Patents in Class 536/27.3

Matches 1 - 50 out of 107

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Match	Document	Document Title
1	8183224	Purine derivatives as adenosine A1 receptor agonists and methods of use thereof The invention relates to Purine Derivatives; compositions comprising an effective amount of a Purine Derivative; and methods for reducing an animal's rate of metabolism, protecting an animal's...
2	8183225	Inhibition of bone resorption using medical implants containing adenosine receptor antagonists The invention provides methods and compositions for reducing or inhibiting bone resorption, osteoclast differentiation and stimulation and the loosening of medical prostheses by administering a...
3	8178509	Method to treat sickle cell disease The present invention provides a therapeutic method for treating an inflammatory response caused by a sickle cell crisis, comprising administration of an effective amount of an A2A adenosine...
4	8168766	Process of making 2-deoxy-2,2-difluoro-D-ribofuranosyl nucleosides and intermediates therefor A compound of formula (A) or salt thereof: wherein each of R1, R2, and R3 independently represents hydrogen, alkyl, aryl, acyl, sulfonyl, or silyl; P represents hydrogen or a hydroxy protective...
5	8153781	Dendrimer conjugates of agonists and antagonists of the GPCR superfamily Disclosed are conjugates comprising a dendrimer and a ligand, which is a functionalized congener of an agonist or antagonist of a receptor of the G-protein coupled receptor (GPCR) superfamily, for...
6	7947824	Process for preparing purine nucleosides The present invention for the stereoselective preparation of 2-deoxy-β-D-adenine nucleosides wherein a blocked 2-deoxy-α-D-arabinofuranosyl halide is coupled with the salt of an adenine derivative.
7	7943760	Non-nucleotide composition for inhibiting platelet aggregation This invention is directed to a method of preventing or treating diseases or conditions associated with platelet aggregation. The method is also directed to a method of treating thrombosis or...
8	7897759	Metabolically stable puromycin analogs Disclosed are structurally modified, metabolically stable nucleosides having antitumor activity wherein the formation of toxic metabolites is blocked and antimicrobial activity. The disclosure...
9	7868163	Adenyl dinucleotides with antitumour activity and a method of preparing thereof The invention relates to novel adenyl dinucleotides which are isomers of the dinucleotide Ap2A, having formulae (I) and (II). The dinucleotides of the invention have antitumour activity,...
10	7820637	Use of 5′-methylthioadenosine (MTA) in the prevention and/or treatment of autoimmune diseases and/or transplant rejection 5′-methylthioadenosine (MTA), its pharmaceutically acceptable salts and/or prodrugs may be used in the prevention and/or treatment of autoimmune diseases, such as, for example, Multiple Sclerosis (...
11	7795236	Purine nucleoside derivative modified in 8-position and medical use thereof The present invention provides an 8-modified purinenucleoside derivative which is useful for diseases associated with an abnormality of plasma uric acid level. An 8-modified purinenucleoside...
12	7792576	Method of treatment for central nervous system injury Injuries to the central nervous system, particularly spinal cord injuries, are treated by administering a purine nucleoside or analog to the patient and, optionally, electrically stimulating the...
13	7737127	2-propynyl adenosine analogs having A2A agonist activity and compositions thereof The invention provides compounds having the following general formula (I): wherein X, R1, R2, R7 and Z are as described here.
14	7696181	Partial and full agonists of A1 adenosine receptors Disclosed are novel compounds that are partial and full A1 adenosine receptor agonists, useful for treating various disease states, in particular tachycardia and atrial flutter, angina, myocardial...
15	7605143	2-propynyl adenosine analogs with modified 5′-ribose groups having A2A agonist activity The invention provides compounds having the following general formula (I): wherein X, R1, R2, R7 and Z are as described herein.
16	7553823	C-pyrazole A2A receptor agonists 2-adenosine C-pyrazole compounds having formula (a) and methods for using the compounds as A2A receptor agonists to stimulate mammalian coronary vasodilatation for therapeutic purposes and for...
