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7338669 |
Inorganic boranophosphate salts
The invention provides novel inorganic boranophosphate salts that can be used as fertilizers, in detergent formulations, as additive in melts for the glass industry, in boron neutron-capture...
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7335765 |
Nucleoside and oligonucleotide analogues
A compound of the formula (1):
wherein R 1 and R 2 are the same or different and represent a hydrogen atom, a hydroxyl protecting group, a phosphate group, or —P(R 3 )R 4 , wherein R 3 and...
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7332479 |
Extracellular NAD+ and cADPR as potent anti-inflammatory agents
A method of prophylaxis or treatment of inflammatory conditions, including, but not limited to, intestinal epithelial inflammation due to intestine-specific conditions (e.g., Crohn's disease or...
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7319093 |
Antidiabetic 2-substituted-5′-O-(1-Boranotriphosphate) adenosine derivatives
2-Substituted-5′-O-(1-boranotriphosphate)adenosine derivatives having at position 2 a radical R1 selected from the group consisting of H; halogen; O-hydrocarbyl; S-hydrocarbyl; NR3R4; and...
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7282581 |
Oligonucleotide labeling reactants based on acyclonucleosides and conjugates derived thereof
The invention relates to a labeling reactant of formula (I) useful for labeling an oligonucleotide
wherein: R is a temporary protecting group. A is either a phosphorylating moiety or a solid...
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7268119 |
Tricyclic nucleosides or nucleotides as therapeutic agents
Nucleosides and nucleotides containing a tricyclic base portion thereof are useful for treating infectious diseases and proliferative disorders, such as viral infections or cancer respectively.
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7247720 |
Phosphitylation process
A process for the phosphitylation of an alcohol or thiol with a phosphitylation agent in the presence of an activator is provided. The activator has the formula:
wherein p is 0 or an integer...
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7247621 |
Antiviral phosphonate compounds and methods therefor
Pharmaceutical compositions comprise a nucleotide analog with a phosphonate group at a concentration effective to act as a substrate and/or inhibitor of a viral polymerase, and especially of the...
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7238476 |
Methods and compositions for genotyping
The invention provides compositions and methods for performing primer extension reactions, including employment of amplification primers having 5′ tags to incorporate into amplicons variant...
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7223744 |
Pharmaceutical formulation comprising dinucleoside polyphosphates and salts thereof
The present invention provides a method of treating edematous retinal disorders. The method comprises administration of a pharmaceutical formulation comprising a hydrolysis-resistant P2Y receptor...
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7220854 |
Sugar moiety labeled nucleotide, and an oligo- or polynucleotide, and other compositions comprising such sugar moiety labeled nucleotides
The present invention provides a nucleotide having the formula,
wherein PM is a phosphate moiety, SM is a ribose or a deoxyribose sugar moiety, and BASE is a pyrimidine, purine or 7-deazapurine...
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7217815 |
2-beta -modified-6-substituted adenosine analogs and their use as antiviral agents
Various 2′-beta-methyl-6-substituted adenosine analogs (including 2,6-disubstituted adenosine, 8-aza-6-substituted adenosine, and 2-aza-6-substituted adenosine) are prepared by conventional and...
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7192700 |
Methods and compositions for conducting primer extension and polymorphism detection reactions
The invention comprises compositions and methods for performing primer extension reactions, including employment of amplification primers having 5′ tags to incorporate into amplicons variant...
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7176305 |
Production method for purine nucleotide derivative disodium crystals and alcohol removing method
Purine nucleotide derivative disodium crystals having a minimized amount of remaining alcohol such as methanol, ethanol or a mixture thereof are produced by overdrying purine nucleotide derivative...
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7164014 |
Protected linker compounds
The invention features linker molecules that have at one terminus a amino-protecting group and at the other terminus a phosphorous activating group, typically phosphoramidite. The linker molecules...
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7144874 |
Aryl phosphate derivatives of d4T having activity against resistant HIV strains
Methods of inhibiting virus replication of in a cell infected with a resistant strain of HIV that includes administering to the infected cell a virus replication inhibiting amount of an aryl...
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7132410 |
Di(uridine 5′-)tetraphosphate and salts thereof
The present invention are directed to P 1 , P 4 -di(uridine 5′-)tetraphosphate, tetra-alkali metal salts such as tetrasodium, tetralithium, tetrapotassium, and mixed tetra-alkali metal cations...
