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7385051 |
Fluorescent N2,N3-etheno-purine (2′-deoxy) riboside derivatives and uses thereof
The invention relates to fluorescent N 2 ,N3-etheno-purine (2′-deoxy) riboside derivatives and fluorescent oligonucleotide probes comprising one or more moieties thereof, their preparation and...
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7365176 |
Detection of Epstein-Barr virus
The invention provides methods to detect EBV in biological samples using real-time PCR. Primers and probes for the detection of EBV are provided by the invention. Articles of manufacture containing...
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7354708 |
Invasion assays
The present invention relates to means for the detection and characterization of nucleic acid sequences, as well as variations in nucleic acid sequences. The present invention also relates to...
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7329493 |
One-tube nested PCR for detecting Mycobacterium tuberculosis
The present invention relates to a kit and method for detecting M. tuberculosis of suspected patient. The present invention also relates to primers and probe used to detect M. tuberculosis by...
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7323571 |
Heterodimeric dye composition
This invention provides for labeling reagents, labeled targets and processes for preparing labeling reagents. The labeling reagents can take the form of cyanine dyes, xanthene dyes, porphyrin dyes,...
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7317097 |
Mutations in the ferroportin 1 gene associated with hereditary haemochromatosis
The present invention relates to mutations in the gene coding for ferroportin 1 associated with hereditary haemochromatosis and methods for the diagnosis of hereditary haemochromatosis based on the...
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7314928 |
Process for manufacturing morpholino-nucleotides, and use thereof for the analysis of and labelling of nucleic acid sequences
The invention relates to the use of morpholino-nucleosides of formula:
in which R 1 represents a nucleic base and R 2 represents a group corresponding to one of the following formulae:
...
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7301041 |
Bi-functional metallocenes, preparation process and use in the labeling or biological molecules
The invention relates to bi-functionalised metallocenes of general formula (I) where Me=a transition metal, preferably chosen from Fe, Ru and Os, Y and Z, when identical are selected from --(CH 2 )...
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7294709 |
Detection of Giardia
Oligonucleotide molecules for the detection of Giardia lamblia ( G. lamblia which molecules hybridise under medium to high stringency conditions to unique 18S rDNA/rRNA sequences of G. lamblia,...
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7282581 |
Oligonucleotide labeling reactants based on acyclonucleosides and conjugates derived thereof
The invention relates to a labeling reactant of formula (I) useful for labeling an oligonucleotide
wherein: R is a temporary protecting group. A is either a phosphorylating moiety or a solid...
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7279311 |
Use of nucleic acids bound to carrier macromolecules
A nucleic acid primer is bound to a soluble carrier macromolecule, a multitude of primer molecules thus being carried by each carrier macromolecule, and hybridisation of the primer to a template...
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7267945 |
Methods of determining the presence of polynucleotides employing amplification
The invention provides methods and kits for determining the presence of polynucleotides in samples. According to certain embodiments, the invention provides methods for determining the presence of...
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7255851 |
Non-invasive localization of a light-emitting conjugate in a mammal
Methods and compositions for detecting and localizing light originating from a mammal are disclosed. Also disclosed are methods for targeting light emission to selected regions, as well as for...
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7244568 |
Isolation of nucleic acid
Provided is a preparative method for isolating RNA comprising an oligo-or polynucleotide from a sample, which method comprises: (a) treating the sample with a reactant capable of covalently...
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7229798 |
Transposon mediated multiplex sequencing
The present invention relates to an automated method of transposon-mediated multiplex sequencing of DNA fragments inserted into a vector. It relates more particularity to an increased efficiency in...
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7223568 |
Methods for determining nucleotide sequences of single nucleic acid molecules
The present invention relates to a method for determining a nucleotide sequence of a nucleic acid by detecting a single dye molecule.
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7220541 |
Homogeneous assay of biopolymer binding by means of multiple measurements under varied conditions
A method for homogeneously assaying biopolymer bonding includes obtaining signals from a test sample before, during and/or after the application of stimulus to the test sample and correlating the...
