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7150978 |
Recombinant template used for producing a carboxy-terminal modified protien and a method of producing a carboxy-terminal modified protein
A translation template comprising an ORF region coding for a protein, a 5′ untranslated region comprising a transcription promoter and a translation enhancer and locating on the 5′ side of the...
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7144700 |
Photolithographic solid-phase polymer synthesis
Methods, employing a polycyclic hydrocarbon or a polycyclic heteroaromatic compound as sensitizers, are provided to increase the efficiency of removing, by irradiation, photolabile protecting...
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7138254 |
Methods and apparatus for performing submicroliter reactions with nucleic acids or proteins
Methods for preparing nanoscale reactions using nucleic acids or proteins are presented. Nucleic acids are captured saturably, yet reversibly, on the internal surface of the reaction chamber,...
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7132409 |
Adenosine derivatives and use thereof
2-(6-Cyano-1-hexyn-1-yl)adenosine, 2-(6-cyano-1-hexyn-1-yl)adenosine 5′-monophosphate, or salts thereof; and drugs containing the same as an active ingredient. The compounds have excellent...
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7132266 |
Method and kit for analyzing target nucleic acid fragment
A method of analyzing a target nucleic acid fragment is provided that is capable of being performed simply and promptly, by anyone, using a compact device without requirement of specific technique...
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7129045 |
Methods of detecting polynucleotide kinase and its use as a label
Methods of detecting or measuring the activity of polynucleotide kinase are disclosed as well as methods of detecting an analyte in an assay using polynucleotide kinase as a label on a member of a...
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7125982 |
Microbial production of nuclease resistant DNA, RNA, and oligo mixtures
The present method describes the use of thio-phosphate as a feed source for micro-organisms and multi-cellular organisms. This compound enters into nucleotide pools and ultimately into polymers of...
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RE39324 |
Pyrimidine derivatives and oligonucleotides containing same
Compounds having structure (1)
wherein R 1 is —H a protecting group, a linker or a binding partner; and R 2 and R 34 are as defined in the specification. The invention also provides...
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7115365 |
Method of analyzing a target nucleic acid
A biological sample containing a target nucleic acid is mixed with a primer, a substrate labeled with fluorescence, and DNA polymerase to prepare a test solution. After a nucleic acid amplification...
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7094568 |
Method for producing proteins tagged at the N- or C-terminus
The present invention relates to novel methods of producing proteins in which one or more domains are full length and correctly folded and which are each tagged at either the N- or C-terminus with...
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7094538 |
Diagnostic assay for cancer susceptibility
The lifetime probability of a person developing cancer can now be determined based on an allelic variation found in the 3′UTR of the prohibitin gene. The probability is dependent on the sequence...
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7090975 |
Pyrophosphorolysis and incorporation of nucleotide method for nucleic acid detection
Processes are disclosed using the depolymerization of a nucleic acid hybrid and incorporation of a suitable nucleotide to qualitatively and quantitatively analyze for the presence of predetermined...
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7081336 |
Dual resonance energy transfer nucleic acid probes
Dual nucleic acid probes with resonance energy transfer moieties are provided. In particular, fluorescent or luminescent resonance energy transfer moieties are provided on hairpin stem-loop...
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7078499 |
Nucleotide analogues comprising a reporter moiety and a polymerase enzyme blocking moiety
Nucleotides comprising a reporter moiety and a polymerase enzyme blocking moiety in which the reporter moiety does not also act as a polymerase enzyme blocking moiety are described. Also described...
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7070933 |
Inversion probes
Unitary hybridization probes having stem-and-loop structures, wherein the stem portion of the structure comprises a pair of interactive arms that are substantially prevented from interacting with...
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7070961 |
Electronically mediated nucleic acid amplification in NASBA
A method of improving amplification of nucleic acids using a nucleic acid sequence-based amplification (“NASBA”) method is provided wherein target nucleic acids and NASBA primers are...
