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7230092 |
Capture moieties for nucleic acids and uses thereof
A unimolecular probe for hybridization to a molecule comprising a target nucleic acid sequence, the probe includes: a first nucleic acid sequence complementary to the target sequence...
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7229798 |
Transposon mediated multiplex sequencing
The present invention relates to an automated method of transposon-mediated multiplex sequencing of DNA fragments inserted into a vector. It relates more particularity to an increased efficiency in...
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7230095 |
Immobilization of oligonucleotides onto solid supports
A solid support bound polynucleotide, preferably a 3′-O- or 5′-O-substituted polynucleotide, is disclosed. The polynucleotides are of formula:
wherein Q is a substantially pure...
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7227017 |
Process for the preparation of phosphorothioate oligonucleotides
A process for the synthesis of phosphorothioate oligonucleotides is provided which comprises assembling an oligonucleotide bound to a solid support in the presence of acetonitrile; prior to...
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7223833 |
Peptide nucleic acid conjugates
A novel class of peptide nucleic acids are described which include a conjugate attached thereto. The peptide nucleic acids generally comprise ligands such as naturally occurring DNA bases attached...
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7223857 |
Chain-shortened polynucleotide and method for preparation thereof
The present invention provides a chain-shortened polynucleotide wherein the proportion of a 2′-5′ phosphodiester bond is up to 3% based on the whole phosphodiester bonds or a salt thereof and a...
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7223568 |
Methods for determining nucleotide sequences of single nucleic acid molecules
The present invention relates to a method for determining a nucleotide sequence of a nucleic acid by detecting a single dye molecule.
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7217512 |
Reagent and method for attaching target molecules to a surface
The present invention provides a method and reagent composition for attachment of target molecules onto the surface of a substrate, such as microwell plates, tubes, beads, microscope slides,...
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7211654 |
Linkers and co-coupling agents for optimization of oligonucleotide synthesis and purification on solid supports
A method of modulation of synthesis capacity on and cleavage properties of synthetic oligomers from solid support is described. The method utilizes linker molecules attached to a solid surface and...
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7205396 |
Benzodeazaadenine derivative base and electronic material containing the same
A nucleic acid base for hole transportation in DNAs which does not cause oxidative decomposition; and an artificial DNA molecule which can realize effective hole transportation in DNAs while...
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7205400 |
Array fabrication
A method, apparatus, and computer program, for fabricating multiple arrays arranged successively in a first direction on a substrate and each having multiple feature sets arranged successively in...
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7205399 |
Methods and reagents for oligonucleotide synthesis
The present invention features novel compositions, linkers, derivatized solid supports, and methods for the efficient solid phase synthesis of oligonucleotides, including RNA, DNA, RNA-DNA...
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7193077 |
Exocyclic amine triaryl methyl protecting groups in two-step polynucleotide synthesis
Precursors for use in the synthesis of polynucleotides and methods of using the precursors in synthesizing polynucleotides are disclosed. The precursors include a heterocyclic base having an...
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7189842 |
High density, miniaturized arrays and methods of manufacturing same
High-density, miniaturized arrays including high surface areas. Arrays described include substrate with a coating of linking agents, as well as arrays with reactants affixed to the substrates....
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7186814 |
Bioconjugate-nanoparticle probes
The invention provides nanoparticle-bioconjugate probes that are useful for detecting target analytes such as nucleic acids. The probes of the invention are stable towards heat and resistant to...
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7186813 |
Biomolecules having multiple attachment moieties for binding to a substrate surface
Biomolecules are provided having multiple binding sites for attachment to a substrate surface. The multiple attachment sites may be produced directly on the biomolecule or through use of branched...
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7186525 |
Methods of RNA and protein synthesis
The present invention relates to methods for RNA and/or protein synthesis using in vitro or in vivo expression systems. More specifically, the present invention provides a method for RNA and/or...
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7183394 |
Helical nucleopeptides
The present invention relates to peptide-based nucleic acid surrogates (PNAs) having a repeating structure of (AA B -aa n ) m and a particular secondary structure that can bind to particular...