17	7550442	Nucleoside analog inhibitors of reverse transcriptase Compounds of formula (XXIII), or pharmaceutically acceptable salts or esters thereof, are inhibitors of reverse transcriptase: R4 is a nucleoside with Q substituting a 3′ hydroxyl group, and Q is a...
18	7528247	Process for preparing purine nucleosides The present invention for the stereoselective preparation of 2-deoxy-β-D-adenine nucleosides wherein a blocked 2-deoxy-α-D-arabinofuranosyl halide is coupled with the salt of an adenine derivative.
19	7514417	A1 adenosine receptor agonists Disclosed are novel compounds that are partial and full A1 adenosine receptor agonists having the structure of Formula I: which are useful for treating various disease states, in particular...
20	7504497	Orally bioavailable compounds and methods for inhibiting platelet aggregation This invention is directed to a method of preventing or treating diseases or conditions associated with platelet aggregation. The method is also directed to a method of treating thrombosis or...
21	7485717	Synthesis of protected 3′-amino nucleoside monomers Orthogonally protected 3′-amino nucleoside monomers and efficient methods for their synthesis are described. The methods employ selective protection of the 3′-amino group in the presence of the unp...
22	7465544	Synthetic cofactor analogs of S-adenosylmethionine as ligatable probes of biological methylation and methods for their use The present invention discloses compounds and methods used to specifically target substrates of methylation by S-adenosyl-L-methionine (SAM)-dependent methyltransferases. The substrates can be...
23	7300923	Partial and full agonists of A1 adenosine receptors Disclosed are syntheses suitable for large scale manufacture of novel compounds that are partial and full A1 adenosine receptor agonists, useful for treating various disease states, in particular...
24	7297787	Process for preparing N6 substituted aminopurine ribofuranose nucleosides An improved process for preparing N6 -substituted aminopurine ribofuranose nucleosides. Compounds of this type are known to be usefull in the prepartation of compounds having activitity at...
25	7294486	Enzymatic process for the synthesis of organo-fluorine compounds There is described a process for the synthesis of a fluoronucleoside compound, said process comprising mixing a substrate and an enzyme from Streptomyces cattelya as catalyst. The process may be...
26	7265111	Adenosine analogues and their use as pharmaceutical agents The present invention relates to compounds according to the general formula (I) wherein X is selected from the group consisting of wherein n and p are independently 0, 1, 2, or 3, provided that n+p...
27	7262176	Adenosine A3 receptor agonists Disclosed are novel compounds that are A3 adenosine receptor agonists, useful for treating various disease states, including cancer, cardiac ischemia, leukopenia, and neutropennia.
28	7217815	2-beta -modified-6-substituted adenosine analogs and their use as antiviral agents Various 2′-beta-methyl-6-substituted adenosine analogs (including 2,6-disubstituted adenosine, 8-aza-6-substituted adenosine, and 2-aza-6-substituted adenosine) are prepared by conventional and c...
29	7179896	Method of making PNA oligomers This application relates to monomers of the general formula (I) for the preparation of PNA (peptide nucleic acid) oligomers and provides method for the synthesis of both predefined sequence PNA...
30	7157440	Partial and full agonists of A1 adenosine receptors Disclosed are novel compounds that are partial and full A1 adenosine receptor agonists, useful for treating various disease states, in particular tachycardia and atrial flutter, angina, and...
31	7148042	Method of preparing a guanosine-group compound and an intermediate thereof A glyoxal-guanosine-group compound is prepared either by reacting glyoxal-guanine with any one of ribose-1-phosphate and 2-deoxyribose-1-phosphate in the presence of purine nucleoside...
32	7094769	2-aminocarbonyl-9H-purine derivatives The present invention relates to compounds of the formula: and pharmaceutically acceptable salts and solvates thereof, and to processes for the preparation of, intermediates used in the preparation...
33	7084127	C2,5′-disubstituted and N6, C2,5′-trisubstituted adenosine derivatives and their different uses The present invention concerns novel C2,5′-disubstituted and N6′,C2,5′-trisubstituted adenosine derivatives and their different uses. These adenosine derivatives were found to be potent adeno...
34	7022727	Crystalline drug form The present invention relates to a crystalline form of...
