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6132995 |
Method for determining activity of reverse transcriptase
A method for determining the activity of a nucleotide polymerizing enzyme in a sample, and use of the method for determining HIV 1 RT- and Herpes Simplex DNA-polymerase activity. The enzyme is...
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6133436 |
Beads bound to a solid support and to nucleic acids
Novel compositions comprised of at least one bead conjugated to a solid support and further conjugated to at least one nucleic acid and preferred methods for making the novel compositions are...
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6130324 |
Amphipathic oligonucleotides and polynucleotides having potent antiviral activity
The present invention provides novel compositions that show potent antiviral activity against both DNA and RNA viruses. In particular, the present invention provides oligo- and polyribonucleotides...
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6130046 |
Techniques for synthesis integrity evaluation utilizing cycle fidelity probes
Techniques for designing polymer probes to verify the integrity of the probe synthesis are provided. Multiple probes with identical sequences are designed so that the probes will be formed...
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6130323 |
Non-nucleotide linking reagents
Non-nucleotide reagents capable of forming oligomers with nucleotide units are disclosed, together with intermediates for synthesizing such non-nucleotide reagents, oligomers incorporating such...
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6127125 |
Sample application method and device
A sample application method including the steps of: rotating a biochip including a plurality of regions bound with various probes; and dropping a sample onto generally a center of rotation of the...
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6127190 |
Method for producing combinatorial libraries having a predetermined frequency of each species of test compound
A technique is disclosed for generating nonrandom combinatorial libraries on solid phase supports in which each of a set of predetermined species of test compounds is present on a predetermined...
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6127346 |
Phosphonomonoester nucleic acids process for their preparation and their use
Novel oligonucleotide analogs of the formula [I] are described, ##STR1## in which A, B, D, G, L, P, Q, Q', R 5 , R 6 , X, Y, Z and n are as defined in the description, which have useful physical,...
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6124445 |
Phosphotriester oligonucleotides, amidities and method of preparation
Oligonucleotides having bioreversible phosphate blocking groups can be used as pro drugs for the oligonucleotides. The bio-reversible blocking groups can be removed by intercellular enzymes,...
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6124093 |
Process for reducing the formation of artifacts during transcription of ribonucleic acids to deoxynucleic acids
A method of transcribing ribonucleic acids of a sample by treating the sample containing ribonucleic acid with a DNA digesting enzyme in the presence of Mn 2 + ions followed by transcribing the...
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6124450 |
Processes and intermediates for phosphorous-containing covalent linkages
Synthetic processes are provided wherein substituted silylalkyl phosphoramidites serve as coupling reagents for preparing phosphate, phosphorothioate, and other phosphorous-containing covalent...
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6117657 |
Non-nucleotide containing enzymatic nucleic acid
Enzymatic nucleic acid molecule containing one or more non-nucleotide mimetics, and having activity to cleave an RNA or DNA molecule.
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6117631 |
Detection of antigens via oligonucleotide antibody conjugates
The present invention provides a method of detecting antigens, which comprises immobilizing an antigen to a solid support and contacting the solid support with a means for hybridizing a labeled...
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6117992 |
Reagents and process for synthesis of oligonucleotides containing phosphorodithioate internucleoside linkages
The invention provides new methods for synthesizing oligonucleotides containing at least one, and preferably all phosphorodithioate internucleoside linkages with less than 5% phosphoromonothioate...
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6117988 |
Nucleotides and oligonucleotides preparable therefrom
Analogues of RNA and DNA compounds contain a neutral, stereoregular linking group based on replacement of the phosphoryl with a sulfonyl group. Precursors to the analogues are also described, as...
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6114149 |
Amplification of mixed sequence nucleic acid fragments
A method of amplifying a mixture of different-sequence DNA fragments which may be formed from RNA transcription, or derived from genomic single- or double-stranded DNA fragments. The fragments are...
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6114518 |
Synthesis and use of labelled phosphoramidite compositions
The present invention provides labelled phosphoramidite compositions, methods for making these labelled phosphoramidite compositions, and methods for using these labelled phosphoramidite...
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6114513 |
Thiol-derivatized oligonucleotides
Nucleosides and linked nucleosides functionalized to include alkylthiol chemical functionality at ribofuranosyl positions, nucleosidic base positions, or on internucleoside linkages. In certain...
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6110426 |
Methods for fabricating microarrays of biological samples
A method and apparatus for forming microarrays of biological samples on a support are disclosed. The method involves dispensing a known volume of a reagent at each selected array position, by...
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6110668 |
Gene synthesis method
A method of gene synthesis is disclosed. The gene synthesis method permits the codons of [m] natural gene to be changed to allow preferential transcription and translation of the synthetic gene in...
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6110709 |
Cleaved amplified modified polymorphic sequence detection methods
The invention features methods for detecting polymorphic restriction sites and single nucleotide polymorphisms in nucleic acid molecules and kits for carrying out these methods.
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6110683 |
Automated DNA Sequencer loading dye which contains a lane tracking aid
The present invention provides a reagent which can be used as a marker to identify individual lanes on an electrophoresis gel which is run on an Automated DNA Sequencer. This reagent is may be...
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6111095 |
Capped synthetic RNA, analogs, and aptamers
A method is provided for making synthetic capped RNAs. These compounds serve as substrates for the virally encoded endonuclease associated with influenza virus. We are able to assay for this unique...
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6107479 |
Process for the preparation of an oligomeric compound
The present invention relates to a process for the preparation of an oligomeric compound, comprising introduction of a lipophilic capping group to an unreacted reactive group, suitable for chain...
