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7851604 |
Transcriptional regulator
Genes each encoding a novel transcriptional regulator having a bromodomain have been successfully isolated from a human testis cDNA library using primers prepared based on an EST sequence found...
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7468432 |
Cobalamin conjugates useful as antitumor agents
The invention provides cobalamin compounds linked to a neutron capture therapy target (e.g. Boron-10 or Gadolinium-157), and optionally linked to a detectable moiety, as well as pharmaceutical...
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7268119 |
Tricyclic nucleosides or nucleotides as therapeutic agents
Nucleosides and nucleotides containing a tricyclic base portion thereof are useful for treating infectious diseases and proliferative disorders, such as viral infections or cancer respectively.
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7220855 |
Process for producing methylcobalamin
The present invention provides a novel industrially excellent and ecological process for producing methylcobalamin which is useful as a medicament etc. More specifically, it provides a process for...
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7045596 |
Family of genes encoding apoptosis-related peptides, peptides encoded thereby and methods of use thereof
An isolated polynucleotide at least 60% homologous to SEQ ID NO: 1, 3, 5 or 18 encoding a SARP polypeptide; vectors comprising a polynucleotide sequence encoding at least 11 consecutive amino acids...
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6657057 |
Process for production of methylcobalamin
The present invention provides an industrially excellent and novel process for producing methylcobalamin useful as medicines. Namely, it provides a process for producing methylcobalamin, which...
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6518418 |
Nucleotide sugars
Phosphite linked nucleotide sugars, e.g. nucleoside-monophosphite-glycosides, are synthesized using phosphoramiditing agents. The success of the synthetic method is largely independent of the...
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6262253 |
Vitamin B12 conjugates with gcsf, analogues thereof and pharmaceutical compositions
The invention describes complexes between VB12 analogues and either GCSF or EPO that retain both significant affinity for intrinsic factor (IF) in the VB12 portion of the complex and significant...
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6187761 |
Production and use of compositions comprising high concentrations of vitamin B12 activity
The present invention provides a process for the preparation of a composition comprising natural vitamin B12, wherein said process comprises the steps of: a) obtaining microbial cells containing...
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6083926 |
Water soluble vitamin B12 receptor modulating agents and methods related thereto
Vitamin B12 receptor modulating agents capable of modulating cell surface receptors by affecting the cell surface receptor trafficking pathway are disclosed. The vitamin B12 receptor modulating...
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5808043 |
Composition for stabilization of labelled nucleoside triphosphates and methods for using same
A preparation of a labelled nucleotide comprising at least one compound having a Mg2+ association constant between 1×10-11 to 1×10-2, inclusive. The compound is preferably selected from the group c...
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5739287 |
Biotinylated cobalamins
A biotinylated cobalamin, formed from a vitamin B12 molecule coupled to a biotin molecule, is disclosed. In a preferred embodiment, the vitamin B12 molecule is cyanocobalamin. The biotin molecule...
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5565558 |
Thioretinaco ozonide and enhanced biological activity of thioretinaco ozonide in combination with interferon
Thioretinaco ozonide and enhancement of the anticarcinogenic, antineoplastic, antiviral, and antiaging activities of thioretinaco ozonide by use of membranergic compositions, specifically the...
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5548064 |
Vitamin B12 conjugates with EPO, analogues thereof and pharmaceutical compositions
The invention describes complexes between VB12 analogues and either GCSF or EPO that retain both significant affinity for intrinsic factor (IF) in the VB12 portion of the complex and significant...
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5405839 |
Vitamin B12 derivative, preparation process thereof, and use thereof
Vitamin B12 compounds, salts and pharmaceutical compositions containing said compounds represented by formula (I): ##STR1## wherein L, a ligand to the cobalt of the corrin ring, is selected from...
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5338418 |
Process for production of hydroxocobalamin
A process for the production of hydroxocobalamin that eliminates cyanocobalamin as an intermediate. Co-enzyme-type vitamin B12 is first absorbed to a divinylbenzene/styrene resin which is washed...
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4925931 |
N-homocysteine thiolactonyl retinamido cobalamin and methods of use thereof
N-Homocysteine thiolactonyl retinamido cobalamin is useful for decreasing the induction of chemically-induced tumors in animals. It is also useful for inhibiting weight gain.
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4704361 |
Pharmaceutical compositions containing the cytidine monophospate of 5-acetamido-3,5-dideoxy-D-glycero-D-galactononulosaminic acid and a method for preparing said compound
The invention relates to pharmaceutical compositions for use in the therapy of pathological states related to disturbances of the nervous stimulus in the central (CNS) and peripheral (PNS) nervous...
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4550163 |
Ligand analog-irreversible enzyme inhibitor conjugates
The present invention encompasses a method for determining ligands in test samples comprising intermixing with the test sample a ligand analog-irreversible enzyme inhibitor conjugate and a binding...
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4465775 |
Vitamin B12 and labelled derivatives for such assay
Vitamin B12 in liquid samples, such as human serum or human plasma, is assayed by a competitive binding technique using intrinsic factor and certain labelled vitamin B12 derivatives. The labelled...
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4364939 |
Derivatives of coenzyme B12
Novel monoesters of cobamide derivatives of coenzyme B12 of the formula: ##STR1## wherein R is acyl of an organic carboxylic acid of 4 to 20 carbon atoms and Co is...
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3936440 |
Method of labeling complex metal chelates with radioactive metal isotopes
A method is provided for labeling a complex metal chelate with a radioactive metal isotope via isotopic exchange between the metal atom of the complex metal chelate and the radioactive metal...
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3928320 |
Process for the preparation of methylcobalamine
This invention relates to a process for the preparation of methylcobalamine by reduction and methylation of cyanocobalamine or hydroxocobalamine. The reduction and methylation are carried out...
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3879378 |
Chemical process for the production of hydroxocobalticorrinoids
Hydroxocobalticorrinoids such as hydroxocobalamin are prepared by reaction under non-oxidising conditions and in the absence of light of a cobalt(I) corrinoid with an alkylating agent to introduce...
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3773756 |
NOVEL PREPARATION OF SUBSTITUTED COBAMIDES
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3798211 |
PROCESS FOR REMOVING CYANIDE IONS FROM SOLUTIONS OF COBALT(I)CORRINOIDS
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3583974 |
HEXOSE AND HEPTOSE PHOSPHONATES,PHOSPHONIC ACIDS,PHOSPHONIC ACID SALTS AND DERIVATIVES THEREOF
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3461114 |
PROCESS FOR THE PREPARATION OF VITAMIN B12 COENZYME AND DERIVATIVES THEREOF
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3459855 |
HYDROXOCOBALAMINE COMPLEXES
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3448099 |
PROCESS FOR THE INDUSTRIAL MANUFACTURE OF HYDROXOCOBALAMIN
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3414561 |
Process for the manufacture of hydroxocobalamine from cyanocobalamine
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3379718 |
Process for preparing cobalaminesulphonic acid
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3213082 |
Cobamide derivatives
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3167539 |
Hydroxocobalamin
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3138583 |
Process for the industrial manufacture of hydroxocobalamin
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3130189 |
Hydroxocobalamin-glutathione
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3120509 |
Process for the manufacture of vitamins of the group b
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3072674 |
Preparation of vitamin b12 derivatives
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3007916 |
Preparation of cobalamins
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2984661 |
Method of preparing pure vitamin b12 and intermediary obtained thereby
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2982766 |
New vitamin b factor
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2976276 |
Pure vitamin b12 and method of making same
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2931799 |
Process for treating cobalamin adsorbates
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2796383 |
Cobalamine analogs and process of preparing the same
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