Patents in Class 536/25.310

Matches 51 - 100 out of 230

< 1 2 3 4 5 >

Match	Document	Document Title
51	6866827	Process and device for the parallel preparation of at least 4n oligonucleotides In a process and a device for the parallel preparation of at least 4n oligonucleotides, at least four inserts each with n reaction vessels are first arranged on a plate ( 16 ), each reaction vessel...
52	6861514	Nucleosidic and non-nucleosidic folate conjugates Oligonucleotide-folate conjugates are described wherein folates are conjugated to one or more sites on an oligonucleotide including the 2′-, 3′-, 5′-, nucleobase and internucleotide linkage...
53	6858722	Oligomer phosphoramidite compositions and processes for synthesizing the same Synthetic processes are provided wherein oligomers are prepared using phosphoramidite compositions. Oligomers having phosphodiester, phosphorothioate, phosphorodithioate covalent linkages are...
54	6849726	Non-nucleotide containing RNA The present invention relates to RNA molecules containing one or more non-nucleotide mimetics.
55	6833450	Phosphite ester oxidation in nucleic acid array preparation Methods are provided for preparing nucleic acid arrays on a support. In these methods a plurality of nucleic acids are synthesized on the support and the synthesis steps include oxidizing a...
56	6828435	Combinatorial protecting group strategy for multifunctional molecules The use of protection schemes and solid phase synthesis reactions to generate molecules of core structure M, which have a plurality of moieties, each of which can be individually deprotected or...
57	6825338	Labeled oligonucleotides, methods for making same, and compounds useful therefor Selectively functionalized oligonucleotides, methods for making same, and compounds useful therefor are disclosed. The oligonucleotides can be selectively functionalized with a first conjugate...
58	6822088	Synthesis of oligonucleotides on solid support The present invention relates to methods for synthesizing an oligomeric compound on a solid support comprising contacting a solid support with a filling material to produce a mixture thereof;...
59	6809195	Process for the preparation of oligonucleotides The present invention discloses methods for synthesizing oligomeric compounds. The methods include a modified phosphoramidite protocol wherein the oxidation and capping steps are combined into a...
60	6800751	Reagent and process for protecting nucleoside hydroxyl groups Silylating reagents having a group other than a divalent oxygen separating two silyl groups provide regioselective protection of reactive groups under robust conditions, such as basic conditions...
61	6794502	Methods for removing dimethoxytrityl groups from oligonucleotides The present invention discloses improved methods for oligonucleotide synthesis and purification. In the methods of the invention, a half-life is determined for deprotection of the 5′-OH...
62	6794142	Amplification using modified primers The present invention provides modified primers for use in the amplification of a nucleic acid sequence. Amplifications carried out using the modified primers result in less template-independent...
63	6790946	Synthesis of oligonucleotides A method of preparing an immobilized oligonucleotide having a free 3′-end comprises the steps of: i) preparing an oligonucleotide attached in a first position to a solid support via its 3′-end...
64	6770436	Chemical amplification for the synthesis of patterned arrays Radiation-activated catalysts (RACs), autocatalytic reactions, and protective groups are employed to achieve a highly sensitive, high resolution, radiation directed combinatorial synthesis of...
65	6762281	Process for preparing peptide derivatized oligomeric compounds Methods of preparing peptide linked oligomeric compounds are provided. The method is useful for preparing larger scale amounts of peptide linked oligomeric compounds. More particularly, the...
66	6762298	Thermolabile phosphorus protecting groups, associated intermediates and methods of use The invention provides a method of thermally deprotecting the internucleosidic phosphorus linkage of an oligonucleotide, which method comprises heating a protected oligonucleotide in a fluid medium...
67	6713622	4,7-dichlororhodamine dye labeled polynucleotides A set of 4,7-dichlororhodamine compounds useful as fluorescent dyes are disclosed having the structures wherein R 1 -R 6 are hydrogen, fluorine, chlorine, lower alkyl, lower alkene, lower...
68	6673918	Deprotection of RNA Method for one-pot deprotection of RNA molecules.
69	6664388	Reagents for oligonucleotide cleavage and deprotection The present invention provides a process for the removal of protecting groups, i.e. deprotection, from chemically synthesized oligonucleotides. In one embodiment, the invention provides reagents...
70	6653468	Universal support media for synthesis of oligomeric compounds Compounds for the synthesis of oligomeric compounds, particularly oligonucleotides and oligonucleotide mimetics, are provided. In addition, methods for functionalizing a support medium with a first...
71	6653458	Modified oligonucleotides Modified oligonucleotides containing at least one 2′,5′-internucleotide linkage are provided. The oligonucleotides of the invention may also bear additional substituents at the 2′- and...
72	6649750	Process for the preparation of oligonucleotide compounds Synthetic processes are provided wherein high purity oligomers are prepared using support bound phosphoramidite protocols starting with a nucleoside or larger synthon linked to a support media...
73	6649348	Methods for manufacturing arrays Apparatus and methods are disclosed for synthesizing a plurality of compounds on the surface of supports. Biopolymer features are attached to the surfaces of the supports. The synthesis generally...
74	6646118	Solid phase synthesis The present invention relates to a support system for solid phase synthesis of oligomers, such as oligonucleotides, wherein the starting compound is bound to the support via a disiloxyl linkage....
75	6632938	Processes of purifying oligonucleotides Methods for preparing purified oligonucleotides by treating a solution comprising an oligonucleotide with an aggregating agent and a precipitation enhancer under conditions sufficient to form an...
76	6630581	Monomers for solid phase synthesis of oligonucleotides using carbonate protecting groups and alpha-effect nucleophile deprotection The invention provides a method for synthesizing oligonucleotides using carbonate protection of hydroxyl groups and nucleophilic deprotection reagents. The deprotection reagents irreversibly cleave...
