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8183355 |
Method for the synthesis of oligonucleotide derivatives
Method for the synthesis of nucleotide derivatives wherein molecules of interest are grafted on the oligonucleotide with the help of a “click chemistry” reaction between an azide function on the...
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8178360 |
Dye compounds and the use of their labelled conjugates
Novel rhodamine dye compounds, labelled conjugates comprising the dyes are described, together with methods for their use. The dyes and labelled conjugates are useful as molecular probes in a...
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8173620 |
BHQ-caged nucleotide probes photolysable by two-photon excitation
The disclosure encompasses caged compounds such as caged nucleoside phosphoesters (caged nucleotides). In an embodiment, the caged nucleotides include compounds corresponding to those described by...
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8168776 |
Method for making a 21 nucleotide double stranded RNA chemically linked at one end
The present invention provides methods and compositions for inhibiting gene expression using double stranded RNA molecules that are between 15 and 21 nucleotides in length and are complementary to...
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8168777 |
Bisulphite reagent treatment of nucleic acid
Methods for treating nucleic acid including: (a) providing an alkali environment to a nucleic acid sample; (b) reacting the nucleic acid sample with a bisulphite reagent and incubating the reaction...
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8163524 |
Comparative analysis of extracellular RNA species
The invention provides methods for detecting tumor-associated RNA in plasma, serum, and other bodily fluids. In particular, the invention provides methods for detecting translocated gene RNA,...
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8163891 |
Process for the preparation of poly(alkoxylated) oligonucleotides
A process for the preparation of a poly(alkoxylated) oligonucleotide is provided. The process comprises reacting an oligonucleotide which has been purified by ultrafiltration with a poly(alkoxide)...
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8163897 |
5-bromo-2′-deoxy-uridine labeled nucleotide triphosphates and nucleic acid probes and methods of making and using the same
5-bromo-2′-deoxy-uridine (BrdU) labeled nucleotide triphosphates and nucleic acid probes are described herein. The BrdU labeled nucleotide triphosphates include a linker between the nucleotide t...
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8158341 |
Efficient algorithm for PCR testing of blood samples
A method is provided for identifying viral positive biological fluid donations in the fewest number of test cycles. The method comprises providing biological fluid donations and defining an...
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8158774 |
Method for introducing a nucleic-acid protecting group
The present invention relates to a simple, economical method for introducing substituent (I) at the 2′-hydroxyl group of the ribose of a ribonucleic acid derivative whose 3′-hydroxyl group and 5′-...
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8153781 |
Dendrimer conjugates of agonists and antagonists of the GPCR superfamily
Disclosed are conjugates comprising a dendrimer and a ligand, which is a functionalized congener of an agonist or antagonist of a receptor of the G-protein coupled receptor (GPCR) superfamily, for...
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8153365 |
Oligonucleotide analogues
The present invention relates to novel bicyclic and tricyclic nucleoside and nucleotide analogues as well as to oligonucleotides comprising such elements. The nucleotide analogues, LNAs (Locked...
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8153375 |
Compositions and methods for nucleic acid sequencing
Compositions and methods for nucleic acid sequencing include template constructs that comprise double stranded portions in a partially or completely contiguous constructs, to provide for redundant...
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8137906 |
Method for the synthesis of DNA fragments
The invention relates to a method that can be carried out in parallel and automated for the production of any nucleic acid, comprising the following steps: a) coupling an oligonucleotide to a solid...
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8133987 |
Primer array synthesis and validation
Methods are presented for generating large sets for polymers. The methods employ high density oligonucleotide array.
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8133719 |
Methods for making single molecule arrays
Random arrays of single molecules are provided for carrying out large scale analyses, particularly of biomolecules, such as genomic DNA, cDNAs, proteins, and the like. In one aspect, arrays of the...
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8129517 |
Labeled solid supports for organic synthesis
The disclosed invention pertains to improved oligonucleotide manufacturing methods, including novel support compositions that are optionally labeled, their methods of preparation and use. The...
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8124333 |
Methods for covalent linking of optical reporters
A method to link a light emitting reporter to biomolecules with nucleotide oligomers is described. The light reporter particles are silylated and functionalized to produce a coated light reporter...
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8101737 |
Parallel preparation of high fidelity probes in an array format
The present invention provides massively parallel oligonucleotide synthesis and purification for applications that utilize large collections of defined high-fidelity oligonucleotides (e.g., from...
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8097715 |
Multitargeting interfering RNAs having two active strands and methods for their design and use
Interfering RNA molecules are now designed and produced with specificity for multiple binding sequences present in distinct genetic contexts in one or more pre-selected target RNA molecules and are...
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8097409 |
Kits for detecting group B Streptococci
Compositions, methods and kits for detecting Group B streptococci. Particularly described are oligonucleotides that are useful as amplification primers and hybridization probes for detecting very...
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8093371 |
Method of producing a nucleic acid
The present invention provides a method of producing a nucleic acid at high reaction efficiency and high reproducibility with a decreased variation in yield and purity among different reaction...
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8093367 |
Preparation and isolation of 5′ capped mRNA
The synthesis of capped/tagged RNA, methods of use and kits providing same are contemplated. Tagged RNA permits isolation of RNA transcripts in vitro. The ability to isolate and purify capped RNA...
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8088575 |
Massive parallel method for decoding DNA and RNA
This invention provides methods for attaching a nucleic acid to a solid surface and for sequencing nucleic acid by detecting the identity of each nucleotide analogue after the nucleotide analogue...
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8084589 |
Phosphoramidite nucleoside analogs
Described are phosphoramidite nucleoside analog monomers, precursors thereof, and oligonucleotides including one or more of the monomers. The monomers can be used during automated synthesis of...