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6107039 |
Assays using base protected table 1
The present invention is directed to protected thiol analogs of pyrimidine bases for syntheses of DNA and RNA by chemical or enzymatic methods. The subject analogs include reagents suitable for DNA...
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6107061 |
Modified primer extension reactions for polynucleotide sequence detection
The present invention relates to assays for the detection of nucleotide bases at predetermined locations on polynucleotides of interest. The embodiments of the invention include techniques relating...
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6107470 |
Histidine-containing peptide nucleic acids
Peptide nucleic acids containing histidine moieties are provided. These compounds have applications including diagnostics, research and potential therapeutics.
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6103463 |
Method of sorting a mixture of nucleic acid strands on a binary array
A method of sorting mixtures of nucleic acid strands comprising hybridizing the strands to an array of immobilized oligonucleotides, each of which includes a constant segment adjacent to a variable...
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6096881 |
Sulfur transfer reagents for oligonucleotide synthesis
In our research, two commercially available compounds, 3-amino-1,2,4-dithiazole-5-thione (1) and xanthane hydride (2), and their derivatives 3-6 are found to be potential sulfur-transfer reagents....
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6090934 |
Universal support for the synthesis of oligonucleotides
A universal polymer support containing an organic aliphatic molecule of structure ##STR1## having at least a pair of cis-hydroxyl groups where one of the hydroxyl groups is attached to the polymer...
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6090933 |
Methods of attaching conductive oligomers to electrodes
The invention relates to nucleic acids covalently coupled to electrodes via conductive oligomers. More particularly, the invention is directed to the site-selective modification of nucleic acids...
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6090932 |
Method of preparation of known and novel 2'-modified nucleosides by intramolecular nucleophilic displacement
A method for the preparation of 2'-modified nucleosides is provided. The method comprises a novel intramolecular nucleophilic displacement reaction. Included in the invention are novel 2'-modified...
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6087482 |
Heteroatomic oligonucleoside linkages
Oligonucleotide-mimicking macromolecules that have improved nuclease resistance are provided. Replacement of the normal phosphorodiester inter-sugar linkages found in natural oligonucleotides with...
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6087095 |
DNA sequencing method
The invention is drawn to a method of DNA sequencing using labeled nucleotides that do not act as chain elongation inhibitors where the label is removed or neutralized for the sequential addition...
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6087490 |
Dinucleotide and oligonucleotide analogues
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6084102 |
Covalently linked oligonucleotide minor grove binder conjugates
Minor groove binding molecules are covalently bound to oligonucleotides which in their base sequence are complementary to a target sequence of single stranded or double stranded DNA, RNA or hybrids...
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6084082 |
Lactam nucleic acids
Novel β-lactam monomers bearing various functional groups are prepared. The novel β-lactam monomers can be joined into oligomeric compounds such as via preferred phosphate linkages including...
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6080852 |
4,7-dichlororhodamine dyes
A set of 4,7-dichlororhodamine compounds useful as fluorescent dyes are disclosed having the structures ##STR1## wherein R 1 -R 6 are hydrogen, fluorine, chlorine, lower alkyl, lower alkene,...
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6077668 |
Highly sensitive multimeric nucleic acid probes
The present invention provides detectably labeled RNA and DNA oligonucleotide multimers useful as diagnostic probes in medical, biological and chemical applications. A method for synthesizing DNA...
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6077674 |
Method of producing oligonucleotide arrays with features of high purity
A method of making full-length oligonucleotide arrays provides for the purification of pre-synthesized full-length oligonucleotides from shorter length oligonucleotides and other impurities at the...
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6074868 |
Alumina plate method and device for controlling temperature
A thermal cycling device comprising a ceramic sample plate, and method of use thereof, is provided.
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6074825 |
Stable encapsulated reference nucleic acid and method of making
Stable reference nucleic acid for use in all steps of molecular screening and diagnostic assays and method of making. A desired nucleic acid sequence is amplified, ligated into an expression...
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6072046 |
Diaziridinyl-aryl and bis-[di(chloroethyl)amino]-aryl oligonucleotide conjugates and reagents for making the same
Diaziridinyl-aryl and bis-[di(chloroethyl)amino]-aryl oligonucleotide conjugates have a sequence that is complementary in the triplex forming sense to a target sequence in duplex nucleic acid. The...
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6072044 |
Nanoconstructions of geometrical objects and lattices from antiparallel nucleic acid double crossover molecules
Two and three dimensional polynucleic acid structures, such as periodic lattices, may be constructed from an ordered array of antiparallel double crossover molecules assembled from single stranded...
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6072043 |
Optimally fluorescent oligonucleotides
A method for the preparation of optimally fluorescent oligonucleotides wherein fluorescent dye-conjugated nucleotide triphosphates are incorporated into a nucleic acid sequence in a defined...
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6066447 |
Modified oligonucleotides
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6063563 |
Method of PCR testing of pooled blood samples
Systems, processes, and devices are provided which are useful for testing blood or plasma donations to detect those specific donations which are contaminated by a virus above a predetermined level....
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6063569 |
Methods for automated synthesis of PNA-DNA chimeras and compositions thereof
A method is disclosed for the preparation of novel PNA synthons compatible with DNA synthetic reagents and instrumentation. Accordingly, the PNA synthons of this invention are particularly suitable...
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6063573 |
Cycling probe technology using electron transfer detection
The invention relates to novel methods and compositions useful in Cycling Probe Technology (CPT) using electron transfer to detect target nucleic acid sequences.
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6060456 |
Chimeric oligonucleoside compounds
Chimeric oligonucleoside compounds, and methods of preparing and formulating the same, are disclosed. The compounds and compositions are useful in activating RNaseH-mediated cleavage of target...
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