|
Match
|
Document |
Document Title |
|
|
7524942 |
Labeled nucleotide composition
Embodiments of labeled nucleotide compositions are described. Methods are described in which a sample containing RNA is contacted with an enzyme having an RNA ligation activity in the presence of a...
|
|
|
7524950 |
Uses of cationic salts for polynucleotide synthesis
Inkjet printhead solvents and methods of forming an addressable nucleotide array are disclosed.
|
|
|
7517646 |
Functional molecule and process for producing the same
A process for producing a functional molecule includes a forming step which forms a modified nucleotide n-mer (where, n represents an integer) containing a modified nucleoside prepared by...
|
|
|
7517538 |
Solid supports functionalised with phosphorus dendrimers, method for preparing same and uses thereof
The present invention relates to solid supports functionalized with phosphorus-containing dendrimers, to a process for preparing them, to their use for preparing biochips and to the uses of these...
|
|
|
7514551 |
Multisignal labeling reagents, and processes and uses therefor
The present invention provides multisignal labeling reagents and these are useful in a number of biochemical applications, including the manufacture of biomolecular probes and their use in...
|
|
|
7511125 |
Pyrimidine derivatives for labeled binding partners
Compounds having structure (1)
wherein R 1 is —H a protecting group, a linker or a binding partner; and R 2 and R 34 are as defined in the specification. The invention also provides...
|
|
|
7504239 |
Method of differentiating beer yeast
The method of differentiating beer yeast of the invention is a method which comprises a first step of synthesizing a primer capable of amplifying the linker portion between a base sequence (A) and...
|
|
|
7504496 |
Water-soluble rhodamine dye conjugates
The present invention provides novel, water-soluble, red-emitting fluorescent rhodamine dyes and red-emitting fluorescent energy-transfer dye pairs, as well as labeled conjugates comprising the...
|
|
|
7495095 |
Thionucleoside-S-nitrosyl derivative
The present invention provides a thionucleoside-S-nitrosyl derivative of the following Formula I or a salt thereof:
[wherein R 1 represents ribose, 2-deoxyribose or a derivative of either, and...
|
|
|
7491706 |
Artificial cpg single-stranded oligodeoxynucleotide and antiviral use thereof
The present invention provides a series of artificial CpG-containing single-stranded oligodeoxynucleotides (ODNs), each of which is consisted of single-stranded oligodeoxynucleotide DNA molecule...
|
|
|
7491817 |
Universal supports for oligonucleotide synthesis
Universal supports for oligonucleotide synthesis include a support material represented by the following formula:
In this formula, substituent A is selected from H, alkyl, aryl, or a polymeric...
|
|
|
7485716 |
Stereoselective synthesis of β-nucleosides
This invention relates to a process for stereoselectively preparing a nucleoside of the following formula:
wherein R 3 , R 4 , and B are defined herein. The process includes reacting a furanose...
|
|
|
7485426 |
Method and kits for preparing multicomponent nucleic acid constructs
The invention provides a highly efficient, rapid, and cost effective method of linking nucleic acid components in a predetermined order to produce a nucleic acid multicomponent construct. The...
|
|
|
7485427 |
Photocleavable bioreactive agents
This invention relates to agents and conjugates that can be used to detect and isolate target components from complex mixtures such as nucleic acids from biological samples, cells from bodily...
|
|
|
7482119 |
Solid phase methods for polynucleotide production
Polynucleotides having in excess of 1,000 nucleotides can be prepared using a solid phase synthesis technique. A feature of the technique is the use of a reusable solid support that contains...
|
|
|
7479548 |
Nucleic acid based ladder copolymers
The present invention relates to a copolymer termed a ladder copolymer because it has two backbones that serve as legs/sides of a ladder structure. These two backbones, one of which is a nucleic...
