Patents in Class 536/26.260

Matches 1 - 50 out of 158

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Match	Document	Document Title
1	7371852	Alkyl-linked nucleotide compositions Alkyl-linked nucleotide non-homogeneous solid supports and nucleotide affinity media comprising an alkyl-linked nucleotide are provided. The linker is generally a hydrophobic linker that can be a...
2	7368439	Dinucleoside poly(borano)phosphate derivatives and uses thereof The present invention provides dinucleoside boranophosphate derivatives of the general formula I: wherein X and X′ each independently is an unsubstituted or substituted purine or pyrimidine...
3	7348315	Methods of treating heart failure with modified ATP, ADP and AMP compounds Disclosed herein are methods of using an adenosine analog or derivative for treating heart failure, increasing cardiac muscle contractility, increasing cardiac diastolic relaxation, and increasing...
4	7319093	Antidiabetic 2-substituted-5′-O-(1-Boranotriphosphate) adenosine derivatives 2-Substituted-5′-O-(1-boranotriphosphate)adenosine derivatives having at position 2 a radical R1 selected from the group consisting of H; halogen; O-hydrocarbyl; S-hydrocarbyl; NR3R4; and...
5	7285658	Nucleotide mimics and their prodrugs The present invention relates to nucleoside diphosphate mimics and nucleoside triphosphate mimics, which contain diphosphate or triphosphate moiety mimics and optionally sugar-modifications and/or...
6	7173125	Triphosphate oligonucleotide modification reagents and uses thereof Hydrazino, oxyamino and carbonyl-based monomers and methods for incorporation into oligonucleotides during enzymatic synthesis are provided. Modified oligonucleotides are provided that incorporate...
7	7157434	Nucleoside compounds for treating viral infections Disclosed are compounds, compositions and methods for treating viral infections caused by a flaviviridae family virus, such as hepatitis C virus. Such compounds are represented by Formula I as...
8	7115585	Compositions for treating epithelial and retinal tissue diseases The present invention relates to mononucleoside phosphate compounds that have the benefits of a dinucleotide pharmaceutical. These mononucleoside phosphates can be made from a mononucleotide that...
9	7094768	Nucleoside derivatives for treating hepatitis C virus infection Disclosed are 6-hydroxyamino- or a 6-alkoxyamino-7-deazapurine-ribofuranose derivatives, salts, pharmaceutical compositions, and methods of use thereof for treating viral infections caused by a...
10	7045617	Bisbubstrate inhibitors of kinases Protein kinase inhibitors have applications as anti-cancer therapeutic agents and biological tools in cell signalling. Potent and selective bisubstrate inhibitors for the insulin receptor tyrosine...
11	7018985	Composition and method for inhibiting platelet aggregation The present invention provides novel compounds of dinucleotide polyphosphates and the method of preventing or treating diseases or conditions associated with platelet aggregation. The method...
12	6960568	Nucleosides and related processes, pharmaceutical compositions and methods The invention provides novel nucleosides and related processes, pharmaceutical compositions, and methods. The novel nucleosides are useful in a wide variety of antiviral, antineoplastic, and...
13	6924271	3-β-D-ribofuranosylthiazolo[4-5-d]pyridimine nucleosides and uses thereof The invention is directed to 3-β-D-ribofuranosylthiazolo[4,5-d]pyridimine nucleosides and pharmaceutical compositions containing such compounds that have immunomodulatory activity. The invention...
14	6911540	2′ Modified oligonucleotides Oligomers which have substituents on the 2′ position are resistant to oligonucleases and furthermore can be derivatized to deliver reagents or drugs, to carry label, or to provide other properties.
15	6897201	Compositions and methods for the treatment of glaucoma or ocular hypertension The present invention is directed to a method of reducing intraocular pressure. The method comprises administering to a subject a pharmaceutical composition comprising an effective amount of a...
16	6875859	Heterocyclic compounds and their use in the detection of nucleic acids The invention concerns compounds of the general formula (I) in which the residues R 1 to R 7 have the meanings given in the application as well as methods for their preparation. The compounds are...
