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7294514 |
Diagnostic method for alzheimer's disease based on holo-transcobalamin II
The invention provides a diagnostic or prognostic assay method for Alzheimer's Disease by assaying a body fluid sample or a test sample derived therefrom for holo-trancobalamin II.
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7229636 |
Cyanocobalamin low viscosity aqueous formulations for intranasal delivery
A stable pharmaceutical mercury-free aqueous solution of cyanocobalamin comprised of cyanocobalamin and water wherein said solution of cyanocobalamin is suitable for intranasal administration, has...
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7179445 |
Cobalamin conjugates useful as imaging and therapeutic agents
The invention provides detectably labeled cobalamin derivatives which are useful for medical treatment and diagnosis.
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6894033 |
Combination therapies using vitamin B12 and therapeutic agents for treatment of viral, proliferative and inflammatory diseases
Pharmaceutical compositions for treating viral, proliferative and inflammatory diseases are disclosed comprising an amount of pharmaceutically acceptable vitamin B12 compounds in combination with...
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6830901 |
Propionibacteruim vector
An endogenous plasmid of Propionibacterium is described, isolated from Propionibacteria freudenreichii LMG 16545 (deposited as CBS 101022), and its sequence provided. This plasmid can be used...
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6752986 |
Composition and methods for affecting metallocorrinoid uptake
The present invention is directed to compositions and methods for affecting metallocorrinoid uptake. The compositions and methods of the present invention are particularly useful in enhancing the...
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6713623 |
Tetraphosphonate bicyclic trisanhydrides
Disclosed are novel bicyclic tris(anhydride)s useful as intermediates in the synthesis of biologically active compounds, and the compounds which may be synthesized from such intermediates.
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6265391 |
Method for preventing peripheral nerve damage
A vitamin B 12 supplement composition comprising vitamin B 12 with and/or without added folic acid that is essentially free of antioxidants, such as vitamin C, as well as iron is disclosed. Also...
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6262253 |
Vitamin B12 conjugates with gcsf, analogues thereof and pharmaceutical compositions
The invention describes complexes between VB 12 analogues and either GCSF or EPO that retain both significant affinity for intrinsic factor (IF) in the VB 12 portion of the complex and...
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6255294 |
Cyanocobalamin (vitamin B12) treatment in allergic disease
Vitamin B 12 is administered to allergy patients via mucosal membranes in a series of lozenges and other patient friendly transmucosal modes of delivery given repeatedly over a period of time to...
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6187761 |
Production and use of compositions comprising high concentrations of vitamin B12 activity
The present invention provides a process for the preparation of a composition comprising natural vitamin B12, wherein said process comprises the steps of: a) obtaining microbial cells containing...
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6083926 |
Water soluble vitamin B.sub.12 receptor modulating agents and methods related thereto
Vitamin B 12 receptor modulating agents capable of modulating cell surface receptors by affecting the cell surface receptor trafficking pathway are disclosed. The vitamin B 12 receptor modulating...
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5932624 |
Vitamin supplement composition
A multiple vitamin supplement composition comprising folic acid and vitamin B 12 disclosed that is essentially free of antioxidants is disclosed. The multiple vitamin supplement composition may...
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5869466 |
Vitamin B.sub.12 mediated oral delivery systems for GCSF
The invention describes complexes between VB 12 analogues and either GCSF or EPO that retain both significant affinity for intrinsic factor (IF) in the VB 12 portion of the complex and...
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5869465 |
Methods of receptor modulation and uses therefor
Receptor modulating agents capable of modulating cell surface receptors by affecting the cell surface receptor trafficking pathway are utilized for the treatment and diagnosis of a variety of...
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5863905 |
2',5'-phosphorothioate/phosphodiester oligoadenylates and anti-viral uses thereof
Optically active antiviral compounds having the formula ##STR1## wherein m is 0, 1, 2, or 3; n and q are selected from the group of 0 and 1, provided that n and q may not both be zero; and R, R 1 ,...
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5840880 |
Receptor modulating agents
Receptor modulating agents capable of modulating cell surface receptors by affecting the cell surface receptor trafficking pathway. The receptor modulating agents are comprised of a covalently...
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5739287 |
Biotinylated cobalamins
A biotinylated cobalamin, formed from a vitamin B 12 molecule coupled to a biotin molecule, is disclosed. In a preferred embodiment, the vitamin B 12 molecule is cyanocobalamin. The biotin...