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7214780 |
Probes, compositions and kits for determining the presence of Mycoplasma pneuomoniae in a test sample
The present invention relates to oligonucleotides useful for determining the presence of Mycoplasma pneumoniae and/or Mycoplasma genitalium in a test sample. The oligonucleotides of the present...
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7205399 |
Methods and reagents for oligonucleotide synthesis
The present invention features novel compositions, linkers, derivatized solid supports, and methods for the efficient solid phase synthesis of oligonucleotides, including RNA, DNA, RNA-DNA...
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7199234 |
Regulatory segments of the human gene for telomerase reverse transcriptase
The invention provides compositions and methods related to human telomerase reverse transcriptase (hTRT), the catalytic protein subunit of human telomerase. The polynucleotides and polypeptides of...
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7173125 |
Triphosphate oligonucleotide modification reagents and uses thereof
Hydrazino, oxyamino and carbonyl-based monomers and methods for incorporation into oligonucleotides during enzymatic synthesis are provided. Modified oligonucleotides are provided that incorporate...
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7157449 |
Medicament for the treatment of diseases caused by parasitic protozoa
The present invention relates to the use of an inhibitor of CTP synthetase, such as a glutamine analogue, and a substance capable of suppressing toxic effects thereof in vivo, in the manufacture of...
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7150978 |
Recombinant template used for producing a carboxy-terminal modified protien and a method of producing a carboxy-terminal modified protein
A translation template comprising an ORF region coding for a protein, a 5′ untranslated region comprising a transcription promoter and a translation enhancer and locating on the 5′ side of the...
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7144700 |
Photolithographic solid-phase polymer synthesis
Methods, employing a polycyclic hydrocarbon or a polycyclic heteroaromatic compound as sensitizers, are provided to increase the efficiency of removing, by irradiation, photolabile protecting...
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7138254 |
Methods and apparatus for performing submicroliter reactions with nucleic acids or proteins
Methods for preparing nanoscale reactions using nucleic acids or proteins are presented. Nucleic acids are captured saturably, yet reversibly, on the internal surface of the reaction chamber,...
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7132409 |
Adenosine derivatives and use thereof
2-(6-Cyano-1-hexyn-1-yl)adenosine, 2-(6-cyano-1-hexyn-1-yl)adenosine 5′-monophosphate, or salts thereof; and drugs containing the same as an active ingredient. The compounds have excellent...
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7132266 |
Method and kit for analyzing target nucleic acid fragment
A method of analyzing a target nucleic acid fragment is provided that is capable of being performed simply and promptly, by anyone, using a compact device without requirement of specific technique...
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7129045 |
Methods of detecting polynucleotide kinase and its use as a label
Methods of detecting or measuring the activity of polynucleotide kinase are disclosed as well as methods of detecting an analyte in an assay using polynucleotide kinase as a label on a member of a...
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7125982 |
Microbial production of nuclease resistant DNA, RNA, and oligo mixtures
The present method describes the use of thio-phosphate as a feed source for micro-organisms and multi-cellular organisms. This compound enters into nucleotide pools and ultimately into polymers of...
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7115365 |
Method of analyzing a target nucleic acid
A biological sample containing a target nucleic acid is mixed with a primer, a substrate labeled with fluorescence, and DNA polymerase to prepare a test solution. After a nucleic acid amplification...
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RE39324 |
Pyrimidine derivatives and oligonucleotides containing same
Compounds having structure (1)
wherein R 1 is —H a protecting group, a linker or a binding partner; and R 2 and R 34 are as defined in the specification. The invention also provides...
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7094568 |
Method for producing proteins tagged at the N- or C-terminus
The present invention relates to novel methods of producing proteins in which one or more domains are full length and correctly folded and which are each tagged at either the N- or C-terminus with...
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7094538 |
Diagnostic assay for cancer susceptibility
The lifetime probability of a person developing cancer can now be determined based on an allelic variation found in the 3′UTR of the prohibitin gene. The probability is dependent on the sequence...
