Patents in Class 536/26.12

Matches 1 - 50 out of 57

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Match	Document	Document Title
1	8173621	Nucleoside cyclicphosphates Cyclic phosphate of nucleoside derivatives for the treatment of viral infections in mammals, which is a compound, its stereoisomers, salts (acid or basic addition salts), hydrates, solvates, or...
2	8153787	Azacytosine derivatives useful as antiviral agents The present invention provides 5-azacytosine derivatives with antiviral activity, specifically having viral replication inhibiting properties, more particularly in DNA viruses such as pox-,...
3	7977343	Adenine derivatives Novel adenine derivatives of the formula (I), in which R1, R2, R3, X and Y have the meanings indicated in Claim 1, are HSP90 inhibitors and can be used for the preparation of a medicament for the...
4	7935814	Nitroguanosine-3′ 5′-cyclic monophosphate compound and protein kinase G activating agent An object of the present invention is to provide a novel compound that is an agonist of guanosine-3′,5′-cyclic monophosphate and has an effect of activating protein kinase G. The present inv...
5	7319093	Antidiabetic 2-substituted-5′-O-(1-Boranotriphosphate) adenosine derivatives 2-Substituted-5′-O-(1-boranotriphosphate)adenosine derivatives having at position 2 a radical R1 selected from the group consisting of H; halogen; O-hydrocarbyl; S-hydrocarbyl; NR3R4; and h...
6	7238476	Methods and compositions for genotyping The invention provides compositions and methods for performing primer extension reactions, including employment of amplification primers having 5′ tags to incorporate into amplicons variant n...
7	7217815	2-beta -modified-6-substituted adenosine analogs and their use as antiviral agents Various 2′-beta-methyl-6-substituted adenosine analogs (including 2,6-disubstituted adenosine, 8-aza-6-substituted adenosine, and 2-aza-6-substituted adenosine) are prepared by conventional and c...
8	7192700	Methods and compositions for conducting primer extension and polymorphism detection reactions The invention comprises compositions and methods for performing primer extension reactions, including employment of amplification primers having 5′ tags to incorporate into amplicons variant n...
9	7105499	Nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase The present invention provides nucleoside derivatives which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA viral replication and are...
10	RE38416	Cross-linking oligonucleotides This invention is directed to novel substituted nucleotide bases with a crosslinking arm which accomplish crosslinking between specific sites on adjoining strands of oligonucleotides a...
11	6538128	Detritylation solvents for nucleic acid synthesis The invention provides improved processes for oligonucleotide synthesis utilizing arenes as solvents for detritylation of oligonucleotides.
12	6537748	Reagent for nucleic acid typing by primer extension This invention concerns a reagent composition comprising at least two different terminators of a nucleic acid template-dependent, primer extension reaction. This invention also concerns a method...
13	6287778	Allele detection using primer extension with sequence-coded identity tags A method for determining the genotype of one or more individuals at a polymorphic locus employs amplification of a region of DNA, labeling of allele-specific extension primers containing tags, and...
14	5859233	Synthons for synthesis of oligonucleotide N3-P5 phosphoramidates The invention provides a method of synthesizing oligonucleotide N3'➝P5' phosphoramidates using an amine-exchange reaction of phosphoramidites in which a -deprotected 3'-amino group of a solid p...
15	5831074	Eucaryotic NAD cyclases Eucaryotic NAD cyclases able to cause production of cyclic adenosine diphosphate ribose from nicotinamide adenine dinucleotide.
16	5780254	Method for detection of herbicides This invention relates to novel screening methods for identifying compounds that specifically inhibit a metabolic target site or pathway in plants. Enzymes which are specifically affected by the...
17	5780253	Screening method for detection of herbicides This invention relates to novel screening methods for identifying compounds that specifically inhibit a biosynthetic pathway in plants. Enzymes which are specifically affected by the novel...
18	5677441	Nucleosides, nucleotides and oligonucleotides containing enzymatically cleavable protecting groups Process for the production of oligonucleotides of formula II, in which the exocyclic amino groups of the bases adenine, guanine, cytosine, 7-deazaadenine and 7-deazaguanine carry N-phenylacetyl...
19	5625056	Derivatives of cyclic guanosine-3',5'-monophosphorothioate New derivatives of SP - and RP -configures cyclic guanosine-3',5'-phosphorothioates and their physiologically and pharmaceutically acceptable salts according to the general formula ##STR1## are...