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7183405 |
Compositions and methods for labeling oligonucleotides
A novel method for the labeling of oligonucleotides which results in the economical synthesis of 5′ labeled molecules. A set of suitably protected and carefully selected set of amino linkers, a...
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7183406 |
Method for the synthesis of DNA sequences
A method is disclosed for the direct synthesis of double stranded DNA molecules of a variety of sizes and with any desired sequence. The DNA molecule to be synthesis is logically broken up into...
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7176297 |
Photoactivatable silane compounds and methods for their synthesis and use
In one aspect of the invention, photoactivatable silane compounds and methods for their synthesis and use are provided. In one embodiment, the photoactivatable silane compounds synthesized are...
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7173125 |
Triphosphate oligonucleotide modification reagents and uses thereof
Hydrazino, oxyamino and carbonyl-based monomers and methods for incorporation into oligonucleotides during enzymatic synthesis are provided. Modified oligonucleotides are provided that incorporate...
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7172863 |
Nucleic acid probes and methods for detecting Neisseria gonorrhoeae
A method for preparing probes, as well as several probes for use in qualitative or quantitative hybridization assays are disclosed. The method comprises constructing an oligonucleotide that is...
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7173115 |
Stra6 polypeptides
The present invention is directed to novel polypeptides having sequence similarity to Stra6, a murine retinoic acid responsive protein, and to nucleic acid molecules encoding those polypeptides....
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7169553 |
2-Azapurine compounds and their use
Within oligonucleotides 2-azapurine and especially 2-azaadenine bases form specifically base pairs with guanine. This base pair is of analogous stability as an adenine-thymine but less stable than...
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7169556 |
Nanoparticles having oligonucleotides attached thereto and uses therefor
The invention provides methods of detecting a nucleic acid. The methods comprise contacting the nucleic acid with one or more types of particles having oligonucleotides attached thereto. In one...
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7169939 |
Energy transfer dyes with enhanced fluorescence
Novel linkers for linking a donor dye to an acceptor dye in an energy transfer fluorescent dye are provided. These linkers faciliate the efficient transfer of energy between a donor and acceptor...
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7169916 |
Chloral-free DCA in oligonucleotide synthesis
A process of manufacturing oligonucleotides includes a 5′-deblocking step in which the 5-blocking group is removed with dichloroacetic acid that is essentially free of chloral. The process is...
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7166718 |
Calix[4]arene-nucleoside and calix[4]oligonucleotide hybrids
The present invention relates to calix[4]arene-nucleoside hybrids containing calix[4]arene moieties and calix[4]arene-oligonucleotide hybrids as a DNA hairpin structure mimics synthesized by using...
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7166715 |
Nitro-substituted non-fluorescent asymmetric cyanine dye compounds
The invention provides an asymmetric cyanine dye compound having the structure
including substituted forms thereof, wherein, at least one of R 1 and R 2 is linking group, X is O, S, or Se,...
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7166478 |
Labeling reagents and labeled targets, target labeling processes and other processes for using same in nucleic acid determinations and analyses
This invention provides for labeling reagents, labeled targets and processes for preparing labeling reagents. The labeling reagents can take the form of cyanine dyes, xanthene dyes, porphyrin dyes,...
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7153954 |
Method for preparation of LNA phosphoramidites
The present invention relates to large scale preparation of LNA phosphoramidites using a 2-cyanoethyl-N,N,N′,N′-tetra-substituted phosphoramidite and a nucleophilic activator, e.g....
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7144700 |
Photolithographic solid-phase polymer synthesis
Methods, employing a polycyclic hydrocarbon or a polycyclic heteroaromatic compound as sensitizers, are provided to increase the efficiency of removing, by irradiation, photolabile protecting...
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7138516 |
Oligonucleotide probes for the detection and/or quantitation of non-viral organisms
A method for preparing probes, as well as several probes for use in qualitative or quantitative hybridization assays are disclosed. The method comprises constructing an oligonucleotide that is...