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8084245 |
Apparatus and method for polymer synthesis using arrays
A polymer synthesis apparatus (20) for building a polymer chain including a head assembly (21) having an array of nozzles (22) with each nozzle coupled to a reservoir (23) of liquid reagent (24),...
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8080644 |
Oligonucleotide analogues
The present invention relates to novel bicyclic and tricyclic nucleoside and nucleotide analogues as well as to oligonucleotides comprising such elements. The nucleotide analogues, LNAs (Locked...
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8076105 |
Device and method for high-throughput quantification of MRNA from whole blood
Disclosed are a method, device kit, and automated system for simple, reproducible, and high-throughput quantification of mRNA from whole blood. More particularly, the method, device, kit and...
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8076063 |
Multiplexed methylation detection methods
The present invention is directed to sensitive and accurate multiplexed assays for target analyte detection and detection of methylation in nucleic acid samples.
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8071755 |
Nucleotide analogs
The invention provides for nucleotide analogs and methods of using the same, e.g., for sequencing nucleic acids.
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8071289 |
Synthesis of hybrid polynucleotide molecules using single-stranded polynucleotide molecules
A method to make libraries of hybrid polynucleotide molecules of two parental polynucleotide molecules utilizing single-stranded DNA was invented. Example of the method comprises several steps: (i)...
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8067578 |
Substrate preparation process
The present invention provides novel processes for the large scale preparation of arrays of polymer sequences wherein each array includes a plurality of different, positionally distinct polymer...
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8067164 |
Microarray system with improved sequence specificity
The invention provides a novel array method for nucleic acid sequence detection with improved specificity which allows for detection of genetic variation, from simple SNPs (where the variation...
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8063199 |
Method for isolating both free and protein association DNA
A method is disclosed for isolating both free and protein-associated DNA from bodily fluids, such as urine, saliva, serum, tears, sweat, cerebral spinal fluid, and plasma. The method comprises as a...
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8062844 |
Use of acid scavengers for the synthesis of standard length and long-mer nucleic acid arrays
Protective groups which may be cleaved with an activatable deprotecting reagents are employed to achieve a highly sensitive, high resolution, combinatorial synthesis of pattern arrays of diverse...
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8058448 |
Processes and reagents for sulfurization of oligonucleotides
The present invention relates to processes and reagents for oligonucleotide synthesis and purification. One aspect of the present invention relates to compounds useful for activating...
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8058415 |
Aptamer- and nucleic acid enzyme-based systems for simultaneous detection of multiple analytes
The present invention provides aptamer- and nucleic acid enzyme-based systems for simultaneously determining the presence and optionally the concentration of multiple analytes in a sample. Methods...
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8043835 |
Methods for detecting and monitoring cancer using extracellular RNA
The invention provides methods, reagents and kits for using extracellular RNA in bodily fluids including plasma and serum to detect, infer, or monitor diseases such as cancer and other neoplasia.
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8039611 |
2′-hydroxyl group-modified ribonucleoside derivatives
Provided is a ribonucleoside derivative represented by General Formula (I): (wherein R1 represents a hydrogen atom or the like, R2 represents a hydrogen atom or the like, R3 represents a methyl...
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8034909 |
Oligonucleotide analogues
The present invention relates to novel bicyclic and tricyclic nucleoside and nucleotide analogues as well as to oligonucleotides comprising such elements. The nucleotide analogues, LNAs (Locked...
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8034912 |
Parallel preparation of high fidelity probes in an array format
The present invention provides massively parallel oligonucleotide synthesis and purification for applications that utilize large collections of defined high-fidelity oligonucleotides (e.g., from...
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8034923 |
Reagents for reversibly terminating primer extension
Processes are disclosed that use 3′-reversibly terminated nucleoside triphosphates to analyze DNA for purposes other than sequencing using cyclic reversible termination. These processes are based o...
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8034924 |
Process for production of crystal of purine nucleoside compound
Crystals of a purine nucleoside compound, particularly crystals of 2′,3′-dideoxyinosine, which have excellent storage stability and have a concentration of phosphate attached to the crystal of 25 ...
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8034588 |
Species-specific, genus-specific and universal DNA probes and amplification primers to rapidly detect and identify common bacterial and fungal pathogens and associated antibiotic resistance genes from clinical specimens for diagnosis in microbiology laboratories
Provided herein are methods and kits for the specific and ubiquitous detection of Streptococcus agalactiae.
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8030096 |
Water-soluble rhodamine dyes conjugates
The present invention provides novel, water-soluble, red-emitting fluorescent rhodamine dyes and red-emitting fluorescent energy-transfer dye pairs, as well as labeled conjugates comprising the...
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8030466 |
3′-o-fluorescently modified nucleotides and uses thereof
The present invention relates to a DNA sequencing method using a nucleoside triphosphate with a fluorescent blocking group on its 3′-OH end as a reversible terminator. Further, the present i...
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8030478 |
Method for nucleic acid replication and novel artificial base pairs
The present invention relates to a method for nucleic acid replication and novel artificial base pairs. The method of the present invention for nucleic acid replication is characterized in that a...
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8029988 |
Oligonucleotide mediated nucleic acid recombination
Methods of recombining nucleic acids, including homologous nucleic acids, are provided. Families of gene shuffling oligonucleotides and their use in recombination procedures, as well as polymerase...
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8030477 |
Methods for the synthesis of arrays of DNA probes
The synthesis of arrays of DNA probes sequences, polypeptides, and the like is carried out using a patterning process on an active surface of a substrate. An image is projected onto the active...
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8026348 |
Nucleoside derivative, modified oligonucleotide, method for their synthesis and applications thereof
Compositions and methods of preparing carboranes and metallacarboranes, which can be used as a new type of electrochemically active label for biological compounds, are disclosed. Nucleic acid...
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