Patents in Class 536/26.1

Matches 1 - 50 out of 174

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Match	Document	Document Title
1	8173621	Nucleoside cyclicphosphates Cyclic phosphate of nucleoside derivatives for the treatment of viral infections in mammals, which is a compound, its stereoisomers, salts (acid or basic addition salts), hydrates, solvates, or...
2	8163707	4′-allene-substituted nucleoside derivatives The present invention discloses compounds of formula (I), or its β-L enantiomer, or a pharmaceutically acceptable salt, ester, stereoisomer, tautomer, solvate, prodrug, or combination thereof: ...
3	8158776	P2Y6 receptor agonists for treating lung diseases This invention is directed to a method of enhancing or facilitating the clearance or the lung mucus secretions in a subject. This invention is also directed to a method of facilitating the...
4	8142800	Oral high potency clinical anti-craving treatment and method of use A practical high potency anti-craving oral medication or combined oral/IV drip medication is disclosed which comprises three components: a group of amino-acid substances, a group of vitamin...
5	8142799	High potency clinical anti-craving treatment and method of use A practical high potency anti-craving medication is disclosed which comprises three components: an amino-acid component, a vitamin component, and a mineral component, wherein each component is...
6	8129315	Labelling strategies for the sensitive detection of analytes The present invention relates to methods and reagents for detecting analytes, e.g. nucleic acids. The new methods and reagents allow a simple and sensitive detection even in complex biological...
7	8106022	Carbohydrate conjugates as delivery agents for oligonucleotides The present invention provides iRNA agents comprising at least one subunit of the formula (I): wherein:A and B are each independently for each occurrence O, N(RN) or S;X and Y are each...
8	8101745	Lung-targeted drugs Methods and compositions are provided for treating lung diseases, including but not limited to infections and small cell and non-small cell lung cancer, by conjugating a drug of interest to...
9	8097711	Thioether substituted aryl carbonate protecting groups Embodiments of the invention include nucleotide and nucleoside monomers protected at the 5′- or 3′-hydroxyls with thioether substituted aryl carbonate protecting groups. In certain cases, the car...
10	8076303	Nucleotide and oligonucleotide prodrugs The present invention discloses compounds of formula (I): which exhibit antiviral properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned...
11	8034923	Reagents for reversibly terminating primer extension Processes are disclosed that use 3′-reversibly terminated nucleoside triphosphates to analyze DNA for purposes other than sequencing using cyclic reversible termination. These processes are based o...
12	8030467	5′-modified bicyclic nucleic acid analogs The present invention provides 5′-modified bicyclic nucleoside analogs and oligomeric compounds comprising at least one of these nucleoside analogs. In preferred embodiments the nucleoside a...
13	7999098	Triphosphate oligonucleotide modification reagents and uses thereof Hydrazino, oxyamino and carbonyl-based monomers and methods for incorporation into oligonucleotides during enzymatic synthesis are provided. Modified oligonucleotides are provided that incorporate...
14	7989430	Antibacterial agents The invention provides compounds of formula (I) and salts thereof: R1-L-R2—B wherein R1, L, R2, and B have any of the values defined herein, as well as compositions comprising such compounds, and t...
15	7989603	2′-arabino-fluorooligonucleotide N3′-P5′ phosphoramidates: their synthesis and use Oligonucleotides with a novel sugar-phosphate backbone containing at least one 2′-arabino-fluoronucleoside and an internucleoside 3′-NH—P(═O)(OR)—O-5′ linkage, where R is a positively charged cou...
16	7968705	Production of 5'-ribonucleotides The present invention describes a composition comprising at least 55% w/w (on sodium chloride free dry matter weight) of 5′-ribonucleotides and a process for the production of this composition c...
17	7964352	3′-OH unblocked nucleotides and nucleosides, base modified with labels and photocleavable, terminating groups and methods for their use in DNA sequencing Provided are novel nucleotides, nucleoside, and their derivatives described herein, that can be used in DNA sequencing technology and other types of DNA analysis. In one embodiment, the nucleotide...
18	7960526	Colorimetric-oxycarbonyl protecting groups for use in organic syntheses The present invention provides for reagents for the introduction of colorimetric-oxycarbonyl protecting groups, compounds bearing colorimetric-oxycarbonyl protecting groups, and the use thereof in...