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7138254 |
Methods and apparatus for performing submicroliter reactions with nucleic acids or proteins
Methods for preparing nanoscale reactions using nucleic acids or proteins are presented. Nucleic acids are captured saturably, yet reversibly, on the internal surface of the reaction chamber,...
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7138384 |
Modulators of DNA cytosine-5 methyltransferase and methods for use thereof
A synthetic oligonucleotide comprising a C-5 methylcytosine and which recognizes and binds an allosteric site on DNA methyltransferase thereby inhibiting DNA methyltransferase activity is...
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7135565 |
Synthesis of polynucleotides using combined oxidation/deprotection chemistry
A method of synthesizing a polynucleotide which can, for example, be used during fabrication of an array. A second nucleoside is coupled to a first nucleoside through a phosphite linkage, with the...
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7135564 |
Reusable solid support for oligonucleotide synthesis
A reusable linker arm for solid support oligonucleotide synthesis, the linker arm comprising formula (a) wherein Z is a linker moiety and T is an organic radical. A method for adding one or more...
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7132519 |
Releasable nonvolatile mass-label molecules
Releasable tag reagents for use in the detection and analysis of target molecules, particular in mass spectrometric analyses are provided. Also provided are methods of detection that employ...
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7132531 |
Reactor
A reactor vessel for carrying out solid phase synthesis, particularly the solid phase synthesis of oligonucleotides, peptides, and combinatorial chemistry is provided. The reactor vessel comprises...
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7129046 |
Linking to chemical array assemblies with metal layers
A method of producing a front surface modified substrate, which substrate includes a metal layer, and which is useful in the fabrication of an array of multiple probes bonded to a front surface of...
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7129045 |
Methods of detecting polynucleotide kinase and its use as a label
Methods of detecting or measuring the activity of polynucleotide kinase are disclosed as well as methods of detecting an analyte in an assay using polynucleotide kinase as a label on a member of a...
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7125982 |
Microbial production of nuclease resistant DNA, RNA, and oligo mixtures
The present method describes the use of thio-phosphate as a feed source for micro-organisms and multi-cellular organisms. This compound enters into nucleotide pools and ultimately into polymers of...
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7125972 |
Solid carriers with peptide nucleic acid probes and methods for regeneration
A method for the detection of point mutation and polymorphisms in nucleic acids or for sequencing of unknown nucleic acids by a simple procedure using arrays uses nucleic acid analoges as sequence...
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7125975 |
Derivatized oligonucleotides having improved uptake and other properties
Linked nucleosides having at least one functionalized nucleoside that bears a substituent such as a steroid molecule, a reporter molecule, a non-aromatic lipophilic molecule, a reporter enzyme, a...
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7122649 |
Derivatized oligonucleotides having improved uptake and other properties
Linked nucleosides having at least one functionalized nucleoside that bears a substituent such as a steroid molecule, a reporter molecule, a non-aromatic lipophilic molecule, a reporter enzyme, a...
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7119186 |
Application of aprataxin gene to diagnosis and treatment for early-onset spinocerebellar ataxia (EAOH)
The present invention provides polynucleotides and proteins, which are involved in early-onset spinocerebellar ataxia with ocular motor apraxia and hypoalbuminemia (EAOH); and methods of using the...
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7119184 |
Oligonucleotides having A-DNA form and B-DNA form conformational geometry
Modified oligonucleotides containing both A-form conformation geometry and B-from conformation geometry nucleotides are disclosed. The B-form geometry allows the oligonucleotide to serve as...
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RE39324 |
Pyrimidine derivatives and oligonucleotides containing same
Compounds having structure (1)
wherein R 1 is —H a protecting group, a linker or a binding partner; and R 2 and R 34 are as defined in the specification. The invention also provides...
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7109316 |
Oligonucleotide tagged nucleoside triphosphates (OTNTPs) for genetic analysis
Oligonucleotide tagged nucleoside triphosphates, OTNTPs, which are substrates for polymerases and or terminal nucleotidyl transferases are provided as well as methods of making these OTNTPs....
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