77	6610842	Processes for the synthesis of oligomers using phosphoramidite compositions Synthetic processes are provided wherein oligomers are prepared using phosphoramidite compositions. Oligomers having phosphodiester, phosphorothioate, phosphorodithioate covalent linkages are...
78	6593464	Method for deblocking of labeled oligonucleotides The invention relates to a process for deblocking substantially a blocked, detectably labeled oligonucleotide by contacting the blocked detectably labeled oligonucleotide with an effective amount...
79	6576426	Tag reagent and assay method This invention provides reagents, libraries and sets of the reagents, and assay methods using the reagents, the reagents comprising an analyte moiety and a tag moiety, wherein the tag moiety...
80	6576752	Aminooxy functionalized oligomers The present invention provides oligomers which are specifically hybridizable with a selected sequence of RNA or DNA wherein at least one of the nucleoside moieties of the oligomer is modified to...
81	6566495	Very large scale immobilized polymer synthesis A synthetic strategy for the creation of large scale chemical diversity. Solid-phase chemistry, photolabile protecting groups, and photolithography are used to achieve light-directed...
82	6538128	Detritylation solvents for nucleic acid synthesis The invention provides improved processes for oligonucleotide synthesis utilizing arenes as solvents for detritylation of oligonucleotides.
83	6531584	2'modified oligonucleotides Compositions and methods are provided for the treatment and diagnosis of diseases amenable to modulation of the production of selected proteins. In accordance with preferred embodiments,...
84	6531589	Base protecting groups and synthons for oligonucleotide synthesis The invention provides new methods for synthesizing oligonucleotides that allow for deprotection of the oligonucleotides under more mild conditions than existing methods. The invention further...
85	6512107	Process for the preparation of 2′-fluoro-5-methyl-β-L-arabinofuranosyluridine The present invention relates to a novel and improved process for preparing 2′-fluoro-5-methyl-β-L-arabinofuranosyluridine represented by formula (I) which shows anti-viral activity, especially...
86	6509459	Base protecting groups and rapid process for oligonucleotide synthesis The invention provides new processes for synthesizing oligonucleotides that allow for deprotection of the oligonucleotide under more rapid and/or more mild conditions than existing methods. The...
87	6506895	Photoactivatable nucleic acids A photoactivatable nucleic acid derivative composition in which one or more photoreactive group(s) are bound to a natural or synthetic nucleic acid. The photoreactive groups can be bound to the...
88	6489466	C-3′ protected monomeric nucleotides and synthesis of oligonucleotides on solid support Immobilized nucleotide primers of this invention include a modified nucleotide tethered to a support substrate through a linking group. In particular, the modified nucleotide is constructed such...
89	6479262	Solid phase enzymatic assembly of polynucleotides The present invention provides methods of preparing large polynucleotides of arbitrary sequence and in a manner that will readily lend itself to automation. The present invention provides methods...
90	6468740	Cyclic and substituted immobilized molecular synthesis A synthetic strategy for the creation of large scale chemical diversity. Solid-phase chemistry, photolabile protecting groups, and photolithography are used to achieve light-directed...
91	6451998	Capping and de-capping during oligonucleotide synthesis A method of capping a hydroxy group of a moiety, comprising coupling the moiety to a phosphor or phosphite derivative of a protected alcohol, so as to form the corresponding phosphate or phosphite...
92	6407223	Process for the synthesis of modified P-chiral nucleotide analogues The process of the instant invention is drawn to the synthesis of modified P-chiral nucleotide analogues in the form of pure diastereomers possessing preselected configuration at the P-atom....
93	6403781	Method of synthesizing phosphorothioate oligonucleotides This invention presents novel methods for synthesizing phosphorothioate oligonucleotides, using support-bound phosphoramidites. Novel intermediates useful in the methods are also provided.
94	6380378	Nucleotide compound, nucleotide block oligonucleotide, and method for producing them Novel nucleotide compounds represented by the formula (I) wherein R 1 represents a protective group or a PEG bearing organic group; R 2 , R 2′ , R 2″ , R 3 , R 3′ and R 3″ each...
95	6362323	Non-nucleotide containing nucleic acid Enzymatic nucleic acid molecule containing one or more non-nucleotide mimetics, and having activity to cleave an RNA or DNA molecule.
96	6337393	Method and composition for chemical synthesis on an open environment support surface using high boiling point organic solvents to control evaporation A method for reducing evaporation of a liquid reagent solution during solid phase, micro-scale chemical synthesis of a molecule comprising sub-units on an open environment solid support surface....
97	6335437	Methods for the preparation of conjugated oligomers The present invention provides novel methods for preparing oligonucleotide conjugates using a novel electrophilic haloacetyl linker. Novel compounds and intermediates are also disclosed.
98	6335438	Method for the manufacture of amino group containing support matrices, support matrices prepared by the method, and use of the support matrices A method for the manufacture of a support matrix exhibiting amino groups I, possibly in acylated form, comprising the step of polymerizing one or more monovinyl monomers (monomer I) with one or...
99	6310189	Nucleotides and analogs having photoremoveable protecting groups A synthetic strategy for the creation of large scale chemical diversity. Solid-phase chemistry, photolabile protecting groups, and photolithography are used to achieve light-directed...
100	6297371	Process for the preparation of endotoxin-free or endotoxin-depleted nucleic acids and/or oligonucleotides for gene therapy A process for the isolation and purification of nucleic acids and/or oligonucleotides for use in gene therapy wherein said nucleic acids and/or oligonucleotides are isolated or purified from an...

Matches 51 - 100 out of 230

< 1 2 3 4 5 >