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7385050 |
Cleavable linker for polynucleotide synthesis
Functionalized supports for polynucleotide synthesis are disclosed. The supports have linker moieties that are stable to conditions used in polynucleotide synthesis, but may be cleaved to release...
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7368550 |
Phosphorus protecting groups
Compounds having a phosphorus group structure of:
wherein:
R is alkyl, modified lower alkyl; and R i and R i are each independently H, alkyl, modified alkyl, or aryl; are provided....
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7355037 |
Thermolabile hydroxyl protecting groups and methods of use
Provided is a hydroxyl-protected alcohol of the formula R—O—Pg, wherein Pg is a protecting group of the formula:
wherein Y, Z, W, R 1 , R 1a , R 2 , R 2a , R 3 , R 3a , R 4 , R 4a , a,...
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7345163 |
Process for separating and deprotecting oligonucleotides
Methods for deprotecting and derivatizing oligonucleotides that are non-covalently bound to a solid support are described. The methods include providing a plurality of oligonucleotides linked to...
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7329515 |
Solid support for the synthesis of 3′-amino oligonucleotides
The present invention discloses novel methods and solid supports for the synthesis of 3′-amino oligonucleotides. The novel supports are based on an unsubstituted or ring-substituted...
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7276598 |
Phosphorylation reagents for improved processes to convert terminal hydroxyl groups of oligonucleotides into phosphate monoesters
The present invention discloses novel phosphoramidite reagents for use in oligonucleotide synthesis. The present invention further discloses novel methods for the conversion of terminal hydroxyl...
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7273933 |
Methods for synthesis of oligonucleotides
Improved methods for synthesis of oligonucleotides and other phosphorus-linked oligomers are disclosed. The methods include the use of aromatic solvents, alkyl aromatic solvents, halogenated...
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7227016 |
Process for the synthesis of oligomeric compounds
Synthetic processes are provided wherein oligomeric compounds are prepared having phosphodiester, phosphorothioate, phosphorodithioate, or other covalent linkages. The oligomers have substantially...
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7205399 |
Methods and reagents for oligonucleotide synthesis
The present invention features novel compositions, linkers, derivatized solid supports, and methods for the efficient solid phase synthesis of oligonucleotides, including RNA, DNA, RNA-DNA...
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7193077 |
Exocyclic amine triaryl methyl protecting groups in two-step polynucleotide synthesis
Precursors for use in the synthesis of polynucleotides and methods of using the precursors in synthesizing polynucleotides are disclosed. The precursors include a heterocyclic base having an...
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7166718 |
Calix[4]arene-nucleoside and calix[4]oligonucleotide hybrids
The present invention relates to calix[4]arene-nucleoside hybrids containing calix[4]arene moieties and calix[4]arene-oligonucleotide hybrids as a DNA hairpin structure mimics synthesized by using...
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7157449 |
Medicament for the treatment of diseases caused by parasitic protozoa
The present invention relates to the use of an inhibitor of CTP synthetase, such as a glutamine analogue, and a substance capable of suppressing toxic effects thereof in vivo, in the manufacture of...
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7144700 |
Photolithographic solid-phase polymer synthesis
Methods, employing a polycyclic hydrocarbon or a polycyclic heteroaromatic compound as sensitizers, are provided to increase the efficiency of removing, by irradiation, photolabile protecting...
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7138384 |
Modulators of DNA cytosine-5 methyltransferase and methods for use thereof
A synthetic oligonucleotide comprising a C-5 methylcytosine and which recognizes and binds an allosteric site on DNA methyltransferase thereby inhibiting DNA methyltransferase activity is...
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7135565 |
Synthesis of polynucleotides using combined oxidation/deprotection chemistry
A method of synthesizing a polynucleotide which can, for example, be used during fabrication of an array. A second nucleoside is coupled to a first nucleoside through a phosphite linkage, with the...
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7132409 |
Adenosine derivatives and use thereof
2-(6-Cyano-1-hexyn-1-yl)adenosine, 2-(6-cyano-1-hexyn-1-yl)adenosine 5′-monophosphate, or salts thereof; and drugs containing the same as an active ingredient. The compounds have excellent...
