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7371579 |
Nickel-based reagents for detecting DNA and DNA-protein contacts
The invention relates to a compound comprising a labeled nickel complex (FIG. 1 ) that is used to detect and purify nucleic acid sequences by forming an adduct between a specific nucleic acid base...
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7371531 |
Use of an extraction control in a method of extracting nucleic acids
The present invention relates to a method of ensuring the effectiveness of the extraction workup from a biological sample of nucleic acid. The inventive method is able to distinguish between...
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7368561 |
Isolation of antisense oligonucleotides
The present invention relates to a method of isolating fully thioated single stranded antisense oligonucleotides from a biological solution, which method comprises the steps of contacting the...
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7368547 |
Use of novel virulence-specific genes as targets for diagnosis and potential control of virulent strains of Listeria monocytogenes
A method for identifying virulent strains of L. monocytogenes that includes the use of primers or probes in a PCR assay or hybridization technique that employs primers or probes, which are...
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7355038 |
Phase isolation process for biomacromolecule components
The present invention relates to a phase isolation process for biomacromolecule components, after pretreating the substance to be isolated: 1) adding sufficient amount of buffer (one of the...
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7345163 |
Process for separating and deprotecting oligonucleotides
Methods for deprotecting and derivatizing oligonucleotides that are non-covalently bound to a solid support are described. The methods include providing a plurality of oligonucleotides linked to...
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7285401 |
Method and reagents for detecting nucleic acid sequences
The present invention is directed to a method for detecting an amplification product. Amplification is accomplished through the use of a plurality of detection probes. The present invention is also...
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7282371 |
Container for nucleic acid analysis
The present invention relates to a receptacle for receiving samples, containing a nucleic-acid stabilizing solution and a nucleic-acid-binding solid phase. The receptacle is especially suited for...
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7279280 |
Apparatus and method for detecting genetic mutations and single nucleotide polymorphisms
A method and means of identifying nucleic acid oligomers is disclosed. A sample is split into parts and the parts are flowed through chromatography columns containing nucleic acid oligomer probes...
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7270953 |
Compositions for isolating and/or stabilising nucleic acids in biological material
The present invention relates to new compositions for isolating and/or stabilising nucleic acids in materials of biological origin. The compositions comprise as an essential ingredient a cationic...
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7267952 |
Method of extracting virus genes and extraction apparatus
The present invention provides a method of extracting virus genes, which is excellent in quickness and convenience and can be automated, and this invention also provides an apparatus for such...
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7264927 |
Isolation and purification of nucleic acids
A method for the isolation and purification of nucleic acids such as DNA, RNA, and PNA from various sources using cellulose particles or cellulose paper. Adjusting the concentrations of the salt...
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7247721 |
Materials and methods for binding nucleic acids to surfaces
Surfaces containing high purity silica (silicon dioxide) exhibit high loading potential for nucleic acids. Formulations containing nucleic acids and materials which mask the electrostatic...
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7238530 |
Isolation and amplification of nucleic acid materials
The invention relates to methods for easily separating single stranded nucleic acid material from double stranded nucleic acid material in a sample containing both. By the right choice of at lease...
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7229595 |
Filtration column devices and methods of filtering therewith
This relates to filter columns for isolating nucleic acids. The filter column is adapted for stable placement within the upper portion of standard plastic collection tubes of various sizes. The...
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7225079 |
System and method for automated matched ion polynucleotide chromatography
In an extensive Matched Ion Polynucleotide Chromatography (MIPC) system and method, and the computer programs or software associated therewith, the system provides automated options for sample...
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7176295 |
Systematic evolution of ligands by exponential enrichment: blended SELEX
A method is described for generating blended nucleic acid ligands containing non-nucleic acid functional units. Specifically, a SELEX identified RNA ligand to the integrin gpIIbIIIa is conjugated...
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7173124 |
Isolation of nucleic acid
The present invention provides a method of isolating nucleic acid from a sample, said method comprising contacting said sample with a detergent and a solid support, whereby soluble nucleic acid in...
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7169917 |
Purification of plasmid DNA by hydrophobic interaction chromatography
The invention refers to a new process for the production of purification of high purity plasmid DNA. The process comprehends: a) the production of cells containing plasmid DNA, b) the disruption of...
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7164014 |
Protected linker compounds
The invention features linker molecules that have at one terminus a amino-protecting group and at the other terminus a phosphorous activating group, typically phosphoramidite. The linker molecules...
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7153948 |
High-affinity oligonucleotide ligands to vascular endothelial growth factor (VEGF)
Methods are described for the identification and preparation of nucleic acid ligand ligands to vascular endothelial growth factor (VEGF). Included in the invention are specific RNA ligands to VEGF...
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7153433 |
Use of functionalized porous membranes or matrices for purification of nucleic acids and corresponding methods
Application of a functionalized porous membrane to purify nucleic acids, the binding properties of the membrane with respect to nucleic acids being adjustable by controlling the conditions of an...
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7148343 |
Compositions and methods for using a solid support to purify RNA
Reagents, methods and kits for the purification of RNA from biological materials are provided.
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7138518 |
Liquid chromatographic separation of polynucleotides
In one aspect, the invention provides a method for separating a mixture of polynucleotides, such as DNA or RNA, including (a) applying the mixture to a polymeric separation medium having non-polar...
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7129344 |
Nucleic acid isolation
A method for isolating plasmids DNA from a DNA containing material which comprises plasmid DNA and genomic DNA, comprising extracting the plasmid DNA into a water-immiscible organic solvent, a...
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7119194 |
Nucleic acid-bondable magnetic carrier and method for isolating nucleic acid using the same
A nucleic acid-bondable magnetic carrier of the present invention is a magnetic silica particle comprising a superparamagnetic metal oxide, wherein the magnetic silica particle has a specific...
