Patents in Class 536/25.34

Matches 1 - 50 out of 297

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Match	Document	Document Title
1	8124756	Method of preparing 5′-amino-linker oligonucleotides derivatives and analogous 5′-labeled-linker oligonucleotides therefrom A method for preparing amino linker oligonucleotides is provided. More specifically, a method of preparing 5′-amino-linker oligonucleotides comprising the steps of: introducing an amino linker h...
2	8039612	Synthesis of oligonucleotides or phosphorothioate oligonucleotide with a capping agent of N-methylimidazole free of 1,3,5-trimethylhexahydro-1,3,5-triazine According to the present invention, there is provided a process for making an oligonucleotide or a phosphorothioate oligonucleotide. The process has the following steps: (a) providing an amount of...
3	8026348	Nucleoside derivative, modified oligonucleotide, method for their synthesis and applications thereof Compositions and methods of preparing carboranes and metallacarboranes, which can be used as a new type of electrochemically active label for biological compounds, are disclosed. Nucleic acid...
4	7999098	Triphosphate oligonucleotide modification reagents and uses thereof Hydrazino, oxyamino and carbonyl-based monomers and methods for incorporation into oligonucleotides during enzymatic synthesis are provided. Modified oligonucleotides are provided that incorporate...
5	7923550	Reagent compounds and methods of making and using the same The present invention describes novel compounds and methods for capping reactive groups on support and during multistep synthesis. These new capping reagents are also useful for high quality...
6	7910726	Amidite for synthesizing modified nucleic acid and method for synthesizing modified nucleic acid The disclosure provides an excellent amidite for synthesizing a modified nucleic acid, which enables a protective group therein to be removed under a moderate condition, thereby stably producing a...
7	7893249	Deprotection and purification of oligonucleotides and their derivatives Method for synthesis, deprotection, and/or purification of nucleic acid molecules, such as oligonucleotides comprising one or more ribonucleotides. Such nucleic acid molecules include siRNA, dsRNA,...
8	7872120	Methods for synthesizing a collection of partially identical polynucleotides Methods for synthesizing a collection of partially identical polynucleotides are disclosed.
9	7858772	Compounds and methods for synthesis and purification of oligonucleotides The present invention provides methods of extending nucleic acids and purifying target nucleic acids. The methods include the use of capping reagents to effect chain termination and provide a...
10	7855285	Methods for selective N-9 glycosylation of purines A process for providing regiospecific and highly stereoselective synthesis of 9-β anomeric purine nucleoside analogs is described. The introduction of the sugar moiety on to 6-(azolyl)-substituted ...
11	7807821	Method for the synthesis of nucleic acid without protecting base moiety A phosphoramidite method for the synthesis of a nucleic acid oligomer without protecting the base moiety characterized in that a 3′ or 5′ hydroxyl group of a nucleotide is reacted with a nuc...
12	7786293	Organic compounds The present invention provides a process for the sulfurization of phosphorus-containing compounds. More particularly, the process involves contacting the compound to be sulfurized with a sulfur...
13	7786294	Compositions and methods for amplification and cloning of near full-length viral genome samples A method of producing a polydeoxyribonucleotide molecule by reverse transcriptase polymerase chain reaction wherein the polydeoxyribonucleotide molecule has a length of greater than 5,000...
14	7777013	Labeled nucleotide analogs and uses therefor Labeled nucleotide analogs used in place of naturally occurring nucleoside triphosphates or other analogs in template directed nucleic acid synthesis reactions and other nucleic acid reactions, and...
15	7759480	Chloral-free DCA in oligonucleotide synthesis A process of manufacturing oligonucleotides includes a 5′-deblocking step in which the 5-blocking group is removed with dichloroacetic acid that is essentially free of chloral. The process is u...
16	7759513	Photolabile protective groups for improved processes to prepare oligonucleotide arrays The present invention discloses novel and improved nucleosidic and nucleotidic compounds that are useful in the light-directed synthesis of oligonucleotides, as well as, methods and reagents for...