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7118871 |
Reagents for monitoring nucleic acid amplification and methods of using same
Described herein are novel indicator molecules of general formula (1):
wherein Q, F, N, Nuc, X 1 and X 2 are as defined herein, including their tautomeric forms and their additive salts. The...
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7115581 |
Chemically-defined non-polymeric valency platform molecules and conjugates thereof
Chemically-defined, non-polymeric valency platform molecules and conjugates comprising chemically-defined valency platform molecules and biological or chemical molecules including polynucleotide...
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7105661 |
Process for manufacturing morpholino-nucleotides, and use thereof for the analysis of and labelling of nucleic acid sequences
The invention relates to the use of morpholino-nucleosides of formula:
in which R 1 represents a nucleic base and R 2 represents a group corresponding to one of the following formulae:
...
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7105648 |
Oligomers substituted by phosphite acid ester, phosphonic acid or carbaborane functions and the corresponding PNA monomers
The invention relates to novel oligomers containing PNA units that are substituted by phosphite ester, phosphonic acid, or carbaborane functions and PNA monomers that are substituted by phosphite...
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7101993 |
Oligonucleotides containing 2′-O-modified purines
Compounds are provided containing purine nucleotides that bear moieties X at the 2′ position thereof wherein X is R 1 —(R 2 ) n ; R 1 is C 3 -C 20 alkyl, C 4 -C 20 alkenyl or C 2 -C 20 ...
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7084128 |
Method for reducing intraocular pressure
The present invention is directed to a method of reducing intraocular pressure. The method comprises administering to a subject a pharmaceutical composition comprising an effective amount of a...
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7083987 |
Activity based probe analysis
Methods and compositions are described for analyzing complex protein mixtures using fluorescent activity-based probes. In particular, probes that specifically react with and bind to the active form...
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7081526 |
Process for manufacturing morpholino-nucleotides, and use thereof for the analysis of and labelling of nucleic acid sequences
The invention relates to the use of morpholino-nucleosides of formula:
in which R 1 represents a nucleic base and R 2 represents a group corresponding to one of the following formulae:
...
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7081449 |
Pyrido[2,3-d]pyrimidine and pyrimido[4,5-d]pyrimidine nucleosides
A purine nucleoside analog includes a pyrido[2,3-d]pyrimidine or a pyrimido[4,5-d]pyrimidine and further has a sugar moiety that is optionally modified at the C2′, C3′, C4′ and/or C5′...
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7078391 |
Method of treating edematous retinal disorders
The present invention provides a method of treating edematous retinal disorders. The method comprises administration of a pharmaceutical formulation comprising a hydrolysis-resistant P2Y receptor...
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7067641 |
Phosphinoamidite carboxylates and analogs thereof in the synthesis of oligonucleotides having reduced internucleotide charge
Nucleoside phosphinoamidite carboxylates and analogs are provided that have the structure of formula (III)
wherein A is hydrogen, hydroxyl, lower alkoxy, lower alkoxy-substituted lower alkoxy,...
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7056894 |
Inhibitors of ADP-ribosyl transferases, cyclases, and hydrolases, and uses thereof
The present invention provides compounds having the formula:
wherein A is chosen from a nitrogen-, oxygen-, or sulfur-linked aryl, alkyl, cyclic, or heterocyclic group; both B and C are...
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7026469 |
Compositions and methods of double-targeting virus infections and cancer cells
The invention includes compositions and methods useful for treatment of a virus infection in a mammal by double-targeting the virus (i.e. targeting the virus at more than one stage of the virus...
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7022680 |
Inhibitors of ADP-ribosyl transferases, cyclases, and hydrolases
The present invention provides compounds having the formula:
wherein A is a nitrogen-, oxygen-, or sulfur-linked aryl, alkyl, cyclic, or heterocyclic group, the group being further substituted...
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7019127 |
Solution phase synthesis of oligonucleotides
A process for the synthesis in solution phase of a phosphorothioate triester is provided. The process comprises the solution phase coupling of an H-phosphonate with an alcohol in the presence of a...
