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8158776 |
P2Y6 receptor agonists for treating lung diseases
This invention is directed to a method of enhancing or facilitating the clearance or the lung mucus secretions in a subject. This invention is also directed to a method of facilitating the...
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8034923 |
Reagents for reversibly terminating primer extension
Processes are disclosed that use 3′-reversibly terminated nucleoside triphosphates to analyze DNA for purposes other than sequencing using cyclic reversible termination. These processes are based o...
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7964352 |
3′-OH unblocked nucleotides and nucleosides, base modified with labels and photocleavable, terminating groups and methods for their use in DNA sequencing
Provided are novel nucleotides, nucleoside, and their derivatives described herein, that can be used in DNA sequencing technology and other types of DNA analysis. In one embodiment, the nucleotide...
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7897737 |
3′-OH unblocked, nucleotides and nucleosides, base modified with photocleavable, terminating groups and methods for their use in DNA sequencing
Provided are novel nucleotides, nucleoside, and their derivatives described herein, that can be used in DNA sequencing technology and other types of DNA analysis. In one embodiment, the nucleotide...
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7893227 |
3′-OH unblocked nucleotides and nucleosides base modified with non-cleavable, terminating groups and methods for their use in DNA sequencing
Provided are novel nucleotides, nucleoside, and their derivatives described herein, that can be used in DNA sequencing technology and other types of DNA analysis. In one embodiment, the nucleotide...
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7816333 |
Oligonucleotide analogues and methods utilizing the same
A method for the prevention or treatment in a mammal of a disease preventable or treatable by the pharmacologically useful antisense or antigene activity of an oligonucleotide analogue or a...
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7666851 |
Three ring fused analogs of isoguanosine
This invention relates to the field of nucleic acid chemistry, more specifically to the field of compositions and processes that are nucleic acid analogs. More specifically, it relates to purine...
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7612047 |
Degradation-resistant mononucleoside phosphate compounds
The present invention relates to mononucleoside phosphate compounds that have the benefits of a dinucleotide pharmaceutical. These mononucleoside phosphates can be made from a mononucleotide that...
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7476734 |
Nucleotide analogs
The invention provides nucleotide analogs for use in sequencing nucleic acid molecules.
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7335765 |
Nucleoside and oligonucleotide analogues
A compound of the formula (1): wherein R1 and R2 are the same or different and represent a hydrogen atom, a hydroxyl protecting group, a phosphate group, or —P(R3)R4, wherein R3 and R4 are the s...
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7285658 |
Nucleotide mimics and their prodrugs
The present invention relates to nucleoside diphosphate mimics and nucleoside triphosphate mimics, which contain diphosphate or triphosphate moiety mimics and optionally sugar-modifications and/or...
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7268119 |
Tricyclic nucleosides or nucleotides as therapeutic agents
Nucleosides and nucleotides containing a tricyclic base portion thereof are useful for treating infectious diseases and proliferative disorders, such as viral infections or cancer respectively.
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7115585 |
Compositions for treating epithelial and retinal tissue diseases
The present invention relates to mononucleoside phosphate compounds that have the benefits of a dinucleotide pharmaceutical. These mononucleoside phosphates can be made from a mononucleotide that...
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7091334 |
Method for large-scale production of di(uridine 5′)-tetraphosphate and salts thereof
The present invention provides new methods for the synthesis of the therapeutic dinucleotide, P1,P4-di(uridine 5′)-tetraphosphate, and demonstrates applicability to the production of large q...
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7056894 |
Inhibitors of ADP-ribosyl transferases, cyclases, and hydrolases, and uses thereof
The present invention provides compounds having the formula: wherein A is chosen from a nitrogen-, oxygen-, or sulfur-linked aryl, alkyl, cyclic, or heterocyclic group; both B and C are hydrogen,...
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7026469 |
Compositions and methods of double-targeting virus infections and cancer cells
The invention includes compositions and methods useful for treatment of a virus infection in a mammal by double-targeting the virus (i.e. targeting the virus at more than one stage of the virus...
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7022680 |
Inhibitors of ADP-ribosyl transferases, cyclases, and hydrolases
The present invention provides compounds having the formula: wherein A is a nitrogen-, oxygen-, or sulfur-linked aryl, alkyl, cyclic, or heterocyclic group, the group being further substituted with...
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6987180 |
Uridine analogs and techniques for making and using
Uridine analogs and techniques for making and using uridine analogs are disclosed in this invention. These uridine analogs include nucleoside phosphates having a 5-aminouracil group. These...
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6900308 |
α-modified nucleoside triphosphates
The present invention is directed to α-modified nucleoside triphosphates and methods for their preparation. The present invention also provides for methods of inhibiting RNA and viral replication ...
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6812342 |
Esters of cyclic ADP ribose derivatives
The present invention is directed to the field of organic chemistry in general and specifically to the preparation of hydrophobic derivatives of cyclic ADP ribose. One form of the present invention...
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6781001 |
Nucleic acids labelled with extended rhodamine dyes
Extended rhodamine compounds exhibiting favorable fluorescence characteristics having the structure are disclosed. In addition, novel intermediates for synthesis of these dyes are disclosed, such...
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6713623 |
Tetraphosphonate bicyclic trisanhydrides
Disclosed are novel bicyclic tris(anhydride)s useful as intermediates in the synthesis of biologically active compounds, and the compounds which may be synthesized from such intermediates.
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6635419 |
Polynucleotide sequencing method
Disclosed is a method for determining a sequence of one or more nucleotides in a target polynucleotide. In the method, a target-specific primer is contacted with a polynucleotide sample under...