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RE39324 |
Pyrimidine derivatives and oligonucleotides containing same
Compounds having structure (1)
wherein R 1 is —H a protecting group, a linker or a binding partner; and R 2 and R 34 are as defined in the specification. The invention also provides...
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7109322 |
Process for the depletion or removal of endotoxins
A process for the depletion or removal of endotoxins from preparations containing active ingredients designated for therapeutical use which are obtained from natural sources by genetic engineering...
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7087735 |
Bivalent binding molecules of 7 transmembrane G protein-coupled receptors
Described herein are methods for identifying and preparing bivalent binding molecules to 7 transmembrane G protein-coupled receptors. The methods disclosed herein are based on the SELEX method for...
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7078517 |
Method of reusing DNA-immobilization substrate
It is intended to provide a method of reusing a DNA-immobilization substrate whereby the expensive DNA-immobilization substrate can be efficiently utilized and a reusable DNA-immobilization...
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7074917 |
Method for purifying 5′ -protected 2′ -deoxypurine nucleosides
A method for efficiently purifying 5′ protected 2′-deoxypurine nucleosides, efficient production of which has previously been difficult. Impurities can be separated by obtaining the 5′...
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7074916 |
Process for the separation of double-stranded/single-stranded nucleic acid structures
The present invention pertains to a process for the chromatographic separation of nucleic acid mixtures into their double-stranded and single-stranded nucleic acid fractions by simultaneously...
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7074596 |
Synthesis and use of anti-reverse mRNA cap analogues
The ability to synthesize capped RNA transcripts in vitro has been of considerable value in a variety of applications. However, one-third to one-half of the caps have, until now, been incorporated...
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7074333 |
Recovery of linear nucleic acids by salt dilution and/or reduced pressure prior to continuous pressure differential ultrafiltration
A method of recovery of DNA fragments using ultrafiltration. The method of the present invention relates to the separation and/or fractionation of double stranded linear nucleic acids using...
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7067287 |
Method for recovery of nucleic acids
Methods for the recovery of nucleic acids from a nucleic acid-containing material are provided, by which nucleic acids can be rapidly and easily recovered at a high purity without deteriorating the...
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7041817 |
Synthesis, deprotection, analysis and purification of RNA and ribozymes
Method for purification and synthesis of RNA molecules and enzymatic RNA molecules in enzymatically active form.
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7037654 |
Methods and compositions for enhancing detection in determinations employing cleavable electrophoretic tag reagents
Probe sets for the multiplexed detection of the binding of, or interaction between, one or more ligands and target antiligands are provided. Detection involves the release of identifying tags as a...
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7030230 |
Process of purifying phosphoramidites
A process of purifying phosphoramidite precursors useful in inter alia synthesis of oligonucleotides comprises dissolving a crude phosphoramidite in a polar phase, adding a basic compound to the...
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7026468 |
Process and equipment for plasmid purification
A scalable alkaline lysis process, including procedures and devices for the isolation of large quantities (grams and kilograms) of plasmid DNA from recombinant E. coli cell. Effective,...
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7022835 |
Method for binding nucleic acids to a solid phase
The invention concerns a method for binding nucleic acids to a solid phase in which a nucleic acid containing solution is contacted with a solid phase which has hydrophobic and hydrophilic groups...
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7018538 |
Use of a composite polymer-coated sorbent for separation, purification, desalting and concentration of biopolymers
Use of a composite sorbent having an at least partial coating on a support, which coating comprises essentially polyanilines or derivatives of polyanilines for the separation, isolation,...
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6992182 |
Method for isolating DNA from biological materials
The invention relates to a method for the stabilization, purification or/and isolation of nucleic acids from biological materials, in particular stool samples which may contain contaminations and...
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6992181 |
DNA isolation method
Disclosed is a method and apparatus for the isolation of DNA or cell nuclei or a mixture thereof from cell samples in a CD device. The method includes treating a suspension of whole cells with a...
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6972329 |
Materials and methods for releasing genetic material
The invention provides methods for isolating and releasing genetic material from a solid medium, such as a DNA array, a filter, a card, or a multiple-well plate, using a wash solution comprising a...
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6969603 |
Method for isolating DNA
Method for isolating DNA contained in a biological sample. The method includes combining in a solution a DNA-containing biological sample, a salt, a cationic surfactant, and a DNA-binding carrier,...
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6969587 |
Detection of nucleic acid heteroduplex molecules by anion-exchange chromatography
The present invention describes a method for separating or partially separating heteroduplex and homoduplex DNA molecules in a mixture. In the method, the mixture is applied to an anion-exchange...
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6962784 |
Vascular endothelial growth factor (VEGF) nucleic acid ligand complexes
This invention discloses a method for preparing a complex comprised of a VEGF Nucleic Acid Ligand and a Non-Immunogenic, High Molecular Weight Compound or Lipophilic Compound by identifying a VEGF...
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6958392 |
Methods for the isolation of nucleic acids and for quantitative DNA extraction and detection for leukocyte evaluation in blood products
A method for isolating nucleic acid which comprises:
(a) applying a sample comprising cells containing nucleic acid to a filter, whereby the cells are retained as a retentate and...
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6958391 |
Method for purifying 5′-protected 2′-deoxypurine nucleosides
A method for efficiently purifying 5′ protected 2′-deoxypurine nucleosides, efficient production of which has previously been difficult. Impurities can be separated by obtaining the 5′...
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6936709 |
Method for purifying protected 2′-deoxycytidines and hydrated crystals thereof
A protected 2′-deoxycytidine is purified by precipitating the protected 2′-deoxycytidine represented by general formula (3) in the form of a hydrated crystal from a solution containing the...
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