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7319093 |
Antidiabetic 2-substituted-5′-O-(1-Boranotriphosphate) adenosine derivatives
2-Substituted-5′-O-(1-boranotriphosphate)adenosine derivatives having at position 2 a radical R1 selected from the group consisting of H; halogen; O-hydrocarbyl; S-hydrocarbyl; NR3R4; and...
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7238476 |
Methods and compositions for genotyping
The invention provides compositions and methods for performing primer extension reactions, including employment of amplification primers having 5′ tags to incorporate into amplicons variant...
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7217815 |
2-beta -modified-6-substituted adenosine analogs and their use as antiviral agents
Various 2′-beta-methyl-6-substituted adenosine analogs (including 2,6-disubstituted adenosine, 8-aza-6-substituted adenosine, and 2-aza-6-substituted adenosine) are prepared by conventional and...
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7192700 |
Methods and compositions for conducting primer extension and polymorphism detection reactions
The invention comprises compositions and methods for performing primer extension reactions, including employment of amplification primers having 5′ tags to incorporate into amplicons variant...
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7105499 |
Nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase
The present invention provides nucleoside derivatives which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA viral replication and are...
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RE38416 |
Cross-linking oligonucleotides
This invention is directed to novel substituted nucleotide bases with a crosslinking arm which accomplish crosslinking between specific sites on adjoining strands of oligonucleotides a...
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6538128 |
Detritylation solvents for nucleic acid synthesis
The invention provides improved processes for oligonucleotide synthesis utilizing arenes as solvents for detritylation of oligonucleotides.
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6537748 |
Reagent for nucleic acid typing by primer extension
This invention concerns a reagent composition comprising at least two different terminators of a nucleic acid template-dependent, primer extension reaction. This invention also concerns a method...
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6287778 |
Allele detection using primer extension with sequence-coded identity tags
A method for determining the genotype of one or more individuals at a polymorphic locus employs amplification of a region of DNA, labeling of allele-specific extension primers containing tags, and...
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5859233 |
Synthons for synthesis of oligonucleotide N3-P5 phosphoramidates
The invention provides a method of synthesizing oligonucleotide N3'➝P5' phosphoramidates using an amine-exchange reaction of phosphoramidites in which a -deprotected 3'-amino group of a solid...
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5831074 |
Eucaryotic NAD cyclases
Eucaryotic NAD cyclases able to cause production of cyclic adenosine diphosphate ribose from nicotinamide adenine dinucleotide.
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5780254 |
Method for detection of herbicides
This invention relates to novel screening methods for identifying compounds that specifically inhibit a metabolic target site or pathway in plants. Enzymes which are specifically affected by the...
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5780253 |
Screening method for detection of herbicides
This invention relates to novel screening methods for identifying compounds that specifically inhibit a biosynthetic pathway in plants. Enzymes which are specifically affected by the novel...
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5677441 |
Nucleosides, nucleotides and oligonucleotides containing enzymatically cleavable protecting groups
Process for the production of oligonucleotides of formula II, in which the exocyclic amino groups of the bases adenine, guanine, cytosine, 7-deazaadenine and 7-deazaguanine carry N-phenylacetyl...
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5625056 |
Derivatives of cyclic guanosine-3',5'-monophosphorothioate
New derivatives of S P - and R P -configures cyclic guanosine-3',5'-phosphorothioates and their physiologically and pharmaceutically acceptable salts according to the general formula ##STR1## are...
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5599798 |
Cyclic AMP derivative-containing ointment
An ointment comprising an adenosine 3',5'-cyclic phosphate derivative, a base having water-absorbing and drying properties and, incorporated in the base, is one or more salts each having pH in an...
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5559102 |
Adenosine and guanosine-3'-5'-cyclic methylphosphonate derivatives
Cyclic AMP and cyclic GMP derivatives, such as 8-bromoadenosine-3', 5'-cyclic methylphosphonate, are effective in inhibiting phosphodiesterases.
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5449664 |
Antiviral agents
Nucleoside compounds of the formula ##STR1## wherein: B is a purine or a pyrimidine; X and X' are H, OH or F, provided that at least one is H; Y and Y' are H, OH, OCH 3 or F, provided that at...
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5346999 |
Method of nucleic acid extraction
An automated apparatus is provided which implements a new method of extracting and purifying nucleic acids from cells without the use of centrifugation. In the method, a lysate is created by...
