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7390792 |
MicroRNA1 therapies
Delta protein expression in a cell is reduced by introducing miR-1 into the cell, and detecting a resultant reduction of Delta protein expression in the cell.
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7381819 |
Composition for treatment or prevention of endometrial cancer and method of preventing or treating endometrial cancer using the composition
Provided are a composition for the treatment or prevention of an endometrial cancer including a nuclear acid molecule inducing RNA interference against human syndecan-1 gene expression and a...
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7381708 |
Suppression of eIF5A1 expression by the use of antisense oligonucleotides for the prevention of retinal cell death in the glaucomatous eye
The present invention provides methods for preventing retinal ganglion cell death in the glaucomatous eye and methods for suppressing apoptosis-specific eIF5A1 expression through the use of...
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7378275 |
Canine IL-13 receptor alpha-1 subunit nucleic acid molecules
The invention relates to canine immunoglobulin G (IgG) and canine interleukin-13 receptors (IL-13R) as well as fusion proteins containing canine IgG and/or canine IL-13R. In particular, the present...
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7375212 |
Modulation of Aurora B expression
Compounds, compositions and methods are provided for modulating the expression of Aurora B. The compositions comprise oligonucleotides, targeted to nucleic acid encoding Aurora B. Methods of using...
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7371850 |
Method and composition for reducing expression of ROCK-II
Methods and pharmaceutical compositions for treating, and delaying the onset of, viral infection, are provided.
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7371735 |
Inhibitor oligonucleotides and their use for specific repression of a gene
A method of treating a disease resulting from the expression of a harmful gene is described. The method includes the step of administering a therapeutically effective amount of a pharmaceutical...
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7368561 |
Isolation of antisense oligonucleotides
The present invention relates to a method of isolating fully thioated single stranded antisense oligonucleotides from a biological solution, which method comprises the steps of contacting the...
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7368559 |
FcγRIIA-specific nucleic acid interference
The present invention provides methods and compositions for attenuating expression of FcγRIIA. In general, the described methodology involves the use of RNAi constructs that are targeted to a...
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7368436 |
TRPM-2 antisense therapy
It has been determined that antisense therapy which reduces the expression of TRPM- 2 provides therapeutic benefits in the treatment of cancer, particularly prostate and renal cell cancers....
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7365058 |
MicroRNA and methods for inhibiting same
The invention relates to isolated DNA or RNA molecules comprising at least ten contiguous bases having a sequence in a pancreatic islet microRNA. In another embodiment, the invention relates to...
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7361752 |
RNAi modulation of MLL-AF4 and uses thereof
The invention relates to compositions and methods for modulating the expression of the MLL-AF4 fusion gene, and more particularly to the downregulation of MLL-AF4 by chemically modified...
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7358418 |
Isoforms of eIF-5A: senescence-induced eLF5A; wounding-induced eIF-4A; growth eIF-5A; and DHS
The present invention relates to unique isoforms of eukaryotic initiation Factor 5A (“eIF-5A”): senescence-induced eIF-5A; wounding-induced eIF-5A; and growth eIF-5A, as well as polynucleotides...
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7358223 |
Biodegradable cationic polymers
Polymers comprising a polyethylenimine, a biodegradable group, and a relatively hydrophobic group are useful for the delivery of bioactive agents to cells.
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7355056 |
Transfection agents
The present invention provides compounds, compositions and methods that enhance the transfer of an agent into a cell. The agents can include polypeptides, polynucleotides such as genes and...
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7355035 |
Catalytic molecules
The present invention relates to DNAzymes which are targeted against mRNA molecules encoding EGR-1 (also known as Egr-1 and NGFI-A). The present invention also relates to compositions including...
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7351535 |
Compositions and methods for increasing cholesterol efflux and raising HDL using ATP binding cassette transporter protein ABC1
The present invention relates to novel ABC1 polypeptides and nucleic acid molecules encoding the same. The invention also relates to recombinant vectors, host cells, and compositions comprising...