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7125982 |
Microbial production of nuclease resistant DNA, RNA, and oligo mixtures
The present method describes the use of thio-phosphate as a feed source for micro-organisms and multi-cellular organisms. This compound enters into nucleotide pools and ultimately into polymers of...
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7119184 |
Oligonucleotides having A-DNA form and B-DNA form conformational geometry
Modified oligonucleotides containing both A-form conformation geometry and B-from conformation geometry nucleotides are disclosed. The B-form geometry allows the oligonucleotide to serve as...
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RE39324 |
Pyrimidine derivatives and oligonucleotides containing same
Compounds having structure (1)
wherein R 1 is —H a protecting group, a linker or a binding partner; and R 2 and R 34 are as defined in the specification. The invention also provides...
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7097974 |
Support for a method for determining an analyte and a method for producing the support
A method for producing a support for determining analytes. The method comprises the steps of (a) providing a support comprising at least one channel, comprising a conduit having an intake and an...
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7087732 |
Nucleotides and analogs having photoremovable protecting groups
A synthetic strategy for the creation of large scale chemical diversity. Solid-phase chemistry, photolabile protecting groups, and photolithography are used to achieve light-directed...
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7078499 |
Nucleotide analogues comprising a reporter moiety and a polymerase enzyme blocking moiety
Nucleotides comprising a reporter moiety and a polymerase enzyme blocking moiety in which the reporter moiety does not also act as a polymerase enzyme blocking moiety are described. Also described...
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7041817 |
Synthesis, deprotection, analysis and purification of RNA and ribozymes
Method for purification and synthesis of RNA molecules and enzymatic RNA molecules in enzymatically active form.
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7038037 |
Method for sequential support-bound synthesis of conjugated oligomeric compounds
A sequential support-bound synthesis method is disclosed for preparing a conjugated oligomeric compound, preferably a PNA-peptide conjugate or an oligonucleotide-peptide conjugate, using a bridging...
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7026468 |
Process and equipment for plasmid purification
A scalable alkaline lysis process, including procedures and devices for the isolation of large quantities (grams and kilograms) of plasmid DNA from recombinant E. coli cell. Effective,...
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7026114 |
Methods and compositions for monitoring polymer array synthesis
VLSIPS™ manufacturing processes are of increasing commercial importance. The present invention provides methods and compositions for monitoring the efficiency and quality of polymer synthesis in...
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6989442 |
Deprotection and purification of oligonucleotides and their derivatives
Method for synthesis, one-pot deprotection, and purification of molecules comprising one or more ribonucleotides.
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6974865 |
C3′ -methylene hydrogen phosphonate oligomers and related compounds
The present invention is directed to nucleoside monomers wherein the 3′-O atom is replaced with a methylene group. The present invention also provides oligomers comprising a plurality of such...
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6967247 |
Deprotection of phosphorus in oligonucleotide synthesis
A process for removing a phosphorus protecting group from a protected phosphate triester or phosphorothioate triester includes contacting a protected phosphate or phosphorothioate triester with a...
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6936709 |
Method for purifying protected 2′-deoxycytidines and hydrated crystals thereof
A protected 2′-deoxycytidine is purified by precipitating the protected 2′-deoxycytidine represented by general formula (3) in the form of a hydrated crystal from a solution containing the...
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6936596 |
Adenosine derivatives and use thereof
2-(6-Cyano-1-hexyn-1-yl)adenosine, 2-(6-cyano-1-hexyn-1-yl)adenosine 5′-monophosphate, or salts thereof; and drugs containing the same as an active ingredient. The compounds have excellent...
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6919437 |
Synthetic methods and intermediates for triester oligonucleotides
Methods for the preparation of oligonucleotides having bioreversible phosphate blocking groups are disclosed. In one aspect, the present invention provides compounds comprising a sequence of...
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6902891 |
Process for labeling a nucleic acid
A process of fragmenting and labeling a synthetic or natural nucleic acid, comprising the steps of providing a mixture containing a nucleic acid, a labeling agent containing a detectable label, and...