|
|
|
7476520 |
Primers for use in detecting beta-lactamases
Oliognucleotide primers are provided that are specific for nucleic acid characteristic of certain beta-lactamases. The primers can be employed in methods to identify nucleic acid characteristic of...
|
|
|
7476853 |
Ion fragmentation by reaction with neutral particles
The invention relates to a method and apparatus for the fragmentation of large molecules, especially biopolymers. The invention consists in reacting analyte ions with excited or radical neutral...
|
|
|
7476734 |
Nucleotide analogs
The invention provides nucleotide analogs for use in sequencing nucleic acid molecules.
|
|
|
7470783 |
Photocleavable protecting groups and methods for their use
Novel compounds are provided which are useful as linking groups in chemical synthesis, preferably in the solid phase synthesis of oligonucleotides and polypeptides. These compounds are generally...
|
|
|
7462468 |
DNA intercalating agents and methods of use
The present invention provides compositions and methods for detecting incorporation of a labeled nucleotide triphosphate onto the growing end of a primer nucleic acid molecule. The method is used,...
|
|
|
7459273 |
Methods for genotyping selected polymorphism
Methods for genotyping polymorphisms using a locus specific primer that is complementary to a region near a selected polymorphism are described. Methods for synthesizing pools of locus specific...
|
|
|
7459547 |
Methods and compositions for controlling efficacy of RNA silencing
Based at least in part on an understanding of the mechanisms by which small RNAs (e.g., naturally-occurring miRNAs) mediate RNA silencing in plants, rules have been established for determining, for...
|
|
|
7459443 |
Synthesis of biologically active compounds in cells
This invention relates to a new method of synthesis of biologically active substances of determined structure directly in the cells of living organisms containing specific RNA or DNA molecules of...
|
|
|
7455968 |
Detection method
A method of identifying a base at a target position in a single-stranded sample DNA sequence, the method characterised by the steps of: (i) providing an oligonucleotide probe which is capable of...
|
|
|
7456266 |
Detectable labeled nucleoside analogs and methods of use thereof
The invention relates to detectable labels useful for detection of nucleotide sequences. Specifically, the invention relates to labeled-imidazole-PEG compounds, such as nucleosides, nucleotides,...
|
|
|
7452673 |
Photoacid generators for the synthesis of oligo-DNA in a polymer matrix
Compounds represented by the following structural formulas can be used as photoacid generators:
Such compounds are useful, for example, in fabricating arrays of polymers.
|
|
|
7446186 |
Pyrroles substituted by oligonucleotides
The invention relates to novel pyrrole derivatives of the formula (I) which make it possible to immobilize and address oligonucleotides by electropolymerization. Said invention also relates to thus...
|
|
|
7446193 |
Methods for detection of chloral hydrate in dichloroacetic acid
Methods for detecting chloral hydrate in dichloroacetic acid are described.
|
|
|
RE40557 |
Methods for labeling nucleotides, labeled nucleotides and useful intermediates
The present invention provides improved methods for labeling nucleotides. The method of the invention for labeling nucleotides comprises the steps of: reacting a reactive moiety of a linker, which...
|
|
|
7439344 |
Selective O-acylation of nucleosides
The present invention relates to a one-step process for the selective O-acylation of the hydroxy groups of a nucleoside under basic conditions utilizing DMAP and a carboxylic acid anhydride in...
|
|
|
7435810 |
Use of ionic liquids for fabrication of polynucleotide arrays
A method of fabricating polynucleotide arrays includes dissolving a nucleotide monomer, oligonucleotide, or polynucleotide in a solvent containing ionic liquid and depositing the resulting solution...
|
|
|
7431685 |
Method and device for investigating substance libraries
The aim of the invention is to investigate the bonding of substances to target molecules. This is achieved by means of a densely packed device wherein various target molecules are bonded in a large...
|
|
|
7432058 |
Methods of labeling nucleic acids with energy transfer dyes
Novel linkers for linking a donor dye to an acceptor dye in an energy transfer fluorescent dye are provided. These linkers faciliate the efficient transfer of energy between a donor and acceptor...