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7018987 |
Synthesis of combretastatin A-4 prodrugs and trans-isomers thereof
The present invention relates to novel water-soluble, stable derivatives of combretastatin A-4, and novel synthesis methods therefore. The combretastatin A-4 prodrugs described herein appear to be...
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6987180 |
Uridine analogs and techniques for making and using
Uridine analogs and techniques for making and using uridine analogs are disclosed in this invention. These uridine analogs include nucleoside phosphates having a 5-aminouracil group. These...
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6977246 |
Certain dinucleotides and their use as modulators of mucociliary clearance and ciliary beat frequency
The present invention relates to certain novel dinucleotides and formulations thereof which are highly selective agonists of the P2Y 2 and/or P2Y 4 purinergic receptor. They are useful in the...
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6974865 |
C3′ -methylene hydrogen phosphonate oligomers and related compounds
The present invention is directed to nucleoside monomers wherein the 3′-O atom is replaced with a methylene group. The present invention also provides oligomers comprising a plurality of such...
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6962991 |
Process for the synthesis of pyrazolopyrimidines
The present invention provides a nucleoside comprising a pyrazolopyrimidine base and a process for producing the same. In particular, the processes of the present invention comprises using a...
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6949639 |
Oligonucleotide labeling reactants and their use
The invention relates to a novel labeling reactant of formula (I) suitable for labeling an oligonucleotide
wherein:
R is a temporary protecting group. A is either a phosphorylating moiety or...
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6900308 |
α-modified nucleoside triphosphates
The present invention is directed to α-modified nucleoside triphosphates and methods for their preparation. The present invention also provides for methods of inhibiting RNA and viral replication...
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6881725 |
Method for treating pain
The present invention is directed to a method of treating pain. The method comprises administering to a subject a pharmaceutical composition comprising an effective amount of a P2X receptor...
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6875859 |
Heterocyclic compounds and their use in the detection of nucleic acids
The invention concerns compounds of the general formula (I) in which the residues R 1 to R 7 have the meanings given in the application as well as methods for their preparation. The compounds are...
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6875858 |
Functionalized polynucleotide compound, optionally marked and method for detecting a target nucleic acid
The invention relates to a functionalized compound of general formula (I):
in which W represents a nucleotide analog, L represents a linker arm comprising at least four atoms, R 1 ...
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6875750 |
Aziridine compounds and methods of making and using them
Aziridine derivatives of formula (I)
are disclosed which can be used as cofactor for S-adenosyl-L-methionine-dependent methyltransferases.
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6861518 |
Preparation of phosphorothioate oligomers
Methods and Intermediates for the Preparation of Oligomers Containing Diastereomerically Enriched Phosphorothioate Linkages are Disclosed.
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6858721 |
Method for producing cytosine nucleoside compounds
The invention provides a method for producing a cytosine nucleoside compound from pentose-1-phosphate and cytosine or a derivative thereof using a nucleoside phosphorylase reactive to cytosine or a...
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6841675 |
Piperazine-based nucleic acid analogs
A novel nucleoside analog is disclosed which comprises a piperazine ring in the place of the ring ribose or deoxyribose sugar. Monomers utilizing a broad variety of nucleobases are disclosed, as...
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6818629 |
Pharmaceutical formulation comprising P1-(2'-deoxycytidine 5'-)P4-(uridine 5'-) tetraphosphate
The present invention provides a method of treating edematous retinal disorders. The method comprises administration of a pharmaceutical formulation comprising a hydrolysis-resistant P2Y receptor...
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6781001 |
Nucleic acids labelled with extended rhodamine dyes
Extended rhodamine compounds exhibiting favorable fluorescence characteristics having the structure are disclosed. In addition, novel intermediates for synthesis of these dyes are disclosed,...
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6750335 |
Nucleoside derivatives with photolabile protective groups
The invention relates to nucleoside derivatives with photolabile protecting groups of general formula (I) wherein R 1 is H, F, Cl, Br, I, or NO 2 ; R 2 is H or CN, provided that R 1 and R 2 ...
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6693187 |
Phosphinoamidite carboxlates and analogs thereof in the synthesis of oligonucleotides having reduced internucleotide charge
Phosphinoamidite carboxylates and analogs are provided that have the structure of formula (I) wherein R 1 , R 2 , R 3 , R 4 , X, Y, Z and n are as defined herein. The compounds are useful as...
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