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6900301 |
Backbone modified oligonucleotide analogues
Therapeutic oligonucleotide analogues which have improved nuclease resistance and improved cellular uptake are provided. Replacement of the normal phosphorodiester inter-sugar linkages found in...
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6894159 |
Process for the preparation of 2′-fluoro-5-methyl-beta-L-arabino-furanosyluridine
The present invention relates to a novel and improved process for preparing 2′-fluoro-5-methyl-β-L-arabinofuranosyluridine represented by formula (1) which shows anti-viral activity, especially...
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6887990 |
Method for deprotecting oligonucleotides
A method for purifying an oligonucleotide that comprises providing an oligonucleotide attached to a substrate, wherein the oligonucleotide contains phosphate protecting groups; contacting the...
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6887665 |
Methods of array synthesis
Radiation-activated catalysts (RACs), autocatalytic reactions, and protective groups are employed to achieve a highly sensitive, high resolution, radiation directed combinatorial synthesis of...
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6884880 |
Process for the preparation of 9-β-anomeric nucleoside analogs
A process for substantially enhancing the regio and stereoselective synthesis of 9-β-anomeric nucleoside analogs is described. The introduction of the sugar moiety onto a 6-substituted purine base...
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6875750 |
Aziridine compounds and methods of making and using them
Aziridine derivatives of formula (I)
are disclosed which can be used as cofactor for S-adenosyl-L-methionine-dependent methyltransferases.
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6867294 |
Gapped oligomers having site specific chiral phosphorothioate internucleoside linkages
Novel chiral compounds that mimic and/or modulate the activity of wild-type nucleic acids are disclosed. In general, the compounds are phosphorothioate oligonucleotides wherein the 5′, and the...
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6866827 |
Process and device for the parallel preparation of at least 4n oligonucleotides
In a process and a device for the parallel preparation of at least 4n oligonucleotides, at least four inserts each with n reaction vessels are first arranged on a plate ( 16 ), each reaction vessel...
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6861514 |
Nucleosidic and non-nucleosidic folate conjugates
Oligonucleotide-folate conjugates are described wherein folates are conjugated to one or more sites on an oligonucleotide including the 2′-, 3′-, 5′-, nucleobase and internucleotide linkage...
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6858722 |
Oligomer phosphoramidite compositions and processes for synthesizing the same
Synthetic processes are provided wherein oligomers are prepared using phosphoramidite compositions. Oligomers having phosphodiester, phosphorothioate, phosphorodithioate covalent linkages are...
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6849726 |
Non-nucleotide containing RNA
The present invention relates to RNA molecules containing one or more non-nucleotide mimetics.
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6833450 |
Phosphite ester oxidation in nucleic acid array preparation
Methods are provided for preparing nucleic acid arrays on a support. In these methods a plurality of nucleic acids are synthesized on the support and the synthesis steps include oxidizing a...
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6828435 |
Combinatorial protecting group strategy for multifunctional molecules
The use of protection schemes and solid phase synthesis reactions to generate molecules of core structure M, which have a plurality of moieties, each of which can be individually deprotected or...
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6825338 |
Labeled oligonucleotides, methods for making same, and compounds useful therefor
Selectively functionalized oligonucleotides, methods for making same, and compounds useful therefor are disclosed. The oligonucleotides can be selectively functionalized with a first conjugate...
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6822088 |
Synthesis of oligonucleotides on solid support
The present invention relates to methods for synthesizing an oligomeric compound on a solid support comprising contacting a solid support with a filling material to produce a mixture thereof;...
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6809195 |
Process for the preparation of oligonucleotides
The present invention discloses methods for synthesizing oligomeric compounds. The methods include a modified phosphoramidite protocol wherein the oxidation and capping steps are combined into a...
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6800751 |
Reagent and process for protecting nucleoside hydroxyl groups
Silylating reagents having a group other than a divalent oxygen separating two silyl groups provide regioselective protection of reactive groups under robust conditions, such as basic conditions...
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