17	6783957	Method for synthesis of polypeptides in cell-free systems The method of polypeptide synthesis in eukaryotic or porkaryotic cell-free systems based on a modified verion of synthesis in the continuous flow or continuous exchange modes when, in addition to...
18	6777395	Nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase of hepatitis C virus The present invention provides nucleoside compounds and certain derivatives thereof which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA...
19	6723737	Methods, pharmaceutical and therapeutic compostions for administering adenosine The invention discloses methods for the chronic administration of adenosine, which contrary to the acute delivery of the drug by injection or infusion, acts in desensitizing adenosine receptors...
20	6680303	3′,5-difluoro-2′,3′-didehydropyrimidine nucleosides and methods of treatment therewith A method and composition for the treatment of HIV and HBV infections in humans and other host animals is disclosed that includes the administration of an effective amount of a [5-carboxamido or...
21	6677310	Ring-expanded nucleosides and nucleotides The present invention relates to compositions comprising analogues of purine nucleosides containing a ring-expanded (“fat”) heterocyclic ring, in place of purine, and an unmodified or modified...
22	6613926	Perchloramido phosphonyl reagents and analogs thereof Novel compounds are provided in the form of nucleoside pyrophosphate and triphosphate analogs. In these analogs, the pyrophosphate or triphosphate group is replaced with a moiety that is...
23	6610841	Nucleotide-based prodrugs This invention relates to nucleotide-based prodrugs and their drug-delivery applications. The nucleotide-based prodrugs of the present invention comprise a drug component covalently attached via...
24	6600028	Tricyclic base analogues Nucleoside analogues have structure (2) wherein Q is H or a sugar moiety or sugar analogue or a modified sugar or a nucleic backbone or backbone analogue, W is an alkylene or alkenylene chain of...
25	6600026	Electronic methods for the detection of analytes utilizing monolayers The present invention relates to the use of self-assembled monolayers with mixtures of conductive oligomers and insulators to detect target analytes.
26	6573374	Nucleotides labelled with an infrared dye and their use in nucleic acid detection Nucleoside-5′-triphosphates and phosphoramidites which carry a residue absorbing in the long wavelength region, preferably a carbocyanine group of the general formula (I), on the base portion or...
27	RE38090	3′-substituted nucleoside derivative The invention relates to a 3′-substituted nucleoside derivative represented by the following general formula (1): wherein B means a nucleic acid base which may have a substituent, Z represents...
28	6509460	Nucleoside triphosphates and their incorporation into oligonucleotides Novel nucleoside triphosphates, methods of synthesis and process of incorporating these nucleoside triphosphates into oligonucleotides are disclosed.
29	6506888	2′-O-amino-containing nucleoside analogs and polynucleotides Novel nucleoside or nucleotide analogs comprising 2′-O-amino residues, processes for their synthesis and incorporation into polynucleotides.
30	6504024	Propargylethoxyamino nucleotide primer extensions Propargylethoxyamino nucleosides are disclosed having the structure wherein R 1 and R 2 are —H, lower alkyl, or label; B is a 7-deazapurine, purine, or pyrimidine nucleoside base; W 1 is...
31	6407223	Process for the synthesis of modified P-chiral nucleotide analogues The process of the instant invention is drawn to the synthesis of modified P-chiral nucleotide analogues in the form of pure diastereomers possessing preselected configuration at the P-atom....
32	6320035	C-nucleoside derivatives and their use in the detection of nucleic acids The invention concerns pyrrolo-[3,2-d]pyrimidine, pyrazolo-[4,3-d]pyrimidine and pyrimidine-furanosides i.e. so-called C-nucleosides of the general formulae I-V ##STR1## or appropriate derivatives...
33	6303774	Nucleoside pyrophosphate and triphosphate analogs and related compounds Novel compounds are provided in the form of nucleoside pyrophosphate and triphosphate analogs. In these analogs, the pyrophosphate or triphosphate group is replaced with a moiety that is...