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7064197 |
System, array and non-porous solid support comprising fixed or immobilized nucleic acids
Nucleic acids are fixed or immobilized to non-porous solid supports (substrates), and include systems containing such supports and arrays with fixed or immobilized nucleic acids. These compositions...
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7052847 |
Method for sequencing nucleic acid molecules
The present invention is directed to a method of sequencing a target nucleic acid molecule having a plurality of bases. In its principle, the temporal order of base additions during the...
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7049129 |
Electro-optical devices and methods for hybridization and detection
The invention provides an apparatus and method for detection of a target molecule. The apparatus includes a probe labeled with a transition metal-ligand complex that hybridizes with the target to...
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7045360 |
Method for analysis of reaction products
The present invention provides methods, compounds, and kits useful in the analysis of reaction products and components of reaction mixtures, and in certain embodiments for the rapid and...
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7034131 |
Nucleic acid derivatives
A compound which comprises a backbone having a plurality of chiral carbon atoms, the backbone bearing a plurality of ligands each being individually bound to a chiral carbon atom of the plurality...
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7026114 |
Methods and compositions for monitoring polymer array synthesis
VLSIPS™ manufacturing processes are of increasing commercial importance. The present invention provides methods and compositions for monitoring the efficiency and quality of polymer synthesis in...
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7022834 |
Isotopically labelled DNA
The present invention relates to a labeled deoxyribonucleic acid (DNA) molecule. In one aspect, the labeled DNA molecule is produced by contacting a cell or subject with a detectable amount of a...
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7019128 |
Propargylethoxyamino nucleotides
Propargylethoxyamino nucleosides are disclosed having the structure
wherein R 1 and R 2 are —H, lower alkyl, or label; B is a 7-deazapurine, purine, or pyrimidine nucleoside base; W 1 is...
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7014994 |
Coupled polymerase chain reaction-restriction-endonuclease digestion-ligase detection reaction process
The present invention provides a method for identifying one or more low abundance sequences differing by one or more single-base changes, insertions, or deletions, from a high abundance sequence in...
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7008770 |
Method for the controlled implementation of complex PCR amplifications
A method is described for controllably conducting complex PCR amplifications, wherein at least the following steps are conducted:
a) PCR amplification with at least 50 primers of a first...
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7001725 |
Kits employing generalized target-binding e-tag probes
Kits for the multiplexed detection of the binding of, or interaction between, one or more ligands and target antiligands are provided. Detection involves the release of identifying tags as a...
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6992180 |
Oligo- or polynucleotides comprising phosphate-moiety labeled nucleotides
The present invention provides a nucleotide having the formula,
Sig-PM-SM-BASE
...
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6979543 |
Method for detecting biological agents
A sensor is provided including a polymer capable of having an alterable measurable property from the group of luminescence and electrical conductivity, the polymer having an intermediate...
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6979542 |
Methods for identifying heterozygous carriers of autosomal recessive diseases
Novel methods are provided for identifying heterozygous carriers of autosomal recessive disorders such as Ataxia telangiectasia.
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6977164 |
Compositions and kits for Herpes Simplex Virus type 1 and 2 nucleic acid detection
The invention relates to polynucleotides for HSV detection and the use of these polypeptides in kits and methods for HSV detection.
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6977161 |
Solid support assay systems and methods utilizing non-standard bases
Solid support assays using non-standard bases are described. A capture oligonucleotide comprising a molecular recognition sequence is attached to a solid support and hybridized with a target...
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6960432 |
Detection/quantification of targeted nucleotide chains, and detection/quantification of multi-stranded nucleotide chains by fluorescence
A method for dry detection/quantification of targeted nucleotide chains, comprising the steps of: (1) realizing a state in which a hybrid (C) of a certain amount of targeted nucleotide chain (A),...