17	7741471	Reagents for the improved synthesis of isoguanosine containing oligonucleotides The present invention provides the combination of the O-2 diphenylcarbamoyl (“DPC”) and N-6 dimethylaminomethylidene (“DMF”) protecting groups for isoguanosine nucleosides that can be utilize...
18	7741472	Polynucleotide containing a phosphate mimetic The present invention concerns modified oligonucleotides and processes for their production wherein these oligonucleotides contain at least once the structure P═N-Acc where Acc is an electron a...
19	7723511	Synthesis of sulfurized oligonucleotides Methods for the formation of sulfurized oligonucleotides are provided. The methods allow for the formation of phosphorothioate linkages in the oligonucleotides or derivatives, without the need for...
20	7723319	Acyclic nucleoside phosphonate derivatives, salts thereof and process for the preparation of the same The present invention relates to an acyclic nucleoside phosphonate derivative which is useful as an antiviral agent (particularly, against hepatitis B virus), pharmaceutically acceptable salts,...
21	7700761	3-deoxypentopyranosyl nucleic acid, its production and its use Provided are processes for preparing a 3′-deoxypentopyranosyl oligomers with linkers for linking biomolecules. The processes can the steps of: bonding a 4′-protected-3′-deoxypentopyranosyl nucle...
22	7700706	Polymeric beads for oligomer synthesis The present invention provides solid support media for use in oligomer synthesis, methods of producing the media, and methods of using the media. In some embodiments, the processes of the invention...
23	7655790	Deprotection and purification of oligonucleotides and their derivatives Method for synthesis, deprotection, and/or purification of nucleic acid molecules, such as oligonucleotides comprising one or more ribonucleotides. Such nucleic acid molecules include siRNA, dsRNA,...
24	7635772	Process for the preparation of oligonucleotides A process for the synthesis of an oligonucleotide is provided in which an oligonucleotide is assembled on a swellable solid support using the phosphoramidite approach in the presence of an...
25	7585970	Method of polynucleotide synthesis using modified support A method for synthesizing a polynucleotide is disclosed. The method comprises providing a functionalized support comprising a triaryl methyl linker bound to the solid support through a substitution...
26	7579459	Activator bound solid supports for nucleic acid synthesis via the phosphoramidite approach The present invention relates to improved methods for the preparation of nucleic acids. More particularly, conventional solid supports used for nucleic acid synthesis are derivatized with...
27	7524950	Uses of cationic salts for polynucleotide synthesis Inkjet printhead solvents and methods of forming an addressable nucleotide array are disclosed.
28	7511125	Pyrimidine derivatives for labeled binding partners Compounds having structure (1) wherein R1 is —H a protecting group, a linker or a binding partner; and R2 and R34 are as defined in the specification. The invention also provides intermediates a...
29	7501505	Activators for oligonucleotide synthesis A process for the synthesis of oligonucleotides using phosphoramidite chemistry is provided. The process employs as activator a 1,1-dioxo-1,2-dihydro-1λ6-benzo[d]isothiazol-3-one, preferably in ...
30	7435810	Use of ionic liquids for fabrication of polynucleotide arrays A method of fabricating polynucleotide arrays includes dissolving a nucleotide monomer, oligonucleotide, or polynucleotide in a solvent containing ionic liquid and depositing the resulting solution...
31	7427678	Method for immobilizing oligonucleotides employing the cycloaddition bioconjugation method This invention discloses a novel method for immobilizing molecules to a support. Specifically, this invention discloses a method of immobilizing derivatized biomolecules, such as oligonucleotides,...
32	7417139	Method for polynucleotide synthesis Methods of forming an internucleotide bond are disclosed. Such methods find use in synthesis of polynucleotides. The method involves contacting a functionalized support with a precursor having an...
33	7411061	Method of synthesizing polynucleotides using ionic liquids A method of synthesizing polynucleotides is disclosed. The method involves contacting a first nucleotide with a selected reactive group in the presence of an ionic liquid. The selected reactive...
34	7385050	Cleavable linker for polynucleotide synthesis Functionalized supports for polynucleotide synthesis are disclosed. The supports have linker moieties that are stable to conditions used in polynucleotide synthesis, but may be cleaved to release...