19	7951787	Phosphoramidate compounds and methods of use Phosphoramidate derivatives of nucleotides and their use in the treatment of cancer are described. The base moieties of, for example, each of deoxyuridine, cytarabine, gemcitabine and citidine may...
20	7935529	Method for excision of plant embryos for transformation This invention describes a simple method useful for the excision and isolation of maize immature embryos. The embryos are useful for plant tissue culture and transformation methods.
21	7935681	Antiviral nucleosides 4-Amino-1-((2R,3S,4S,5R)-5-azido-4-hydroxy-5-hydroxymethyl-3 -methyl-tetrahydro-furan-2-yl)-1H-pyrimidin-2-one (22) and prodrugs thereof are hepatitis C (HCV) polymerase inhibitors. Also disclosed...
22	7897737	3′-OH unblocked, nucleotides and nucleosides, base modified with photocleavable, terminating groups and methods for their use in DNA sequencing Provided are novel nucleotides, nucleoside, and their derivatives described herein, that can be used in DNA sequencing technology and other types of DNA analysis. In one embodiment, the nucleotide...
23	7893227	3′-OH unblocked nucleotides and nucleosides base modified with non-cleavable, terminating groups and methods for their use in DNA sequencing Provided are novel nucleotides, nucleoside, and their derivatives described herein, that can be used in DNA sequencing technology and other types of DNA analysis. In one embodiment, the nucleotide...
24	7786296	Silyl linker for solid-phase synthesis of nucleic acid The purpose of the invention is to develop a silyl linker that can be efficiently introduced on a solid-phase support used for the synthesis of nucleic acid oligomers such as DNA. The present...
25	7745591	Phosphinoamidite carboxylates and analogs thereof in the synthesis of oligonucleotides having reduced internucleotide charge Nucleoside phosphinoamidite carboxylates and analogs are provided that have the structure of formula (III) wherein A is hydrogen, hydroxyl, lower alkoxy, lower alkoxy-substituted lower alkoxy,...
26	7741295	Sir2 products and activities A novel compound, 2′/3′-O-acetyl-ADP-ribose, is provided. The compound is a mixture of the 2′ and 3′ regioisomers of O-acetyl-ADP ribose, and is formed nonenzymatically from 2′-O-ac...
27	7723495	Amidite for nucleic acid synthesis and nucleic acid synthesizing method To provide an amidite for nucleic acid synthesis, which enables a protective group therein to be removed under moderate conditions and can be practically used, and a nucleic acid synthesizing...
28	7723319	Acyclic nucleoside phosphonate derivatives, salts thereof and process for the preparation of the same The present invention relates to an acyclic nucleoside phosphonate derivative which is useful as an antiviral agent (particularly, against hepatitis B virus), pharmaceutically acceptable salts,...
29	7713941	Tricyclic nucleosides or nucleotides as therapeutic agents Nucelosides and nucleotides containing a tricyclic base portion thereof are useful for treating infectious diseases and proliferative disorders, such as viral infections or cancer respectively.
30	7666856	Antiviral nucleosides 4-Amino-1-((2R,3S,4S,5R)-5-azido-4-hydroxy-5-hydroxymethyl-3 -methyl-tetrahydro-furan-2-yl)-1H-pyrimidin-2-one (22) and prodrugs thereof are hepatitis C (HCV) polymerase inhibitors. Also disclosed...
31	7629457	Method for producing cytosine nucleoside compounds The invention provides a method for producing a cytosine nucleoside compound from pentose-1-phosphate and cytosine or a derivative thereof using a nucleoside phosphorylase reactive to cytosine or a...
32	7608599	Antiviral phosphoramidates The invention provides novel nucleoside compounds of formula I wherein R1, R2a, R2b, R3, R4, R5 R6, R8a, R9 and R10 are as defined herein which are useful for the treatment of Hepatitis C Virus...
33	7589079	Crystalline and amorphous forms of beta-L-2′-deoxythymidine Physical forms of beta-L-2′-deoxythymidine are disclosed that can be characterized by physical appearance, purity levels, Infra-Red and Raman spectroscopy, X-ray powder diffraction patterns, t...
