Patents in Class 536/27.1

Matches 1 - 50 out of 181

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Match	Document	Document Title
1	8183216	Nucleoside derivatives as inhibitors of viral polymerases A class of nucleoside derivatives of formula (I), as defined herein, that are useful as inhibitors of RNA-dependent RNA viral replication and in particular HCV replication, are provided. Also...
2	8173620	BHQ-caged nucleotide probes photolysable by two-photon excitation The disclosure encompasses caged compounds such as caged nucleoside phosphoesters (caged nucleotides). In an embodiment, the caged nucleotides include compounds corresponding to those described by...
3	8163707	4′-allene-substituted nucleoside derivatives The present invention discloses compounds of formula (I), or its β-L enantiomer, or a pharmaceutically acceptable salt, ester, stereoisomer, tautomer, solvate, prodrug, or combination thereof: ...
4	8153781	Dendrimer conjugates of agonists and antagonists of the GPCR superfamily Disclosed are conjugates comprising a dendrimer and a ligand, which is a functionalized congener of an agonist or antagonist of a receptor of the G-protein coupled receptor (GPCR) superfamily, for...
5	8114986	Analogous compounds of 6-thioguanosine triphosphate, their use in medical fields and processes for their preparation The invention relates to analogous compounds of 6-thioguanosine triphosphate of general formula (I). A compound of the general formula (I); wherein the dashed bond in the sugar moiety can be either...
6	8101740	Positron emission tomography probes for imaging immune activation and selected cancers Compounds for use as PET probes and methods for synthesizing and using these, comprising [18F]D-FAC and other cytosine and adenosine analogs.
7	8093226	Cytostatic 7-deazapurine nucleosides The invention provides compounds of formula I: wherein R1 and R2 have any of the values defined in the specification and salts thereof, as well as compositions comprising such compounds and...
8	8034767	Method for producing purine nucleosides and nucleotides by fermentation using a bacterium belonging to the genus Escherichia or Bacillus A method is provided for producing a purine nucleoside, such as inosine and guanosine, and a method for producing a 5′-purine nucleotide such as 5′-inosinic acid or 5′-guanylic acid, using a bacte...
9	8034924	Process for production of crystal of purine nucleoside compound Crystals of a purine nucleoside compound, particularly crystals of 2′,3′-dideoxyinosine, which have excellent storage stability and have a concentration of phosphate attached to the crystal of 25 ...
10	8030478	Method for nucleic acid replication and novel artificial base pairs The present invention relates to a method for nucleic acid replication and novel artificial base pairs. The method of the present invention for nucleic acid replication is characterized in that a...
11	7999098	Triphosphate oligonucleotide modification reagents and uses thereof Hydrazino, oxyamino and carbonyl-based monomers and methods for incorporation into oligonucleotides during enzymatic synthesis are provided. Modified oligonucleotides are provided that incorporate...
12	7989430	Antibacterial agents The invention provides compounds of formula (I) and salts thereof: R1-L-R2—B wherein R1, L, R2, and B have any of the values defined herein, as well as compositions comprising such compounds, and t...
13	7989422	Antibacterial agents The present invention, in one aspect, provides a method of inhibiting bacterial growth by contacting bacteria with an effective amount of at least one monosaccharide compound of formula (1) as...
14	7960526	Colorimetric-oxycarbonyl protecting groups for use in organic syntheses The present invention provides for reagents for the introduction of colorimetric-oxycarbonyl protecting groups, compounds bearing colorimetric-oxycarbonyl protecting groups, and the use thereof in...
15	7947824	Process for preparing purine nucleosides The present invention for the stereoselective preparation of 2-deoxy-β-D-adenine nucleosides wherein a blocked 2-deoxy-α-D-arabinofuranosyl halide is coupled with the salt of an adenine derivative.
16	7935674	Indole derivatives Novel indole derivatives of formula (I) or a pharmaceutically acceptable salt thereof: wherein R1 is halogen, or alkyl, R2 is hydrogen, or halogen, Ar is phenyl, or thienyl, which may be...
17	7928210	Nucleoside based proliferation imaging markers Disclosed herein are novel radiolabeled nucleosides and methods for detecting cellular proliferation in a mammal, the method comprising administrating an effective amount of a radiolabeled...