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5248770 |
Molecular probes for adenosine receptors
This application discloses probes for adenosine receptors which are functionalized congeners of the following compound: ##STR1## wherein R is --CH 2 --C(O)--R' or ##STR2## These probes bind to A 2...
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5218102 |
Nucleic acid probe containing a terminal carbamyl linking non-radioactive labeling and preparating processes
The subject of the present invention is a nucleic acid probe containing a nucleic acid sequence, wherein the said sequence is linked at its 5' end, via a divalent bifunctional chemical "arm" L, to...
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5192749 |
4'-substituted nucleosides
Nucleosides compounds of Formula I: ##STR1## wherein B is a purine or a pyrimidine; X and X' are H; Y is H; Y' is OH, F or H; or Y' and X' together makes a bond; Z is ##STR2## where...
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5039797 |
2'-O-(4-benzoyl)benzoyl nucleoside cyclic monophosphate
The invention is a 2'-O-(4-benzoyl)benzoyl nucleoside 3', 5'-cyclic monophosphate of formula (I) ##STR1## wherein R' is guanine or adenine. Also disclosed are topical pharmaceutical compositions...
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5026836 |
6-sulfenamide, 6-sulfinamide and 6-sulfonamide purines, purine nucleosides, purine nucleotides, pharmaceutical compositions, and processes of making
6-Sulfenamide, 6-sulfinamide and 6-sulfonamide purines, purine nucleosides, purine nucleotides and 3 and 7 deaza and 8 aza derivatives thereof of structure: ##STR1## wherein Z is H or --NH 2 ; ...
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4956348 |
Stimulation of tear secretion with cyclic nucleotides
A method and preparation for the stimulation of tear secretion. The method involves topically applying a phosphodiesterase inhibitor and/or cyclic nucleotide analogue to the ocular surface....
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4902677 |
Treatment of heart failure of mammals with N.sup.6 -substituted cyclic adenosine monophosphates
A composition for use in the treatment of heart failure of mammals which comprises, as its active ingredient, an N 6 -substututed-adenosine-3',5'-cyclic phosphate represented by the following...
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4880784 |
Antiviral methods utilizing ribofuranosylthiazolo[4,5-d]pyrimdine derivatives
Compounds of the structure: ##STR1## wherein R 1 and R 2 individually are H or C 1 -C 18 acyl and R 3 is H, C 1 -C 18 acyl or ##STR2## or R 1 is H and together R 2 and R 3 are ##STR3##...
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4873227 |
3',5'-Camp derivatives for treatment of certain types of skin ulcers
A novel therapeutic agent for skin ulcers comprising as its active component adenosine-3',5'-cyclic phosphate or a derivative thereof, and a method for the treatment of skin ulcers by using the...
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4797480 |
New biologically active fluorescent cyclic nucleotides
Sybthesis of new biologically active fluorescent cyclic nucleotides of general formula: ##STR1## wherein X=OH and Y=NH 2 or X=NH 2 and Y=H and L is a fluorescent group of the class of 5 (or...
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4728730 |
Synthesis of nucleoside thiophosphoanhydrides
A method for preparing sulfur and/or selenium containing phosphoanhydrides that have at least a triphosphate moiety is disclosed, together with a cyclo-intermediate formed during the reaction. The...
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4587044 |
Linkage of proteins to nucleic acids
A nucleic acid-protein conjugate which is specific with respect to a selected living cell is prepared by linking said nucleic acid to a protein specific to said living cell.
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4369181 |
Process for treating proliferative skin diseases using certain 6,8-substituted ribofuranosylpurine-3',5'-cyclic phosphates
Proliferative skin diseases such as psoriasis are treated by topically administering cAMP analogs of the following formula to the afflicted skin site at a dose that preferentially and significantly...
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4208406 |
Composition for the treatment and prevention of skin, eye and mucosal inflammation
Composition for treatment or prevention of skin, eye or mucosal inflammation in human and animals, especially but not exclusively by external topical application comprising an effective amount of a...
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4058659 |
6,8-Disubstituted purine derivatives of 9-β-D-ribofuranosyl 3',5'-cyclic phosphate
Compounds of formula ##STR1## wherein X is --NR 1 R 2 , --Cl, --Br or SR; Y is --X, --OH or --NH 2 ; Z is hydrogen or --NH 2 ; and R' is hydrogen or C 1 -C 18 acyl; R being hydrogen, aryl,...