34	6281201	Base-modified derivatives of 2',5'-oligoadenylate and antiviral uses thereof Antiviral compounds have the formula ##STR1## wherein m is zero, 1, 2 or 3; n is from 1 to 8, preferably 1, 2 or 3; most preferably 1 or 2; R is independently selected from the group...
35	6274725	Activators for oligonucleotide synthesis The present invention relates to improved methods for the preparation of nucleoside phosphoramidites and oligonucleotides. In one aspect, the methods of the invention are used to prepare...
36	6271358	RNA targeted 2'-modified oligonucleotides that are conformationally preorganized 2'-O-modified ribosyl nucleosides and modified oligonucleotides containing such nucleotides are disclosed. Oligonucleotides are disclosed that have increased binding affinity as shown by molecular...
37	6271212	Prodrug azide compositions and compounds Pharmaceutical prodrug compositions are provided comprising azide derivatives of drugs which are capable of being converted to the drug in vivo. Azide derivatives of drugs having amine, ketone and...
38	6265569	3'-Deoxyribonucleotide derivatives Disclosed are 3'-deoxyribonucleotide derivatives represented by the following general formula [I]: Q--V--(CH 2 ) n --NH--R [I] wherein Q represents a 3'-deoxyribonucleotide residue, n...
39	6255475	Chain terminators, the use thereof for nucleic acid sequencing and synthesis and a method of their preparation The invention relates to compounds of general structure (I) or salts thereof, wherein B is a nucleobase, X and Z independently are oxygen or sulphur, Y is hydrogen or hydroxy, which optionally may...
40	6255292	Purine nucleotide analogues, pharmaceutical compositions thereof, and methods of improving cardiac functions The specification discloses purine nucleotide analogues which modulate cardiac muscle contractility and possess vasodilator activity. In addition, related methods of administration and the identity...
41	6248878	Nucleoside analogs Novel nucleoside analogs, such as 3-(β-D-Ribofuranosyl)-2-fluoropyridine, 3-(β-D-Ribofuranosyl)-pyridin-2-one, 3-(β-D-Ribofuranosyl)-pyridin-2-(4-nitrophenylethyl)-one,...
42	6232465	Compositions for enzyme catalyzed template-independent creation of phosphodiester bonds using protected nucleotides A method for the stepwise creation of phosphodiester bonds between desired nucleosides resulting in the synthesis of polynucleotides having a predetermined nucleotide sequence by preparing an...
43	6207649	Nucleoside analogs and uses in treating disease The invention relates to pharmaceutical compositions of nucleoside dimers containing an L-sugar in at least one of the nucleosides.
44	6175001	Functionalized pyrimidine nucleosides and nucleotides and DNA's incorporating same Modified pyrimidine nucleotides derivatized at C5 to contain a functional group that mimics the property of a naturally occurring amino acid residues are provided. DNA molecules containing the...
45	6153745	Relating to mutagenesis of nucleic acids
46	6132957	Method and compounds for the inhibition of adenylyl cyclase The present invention reveals a new series of derivatives and analogues of adenine and adenosine, i.e., 3'-adenosine derivatives, which inhibit adenylyl cyclase activity. These newly synthesized...
47	6121431	Nucleoside derivatives
48	6054442	Methods and compositions for modulation and inhibition of telomerase in vitro It was found that normal human stem cells produce a regulated non-processive telomerase activity, while cancer cells produce a processive telomerase activity. Nucleotide analogs, such as...
49	6025482	Backbone modified oligonucleotide analogs and preparation thereof through reductive coupling Methods for preparing oligonucleotide analogs which have improved nuclease resistance and improved cellular uptake are provided. In preferred embodiments, the methods involve reductive coupling of...
50	6025335	L-Nucleoside Dimer Compounds and therapeutic uses The invention relates to nucleoside dimers containing an L-sugar in at least one of the nucleosides and their pharmaceutical compositions.

Matches 1 - 50 out of 158

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