35	6914138	Urea nucleosides as therapeutic and diagnostic agents Modified nucleosides and methods of making and using the nucleosides are disclosed. The compounds can be prepared by reacting nucleoside starting materials that contain a suitable leaving group at...
36	6903079	Nucleoside compounds and compositions thereof The invention provides a novel class of substituted nucleoside derivatives having the formula: A-Z1-L-Z2-G wherein: A and G are connected via Z1 and Z2 respectively, to a linker, L; and A is:...
37	6884880	Process for the preparation of 9-β-anomeric nucleoside analogs A process for substantially enhancing the regio and stereoselective synthesis of 9-β-anomeric nucleoside analogs is described. The introduction of the sugar moiety onto a 6-substituted purine base ...
38	6759395	Soft-gelatin capsule comprising S-adenosylmethionine and a method for producing the same The invention provides a novel soft gelatin capsule comprising a fill material consisting essentially of S-adenosylmethionine (SAMe) salt disposed within an enteric coated soft gelatin film.
39	6740644	Chemical compounds A compound of formula (I), wherein R2 represents C1-3alkyl, halogen or hydrogen; R3 represents straight or branched alkyl group of 1-6 carbon atoms; with the proviso that, when R3 represents...
40	6713623	Tetraphosphonate bicyclic trisanhydrides Disclosed are novel bicyclic tris(anhydride)s useful as intermediates in the synthesis of biologically active compounds, and the compounds which may be synthesized from such intermediates.
41	6686463	Methods for synthesizing nucleosides, nucleoside derivatives and non-nucleoside derivatives The present invention provides methods for the chemical synthesis of nucleosides and derivatives thereof, including 2′-amino, 2′-N-phthaloyl, 2′-O-methyl, 2′-O-silyl, 2′-OH nucleosides, C-nucleos...
42	6677316	Adenosine derivatives and methods of administration A method of treating a patient suffering from or susceptible to ischemic heart disease, peripheral vascular disease or stroke or which subject is suffering pain, a CNS disorder or sleep apnea which...
43	6664388	Reagents for oligonucleotide cleavage and deprotection The present invention provides a process for the removal of protecting groups, i.e. deprotection, from chemically synthesized oligonucleotides. In one embodiment, the invention provides reagents...
44	6649753	Stable salts of S-adenosyl-L-methionine (SAMe) and the process for their preparation This invention relates to the production of new & stable salts of S-adenosyl-L-methionine SAMe). The source of SAMe used in the salt formation is from chemical process wherein stereoselective...
45	6635615	Stable salts of S-adenosyl-l-methionine Stable salts of S-adenosyl-1-methionine with polycations such as chitosan are described. The salts according to the invention are very stable and are valuable for use as active constituents in...
46	6610520	Gene encoding human manganese superoxide dismutase and recombinant polypeptide encoded thereby A double-stranded cDNA molecule which includes DNA encoding human manganese superoxide dismutase has been created. The sequence of one strand of a double-stranded DNA molecule which encodes human...
47	6605597	Partial or full A1agonists-N-6 heterocyclic 5′-thio substituted adenosine derivatives N6 heterocyclic 5′ modified adenosine derivatives that are adenosine A1 receptor partial or full agonists, and as such, are useful for modifying cardiac activity, modifying adipocyte function, t...
48	6545134	Method for the production of pentopyranosyl nucleosides Processes for the preparation of 3′,4′-cyclic acetals of pentopyranosylnucleosides, in which the pentopyranosyl nucleoside is reacted with an aldehyde, ketone, acetal, or ketal under reduced pre...
49	6492348	Adenosine derivatives A compound of formula (I) which is an agonist at the adenosine Al receptor, wherein Y, Z, and W represent heteroatoms, and salts and solvates thereof, in particular, physiologically acceptable...
50	6455510	Chemical Compounds A compound of formula (I) which is an agonist at the adenosine A1 receptor wherein R2 represents C1-3alkyl, halogen or hydrogen; R3 represents a fluorinated straight or branched alkyl group of 1-6...

Matches 1 - 50 out of 107

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