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4054735 |
Stabilized N.sup.2,2-O-dibutyrylguanosine-3,5-cyclic phosphate and salts thereof
N 2 ,2'-O-dibutyrylguanosine-3',5'-cyclic phosphate or a salt thereof is stabilized by adjusting the moisture content thereof to 3 percent or less by weight.
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4048307 |
Cyclic adenosine monophosphate 8-substituted derivatives
Novel cyclic adenosine monophosphate derivatives represented by the following general formula: ##STR1## wherein A stands for --S-- or --NH-- and n is an integer of from 2 to 12, ARE SUPERIOR TO...
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4038033 |
Selenium labelled compounds in the saturation analysis of cyclic nucleotide
New selenium-75 labelled derivatives of cyclic nucleotides are described, which are of value in the saturation analysis of cyclic nucleotides, particularly adenosine-3', 5'-cyclic monophosphate...
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3988442 |
Cyclic nucleotide derivatives for treatment of hypothyroidism
A method for stimulating the production of thyroid stimulating hormone (TSH) and enhancing thyroid function in animals comprising administering to an animal having low thyroid function an effective...
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3968101 |
8-Substituted cyclic nucleotides by free radical alkylation and acylation
Novel compounds of the general formula ##SPC1## Wherein X is H or NH 2 ; R' is C 1 to C 8 alkyl, C 1 to C 8 substituted alkyl, benzyl, C 1 to C 8 acyl, benzoyl, carbamoyl, are disclosed as...
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3948886 |
6-Substituted purine 3',5'-cyclic nucleotides
Described herein are novel 6-alkylthio and 6-arylalkylthio purine 3',5' cyclic nucleotides variously exhibiting adenyl cyclase and (in animal studies) tumor inhibitory properties, interferon...
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3917583 |
2-Substituted cyclic AMP derivatives
2-Substituted derivatives of cyclic AMP and a process of making the same are disclosed which are useful to inhibit the enzyme phosphodiesterase, to activate protein kinase and steriodogenesis, and...
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3897413 |
2,6-Disubstituted purine cyclic nucleotides
Compounds of structure ##SPC1## Wherein X is Cl, F or Br and Y is Cl or Br, are prepared by diazotization of 2-amino-6-halo-9-β-D-ribofuranosylpurine 3',5'-cyclic phosphates in the presence of an...
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3883508 |
Process for the preparation of guanosine tetra- and penta-phosphates and products
The chemical synthesis of guanosine 3',5'-bis-diphosphate (Magic Spot I) and guanosine 3'-diphosphate, 5'-triphosphate (Magic Spot II) starting from the readily available guanosine 2',3'-cyclic...
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3872084 |
PURINE NUCLEOSIDE 3,5-CYCLICPHOSPHATE COMPOUNDS
New purine nucleoside 3',5'-cyclicphosphate compounds are disclosed wherein the 5' carbon atom of the furanose sugar moiety bears one or two alkyl groups. Also disclosed are methods for the...
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3872082 |
SUBSTITUTED PURINERIBOFURANOSIDE-3,5-CYCLOPHOSPHATE COMPOUNDS AND PROCESS FOR THEIR PREPARATION
Novel substituted cyclophosphate compounds of the formula: ##SPC1## Wherein X is halogen, hydrocarbyl, sulfhydryl, thioether, alkylsulfoxy, alkylsulfonyl or hydrocarbyl-substituted amino wherein...
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3860706 |
METHOD FOR CURING STOCK SYMPTOMS
A shock symptom-curing preparation containing N 6 -2'-0-dibutyryl adenosine-3',5'-cyclic-monophosphate (D-CAMP) or its salt and/or 2'-0-monobutyryl adenosine -3',5'-cyclic-monophosphate (M-CAMP)...
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3853844 |
NUCLEOSIDE 3',5',-CYCLIC PHOSPHOROTHIOATES
3',5'-CYCLIC PHOSPHOROTHIOATES OF CERTAIN 9(β-D-ribofuranosyl)purine nucleosides are prepared from the corresponding 5'-deoxy-5'-iodoribosides. The compounds exhibit kinase activity in order of...
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3852267 |
PHOSPHORAMIDATES OF 3',5'-CYCLIC PURINE NUCLEOTIDES
Exocyclic phosphoramidates of 3',5'-cyclic purine nucleotides are prepared by activation of nucleoside 3',5'-cyclic phosphates to nucleophilic attack by reaction with phosphorus oxychloride (POCl 3...
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3062808 |
Process for preparing ribonucleoside-2', 3'-cyclicphosphate
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3778513 |
Title is not available
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