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9040678 Functionalization and purification of molecules by reversible group exchange  
Embodiments of the present disclosure include methods and compositions for functionalizing molecules, such as oligonucleotides, with functional groups, including polyhistidine tags useful in...
9029529 Methods for improved DNA release from binding substrates and/or decreasing PCR inhibition in pathogen detection  
Disclosed herein are processes for collecting nucleic acids from particulate samples. One embodiment disclosed herein relates to the use of ultrasonic energy to simultaneously shear large nucleic...
9024008 Procedure for the specific isolation of total DNA content of bacterial germs and a kit for this purpose  
Procedure for the specific isolation of total DNA content of bacterial germs of different samples, in the course of which the cells are lysated, the DNA content of the lysate is bound selectively,...
9017621 Preparation system and method  
Systems and methods for preparing a sample for further analysis are provided. The system can include an enclosure. A membrane can be disposed within the enclosure. First and second reservoirs can...
9012212 Method and device for continuous membrane adsorption  
A method and system is provided for yielding biopharmaceutical products involving a chromatographic separation process. The method comprises: providing a plurality of membrane adsorber cartridges;...
9006419 Method for isolating nucleic acids  
A method for isolating nucleic acids is provided. The method includes providing a biological sample containing at least one nucleic acid, and mixing the biological sample with an isolating agent...
9006420 Method for concentrating and isolating biomolecules or viruses  
A simple and convenient method for concentrating a biomolecule, including protein or nucleic acid molecules, from a sample. Purified and isolated biomolecules obtained by this method. Methods for...
9000146 Isolation of nucleic acids  
Provided herein is technology relating to isolating nucleic acids. In particular, the technology relates to methods and kits for extracting multiple DNA targets from a human stool sample with, for...
8980553 Methods and compositions for enriching either target polynucleotides or non-target polynucleotides from a mixture of target and non-target polynucleotides  
Compositions and methods are provided for enriching non-target polynucleotides from a mixture of non-target and target polynucleotides where differences between the target polynucleotides and the...
8980552 Method for isolating nucleic acids  
The invention describes a method of and kits for isolating and/or purifying nucleic acids, more specifically short-chain nucleic acids such as miRNA, from a nucleic acid-containing starting...
8969545 Alkynyl-derivatized cap analogs, preparation and uses thereof  
Alkynyl-derivatized cap analogs, alkynyl-modified capped RNA, 1,4-disubstituted triazole-derivatized capped RNA, methods of preparation, methods of isolation, and uses thereof are provided. The...
8956817 Identification of microRNAs (miRNAs) in fecal samples as biomarkers for gastroenterological cancers  
A simple, rapid, inexpensive, and promising commercial biomarker assay method for multiple diseases is described herein. The present invention detects miRNA-based biomarkers in human stool...
8937174 Method and device for the automated processing of a sample  
The invention relates to a method and a device for the automatic processing of biological samples which can have a relatively large volume and which can be further processed by a microfluidic...
8932809 Methods and kits for isolating nucleic acid from an organism  
The invention generally relates to methods and kits for isolating nucleic acids from an organism. In certain embodiments, methods of the invention involve contacting a plurality of lytic enzymes...
8921539 Methods and devices for nucleic acid purification  
The invention provides pipette tip columns and automated methods for the purification of nucleic acids such as plasmids from unclarified cell lysates containing cell debris as well as methods for...
8911992 DNA removal in target molecule purification  
Removal of genomic DNA from biological samples using cation exchange is described.
8895240 Method, kit and system for collecting and processing samples for DNA and RNA detection  
This invention relates to a method, kit and system for collecting and processing of samples to release and treat DNA and RNA for gene sequence detection. The method described here in provides for...
8889851 Methods for the synthesis and purification of oligomers  
A reagent for oligonucleotide synthesis or purification, wherein the reagent has a structure of: X—C—L—H (Formula A) wherein X is a phosphoramidite group, an H-phosphonate group, an acetal group,...
8889852 Plasmid DNA extraction process  
A process for the extraction of pDNA from cells is provided. In one aspect, the process comprises heating a liquid comprising the cells to an average temperature of from 95° C. to about 120° C....
8877918 Nucleic acid extraction method  
There is provided a nucleic acid extraction method applicable to microbes in a relatively wide range, and capable of rapidly extracting nucleic acid. The nucleic acid extraction method comprises...
8865405 Compositions and methods of selective nucleic acid isolation  
The invention relates to methods for isolating and/or identifying nucleic acids. The invention also provides kits for isolating and/or identifying nucleic acids.
8859199 Use of an extraction control in a method of extracting nucleic acids  
The present invention relates to a method of ensuring the effectiveness of the extraction workup from a biological sample of nucleic acid. The inventive method is able to distinguish between...
8846897 Method for filtering nucleic acids, in particular from fixed tissue  
The invention relates to a method for filtering nucleic acids, to a kit for carrying out the method according to the invention and to a novel use of magnetic particles for filtering a biological...
8828664 Sample preparation for in situ nucleic acid analysis, methods and compositions therefor  
Sample preparation processes for in situ RNA or DNA analysis, methods and compositions therefor are provided. Processes provided herein allow DNA or RNA analysis to be carried out in the same tube...
8828716 Disposable and removable nucleic acid extraction and purification cartridges for automated flow-through systems  
Removable cartridges are used on automated flow-through systems for the purpose of extracting and purifying genetic material from complex matrices. Different types of cartridges are paired with...
