin-9-yl)-Tetrahydrofuran-3,4-diol derivatives A series of 2-(Purin-9-yl)-tetrahydrofuran-3,4-diol derivatives with broad anti-inflammatory properties which inhibit leukocyte recruitment and activation and which are agonists of the adenosine 2a...
22	6531589	Base protecting groups and synthons for oligonucleotide synthesis The invention provides new methods for synthesizing oligonucleotides that allow for deprotection of the oligonucleotides under more mild conditions than existing methods. The invention further...
23	6506888	2′-O-amino-containing nucleoside analogs and polynucleotides Novel nucleoside or nucleotide analogs comprising 2′-O-amino residues, processes for their synthesis and incorporation into polynucleotides.
24	6504024	Propargylethoxyamino nucleotide primer extensions Propargylethoxyamino nucleosides are disclosed having the structure wherein R 1 and R 2 are —H, lower alkyl, or label; B is a 7-deazapurine, purine, or pyrimidine nucleoside base; W 1 is...
25	6498241	2-deoxy-isoguanosines isosteric analogues and isoguanosine derivatives as well as their synthesis 2′-Deoxyisoguanosine, isosteric analogues and isoguanosine derivatives of formulae I-V, processes for their production via compounds of the general formulae a or b and reaction with aroyl...
26	6498149	Natural antitumor or antiviral substances and use of the same The present invention provides substances having an efficacy against tumors and viruses on which the conventional anti-tumor agents and anti-virus agents exhibit only insufficient effects, and...
27	6495528	2-(Purin -9-yl)-tetrahydrofuran-3,4-diol derivatives A series of 2-(Purin-9-yl)-tetrahydrofuran-3,4-diol derivatives with broad anti-inflammatory properties which inhibit leukocyte recruitment and activation and which are agonists of the adenosine 2...
28	6455690	L-8-oxo-7-propyl-7,8-dihydro-(9H)-guanosine Novel nucleosides having the structure of Formula 1 and Formula 2 are contemplated. In one aspect of the invention, controlled release dosage forms are particularly contemplated. Further,...
29	6414137	Selective solvent extraction for the purification of protected nucleosides A process for the purification of nucleosides, and more particularly to a selective solvent extraction method for purifying protected nucleosides. In the purification process, solid particles of...
30	6355787	Purine nucleoside modifications by palladium catalyzed methods and compounds produced This invention discloses a method for the preparation of 2′-modified nucleosides, using a palladium catalyst and an alkene functionalized with a heteroatom. Included in the invention are the...
31	6333315	4'-C-ethynyl purine nucleoside compounds The invention provides 4'-C-ethynyl purine nucleosides represented by formula [I]: ##STR1## wherein B represents a base selected from the group consisting of purine and derivatives thereof; X...
32	6320040	4-desmethyl nucleoside analogs and oligomers thereof Tetrahydrofuranyl compounds are provided that are functionalized to include pendant conjugate groups, and which are useful in diagnosis assays and as research reagents. Novel intermediates for the...
33	6274725	Activators for oligonucleotide synthesis The present invention relates to improved methods for the preparation of nucleoside phosphoramidites and oligonucleotides. In one aspect, the methods of the invention are used to prepare...
34	6271358	RNA targeted 2'-modified oligonucleotides that are conformationally preorganized 2'-O-modified ribosyl nucleosides and modified oligonucleotides containing such nucleotides are disclosed. Oligonucleotides are disclosed that have increased binding affinity as shown by molecular...
35	6265558	Thiol-derivatized nucleosides and oligonucleosides Nucleosides and linked nucleosides functionalized to include alkylthiol chemical functionality at ribofuranosyl positions, nucleosidic base positions, or on internucleoside linkages. In certain...
36	6262254	8-fluoropurine compounds An efficient, regiocontrolled approach to the synthesis of 8-fluoropurines by direct fluorination of purines with dilute elemental fluorine, or acetyl hypofluorite, is provided. In a preferred...
37	6194390	Procedure to block the replication of reverse transcriptase dependent viruses by the use of inhibitors of deoxynucleotides synthesis A method for inhibiting replication of reverse transcriptase dependent virus in plant or animal cells, comprising the step of administering to said cells a compound that depletes the intracellular...
38	6187914	Nucleoside derivatives, and their use in oligonucleotide synthesis The invention relates to nucleoside derivatives bearing electrolabile protector groupings and their use in an oligonucleotide synthesis method comprising at least one step of electronic deprotection.
39	6172209	Aminooxy-modified oligonucleotides and methods for making same Oligonucleotides and other macromolecules are provided which have increased nuclease resistance, substituent groups (such as 2'-aminooxy groups) for increasing binding affinity to complementary...
40	6166199	N-2 substituted purines This invention presents novel purine-based compounds for inclusion into oligonucleotides. The compounds of the invention, when incorporated into oligonucleotides are especially useful as...
41	6153594	5'-O-acylated antiviral nucleosides A monoester compound of formula I: Nu--O--Fa wherein O is oxygen, Nu is a nucleoside analog, Fa is an acyl group of a mono-unsaturated C18 or C20 omega-9 fatty acid, which fatty acid is...
42	6147200	2'-O-acetamido modified monomers and oligomers Nucleosidic monomers and oligomeric compounds prepared therefrom are provided. Also provided is a novel method of deprotection of oligomeric compounds. Oligomeric compounds having at least one...
43	6133438	Process for the preparation of 2'-O-alkyl purine phosphoramidites Processes for preparing 2'-O-alkylated guanosine, uridine, cytidine, and 2,6-diaminopurine 3'-O-phosphoramidites include the steps of alkylating nucleoside precursors, adding suitable blocking...
44	6127533	2'-O-aminooxy-modified oligonucleotides Nucleotide compositions containing aminooxy moieties are provided. In accordance with preferred embodiments, oligonucleotides and oligonucleotide analogs are provided which are specifically...
45	6121431	Nucleoside derivatives
46	6117988	Nucleotides and oligonucleotides preparable therefrom Analogues of RNA and DNA compounds contain a neutral, stereoregular linking group based on replacement of the phosphoryl with a sulfonyl group. Precursors to the analogues are also described, as...
47	6096724	Pyrimidine derivatives and guanine derivatives, and their use in treating tumor cells The present invention provides certain 6-hetarylalkyloxy pyrimidine derivatives of formula II ##STR1## wherein R is (i) a cyclic group having at least one 5- or 6-membered heterocyclic ring,...
48	6054442	Methods and compositions for modulation and inhibition of telomerase in vitro It was found that normal human stem cells produce a regulated non-processive telomerase activity, while cancer cells produce a processive telomerase activity. Nucleotide analogs, such as...
49	6043228	O.sup.6 -substituted guanine derivatives, a process for their preparation and their use in treating tumor cells O 6 -hetarylalkyl- or naphthylalkylguanine derivatives of the formula ##STR1## wherein Y is H, ribosyl, deoxyribosyl, or R"XCHR', wherein X is O or S, R" and R"' are alkyl, or substituted...
50	6001817	Pharmaceutical composition comprised of cisplatin, and processes for making and using same A pharmaceutical composition, comprising cisplatin, a special carrier and, optionally, customary pharmaceutical excipients, is disclosed. The preparation of this pharmaceutical composition is also...

Matches 1 - 50 out of 182

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