Patents in Class 536/26.6

Matches 1 - 50 out of 402

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Match	Document	Document Title
1	8183355	Method for the synthesis of oligonucleotide derivatives Method for the synthesis of nucleotide derivatives wherein molecules of interest are grafted on the oligonucleotide with the help of a “click chemistry” reaction between an azide function on the...
2	8178360	Dye compounds and the use of their labelled conjugates Novel rhodamine dye compounds, labelled conjugates comprising the dyes are described, together with methods for their use. The dyes and labelled conjugates are useful as molecular probes in a...
3	8158346	Labelled nucleotides Nucleosides and nucleotides are disclosed that are linked to detectable labels via a cleavable linker group.
4	8153780	Reporter unit for detection of target molecules using polymerisable substrate The invention relates to a reporter unit for detecting a target molecule comprising at least one component attached to a target molecule specific probe, wherein said at least one component is...
5	8148516	Flowcell systems for single molecule detection The present invention provides compounds, methods and systems for sequencing nucleic acid using single molecule detection. Using labeled NPs that exhibit charge-switching behavior, single-molecule...
6	8148515	Detection using a dye and a dye modifier The present invention relates to dyes in general. The present invention provides a wide range of dyes and kits containing the same, which are applicable for labeling a variety of biomolecules such...
7	8148064	Labelled nucleotides Nucleosides and nucleotides are disclosed that are linked to detectable labels via a cleavable linker group.
8	8133701	Detection and quantification of biomolecules using mass spectrometry The present invention is directed in part to a method for detecting a target nucleic acid using detector oligonucleotides detectable by mass spectrometry. This method uses the 5′ to 3′ nuclease act...
9	8133669	Chemically modified nucleoside 5′-triphosphates for thermally initiated amplification of nucleic acid Provided herein are methods and compositions for nucleic acid replication. These methods involve the use of 3′-substituted nucleoside 5′-triphosphates or 3′-substituted terminated primers in nucle...
10	8129529	UV excitable fluorescent energy transfer dyes Novel energy transfer dyes which can be used with shorter wavelength light sources are provided. These dyes include a donor dye with an absorption maxima at a wavelength between about 250 to 450 nm...
11	8129106	Sequence-specific detection of methylation in biomolecules A method for detecting sequence specific methylation in a biomolecule, comprising: (a) contacting the biomolecule with an S-adenosyl-L-methionine-dependent methyltransferase in the presence of a...
12	8129509	Method for single-step attachment of a label to target molecules Compounds and methods are provided for a single-step covalent attachment of a label to a molecule comprising forming a covalently attachable labeling reagent for alkylating the molecule. Then,...
13	8124333	Methods for covalent linking of optical reporters A method to link a light emitting reporter to biomolecules with nucleotide oligomers is described. The light reporter particles are silylated and functionalized to produce a coated light reporter...
14	8114636	Labeling and detection of nucleic acids Provided in certain embodiments are new methods for forming azido modified nucleic acid conjugates of reporter molecules, carrier molecules or solid support. In other embodiments are provided...
15	8114973	Nucleotide analogs The invention provides for nucleotide analogs and methods of using the same, e.g., for sequencing nucleic acids.
16	8110554	Peptides whose uptake by cells is controllable A generic structure for the peptides of the present invention includes A-X-B-C, where C is a cargo moiety, the B portion includes basic amino acids, X is a cleavable linker sequence, and the A...
17	8105770	Method of detecting amplification or deletion in genomic DNA Fragment [PROBLEMS] To provide a CGH method, in particular a CGH microarray method, enabling detection at an elevated accuracy and elevated sensitivity. [MEANS FOR SOLVING PROBLEMS] A method which...
18	8101416	Compositions for detection and analysis of polynucleotides using light harvesting multichromophores Methods, compositions and articles of manufacture for assaying a sample for a target polynucleotide are provided. A sample suspected of containing the target polynucleotide is contacted with a...
19	RE43096	Tagged extendable primers and extension products This invention provides a duplex comprising an oligonucleotide primer and a template, wherein the primer is coupled chemically to a chromophore or fluorophore so as to allow chain extension by a...
20	RE43097	Massively parallel signature sequencing by ligation of encoded adaptors The invention provides a method of nucleic acid sequence analysis based on the ligation of one or more sets of encoded adaptors to the terminus of a target polynucleotide. Encoded adaptors whose...
21	8093367	Preparation and isolation of 5′ capped mRNA The synthesis of capped/tagged RNA, methods of use and kits providing same are contemplated. Tagged RNA permits isolation of RNA transcripts in vitro. The ability to isolate and purify capped RNA...
22	8088575	Massive parallel method for decoding DNA and RNA This invention provides methods for attaching a nucleic acid to a solid surface and for sequencing nucleic acid by detecting the identity of each nucleotide analogue after the nucleotide analogue...
23	8084590	Labelled nucleotides The invention provides a nucleotide or nucleoside having a base attached to a detectable label via a cleavable linker, characterised in that the cleavable linker contains a moiety selected from the...
24	8084201	Fluorescent molecule It is an object of the present invention to provide an on-off type fluorescent compound (a fluorescence-producing molecule system) used in gene analyses, which is highly stable (namely, being...
25	8080235	Protein kinase A reporters useful in high throughput assays Protein kinase A reporters useful for obtaining measurements of protein kinase A activity with high spatial and temporal resolution can be used in high throughput assays to identify potentially...
26	8071739	Modified nucleotides The invention provides modified nucleotide or nucleoside molecule comprising a purine or pyrimidine base and a ribose or deoxyribose sugar moiety having a removable 3′-OH blocking group c...