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6448392 |
Lipid derivatives of antiviral nucleosides: liposomal incorporation and method of use
Compounds are disclosed for treating AIDS, herpes, and other viral infections by means of lipid derivatives of antiviral agents. The compounds consist of nucleoside analogues having antiviral...
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6255475 |
Chain terminators, the use thereof for nucleic acid sequencing and synthesis and a method of their preparation
The invention relates to compounds of general structure (I) or salts thereof, wherein B is a nucleobase, X and Z independently are oxygen or sulphur, Y is hydrogen or hydroxy, which optionally may...
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5872243 |
Caged nucleotides
The present invention describes a family of photolabile caged nucleotides, including cyclic nucleotides. The compounds of the present invention are caged analogs and derivatives of NAD+, NADH,...
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5658731 |
2'-O-alkylnucleotides as well as polymers which contain such nucleotides
Oligonucleotides having the general formula, ##STR1## in which B denotes an arbitrary nucleobase, A equals 0 or CH2 ; X or Z equals O, S, NH or denotes CH2 whereby X and Z can be the same or...
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5656742 |
Ring-opened purine compounds for labeling polynucleotides
The invention provides methods for attaching detectable labels to the N7 -formyl group, of imidazole ring-opened alkylated purines and purine derivatives, directly, through a linking group, or by...
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5587472 |
Coumarin-labeled nucleoside 5'-triphosphates
A fluorescent label compound having the formula A--B1 --B2 --B3 --Cwherein A represents the residue of a natural or synthetic nucleotide or nucleoside or a derivative thereof; B1 represents a...
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5585481 |
Linking reagents for nucleotide probes
A versatile reagent with a non-nucleotide monomeric unit having a ligand, and first and second coupling groups which are linked to the non-nucleotide monomeric unit. The ligand can be either a...
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5547941 |
Cyclic dinucleoside diphosphorothioates, related compounds and pharmaceutical compositions
There are provided compounds of formula (I) ##STR1## wherein each group B is, independently, a naturally occurring or modified heterocyclic base linked through a nitrogen or a carbon atom of the...
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5525711 |
Pteridine nucleotide analogs as fluorescent DNA probes
The invention provides novel pteridine nucleotides which are highly fluorescent under physiological conditions and which may be used in the chemical synthesis of fluorescent oligonucleotidcs. The...
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5512671 |
Ether lipid-nucleoside covalent conjugates
Ether lipid nucleoli covalent conjugates and derivatives thereof are disclosed, along with pharmaceutical compositions containing the same and methods of using the same to combat HIV-1 infections....
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5486604 |
Cyclic ADP ribose antagonists
Cyclic ADP-ribose (cADPR) analogs block cADPR from releasing Ca+2, and also inhibit cADPR from potentiating Ca+2 release induced by either divalent cations or by caffeine. 8-amino-cADPR and two...
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5466677 |
Dinucleoside phosphinates and their pharmaceutical compositions
A dinucleotide analogue of formula ##STR1## where B1 and B2 are each independently a monovalent nucleoside base radical; R1 is R1a or Z; R1a, R2, R3 and R4 are each independently hydrogen, halogen...
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5401725 |
Neovascularization inhibition by adenosine-5'-phosphosulfates
The present invention provides, as a noval and safe vascularization inhibitor having an excellent effect, a vascularization inhibitor which is characterized by containing, as the effective...
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5049550 |
Diadenosine 5', 5'"-p1, p4,-tetraphosphate analogs as antithrombotic agents
A component of blood platelets analogues thereof are described. The invention is based on the discovery that this component, a dinucleotide, as well as several of its chemically synthesized...
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4966965 |
Method for preparing all-trans retinoyl CoA
The invention relates to a new method for preparing all trans retinoyl CoA.
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4291024 |
Cytotoxic liponucleotide analogs
Nucleotides of nucleosides or bases having known cytotoxic activity are reacted to form corresponding cytotoxic liponucleotide analogs by phosphorylation of molecular species of phosphatidic acids....
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4141972 |
Purine nucleoside 5'-phosphate (mono, di or tri) 3'(2')-diphosphates and processes for their preparation
New purine nucleoside 5'-phosphate (mono, di or tri) 3'(2')-diphosphates and the sodium, lithium and potassium salts thereof are elaborated by the enzymatic transfer of pyrophosphoryl group from...
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4086417 |
Cytidine nucleotide derivatives
A nucleotide derivative represented by the general formula: ##STR1## wherein R represents an acyl group having 14 - 22 carbon atoms and having an aliphatic acyl moiety; X represents a hydrogen...
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3935072 |
Purification of coenzyme A
Coenzyme A is purified by a process involving contacting a cyanogen halide-activated water-insoluble polysaccharide with a cell-free extract of a coenzyme A-producing microorganism to immobilize...
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3878194 |
Novel phosphorylated phosphonium ylids
Novel phosphorylated phosphonium ylids are prepared by reacting a monosubstituted phosphonium ylid with an appropriately disubstituted phosphoryl halide or thiophosphoryl halide. The novel ylids...
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3662031 |
PHOSPHORYLATED PHOSPHONIUM YLIDS
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3560478 |
ANALOGUES OF NUCLEOSIDE PHOSPHATES
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3830798 |
HYDROLYSIS OF RIBONUCLEIC ACID CONTAINING MATERIAL
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3299042 |
Iodination of the heterocyclic bases in nucleosides, nucleotides, nucleoside-5'-polyphosphates, and nucleic acids
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3284440 |
Phosphate esters of cytosine arabinoide and process for preparing same
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3238191 |
Phosphonic acid analogs of nucleoside phosphates and method
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2970139 |
5-fluorouracil nucleotides and preparation thereof
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