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7385053 |
Functionalized compositions for improved immobilization
The present invention relates to improved covalent coupling of two or more entities such as biomolecules, polymer compositions, organic/inorganic molecules/materials, and the like, including their...
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7385050 |
Cleavable linker for polynucleotide synthesis
Functionalized supports for polynucleotide synthesis are disclosed. The supports have linker moieties that are stable to conditions used in polynucleotide synthesis, but may be cleaved to release...
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7384737 |
Synthesis of spatially addressed molecular arrays
Methods are disclosed for forming spatially addressable arrays of polynucleotides of known squence, by using blocking groups that prevent the incorporation of multiple nucleotides during each...
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7381820 |
α-1-phosphorylated-2-deoxy-2-fluoroarabinoside and process for producing 2′-deoxy-2′-fluoro-β-d-arabinonucleoside
A method for producing 2′-deoxy-2′-fluoro-β-D-arabinonucleoside represented by formula (II):
(wherein B represents a base), in particular,...
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7378516 |
Synthesis of sulfurized oligonucleotides
Methods for the formation of sulfurized oligonucleotides are provided. The methods allow for the formation of phosphorothioate linkages in the oligonucleotides or derivatives, without the need for...
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7378485 |
Peptide nucleic acids with polyamide-containing backbones
A novel class of compounds, known as peptide nucleic acids, bind complementary ssDNA and RNA strands more strongly than a corresponding DNA. The peptide nucleic acids generally comprise ligands...
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7371852 |
Alkyl-linked nucleotide compositions
Alkyl-linked nucleotide non-homogeneous solid supports and nucleotide affinity media comprising an alkyl-linked nucleotide are provided. The linker is generally a hydrophobic linker that can be a...
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7371851 |
Methods of cloning and producing fragment chains with readable information content
The present invention provides a method of attaching a fragment of a first nucleic acid molecule to a second nucleic acid molecule using adapters to mediate the binding particularly in methods of...
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7368560 |
Intercalation-mediated synthesis of polymers
Methods and compositions for synthesizing biopolymers using an intercalator are provided. Aspects provide compositions and methods for synthesizing biopolymers with non-natural backbones or...
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7368236 |
Methods of producing nucleic acid ligands
The present invention includes methods for the identification and production of improved nucleic acid ligands based on the SELEX process. Also included are nucleic acid ligands to the HIV-RT...
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7365178 |
Acyl-nucleotide probes and methods of their synthesis and use in proteomic analysis
The present invention provides tagged acyl phosphate probes (“TAPPs”), and methods of their preparation and use. The subject methods and compositions can provide enhanced simplicity and...
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7361489 |
Nucleic acid amplification methods
The present invention relates to assays and kits for carrying out said assays for the rapid, automated detection of infectious pathogenic agents and normal and abnormal genes. The present invention...
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7358347 |
MEN1, the gene associated with multiple endocrine neoplasia type 1, menin polypeptides and uses thereof
The invention relates to the discovery of a novel tumor suppressor gene which is associated with multiple endocrine neoplasia type 1. The gene has been designated MEN1 and the gene product is...
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7355036 |
Two-stage protective groups for the synthesis of biopolymers
The invention relates to a method for the synthesis of a nucleic acid by gradual breakdown from protected synthesis building blocks carrying two-stage protective groups. The two-stage protective...
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7354907 |
Short immunomodulatory oligonucleotides
The invention relates to modulation of the immune system. More particularly, the invention relates to modulating the immune system through the use of oligonucleotide-derived compounds. The...
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7354708 |
Invasion assays
The present invention relates to means for the detection and characterization of nucleic acid sequences, as well as variations in nucleic acid sequences. The present invention also relates to...
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7348391 |
Polymeric beads for oligomer synthesis
The present invention provides solid support media for use in oligomer synthesis, methods of producing the media, and methods of using the media. In some embodiments, the processes of the invention...