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5565558 |
Thioretinaco ozonide and enhanced biological activity of thioretinaco ozonide in combination with interferon
Thioretinaco ozonide and enhancement of the anticarcinogenic, antineoplastic, antiviral, and antiaging activities of thioretinaco ozonide by use of membranergic compositions, specifically the...
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5550111 |
Dual action 2',5'-oligoadenylate antiviral derivatives and uses thereof
Viral infection is inhibited in mammals by administration of metabolically stable, non-toxic 2', 5'-oligoadenylate (2-5A) derivatives that have a dual therapeutic effect. The compounds activate the...
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5548064 |
Vitamin B12 conjugates with EPO, analogues thereof and pharmaceutical compositions
The invention describes complexes between VB 12 analogues and either GCSF or EPO that retain both significant affinity for intrinsic factor (IF) in the VB 12 portion of the complex and...
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5510479 |
Hydrophobic vitamin B.sub.12 derivatives
A novel hydrophobic vitamin B 12 derivative represented by the formula: ##STR1## wherein R represents an alkyl group having 2 to 17 carbon atoms, and X represents a cyano group, a hydroxyl group,...
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5405839 |
Vitamin B.sub.12 derivative, preparation process thereof, and use thereof
Vitamin B 12 compounds, salts and pharmaceutical compositions containing said compounds represented by formula (I): ##STR1## wherein L, a ligand to the cobalt of the corrin ring, is selected from...
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5272250 |
Boronated phosphoramidate compounds
A class of pharmaceutically active boronated compounds are provided. The boronated compounds include boronated phosphoramidates, and boronated nucleosides, and oligomers thereof. The compounds are...
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5135918 |
Method for decreasing reaginic antibody levels
A method for achieving long term relief from the symptoms of atopic allergy, comprising parenteral administration of Vitamin B 12 to selected patients, is produced. Vitamin B 12 acts to reduce...
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5026640 |
Process for the conversion of corrinoids produced by microorganisms into cyanocorrinoids
The invention relates to a process for the conversion of corrinoids produced by microorganisms into cyanocorrinoids by reaction with cyanides. According to the invention a fermentation broth...
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4925931 |
N-homocysteine thiolactonyl retinamido cobalamin and methods of use thereof
N-Homocysteine thiolactonyl retinamido cobalamin is useful for decreasing the induction of chemically-induced tumors in animals. It is also useful for inhibiting weight gain.
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4550163 |
Ligand analog-irreversible enzyme inhibitor conjugates
The present invention encompasses a method for determining ligands in test samples comprising intermixing with the test sample a ligand analog-irreversible enzyme inhibitor conjugate and a binding...
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4465775 |
Vitamin B.sub.12 and labelled derivatives for such assay
Vitamin B 12 in liquid samples, such as human serum or human plasma, is assayed by a competitive binding technique using intrinsic factor and certain labelled vitamin B 12 derivatives. The...
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4364939 |
Derivatives of coenzyme B.sub.12
Novel monoesters of cobamide derivatives of coenzyme B 12 of the formula: ##STR1## wherein R is acyl of an organic carboxylic acid of 4 to 20 carbon atoms and Co is...
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3981863 |
Cyanocobalamin derivatives
The present invention is concerned with novel derivatives of cyanocobalamin (vitamin B 12 ), especially of the monocarboxylic acid hydrolysates thereof, by which (1) an antigenic conjugate thereof...
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3459855 |
HYDROXOCOBALAMINE COMPLEXES
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3287351 |
Organic nucleotide derivatives and method of manufacturing the same
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3164582 |
Cyanocobalamin complexes
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3159616 |
Novel salt of hydroxocobalamine
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3115489 |
Cyanocobalt and cyanoiron complexes of cobalamin
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3035983 |
Process for the production of cobalamin/peptide compositions
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3035982 |
Repository vitamin b12 gelatin compositions and preparation thereof
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3026316 |
New analogues of vitamin b12 and process for their biosynthesis
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2984661 |
Method of preparing pure vitamin b12 and intermediary obtained thereby
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2976276 |
Pure vitamin b12 and method of making same
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2967860 |
5-trifluoromethyl derivatives of vitamin b12
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2937167 |
Vitamin b12 factor
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2920015 |
Long-acting vitamin b12
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2914446 |
Nitrite stabilized ascorbic acid-cyanocobalamin compositions
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2893988 |
Therapeutically valuable substances pertaining to the group of vitamins b12
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2874089 |
Stable vitamin b12 solutions
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2861025 |
Process for obtaining vitamin b12 and vitamin b12-like substances and the products thereof
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2842540 |
Preparation of new cobalamines
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2830933 |
Vitamin b12 products and preparation thereof
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