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7351532 |
DNA sequence analysis
There is disclosed a method for determining the identity of one or more mutations or single nucleotide polymorphisms (SNPs) in a genome, comprising: a contacting a sample genome, under conditions...
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7349808 |
System and method for tracking and controlling infections
The present invention is a system and method for performing real-time infection control over a computer network. The method comprises obtaining a sample of a microorganism at a health care...
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7348314 |
Compositions and methods for inhibiting viral replication
The present invention relates to a double-stranded ribonucleic acid (dsRNA) having a nucleotide sequence which is less that 30 nucleotides in length and which is substantially identical to at least...
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7345027 |
Compositions and methods for siRNA inhibition of angiogenesis
RNA interference using small interfering RNAs which are specific for the vascular endothelial growth factor (VEGF) gene and the VEGF receptor genes Flt-1 and Flk-1/KDR inhibit expression of these...
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7345025 |
Methods for genetic modification of hematopoietic progenitor cells and uses of the modified cells
Described are compositions and methods relating to gene therapy, particularly as applied to hematopoietic progenitor (HP) cells, to transduced cells and methods of obtaining them, and to methods of...
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7342111 |
Adeno-associated virus-delivered ribozyme compositions and methods of use
Provided are methods for the identification of novel genes involved in a variety of cellular processes, including retinal degeneration, retinal disease, cancer, memory and learning, amylotropic...
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7339051 |
Compositions and methods for the treatment of severe acute respiratory syndrome (SARS)
The present invention provides design and synthesis of oligomeric compounds and compositions that can be administered to reduce the activity of SARS virus in vivo or in vitro, to prevent or treat...
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7335764 |
Antisense modulation of acyl CoA cholesterol acyltransferase-2 expression
Antisense compounds, compositions and methods are provided for modulating the expression of acyl CoA cholesterol acyltransferase-2. The compositions comprise antisense compounds, particularly...
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7335763 |
Herpesvirus ribozymes and vectors
Hammerhead ribozymes that target components critical to HSV replication (ICP4, UL20, UL30, and UL54) were synthesized and shown to efficiently cleave target RNA encoding a portion of these...
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7335750 |
Hybrid compositions for intracellular targeting
Hybrid compounds comprising a first domain and a second domain are provided. The first domain and the second domain are preferably covalently linked, and the first domain comprises a domain which...
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7332335 |
Decreasing cell proliferation by decreasing levels of PP5
The invention provides a method of increasing expression of p21 WAF1/Cip 1 in cells to decrease proliferation of the cells, the method comprising decreasing levels of PP5 protein in the cells. The...
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7329741 |
Polynucleotides that hybridize to DP-75 and their use
The present invention is a novel nucleic acid sequence which hybridizes to SEQ ID NO:6 or fragments thereof under stringent conditions, or fragments thereof. The invention also includes diagnostic...
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7329649 |
Combinatorial methods for inducing cancer cell death
The present invention relates to methods and compositions for inhibiting proliferation and inducing cell death in a population of cancer cells by (i) increasing the amount of the differentiation...
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7326783 |
Pharmaceutical composition comprising antisense-nucleic acid for prevention and/or treatment of neuronal injury, degeneration and cell death and for the treatment of neoplasms
A pharmaceutical composition comprising an effective amount of a compound which is capable from preventing and treating neuronal injury, degeneration, cell death and/or neoplasms in which...
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7326693 |
Antisense modulation of c-reactive protein expression
Antisense compounds, compositions and methods are provided for modulating the expression of C-reactive protein. The compositions comprise antisense compounds, particularly antisense...
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7323560 |
Plastidic phosphoglucomutase genes
An isolated nucleic acid fragment encoding a plastidic phosphoglucomutase protein is disclosed. Also disclosed is the construction of a chimeric gene encoding all or a substantial portion of the...
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7323319 |
RNA containing coenzymes, biotin, or fluorophores, and methods for their preparation and use
Materials and methods for incorporating adenosine derivatives into the 5′ end of transcribed RNA are disclosed. Adenosine derivatives include naturally occurring compounds such as Coenzyme A,...