18	7897759	Metabolically stable puromycin analogs Disclosed are structurally modified, metabolically stable nucleosides having antitumor activity wherein the formation of toxic metabolites is blocked and antimicrobial activity. The disclosure...
19	7863438	Stable salt of 3′-phosphoadenosine 5′-phosphosulfate The present invention provides a stable salt of 3′-phosphoadenosine 5′-phosphosulfate (PAPS) and a production method therefor. The present invention is directed to a stable salt of PAPS (amine sal...
20	7824851	2′-branched nucleosides and Flaviviridae mutation The present invention discloses a method for the treatment of Flaviviridae infection that includes the administration of a 2′-branched nucleoside, or a pharmaceutically acceptable prodrug and/or s...
21	7816513	Inosine derivatives and production methods therefor The present invention provides a method for producing an inosine derivative represented by the following general formula (1) including the steps of subjecting an inosine derivative of general...
22	7781576	Process for preparing a synthetic intermediate for preparation of branched nucleosides A process is provided for the preparation of a key intermediate in the preparation of 2′-branched nucleoside compounds. The process includes contacting a protected precursor 3...
23	7745591	Phosphinoamidite carboxylates and analogs thereof in the synthesis of oligonucleotides having reduced internucleotide charge Nucleoside phosphinoamidite carboxylates and analogs are provided that have the structure of formula (III) wherein A is hydrogen, hydroxyl, lower alkoxy, lower alkoxy-substituted lower alkoxy,...
24	7723512	Oligonucleotides comprising a non-phosphate backbone linkage One aspect of the present invention relates to a ribonucleoside substituted with a phosphonamidite group at the 3′-position. In certain embodiments, the phosphonamidite is an alkyl p...
25	7713941	Tricyclic nucleosides or nucleotides as therapeutic agents Nucelosides and nucleotides containing a tricyclic base portion thereof are useful for treating infectious diseases and proliferative disorders, such as viral infections or cancer respectively.
26	7709448	Prodrugs of 5-amino-3-(3′-deoxy-β-D-ribofuranosyl)-thiazolo[4,5-d]pyrimidin-2,7-dione The invention is directed to 5-amino-3-(3′-deoxy-β-D-ribofuranosyl)-thiazolo[4,5-d]pyr imidin-2,7-dione prodrugs, whose metabolized parent compound has immunomodulatory activity. The invention al...
27	7632821	Ribonucleoside cyclic acetal derivatives for the treatment of RNA-dependent RNA viral infection The present invention provides ribonucleoside 2′,3′-cyclic acetals of structural formula I which are precursors or prodrugs of inhibitors of RNA-dependent RNA viral polymerase. These compounds are...
28	7615628	Imidazopyridine derivatives The present invention relates to a novel imidazo[4,5-b]pyridine derivative compound represented by Formula (I) and a pharmaceutically acceptable salt thereof. The present invention also relates to...
29	7615619	Nucleoside analogues and oligonucleotide derivative comprising nucleotide analogue thereof A nucleotide analogue compound represented by formula (1) and salts thereof. In formula (1), A represents a direct bond, C1-4 alkylene, etc.; B represents an optionally substituted aromatic...
30	7598361	Nucleic acid molecules and other molecules associated with the sucrose pathway The present invention is in the field of plant biochemistry. More specifically the invention relates to nucleic acid sequences from plant cells, in particular, nucleic acid sequences from maize and...
31	7563886	Nucleoside releasing functional unit through oxidation and process for producing oligonucleotide containing thereof A method of easily releasing a useful substance bonded to oligonucleotide without impairing a target nucleic acid; and a novel base therefore. A nucleoside of nucleotide (oligonucleotide containing...
32	7563887	Universal nucleobase analogs This invention relates to the field of nucleic acid chemistry, more specifically to the field of compositions and processes that can bind to nucleic acids, including compositions and processes that...
33	7547776	Process for the production of fludarabine-phosphate lithium, sodium, potassium, calcium and magnesium salts and purification process for the production of fludarabine-phosphate and fludarabine-phosphate with a purity of at least 99.5% The present invention generally relates to a fludarabine-phosphate with a purity of at least 99.5%.
34	7534771	Tricyclic-nucleoside prodrugs for treating viral infections Disclosed are compounds, compositions and methods for treating viral infections caused by a Flaviviridae family virus, such as hepatitis C virus.