8822672 Method and device for producing and/or purifying polynucleotides and products obtainable thereof  
An apparatus and a method for obtaining a (poly)nucleotide sequence of interest include steps of cultivating hosts cells to produce a nucleotide sequence of interest and harvesting these cells,...
8815517 Methods for identifying functionally related genes and drug targets  
The identification and evaluation of mRNA and protein targets associated with mRNP complexes and implicated in the expression of proteins involved in common physiological pathways is described....
8816064 Purification of nucleic acids  
The present invention solves the problem of isolating nucleic acids from cells in the presence of the growth medium. The invention is particularly useful for isolating extrachromosomal replicons...
8816063 Nucleic acid purification method  
The present invention relates to a method for purifying a defined amount of nucleic acids from a nucleic acid-containing sample, which has at least the following steps: (a.) contacting the nucleic...
8815510 Combinatorial affinity selection  
In one aspect of the invention, methods for analyzing nucleic acid sample are provided. In a preferred embodiment, nucleic acids are selected using affinity matrices prior hybridization with a...
8809519 Method for nucleic acids isolation  
Methods for isolating nucleic acids using a solid phase having alkylene sulfonyl-containing compounds on its surface are provided. In one embodiment, the method comprises: contacting a sample...
8808990 Serial isolation of multiple DNA targets from stool  
Provided herein is technology relating to isolating nucleic acids. In particular, the technology relates to methods and kits for serial extraction of multiple DNA targets from a human stool sample.
8785718 Methods for producing genetically modified animals using hypermethylated transposons  
Methods of using hypermethylated transposons to create genetically modified animals that express interfering RNAs are described.
8785120 Method for the treatment of a sample containing biomolecules  
The invention generally provides a method for the sample preparation for a subsequent preparation, processing or analysis method of a sample containing an at least one species of nucleic acid...
8785348 Method of preparing carrier to separate nucleic acids, carrier and micro channel to separate nucleic acids, and method and apparatus for separating nucleic acids  
The present disclosure relates to a method and apparatus for separating nucleic acids. A carrier may include a porous microbead having cation-exchangeable groups attached to the surface of the...
8753842 Method for production of isoprenoid compounds  
The present invention is directed to variant squalene synthase enzymes, including Saccharomyces cerevisiae squalene synthase enzymes, and to nucleic acid molecules encoding these variant enzymes....
8754204 Method for preparing stool sample, solution for preparing stool sample, and kit for collecting stool  
A method for preparing a stool sample without any need for complicated operations is provided which is capable of efficiently recovering a nucleic acid originating from mammalian cells, such as...
8748134 Transcription activator-like effector assembly  
Described herein are techniques for assembling a polynucleotide encoding a transcription activator-like effector nucleases (TALEN). The techniques ligate and digest necessary modules for a TALEN...
8729252 Method for facilitating an automated isolation of a biopolymer using magnetic particles  
A method for isolating polynucleotides, such as DNA, RNA and hybrids thereof from an aqueous solution containing polynucleotides by reversibly binding the polynucleotides to silica-coated magnetic...
8710211 Polynucleotide capture materials, and methods of using same  
Methods for processing polynucleotide-containing biological samples, and materials for capturing polynucleotide molecules such as RNA and/or DNA from such samples. The RNA and/or DNA is captured...
8703931 Method for purification of nucleic acids, particularly from fixed tissue  
The invention relates to a method for purification of nucleic acids, to a kit for performing the method according to the invention and to a new application of magnetic particles for purification...
8691969 Isolation of nucleic acid  
The present invention provides a method of isolating nucleic acid from a sample, said method comprising contacting said sample with a detergent and a solid support, whereby soluble nucleic acid in...
8686129 Methods for the separation of biological molecules using sulfolane  
The present invention provides a method for the isolation of biological molecules by the adsorption of the molecules onto a mineral substrate in the presence of an appropriate mixture of salts and...
8680261 Methods for purifying nucleic acids  
Methods are provided for producing highly purified compositions of nucleic acids by using a highly streamlined and readily automated process. The methods use static mixers for lysing cells and...
8680262 Purification of oligonucleotides  
A method for purifying a protected oligonucleotide comprising the steps of: a) providing a solution of the protected oligonucleotide in at least one solvent A having a boiling point below the...
8669316 Magnetic ion-exchange resin and method for the preparation thereof  
Magnetic ion-exchange polymer microspheres and a method for preparing the same are provided. The method for preparing the magnetic ion-exchange polymer microspheres includes swelling the...
8664378 ***WITHDRAWN PATENT AS PER THE LATEST USPTO WITHDRAWN LIST***
Purification of nucleic acids
 
The present invention solves the problem of isolating nucleic acids from cells in the presence of the growth medium. The invention is particularly useful for isolating extrachromosomal replicons...
8664357 Solvent resistant diafiltration of peptides, PNA or oligonucleotides  
According to the present invention, there is provided a process for the preparation of a first compound selected from peptides, oligonucleotides and peptide nucleic acids. The process comprises...
8658359 Method and apparatus for disrupting cells and purifying nucleic acid using a single chip  
Provided herein is a method and apparatus for disrupting cells and purifying nucleic acids in a single chip. The method comprises irradiating a chip with a laser beam, wherein the chip comprises a...
8648187 Method for separation of double-stranded and single-stranded nucleic acids from the same sample  
The invention provides systems, methods and kits for the separation and/or purification of double-stranded and single-stranded nucleic acids from the same sample. The method includes first mixing...