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7320965 |
Compositions and methods for inhibiting expression of Huntingtin gene
The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of the Huntingtin gene (HD gene), comprising an antisense strand having a nucleotide sequence which...
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7320964 |
Modulation of expression of STAT-1 dependent genes
The invention relates to decoy oligonucleotides and antisense oligonucleotides comprising a nucleic acid sequence according to SEQ ID NO: 1 to 43, in addition to the use of said nucleotides as...
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7319145 |
Methylenetetrahydrofolate reductase inhibitors and use thereof
The present invention provides methylenetetrahydrofolate reductase (MTHFR) inhibitors for use in selective inhibition of cancer cell growth in a mammal. These inhibitors can be a small molecule, an...
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7314927 |
Regulation of bcl-2 gene expression
The present invention provides novel anticode oligomers and methods of using them for controlling the growth of cancer cells expressing the bcl-2 gene.
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7312325 |
RNA aptamers and methods for identifying the same
RNA aptamers and methods for identifying the same are disclosed. The RNA aptamers selectively bind coagulation factors, E2F family members, Ang1 or Ang2, and therapeutic and other uses for the RNA...
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7309786 |
Oligonucleotide antagonist for human tumor necrosis factor α (TNF-α)
The present invention relates to a group of new oligonucleotides sequences with human tumor necrosis factor α (TNF-α) inhibiting activity, which includes DNA sequences and RNA sequences. These...
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7309695 |
Pharmaceutical compositions for the prevention and treatment of atherosclerosis and restenosis after PTCA
The present invention provides a pharmaceutical composition for the prevention or treatment of angiostenosis, comprising a compound inhibiting the function of midkine (MK) in blood vessel tissues...
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7309692 |
Inhibition of chronic myelogenous leukemic cell growth by liposomal-antisense oligodeoxy-nucleotides targeting to GRB2 or CRK1
The present invention provides novel compositions and methods for use in the treatment of cancer, specifically, in the treatment of chronic myelogenous leukemia (CML). The compositions contain...
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7307069 |
Antisense oligonucleotide modulation of STAT3 expression
Compounds, compositions and methods are provided for inhibiting the expression of human STAT3. The compositions comprise antisense oligonucleotides targeted to nucleic acids encoding STAT3. Methods...
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7304042 |
Potent inhibition of influenza virus by specifically designed short interfering RNA
This patent application discloses siRNA sequences against the constant region of the ,8 influenza virus nucleoprotein gene comprising:
(SEQ ID NO: 1) Sense strand: 5′ UGAAGGAUCUUAUUUCUUCdTdT...
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7304041 |
Modulators of coagulation factors
The invention provides improved nucleic acid ligands that inhibit coagulation and improved modulators of the nucleic acids to provide ideal modulators of coagulation. These improved nucleic acids...
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7301071 |
Method for the production of plant seed with modified fiber content and modified seed coat
The present invention relates to nucleotide sequences commonly designated CJAS1 comprising a novel gene from plants. The novel gene encodes a protein that is involved in seed formation and is...
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7301017 |
Kinase suppressor of Ras inactivation for therapy of Ras mediated tumorigenesis
The present invention relates to methods and compositions for the specific inhibition of kinase suppressor of Ras (KSR). In particular, the invention provides genetic approaches and nucleic acids...
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7300922 |
Modulators of pharmacological agents
The biological activity of nucleic acid ligand is regulated (i.e. enhanced or inhibited) in vivo to produce a desired biological effect. This is accomplished through the administration of a...
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7297786 |
RNA interference in respiratory epitheial cells
The present invention is directed to small interfering RNA molecules targeted against a gene of interest in respiratory epithelial cells, and methods of using these RNA molecules.
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7297779 |
Colon cancer metastasis inhibitor
The present invention provides an agent for inhibiting metastasis of colorectal cancer and a method for inhibiting metastasis of colorectal cancer, which inhibit the function of Asef (i.e., binding...
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