35	7381820	α-1-phosphorylated-2-deoxy-2-fluoroarabinoside and process for producing 2′-deoxy-2′-fluoro-β-d-arabinonucleoside A method for producing 2′-deoxy-2′-fluoro-β-D-arabinonucleoside represented by formula (II): (wherein B represents a base), in particular, 2′-deoxy-2′-fluoro-β-D-arabinopurinenucleoside, which met...
36	7378516	Synthesis of sulfurized oligonucleotides Methods for the formation of sulfurized oligonucleotides are provided. The methods allow for the formation of phosphorothioate linkages in the oligonucleotides or derivatives, without the need for...
37	7339052	Phosphoramidite activator for oligonucleotide synthesis The present invention provides an improved phosphoramidite activator comprising a solution of 5-benzylmercaptotetrazole in acetonitrile and N-alkyimidazole. Further provided are improved methods of...
38	7276599	Oligonucleotide synthesis with alternative solvents The invention provides for methods of manufacturing an oligonucleotide comprising a pentavalent phosphate triester. In particular, the method comprises providing a 5′ blocked-nucleoside, d...
39	7271258	Methods of synthesizing oligonucleotides using carbonate protecting groups and alpha-effect nucleophile deprotection The invention provides methods for synthesizing oligonucleotides using nucleoside monomers having carbonate protected hydroxyl groups that are deprotected with α-effect nucleophiles. The α-effect n...
40	7227017	Process for the preparation of phosphorothioate oligonucleotides A process for the synthesis of phosphorothioate oligonucleotides is provided which comprises assembling an oligonucleotide bound to a solid support in the presence of acetonitrile; prior to...
41	7227016	Process for the synthesis of oligomeric compounds Synthetic processes are provided wherein oligomeric compounds are prepared having phosphodiester, phosphorothioate, phosphorodithioate, or other covalent linkages. The oligomers have substantially...
42	7217814	Methods of producing phosphitylated compounds Provided are methods of producing phosphitylated compounds, including 3′-O-phosphoramidites, comprising the step of reacting a hydroxyl-containing compound with a phosphitylating agent in the p...
43	7193077	Exocyclic amine triaryl methyl protecting groups in two-step polynucleotide synthesis Precursors for use in the synthesis of polynucleotides and methods of using the precursors in synthesizing polynucleotides are disclosed. The precursors include a heterocyclic base having an...
44	7169916	Chloral-free DCA in oligonucleotide synthesis A process of manufacturing oligonucleotides includes a 5′-deblocking step in which the 5-blocking group is removed with dichloroacetic acid that is essentially free of chloral. The process is u...
45	7153954	Method for preparation of LNA phosphoramidites The present invention relates to large scale preparation of LNA phosphoramidites using a 2-cyanoethyl-N,N,N′,N′-tetra-substituted phosphoramidite and a nucleophilic activator, e.g. 2-c...
46	7144700	Photolithographic solid-phase polymer synthesis Methods, employing a polycyclic hydrocarbon or a polycyclic heteroaromatic compound as sensitizers, are provided to increase the efficiency of removing, by irradiation, photolabile protecting...
47	7135565	Synthesis of polynucleotides using combined oxidation/deprotection chemistry A method of synthesizing a polynucleotide which can, for example, be used during fabrication of an array. A second nucleoside is coupled to a first nucleoside through a phosphite linkage, with the...
48	7135564	Reusable solid support for oligonucleotide synthesis A reusable linker arm for solid support oligonucleotide synthesis, the linker arm comprising formula (a) wherein Z is a linker moiety and T is an organic radical. A method for adding one or more...
49	7125982	Microbial production of nuclease resistant DNA, RNA, and oligo mixtures The present method describes the use of thio-phosphate as a feed source for micro-organisms and multi-cellular organisms. This compound enters into nucleotide pools and ultimately into polymers of...
50	RE39324	Pyrimidine derivatives and oligonucleotides containing same Compounds having structure (1) wherein R1 is —H a protecting group, a linker or a binding partner; and R2 and R34 are as defined in the specification. The invention also provides intermediates a...

Matches 1 - 50 out of 297

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