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7109316 |
Oligonucleotide tagged nucleoside triphosphates (OTNTPs) for genetic analysis
Oligonucleotide tagged nucleoside triphosphates, OTNTPs, which are substrates for polymerases and or terminal nucleotidyl transferases are provided as well as methods of making these OTNTPs....
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7105661 |
Process for manufacturing morpholino-nucleotides, and use thereof for the analysis of and labelling of nucleic acid sequences
The invention relates to the use of morpholino-nucleosides of formula:
in which R 1 represents a nucleic base and R 2 represents a group corresponding to one of the following formulae:
...
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7102024 |
Functional biopolymer modification reagents and uses thereof
Hydrazino, oxyamino and carbonyl-based reagents and methods for incorporation into oligonucleotides during their solid phase synthesis are provided. Modified oligonucleotides are provided that...
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7101986 |
Methods of synthesizing oligonucleotides using carbonate protecting groups and alpha-effect nucleophile deprotection
The invention provides methods for synthesizing oligonucleotides using nucleoside monomers having carbonate protected hydroxyl groups that are deprotected with α-effect nucleophiles. The α-effect...
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7101992 |
Nucleic acid base pair
A novel artificial nucleic acid base pair which is obtained by forming a selective base pair by introducing a group having steric hindrance (preferably a group having steric hindrance and static...
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7098326 |
Methods for the integrated synthesis and purification of oligonucleotides
The present invention discloses novel methods for the integrated synthesis and purification of oligonucleotides. The methods employ novel capping reagents carrying two functional groups. The first...
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7097972 |
Method and composition for regulating apoptosis
This invention provides non-naturally occurring and isolated naturally occurring nucleic acid molecules which encode proteins designated pro-Yama, p11 Yama and p20 Yama. This invention also...
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7098321 |
Homologous peptide nucleic acids
The invention discloses compounds of the formula:
where n is 1, or 2 to 200 in which case each recurring unit can be the same or different, B is a protected or unprotected base capable of...
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7098320 |
Nanoparticles having oligonucleotides attached thereto and uses therefor
The invention provides methods of detecting a nucleic acid. The methods comprise contacting the nucleic acid with one or more types of particles having oligonucleotides attached thereto. In one...
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7097974 |
Support for a method for determining an analyte and a method for producing the support
A method for producing a support for determining analytes. The method comprises the steps of (a) providing a support comprising at least one channel, comprising a conduit having an intake and an...
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7098325 |
Process for the sulfurization of a phosphorus-containing compound
The invention relates to a process for the sulfurization of phosphorus-containing compounds which comprises contacting the phosphorus compound to be sulfurized with a sulfur transfer reagent of...
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7094568 |
Method for producing proteins tagged at the N- or C-terminus
The present invention relates to novel methods of producing proteins in which one or more domains are full length and correctly folded and which are each tagged at either the N- or C-terminus with...
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7094609 |
Spatially addressable combinatorial chemical arrays in encoded optical disk format
A method for preparing very large spatially-addressable arrays of chemical compounds by light-directed synthesis is provided, wherein the light is provided by a laser and the compounds are arrayed...
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7090972 |
Methods for determining the presence of non-viral organisms in a sample
A method for preparing probes, as well as several probes for use in qualitative or quantitative hybridization assays are disclosed. The method comprises constructing an oligonucleotide that is...
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7087742 |
Oligonucleotide probes for the detection and/or quantitation of non-viral organisms
A method for preparing probes, as well as several probes for use in qualitative or quantitative hybridization assays are disclosed. The method comprises constructing an oligonucleotide that is...
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7087744 |
Fluorescent nucleotides and labeling methods using the same
Fluorescent nucleotides useful for labeling nucleic acids which are represented by the formula: X—Y—Z wherein X represents a residue of natural or non-natural nucleotide and the like and binds...