20	5599798	Cyclic AMP derivative-containing ointment An ointment comprising an adenosine 3',5'-cyclic phosphate derivative, a base having water-absorbing and drying properties and, incorporated in the base, is one or more salts each having pH in an...
21	5559102	Adenosine and guanosine-3'-5'-cyclic methylphosphonate derivatives Cyclic AMP and cyclic GMP derivatives, such as 8-bromoadenosine-3', 5'-cyclic methylphosphonate, are effective in inhibiting phosphodiesterases.
22	5449664	Antiviral agents Nucleoside compounds of the formula ##STR1## wherein: B is a purine or a pyrimidine;X and X' are H, OH or F, provided that at least one is H;Y and Y' are H, OH, OCH3 or F, provided that at least...
23	5346999	Method of nucleic acid extraction An automated apparatus is provided which implements a new method of extracting and purifying nucleic acids from cells without the use of centrifugation. In the method, a lysate is created by...
24	5248770	Molecular probes for adenosine receptors This application discloses probes for adenosine receptors which are functionalized congeners of the following compound: ##STR1## wherein R is --CH2 --C(O)--R' or ##STR2## These probes bind to A2...
25	5218102	Nucleic acid probe containing a terminal carbamyl linking non-radioactive labeling and preparating processes The subject of the present invention is a nucleic acid probe containing a nucleic acid sequence, wherein the said sequence is linked at its 5' end, via a divalent bifunctional chemical "arm" L, to...
26	5192749	4'-substituted nucleosides Nucleosides compounds of Formula I: ##STR1## wherein B is a purine or a pyrimidine; X and X' are H; Y is H; Y' is OH, F or H; or Y' and X' together makes a bond; Z is ##STR2## where n is zero, one,...
27	5039797	2'-O-(4-benzoyl)benzoyl nucleoside cyclic monophosphate The invention is a 2'-O-(4-benzoyl)benzoyl nucleoside 3', 5'-cyclic monophosphate of formula (I) ##STR1## wherein R' is guanine or adenine. Also disclosed are topical pharmaceutical compositions...
28	5026836	6-sulfenamide, 6-sulfinamide and 6-sulfonamide purines, purine nucleosides, purine nucleotides, pharmaceutical compositions, and processes of making 6-Sulfenamide, 6-sulfinamide and 6-sulfonamide purines, purine nucleosides, purine nucleotides and 3 and 7 deaza and 8 aza derivatives thereof of structure: ##STR1## wherein Z is H or --NH2 ; X is...
29	4956348	Stimulation of tear secretion with cyclic nucleotides A method and preparation for the stimulation of tear secretion. The method involves topically applying a phosphodiesterase inhibitor and/or cyclic nucleotide analogue to the ocular surface....
30	4902677	Treatment of heart failure of mammals with N6 -substituted cyclic adenosine monophosphates A composition for use in the treatment of heart failure of mammals which comprises, as its active ingredient, an N6 -substututed-adenosine-3',5'-cyclic phosphate represented by the following...
31	4880784	Antiviral methods utilizing ribofuranosylthiazolo[4,5-d]pyrimdine derivatives Compounds of the structure: ##STR1## wherein R1 and R2 individually are H or C1 -C18 acyl and R3 is H, C1 -C18 acyl or ##STR2## or R1 is H and together R2 and R3 are ##STR3## and X is O or S, Y i...
32	4873227	3',5'-Camp derivatives for treatment of certain types of skin ulcers A novel therapeutic agent for skin ulcers comprising as its active component adenosine-3',5'-cyclic phosphate or a derivative thereof, and a method for the treatment of skin ulcers by using the...
33	4797480	New biologically active fluorescent cyclic nucleotides Sybthesis of new biologically active fluorescent cyclic nucleotides of general formula: ##STR1## wherein X=OH and Y=NH2 or X=NH2 and Y=H and L is a fluorescent group of the class of 5 (or...
34	4728730	Synthesis of nucleoside thiophosphoanhydrides A method for preparing sulfur and/or selenium containing phosphoanhydrides that have at least a triphosphate moiety is disclosed, together with a cyclo-intermediate formed during the reaction. The...
35	4587044	Linkage of proteins to nucleic acids A nucleic acid-protein conjugate which is specific with respect to a selected living cell is prepared by linking said nucleic acid to a protein specific to said living cell.
36	4369181	Process for treating proliferative skin diseases using certain 6,8-substituted ribofuranosylpurine-3',5'-cyclic phosphates Proliferative skin diseases such as psoriasis are treated by topically administering cAMP analogs of the following formula to the afflicted skin site at a dose that preferentially and significantly...