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7348314 |
Compositions and methods for inhibiting viral replication
The present invention relates to a double-stranded ribonucleic acid (dsRNA) having a nucleotide sequence which is less that 30 nucleotides in length and which is substantially identical to at least...
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7348141 |
Hybridization beacon and method of rapid sequence detection and discrimination
A method for detecting specific DNA sequences and discriminating single nucleotide polymorphisms (SNPs) using fluorescently labelled oligonucleotide probes is disclosed. Oligonucleotide probes are...
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7345159 |
Massive parallel method for decoding DNA and RNA
This invention provides methods for attaching a nucleic acid to a solid surface and for sequencing nucleic acid by detecting the identity of each nucleotide analogue after the nucleotide analogue...
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7329515 |
Solid support for the synthesis of 3′-amino oligonucleotides
The present invention discloses novel methods and solid supports for the synthesis of 3′-amino oligonucleotides. The novel supports are based on an unsubstituted or ring-substituted...
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7329491 |
Methods for isolating nucleic acids
A method for purification of a nucleic acid comprising the steps of (a) adsorbing on a substrate the nucleic acid from a composition containing (i) an aqueous buffer, (ii) salts in a high...
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7326783 |
Pharmaceutical composition comprising antisense-nucleic acid for prevention and/or treatment of neuronal injury, degeneration and cell death and for the treatment of neoplasms
A pharmaceutical composition comprising an effective amount of a compound which is capable from preventing and treating neuronal injury, degeneration, cell death and/or neoplasms in which...
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7321832 |
Method of designing probe from polynucleotide group comprising plurality of polynucleotides
There is provided a method of designing a probe from a polynucleotide group comprising a plurality of polynucleotides, the method including: forming a polynucleotide group by selecting...
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7321029 |
2′-arabino-fluorooligonucleotide N3′→P5′ phosphoramidates: their synthesis and use
Oligonucleotides with a novel sugar-phosphate backbone containing at least one 2′-arabino-fluoronucleoside and an internucleoside 3′-NH—P(—O)(OR)—O-5′ linkage, where R is a positively...
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7319920 |
Method and apparatus for self-calibration of a substrate handling robot
A substrate-handling robot which serves a processing tool such as a plating tool may be automatically controlled by a controller to perform a self-calibration procedure. As part of the procedure,...
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7319145 |
Methylenetetrahydrofolate reductase inhibitors and use thereof
The present invention provides methylenetetrahydrofolate reductase (MTHFR) inhibitors for use in selective inhibition of cancer cell growth in a mammal. These inhibitors can be a small molecule, an...
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7314928 |
Process for manufacturing morpholino-nucleotides, and use thereof for the analysis of and labelling of nucleic acid sequences
The invention relates to the use of morpholino-nucleosides of formula:
in which R 1 represents a nucleic base and R 2 represents a group corresponding to one of the following formulae:
...
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7314714 |
Method of oligonucleotide synthesis
Methods and kits for synthesizing a plurality of oligonucleotides are provided. Methods for providing a plurality of oligonucleotides enriched for full length oligonucleotides are provided....
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7314708 |
Method and apparatus for electronic synthesis of molecular structures
A self-addressable, self-assembling microelectronic device is designed and fabricated to actively carry out and control multi-step and multiplex molecular biological reactions in microscopic...
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7297518 |
Methods and apparatus for analyzing polynucleotide sequences by asynchronous base extension
The invention provides methods and apparatus for analyzing polynucleotide sequences by asynchronous base extension. Some applications of the invention utilize total internal reflection fluorescence...
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7294487 |
Combinatorial oligonucleotide PCR: a method for rapid, global expression analysis
The present invention relates to a method for the detection of gene expression and analysis of both known and unknown genes. The invention is a highly sensitive, rapid and cost-effective means of...
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7294465 |
Polycystic kidney disease PKD2 gene and uses thereof
The present invention provides a purified and isolated wild type PKD2 gene, as well as mutated forms of this gene. The present invention also provides one or more single-stranded nucleic acid...