35	7528247	Process for preparing purine nucleosides The present invention for the stereoselective preparation of 2-deoxy-β-D-adenine nucleosides wherein a blocked 2-deoxy-α-D-arabinofuranosyl halide is coupled with the salt of an adenine derivative.
36	7528115	Carbonate and carbamate prodrugs of thiazolo[4,5-d]pyrimidines The invention is directed to carbonate and carbamate prodrugs of thiazolo[4,5-d]pyrimidine compounds, whose metabolized parent compound has immunomodulatory activity. The invention also relates to...
37	7524825	Tricyclic-nucleoside compounds for treating viral infections Disclosed are compounds represented by formulae I, II, and III, and the compositions and methods thereof for treating viral infections caused by a Flaviviridae family virus.
38	7511133	Adenosine A3 receptor agonists The compounds of the following formula: wherein Ar, R and R1 have the meanings given in the specification. This series of sulfonamido derivatives with a conserved uronamide group at the 5′ p...
39	7495095	Thionucleoside-S-nitrosyl derivative The present invention provides a thionucleoside-S-nitrosyl derivative of the following Formula I or a salt thereof: [wherein R1 represents ribose, 2-deoxyribose or a derivative of either, and R2...
40	7470784	Methods for synthesizing 2-chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-9H-purin-6-amine 2-Chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-9H-purin -6-amine is synthesized by reacting a 2-chloro-6-substituted purine with a protected and activated 2-deoxy-2-fluoro-D-arabinofiranose; ...
41	7439351	2′ or 3′ -deoxy and 2′, 3′-dideoxy-β-L-pentofuranonucleo-side compounds, method of preparation and application in therapy, especially as anti-viral agents Method for the sterospecific preparation of 2′ or 3′ deoxy and 2′,3′-dideoxy-β-L-pentafuranonucleoside compounds. 2′ or 3′ deoxy and 2′,3′-dideoxy-β-L-pentofuranonucleoside compounds are als...
42	7432272	Antiviral analogs The application relates to 4′-substituted nucleoside derivatives of Formula I: wherein B and R1 have any of the values described in the application, as well as to compositions comprising such c...
43	7405204	Nucleoside compounds for treating viral infections Disclosed are compounds, compositions and methods for treating viral infections caused by a Flaviviridae family virus, such as hepatitis C virus.
44	7399754	N2-quinoline or isoquinoline substituted purine derivatives Novel compound having the following formula: wherein W represents a hydrogen, an optionally substituted C1-6 alkyl, an optionally substituted C3-6 cycloalkyl, or an optionally substituted C1-6...
45	7393954	Process for the production of pentostatin aglycone and pentostatin A novel, scaleable and improved process for preparing pentostatin and its analogs is disclosed. The method comprises the diastereospecific synthesis of the nucleobase from commercially available...
46	7371737	2-substituted-6-trifluoromethyl purine derivatives with adenosine-A3 antagonistic activity The present invention relates to 2-substituted-6-trifluoromethyl purine derivatives as selective adenosine antagonists, in particular adenosine-A3 receptor antagonists, to methods for the...
47	7321033	3-B-D-ribofuranosylthiazolo [4,5-d] pyrimidine nucleosides and uses thereof The invention is directed to 3-β-D-ribofuranosylthiazolo[4,5-d]pyridimine nucleosides and pharmaceutical compositions containing such compounds that have immunomodulatory activity. The invention ...
48	7294486	Enzymatic process for the synthesis of organo-fluorine compounds There is described a process for the synthesis of a fluoronucleoside compound, said process comprising mixing a substrate and an enzyme from Streptomyces cattelya as catalyst. The process may be...
49	7282581	Oligonucleotide labeling reactants based on acyclonucleosides and conjugates derived thereof The invention relates to a labeling reactant of formula (I) useful for labeling an oligonucleotide wherein: R is a temporary protecting group. A is either a phosphorylating moiety or a solid...
50	7268119	Tricyclic nucleosides or nucleotides as therapeutic agents Nucleosides and nucleotides containing a tricyclic base portion thereof are useful for treating infectious diseases and proliferative disorders, such as viral infections or cancer respectively.

Matches 1 - 50 out of 181

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