37	4208406	Composition for the treatment and prevention of skin, eye and mucosal inflammation Composition for treatment or prevention of skin, eye or mucosal inflammation in human and animals, especially but not exclusively by external topical application comprising an effective amount of a...
38	4058659	6,8-Disubstituted purine derivatives of 9-β-D-ribofuranosyl 3',5'-cyclic phosphate Compounds of formula ##STR1## wherein X is --NR1 R2, --Cl, --Br or SR; Y is --X, --OH or --NH2 ; Z is hydrogen or --NH2 ; and R' is hydrogen or C1 -C18 acyl; R being hydrogen, aryl, aralkyl,...
39	4054735	Stabilized N2,2-O-dibutyrylguanosine-3,5-cyclic phosphate and salts thereof N2,2'-O-dibutyrylguanosine-3',5'-cyclic phosphate or a salt thereof is stabilized by adjusting the moisture content thereof to 3 percent or less by weight.
40	4048307	Cyclic adenosine monophosphate 8-substituted derivatives Novel cyclic adenosine monophosphate derivatives represented by the following general formula: ##STR1## wherein A stands for --S-- or --NH-- and n is an integer of from 2 to 12, ARE SUPERIOR TO...
41	4038033	Selenium labelled compounds in the saturation analysis of cyclic nucleotide New selenium-75 labelled derivatives of cyclic nucleotides are described, which are of value in the saturation analysis of cyclic nucleotides, particularly adenosine-3', 5'-cyclic monophosphate...
42	3988442	Cyclic nucleotide derivatives for treatment of hypothyroidism A method for stimulating the production of thyroid stimulating hormone (TSH) and enhancing thyroid function in animals comprising administering to an animal having low thyroid function an effective...
43	3968101	8-Substituted cyclic nucleotides by free radical alkylation and acylation Novel compounds of the general formula ##SPC1##Wherein X is H or NH2 ; R' is C1 to C8 alkyl, C1 to C8 substituted alkyl, benzyl, C1 to C8 acyl, benzoyl, carbamoyl, are disclosed as well as a novel...
44	3948886	6-Substituted purine 3',5'-cyclic nucleotides Described herein are novel 6-alkylthio and 6-arylalkylthio purine 3',5' cyclic nucleotides variously exhibiting adenyl cyclase and (in animal studies) tumor inhibitory properties, interferon...
45	3917583	2-Substituted cyclic AMP derivatives 2-Substituted derivatives of cyclic AMP and a process of making the same are disclosed which are useful to inhibit the enzyme phosphodiesterase, to activate protein kinase and steriodogenesis, and...
46	3897413	2,6-Disubstituted purine cyclic nucleotides Compounds of structure ##SPC1## Wherein X is Cl, F or Br and Y is Cl or Br, are prepared by diazotization of 2-amino-6-halo-9-β-D-ribofuranosylpurine 3',5'-cyclic phosphates in the presence of an ...
47	3883508	Process for the preparation of guanosine tetra- and penta-phosphates and products The chemical synthesis of guanosine 3',5'-bis-diphosphate (Magic Spot I) and guanosine 3'-diphosphate, 5'-triphosphate (Magic Spot II) starting from the readily available guanosine 2',3'-cyclic...
48	3872084	PURINE NUCLEOSIDE 3,5-CYCLICPHOSPHATE COMPOUNDS New purine nucleoside 3',5'-cyclicphosphate compounds are disclosed wherein the 5' carbon atom of the furanose sugar moiety bears one or two alkyl groups. Also disclosed are methods for the...
49	3872082	SUBSTITUTED PURINERIBOFURANOSIDE-3,5-CYCLOPHOSPHATE COMPOUNDS AND PROCESS FOR THEIR PREPARATION Novel substituted cyclophosphate compounds of the formula: ##SPC1## Wherein X is halogen, hydrocarbyl, sulfhydryl, thioether, alkylsulfoxy, alkylsulfonyl or hydrocarbyl-substituted amino wherein...
50	3860706	METHOD FOR CURING STOCK SYMPTOMS A shock symptom-curing preparation containing N6 -2'-0-dibutyryl adenosine-3',5'-cyclic-monophosphate (D-CAMP) or its salt and/or 2'-0-monobutyryl adenosine -3',5'-cyclic-monophosphate (M-CAMP) or...

Matches 1 - 50 out of 57

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