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7291471 |
Cleavable oligonucleotide arrays
Oligonucleotide arrays having features that include cleavable oligonucleotides are disclosed, as well as methods of making such arrays. Methods of synthesizing an oligonucleotide on a surface of a...
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7285401 |
Method and reagents for detecting nucleic acid sequences
The present invention is directed to a method for detecting an amplification product. Amplification is accomplished through the use of a plurality of detection probes. The present invention is also...
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7282581 |
Oligonucleotide labeling reactants based on acyclonucleosides and conjugates derived thereof
The invention relates to a labeling reactant of formula (I) useful for labeling an oligonucleotide
wherein: R is a temporary protecting group. A is either a phosphorylating moiety or a solid...
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7282355 |
Nucleic acid detection method
Disclosed are methods for detecting a target nucleic acid molecule having a known sequence among a plurality of nucleic acid molecules. The method includes hybridizing two oligonucleotides to...
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7279311 |
Use of nucleic acids bound to carrier macromolecules
A nucleic acid primer is bound to a soluble carrier macromolecule, a multitude of primer molecules thus being carried by each carrier macromolecule, and hybridisation of the primer to a template...
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7276599 |
Oligonucleotide synthesis with alternative solvents
The invention provides for methods of manufacturing an oligonucleotide comprising a pentavalent phosphate triester. In particular, the method comprises providing a 5′ blocked-nucleoside,...
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7276598 |
Phosphorylation reagents for improved processes to convert terminal hydroxyl groups of oligonucleotides into phosphate monoesters
The present invention discloses novel phosphoramidite reagents for use in oligonucleotide synthesis. The present invention further discloses novel methods for the conversion of terminal hydroxyl...
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7276592 |
Nucleotide analogs with six-membered rings
The present invention is related to compounds comprising six-membered rings capable of being incorporated into nucleic acids. Particularly, the six-membered ring is a derivative of cyclohexane,...
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7273933 |
Methods for synthesis of oligonucleotides
Improved methods for synthesis of oligonucleotides and other phosphorus-linked oligomers are disclosed. The methods include the use of aromatic solvents, alkyl aromatic solvents, halogenated...
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7271156 |
Immunostimulatory nucleic acids
The invention relates to immunostimulatory nucleic acid compositions and methods of using the compositions. The T-rich nucleic acids contain poly T sequences and/or have greater than 25% T...
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7264963 |
Protein(poly)peptide libraries
The present invention relates to synthetic DNA sequences which encode one or more collections of homologous proteins/(poly)peptides, and methods for generating and applying libraries of these DNA...
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7262008 |
Nucleic acid assays
The present invention relates to the detection of specific nucleic acid sequences, either by a process of amplification of specific nucleic acid sequences or not. More particularly the invention...
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7252974 |
Human growth gene and short stature gene region
Subject of the present invention is an isolated human nucleic acid molecule encoding polypeptides containing a homeobox domain of sixty amino acids having the amino acid sequence of SEQ ID NO: 1...
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7252936 |
Method for the detection of the antibiotic resistance spectrum of Mycobacterium species
Method for the detection of the antibiotic resistance spectrum of Mycobacterium species present in a sample, possibly coupled to the identification of the Micobacterium species involved,...
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7238795 |
Nucleic acid binding compounds containing pyrazolo[3,4-d]pyrimidine analogues of purin-2,6-diamine and their uses
The present invention is in the field of nucleic acid binding compounds comprising 7-substituted 7-deaza-8aza-2,6-diamino-purine bases, compounds useful for the preparation of such compounds,...
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7235650 |
Derivatized oligonucleotides having improved uptake and other properties
Linked nucleosides having at least one functionalized nucleoside that bears a substituent such as a steroid molecule, a reporter molecule, a non-aromatic lipophilic molecule, a reporter enzyme, a...
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7235386 |
Method of increasing complementarity in a heteroduplex
We describe here an in vitro method of increasing complementarity in a heteroduplex polynucleotide sequence. The method uses annealing of opposite strands to form a polynucleotide duplex with...
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