27	8067177	Amplification methods Methods are provided for amplification and monitoring of oligonucleotide amplification in which a primer has an overlap with one or more bases of a detection probe.
28	8067164	Microarray system with improved sequence specificity The invention provides a novel array method for nucleic acid sequence detection with improved specificity which allows for detection of genetic variation, from simple SNPs (where the variation...
29	8067581	Biomolecules having multiple attachment moieties for binding to a substrate surface Compounds relating to attachment chemistries for binding biomolecules to a substrate surface are described. These include compounds of the following structure: The biomolecule includes a single...
30	8063200	Labeled compound and detection method using the same A labeled compound is so designed that an aromatic tertiary amine compound is bondable with a biomolecule. One of S1 and S2 contains a group bound with a molecular chain 10 (e.g. an...
31	8058414	Unnatural polymerase substrates that can sustain enzymatic synthesis of double stranded nucleic acids from a nucleic acid template and methods of use Nucleotide analogs that can sustain the enzymatic synthesis of double-stranded nucleic acid from a nucleic template are described. The nucleotide analogs include: (i) a base selected from the group...
32	8058031	Labeled nucleotide analogs and uses therefor Labeled nucleotide analogs used in place of naturally occurring nucleoside triphosphates or other analogs in template directed nucleic acid synthesis reactions and other nucleic acid reactions, and...
33	8057997	Nucleic acid binding compounds containing pyrazolo[3,4-D]pyrimidine analogues of purin-2,6-diamine and their uses The present invention is in the field of nucleic acid binding compounds comprising 7-substituted 7-deaza-8aza-2,6-diamino-purine bases, compounds useful for the preparation of such compounds,...
34	8053415	Compounds having RD targeting motifs The present invention provides compounds that have motifs that target the compounds to cells that express integrins. In particular, the compounds have peptides with one or more RD motifs conjugated...
35	8053213	Detection of PCR products in gel electrophoresis Disclosed is a method for analyzing nucleic acids in a sample comprising the following steps: (i) adding a DNA binding dye containing a benzothiazolium or benzoxazolium group to the sample to be...
36	8034558	Acridone derivatives as labels for fluorescence detection of target materials Disclosed are new acridone dye derivatives having characteristic fluorescence lifetimes. Also disclosed are methods for labelling target biological materials employing the acridone dyes and use of...
37	8034912	Parallel preparation of high fidelity probes in an array format The present invention provides massively parallel oligonucleotide synthesis and purification for applications that utilize large collections of defined high-fidelity oligonucleotides (e.g., from...
38	8030096	Water-soluble rhodamine dyes conjugates The present invention provides novel, water-soluble, red-emitting fluorescent rhodamine dyes and red-emitting fluorescent energy-transfer dye pairs, as well as labeled conjugates comprising the...
39	8030460	Compounds and methods for labeling oligonucleotides A compound having the general formula shown below: where R1-6 are independently selected from the group consisting of an electron withdrawing group, an alkyl group, an aryl group, hydrogen, a...
40	8030466	3′-o-fluorescently modified nucleotides and uses thereof The present invention relates to a DNA sequencing method using a nucleoside triphosphate with a fluorescent blocking group on its 3′-OH end as a reversible terminator. Further, the present i...
41	8026348	Nucleoside derivative, modified oligonucleotide, method for their synthesis and applications thereof Compositions and methods of preparing carboranes and metallacarboranes, which can be used as a new type of electrochemically active label for biological compounds, are disclosed. Nucleic acid...
42	8022194	2′-nitrobenzyl-modified ribonucleotides This disclosure provides novel reversibly terminated ribonucleotides which can be used as a reagent for DNA sequencing reactions. Methods of sequencing nucleic acids using the disclosed nucleotides...
43	8021839	Methods and compositions for detecting polynucleotides Methods of determining the presence or amount of a target polynucleotide in a sample are provided. A sample that contains a target polynucleotide, a polynucleotide that may include nucleic acid...
44	7999091	5-methylcytosine detection, compositions and methods therefor Compositions and methods for detecting 5-methylcytosine in a nucleic acid are disclosed. A 5-methylcytosine discriminator, which is a deoxyribonucleosidetriphosphate comprising a cytosine-pairing...
45	7985557	Polymeric carriers for immunohistochemistry and in situ hybridization Certain disclosed embodiments of the present invention concern the synthesis, derivatization, conjugation to immunoglobulins and signal amplification based on discrete, relatively short polymers...
46	7982029	Synthesis of four color 3′O-allyl, modified photocleavable fluorescent nucleotides and related methods This invention provides a process for making 3′-O-allyl-dGTP-PC-Biodopy-FL-510, 3′-O-allyl-dATP-PC-ROX, 3′-O-allyl-dCTP-PC-Bodipy-650 and 3′-O-allyl-dUTP-PC-R6G, and related methods.
47	7977057	Detection of immobilized nucleic acid The present invention provides methods for determining the presence of immobilized nucleic acid employing unsymmetrical cyanine dyes that are derivatives of thiazole orange, a staining solution and...
48	7973146	Engineered fluorescent dye labeled nucleotide analogs for DNA sequencing Engineered nucleotide compositions, having polymerase interacting components that improve the interactivity of the polymerase and the nucleotide, particularly for nucleic acid sequencing...
49	7972789	Dye compounds The present disclosure provides compounds that may be used as chromogens, fluorochromes, or as both. Said compounds may further be used as substrate for at least one enzyme, wherein said enzyme is...
50	7972792	Sequence-specific nucleic acid purification method manner Disclosed is a method for the purification and collection of a nucleic acid comprising a specific nucleotide sequence, which can be carried out within an extremely short period and can achieve both...

Matches 1 - 50 out of 402

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