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6955874 |
Kits employing oligonucleotide-binding e-tag probes
Kits for the multiplexed detection of known, selected nucleotide target sequences are provided. Detection involves the release of identifying tags as a consequence of target recognition. The kits...
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6956112 |
Rapidly degrading GFP-fusion proteins and methods of use
Green fluorescent protein (GFP) is widely used as a reporter in determining gene expression and protein localization. The present invention provides fusion proteins with a half life of ten hours or...
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6949633 |
Primers useful for sizing nucleic acids
The present invention provides modified oligonucleotide primers designed to incorporate a cleavable moiety so that a 3′ portion of the primer (linked to an extension product) can be released from...
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6949639 |
Oligonucleotide labeling reactants and their use
The invention relates to a novel labeling reactant of formula (I) suitable for labeling an oligonucleotide
wherein:
R is a temporary protecting group. A is either a phosphorylating moiety or...
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6936596 |
Adenosine derivatives and use thereof
2-(6-Cyano-1-hexyn-1-yl)adenosine, 2-(6-cyano-1-hexyn-1-yl)adenosine 5′-monophosphate, or salts thereof; and drugs containing the same as an active ingredient. The compounds have excellent...
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6930097 |
Matrix metalloproteinase and tumor necrosis factor inhibitors
A compound of formula 1-[3,4-dihydroxy-5-(2-hydroxyethyl)tetrahydrofuran-2-yl]pryi
midine-2,4(1H,3H)-dione has inhibitory effects of matrix metalloproteinase-2 (gelatinase A) enzyme and binding of...
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6921640 |
Process for labeling a ribonucleic acid
The present invention relates to a process for labeling a synthetic or natural ribonucleic acid (RNA). It also relates to RNA fragments, which have been labeled by fragmenting the RNA to free a...
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6916612 |
Sets of oligonucleotide-binding e-tag probes
Probe sets for the multiplexed detection of known, selected nucleotide target sequences are provided. Detection involves the release of identifying tags as a consequence of target recognition. The...
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6913884 |
Compositions and methods for repetitive use of genomic DNA
The present invention relates to detection or genotyping (or other sample analysis) of target nucleic acids following immobilization of the target nucleic acids onto a surface. The target nucleic...
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6908736 |
DNA sequencing method
The present invention pertains to a method for determining the sequence of a polynucleotide, the method relying on the detection of a conformational change in an enzyme that interacts with and...
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6905828 |
Fluorescent probes for chromosome painting
The present invention relates to fluorescent probes which can be used in multicolor fluorescence in situ hybridization, and mainly chromosome painting. The probes intended for labeling a chromosome...
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6903206 |
Kits for amplifying target nucleic acid sequences using modified oligonucleotides
The present invention concerns oligonucleotides containing one or more modified nucleotides which increase the binding affinity of the oligonucleotides to target nucleic acids having a...
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6902900 |
Nucleic acid probes and methods to detect and/or quantify nucleic acid analytes
The invention comprises novel methods and strategies to detect and/or quantify nucleic acid analytes. The methods involve nucleic acid probes with covalently conjugated dyes, which are attached...
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6897023 |
Method for determining relative abundance of nucleic acid sequences
Disclosed are methods for identifying nucleic acid sequences which are of different abundances in different nucleic acid source populations, e.g. differentially expressed genes or genomic...
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6890742 |
Automated process for isolating and amplifying a target nucleic acid sequence
An automated analyzer for performing multiple diagnostic assays simultaneously includes multiple stations, or modules, in which discrete aspects of the assay are performed on fluid samples...
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6890718 |
External control reagents for nucleic acid amplification
External control reagents for nucleic acid amplification are provided that verify the absence or presence of specific target sequences, and correct primers and probes. A single-stranded, external...
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6884880 |
Process for the preparation of 9-β-anomeric nucleoside analogs
A process for substantially enhancing the regio and stereoselective synthesis of 9-β-anomeric nucleoside analogs is described. The introduction of the sugar moiety onto a 6-substituted purine base...
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