34	7521432	Compositions and methods for identifying agents which regulate chromosomal stability, gene activation and aging Novel compositions and methods are provided for identifying agents which affect chromosomal stability and aging.
35	7476734	Nucleotide analogs The invention provides nucleotide analogs for use in sequencing nucleic acid molecules.
36	7439349	Method for preparation of large volume batches of poly-ICLC with increased biological potency; therapeutic, clinical and veterinary uses thereof Method for producing large lots of final sterile Poly-ICLC suitable for clinical use with reduced toxicity at effective dose levels, and method for using Poly-ICLC to regulate genes, and method for...
37	7432246	Sir2 products and activities A novel compound, 2′/3′-O-acetyl-ADP-ribose, is provided. The compound is a mixture of the 2′ and 3′ regioisomers of O-acetyl-ADP ribose, and is formed nonenzymatically from 2′-O-ac...
38	7405204	Nucleoside compounds for treating viral infections Disclosed are compounds, compositions and methods for treating viral infections caused by a Flaviviridae family virus, such as hepatitis C virus.
39	7338669	Inorganic boranophosphate salts The invention provides novel inorganic boranophosphate salts that can be used as fertilizers, in detergent formulations, as additive in melts for the glass industry, in boron neutron-capture...
40	7335765	Nucleoside and oligonucleotide analogues A compound of the formula (1): wherein R1 and R2 are the same or different and represent a hydrogen atom, a hydroxyl protecting group, a phosphate group, or —P(R3)R4, wherein R3 and R4 are the s...
41	7332479	Extracellular NAD+ and cADPR as potent anti-inflammatory agents A method of prophylaxis or treatment of inflammatory conditions, including, but not limited to, intestinal epithelial inflammation due to intestine-specific conditions (e.g., Crohn's disease or...
42	7319093	Antidiabetic 2-substituted-5′-O-(1-Boranotriphosphate) adenosine derivatives 2-Substituted-5′-O-(1-boranotriphosphate)adenosine derivatives having at position 2 a radical R1 selected from the group consisting of H; halogen; O-hydrocarbyl; S-hydrocarbyl; NR3R4; and h...
43	7282581	Oligonucleotide labeling reactants based on acyclonucleosides and conjugates derived thereof The invention relates to a labeling reactant of formula (I) useful for labeling an oligonucleotide wherein: R is a temporary protecting group. A is either a phosphorylating moiety or a solid...
44	7268119	Tricyclic nucleosides or nucleotides as therapeutic agents Nucleosides and nucleotides containing a tricyclic base portion thereof are useful for treating infectious diseases and proliferative disorders, such as viral infections or cancer respectively.
45	7247621	Antiviral phosphonate compounds and methods therefor Pharmaceutical compositions comprise a nucleotide analog with a phosphonate group at a concentration effective to act as a substrate and/or inhibitor of a viral polymerase, and especially of the...
46	7247720	Phosphitylation process A process for the phosphitylation of an alcohol or thiol with a phosphitylation agent in the presence of an activator is provided. The activator has the formula: wherein p is 0 or an integer from 1...
47	7238476	Methods and compositions for genotyping The invention provides compositions and methods for performing primer extension reactions, including employment of amplification primers having 5′ tags to incorporate into amplicons variant n...
48	7223744	Pharmaceutical formulation comprising dinucleoside polyphosphates and salts thereof The present invention provides a method of treating edematous retinal disorders. The method comprises administration of a pharmaceutical formulation comprising a hydrolysis-resistant P2Y receptor...
49	7220854	Sugar moiety labeled nucleotide, and an oligo- or polynucleotide, and other compositions comprising such sugar moiety labeled nucleotides The present invention provides a nucleotide having the formula, wherein PM is a phosphate moiety, SM is a ribose or a deoxyribose sugar moiety, and BASE is a pyrimidine, purine or 7-deazapurine...
50	7217815	2-beta -modified-6-substituted adenosine analogs and their use as antiviral agents Various 2′-beta-methyl-6-substituted adenosine analogs (including 2,6-disubstituted adenosine, 8-aza-6-substituted adenosine, and 2-aza-6-substituted adenosine) are prepared by conventional and c...

Matches 1 - 50 out of 174

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