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7090975 |
Pyrophosphorolysis and incorporation of nucleotide method for nucleic acid detection
Processes are disclosed using the depolymerization of a nucleic acid hybrid and incorporation of a suitable nucleotide to qualitatively and quantitatively analyze for the presence of predetermined...
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7081336 |
Dual resonance energy transfer nucleic acid probes
Dual nucleic acid probes with resonance energy transfer moieties are provided. In particular, fluorescent or luminescent resonance energy transfer moieties are provided on hairpin stem-loop...
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7078499 |
Nucleotide analogues comprising a reporter moiety and a polymerase enzyme blocking moiety
Nucleotides comprising a reporter moiety and a polymerase enzyme blocking moiety in which the reporter moiety does not also act as a polymerase enzyme blocking moiety are described. Also described...
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7070961 |
Electronically mediated nucleic acid amplification in NASBA
A method of improving amplification of nucleic acids using a nucleic acid sequence-based amplification (“NASBA”) method is provided wherein target nucleic acids and NASBA primers are...
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7070933 |
Inversion probes
Unitary hybridization probes having stem-and-loop structures, wherein the stem portion of the structure comprises a pair of interactive arms that are substantially prevented from interacting with...
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7064197 |
System, array and non-porous solid support comprising fixed or immobilized nucleic acids
Nucleic acids are fixed or immobilized to non-porous solid supports (substrates), and include systems containing such supports and arrays with fixed or immobilized nucleic acids. These compositions...
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7052847 |
Method for sequencing nucleic acid molecules
The present invention is directed to a method of sequencing a target nucleic acid molecule having a plurality of bases. In its principle, the temporal order of base additions during the...
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7049129 |
Electro-optical devices and methods for hybridization and detection
The invention provides an apparatus and method for detection of a target molecule. The apparatus includes a probe labeled with a transition metal-ligand complex that hybridizes with the target to...
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7045360 |
Method for analysis of reaction products
The present invention provides methods, compounds, and kits useful in the analysis of reaction products and components of reaction mixtures, and in certain embodiments for the rapid and...
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7034131 |
Nucleic acid derivatives
A compound which comprises a backbone having a plurality of chiral carbon atoms, the backbone bearing a plurality of ligands each being individually bound to a chiral carbon atom of the plurality...
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7026114 |
Methods and compositions for monitoring polymer array synthesis
VLSIPS™ manufacturing processes are of increasing commercial importance. The present invention provides methods and compositions for monitoring the efficiency and quality of polymer synthesis in...
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7022834 |
Isotopically labelled DNA
The present invention relates to a labeled deoxyribonucleic acid (DNA) molecule. In one aspect, the labeled DNA molecule is produced by contacting a cell or subject with a detectable amount of a...
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7019128 |
Propargylethoxyamino nucleotides
Propargylethoxyamino nucleosides are disclosed having the structure
wherein R 1 and R 2 are —H, lower alkyl, or label; B is a 7-deazapurine, purine, or pyrimidine nucleoside base; W 1 is...
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7014994 |
Coupled polymerase chain reaction-restriction-endonuclease digestion-ligase detection reaction process
The present invention provides a method for identifying one or more low abundance sequences differing by one or more single-base changes, insertions, or deletions, from a high abundance sequence in...
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7008770 |
Method for the controlled implementation of complex PCR amplifications
A method is described for controllably conducting complex PCR amplifications, wherein at least the following steps are conducted:
a) PCR amplification with at least 50 primers of a first...
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7001725 |
Kits employing generalized target-binding e-tag probes
Kits for the multiplexed detection of the binding of, or interaction between, one or more ligands and target antiligands are provided. Detection involves the release of identifying tags as a...
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6992180 |
Oligo- or polynucleotides comprising phosphate-moiety labeled nucleotides
The present invention provides a nucleotide having the formula,
Sig-PM-SM-BASE
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