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7087732 |
Nucleotides and analogs having photoremovable protecting groups
A synthetic strategy for the creation of large scale chemical diversity. Solid-phase chemistry, photolabile protecting groups, and photolithography are used to achieve light-directed...
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7087378 |
Design, synthesis and use of specific polyamide DNA-binding ligands
The invention encompasses improved selective polyamides for binding to specific nucleotide sequences of double stranded DNA as well as methods for designing and synthesizing polyamide DNA binding...
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7081526 |
Process for manufacturing morpholino-nucleotides, and use thereof for the analysis of and labelling of nucleic acid sequences
The invention relates to the use of morpholino-nucleosides of formula:
in which R 1 represents a nucleic base and R 2 represents a group corresponding to one of the following formulae:
...
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7078505 |
Manufacture of arrays with varying deposition parameters
Methods are disclosed for synthesizing a plurality of compounds on the surface of supports. The synthesis comprises a series of cycles of steps in which reagents for conducting the synthesis are...
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7074569 |
Mobility-modified nucleobase polymers and methods of using same
The present invention relates generally to nucleobase polymer functionalizing reagents, to mobility-modified sequence-specific nucleobase polymers, to compositions comprising a plurality of...
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7074917 |
Method for purifying 5′ -protected 2′ -deoxypurine nucleosides
A method for efficiently purifying 5′ protected 2′-deoxypurine nucleosides, efficient production of which has previously been difficult. Impurities can be separated by obtaining the 5′...
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7070933 |
Inversion probes
Unitary hybridization probes having stem-and-loop structures, wherein the stem portion of the structure comprises a pair of interactive arms that are substantially prevented from interacting with...
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7070962 |
Positive controls in polynucleotide amplification
The present invention relates to an improvement in a method for amplifying a target sequence of a target polynucleotide. The method comprises the step of forming extension products of an...
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7057026 |
Labelled nucleotides
Nucleosides and nucleotides are disclosed that are linked to detectable labels via a cleavable linker group.
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7056659 |
Characterizing nucleic acids
A method for characterizing DNA, which comprises: (i) providing a population of DNA fragments, each fragment having cleavably attached thereto a mass label for identifying a feature of that...
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7056510 |
Streptococcus pneumoniae SP036 polynucleotides, polypeptides, antigens and vaccines
The present invention relates to novel vaccines for the prevention or attenuation of infection by Streptococcus pneunoniae. The invention further relates to isolated nucleic acid molecules...
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7057031 |
Nucleotide compositions comprising photocleavable markers and methods of preparation thereof
Labelled nucleotides and polynucleotides useful in the sequencing of nucleic acids are described. Methods of preparing photocleavable marker nucleotides and photocleavable marker-polynucleotide...
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7053207 |
L-ribo-LNA analogues
Provided are L-ribo bicyclic nucleotide compounds as well as syntheses of such compounds. The nucleoside compounds of the invention are useful in forming oligonucleotides that can produce...
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7053206 |
Methods and compositions for multiplex amplification of nucleic acids
A method is described for predetermining ratios of primer pairs present in a single reaction vessel so as to achieve approximately equimolar yield of products. The ratios are determined as a...
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7053198 |
Functionated photoacid generator and functionated polymer system for biological microarray synthesis
In some embodiment of the invention, methods are provided for the synthesis of polymer arrays. In one embodiment, a reactive polymer and a photo acid generator is used for the photodirected polymer...
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7053195 |
Locked nucleic acid containing heteropolymers and related methods
The present invention relates to methods of replacing nucleotides in target nucleic acid sequences using DNA-LNA chimeras. The method of the present invention provides for replacing a first...
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7049073 |
Double stranded nucleic acid biochips
This invention describes a new method of constructing double-stranded DNA (dsDNA) microarrays based on the use of pre-synthesized or natural DNA duplexes without a stem-loop structure. The...
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7049432 |
Oligonucleotides having alkylphosphonate linkages and methods for their preparation
The present invention provides alkylphosphonate dimers and oligonucleotides prepared therefrom. The invention further provides novel methods for the preparation of these alkylphosphonate dimers....