|
|
|
7432368 |
Photolabile protecting groups
The present invention relates to novel nucleoside derivatives of general formula (I)
wherein R 1 =H, halogen, NO 2 , CN, OCH 3 , an alkyl, alkoxy or alkoxyalkyl residue having 1 to 4 C atoms,...
|
|
|
7427678 |
Method for immobilizing oligonucleotides employing the cycloaddition bioconjugation method
This invention discloses a novel method for immobilizing molecules to a support. Specifically, this invention discloses a method of immobilizing derivatized biomolecules, such as oligonucleotides,...
|
|
|
7427675 |
Compounds and methods for the characterization of oligonucleotides
The present invention relates to oligonucleotide synthesis. In particular, the present invention provides methods for characterizing samples useful for making oligonucleotides.
|
|
|
7422851 |
Correction for illumination non-uniformity during the synthesis of arrays of oligomers
The present invention provides an apparatus and a method for the synthesis of arrays of oligomers that have tight illumination intensity requirement. The apparatus and the method contains a...
|
|
|
7420050 |
TGF-β-specific covalently closed antisense molecule
The present application describes a purified covalently closed antisense molecule, which specifically inhibits expression of TGF-β.
|
|
|
7417139 |
Method for polynucleotide synthesis
Methods of forming an internucleotide bond are disclosed. Such methods find use in synthesis of polynucleotides. The method involves contacting a functionalized support with a precursor having an...
|
|
|
7414117 |
Nucleotide derivative and DNA microarray
A novel nucleotide derivative, in case of existing as a member of a single-stranded sequence, undergoing a change in the fluorescent signal intendity depending on the corresponding base type in the...
|
|
|
7411061 |
Method of synthesizing polynucleotides using ionic liquids
A method of synthesizing polynucleotides is disclosed. The method involves contacting a first nucleotide with a selected reactive group in the presence of an ionic liquid. The selected reactive...
|
|
|
7407747 |
Method for drying dye-terminator sequencing reagents
A dry composition comprising a nucleotide linked to a fluorescent dye is provided. A method of making a dry composition comprising the step of drying a solution comprising a nucleotide linked to a...
|
|
|
7405281 |
Fluorescent nucleotide analogs and uses therefor
Labeled nucleotide analogs used in place of naturally occurring nucleoside triphosphates or other analogs in template directed nucleic acid synthesis reactions and other nucleic acid reactions, and...
|
|
|
7402384 |
Methods for evaluating probe arrays
A probe array comprises a plurality of probes immobilized at a plurality of matrix sites on a substrate for capturing a target substance, wherein the probes are sequentially synthesized at the...
|
|
|
7399752 |
High affinity nucleic acid ligands to lectins
This invention discloses high-affinity oligonucleotide ligands to lectins, specifically nucleic acid ligands having the ability to bind to the lectins, wheat germ agglutinin, L-selectin, E-selectin...
|
|
|
7399846 |
Libraries of oligomers labeled with different tags
A method of making a set of labelled compounds by the use of a preferably particulate support, comprises dividing the support into lots, performing a different chemical reaction on each lot of the...
|
|
|
7384737 |
Synthesis of spatially addressed molecular arrays
Methods are disclosed for forming spatially addressable arrays of polynucleotides of known squence, by using blocking groups that prevent the incorporation of multiple nucleotides during each...
|
|
|
7385050 |
Cleavable linker for polynucleotide synthesis
Functionalized supports for polynucleotide synthesis are disclosed. The supports have linker moieties that are stable to conditions used in polynucleotide synthesis, but may be cleaved to release...
|
|
|
7385053 |
Functionalized compositions for improved immobilization
The present invention relates to improved covalent coupling of two or more entities such as biomolecules, polymer compositions, organic/inorganic molecules/materials, and the like, including their...
|