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7045610 |
Modified oligonucleotides for mismatch discrimination
Modified oligonucleotides are provided containing bases selected from unsubstituted and 3-substituted pyrazolo[3,4-d]pyrimidines and 5-substituted pyrimidines, and optionally have attached minor...
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7038027 |
Method of preventing modification of synthetic oligonucleotides
The present invention relates to a method of preventing modification of a synthetic oligonucleotide or oligonucleotide analog during removal of at least one β-cyanoethyl protecting group from the...
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7037661 |
Compositions and methods for labeling of nucleic acid molecules
The present invention is generally related to compositions, kits and methods for labeling nucleic acid molecules using reverse transcriptases, preferably multi-subunit reverse transcriptases such...
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7038037 |
Method for sequential support-bound synthesis of conjugated oligomeric compounds
A sequential support-bound synthesis method is disclosed for preparing a conjugated oligomeric compound, preferably a PNA-peptide conjugate or an oligonucleotide-peptide conjugate, using a bridging...
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7037659 |
Apparatus for constructing DNA probes having a prismatic and kaleidoscopic light homogenizer
The present invention provides an apparatus for constructing arrays of DNA sequences using the image of a micromirror array projected on a reaction site using a highly uniform beam of light...
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7037650 |
Cancer diagnostic method based upon DNA methylation differences
There is disclosed a cancer diagnostic method based upon DNA methylation differences at specific CpG sites. Specifically, the inventive method provides for a bisulfite treatment of DNA, followed by...
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7034131 |
Nucleic acid derivatives
A compound which comprises a backbone having a plurality of chiral carbon atoms, the backbone bearing a plurality of ligands each being individually bound to a chiral carbon atom of the plurality...
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7034147 |
Nucleoside analog libraries
The present invention provides combinatorial libraries of nucleoside analog compounds and methods of making the libraries. In addition, the present invention provides methods of assaying the...
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7026114 |
Methods and compositions for monitoring polymer array synthesis
VLSIPS™ manufacturing processes are of increasing commercial importance. The present invention provides methods and compositions for monitoring the efficiency and quality of polymer synthesis in...
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7026468 |
Process and equipment for plasmid purification
A scalable alkaline lysis process, including procedures and devices for the isolation of large quantities (grams and kilograms) of plasmid DNA from recombinant E. coli cell. Effective,...
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7022833 |
Process for the preparation of phosphorothioate triesters
A process for the synthesis of a phosphorothioate triester is provided. The process comprises the coupling of an H-phosphonate with an alcohol in the presence of a solution comprising both a...
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7022835 |
Method for binding nucleic acids to a solid phase
The invention concerns a method for binding nucleic acids to a solid phase in which a nucleic acid containing solution is contacted with a solid phase which has hydrophobic and hydrophilic groups...
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7022473 |
Substrates for immobilizing and amplifying DNA and DNA-immobilized chips
Substrates for producing a DNA library are produced by immobilizing DNA onto a suitable substrate having excellent thermal conductivity. A surface of the substrate is chemically modified with a...
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7019128 |
Propargylethoxyamino nucleotides
Propargylethoxyamino nucleosides are disclosed having the structure
wherein R 1 and R 2 are —H, lower alkyl, or label; B is a 7-deazapurine, purine, or pyrimidine nucleoside base; W 1 is...
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7019127 |
Solution phase synthesis of oligonucleotides
A process for the synthesis in solution phase of a phosphorothioate triester is provided. The process comprises the solution phase coupling of an H-phosphonate with an alcohol in the presence of a...
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7014997 |
Chromosome structural abnormality localization with single copy probes
Nucleic acid (e.g., DNA) hybridization probes are described which comprise a labeled, single copy nucleic acid which hybridizes to a deduced single copy sequence interval in target nucleic acid of...
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