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7189832 |
Gamma subunit of cytokine responsive IκB-alpha kinase complex and methods of using same
The present invention provides a novel essential regulatory subunit of the IκB kinase (IKK) complex, IKK-γ. The isolated IKK-γ subunit of the invention has substantially the same amino acid...
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7186530 |
Protein associated with cell stress response
A stress-phosphorylated endoplasmic reticulum protein, Nogo B, is provided. The protein is hyperphosphorylated as a result of exposure of cells to stress. Two transcripts of Nogo B are identified...
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7186898 |
Nucleic acid molecules from maize and their use for the production of modified starch
Nucleic acid molecules are described encoding a starch granule-bound protein from maize as well as methods and recombinant DNA molecules for the production of transgenic plant cells and plants...
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7186887 |
Nucleic acids encoding oryza sativa nuclear cap binding protein 80 and methods of use
An isolated polynucleotide encoding a full-length rice cap binding protein 80 (CBP80) is provided. The reduction in expression or activity of CBP80 in a transgenic rice plant cell may be...
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7186702 |
Method of treating leishmaniasis using methyl-beta-cyclodextrin
The present invention relates to a composition useful for the treatment of leishmaniasis said composition comprising pharmaceutically effective amount of methyl-beta-cyclodextrin, optionally...
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7179894 |
Combinatorial selection of oligonucleotide aptamers
A random combinatorial selection method is disclosed for the construction of oligonucleotide aptamers in which nuclease resistance is conferred by the inclusion of modified nucleotides. The...
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7179796 |
Antisense modulation of PTP1B expression
Compounds, compositions and methods are provided for modulating the expression of PTP1B. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic...
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7179593 |
Estrogen receptor site-specific ribozymes and uses thereof for estrogen dependent tumors
Highly specific hammerhead ribozymes are provided that human target estrogen receptor mRNA. These ribozymes, designated RZ1 through RZ7 provide predictable mRNA cleavage products. Methods for...
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7176304 |
RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfering nucleic acid (siNA)
The present invention concerns methods and reagents useful in modulating vascular endothelial growth factor (VEGF, VEGF-A, VEGF-B, VEGF-C, VEGF-D) and/or vascular endothelial growth factor receptor...
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7176293 |
Compositions and methods to enhance sensitivity of cancer cells to mitotic stress
An isolated nucleic acid sequence of a mitotic checkpoint gene, chfr, encodes a Chfr protein having a Forkhead-associated domain and a Ring Finger. This protein is required for regulation of the...
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7176302 |
Liposomal phosphodiester, phosphorothioate, and p-ethoxy oligonucleotides
An improved delivery system for antisense oligonucleotides involves a liposomal composition, comprising a liposome which consists essentially of neutral phospholipids and an antisense...
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7176005 |
Modulation of sulfate permease for photosynthetic hydrogen production
Sustained hydrogen production is obtained by the culturing of a genetically-modified algae, where the ability of the chloroplasts to intake sulfate is reduced or eliminated compared to wild-type...
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7176303 |
Modulation of STAT5 expression
Compounds, compositions and methods are provided for modulating the expression of STAT5. The compositions comprise oligonucleotides, targeted to nucleic acid encoding STAT5. Methods of using these...
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7173015 |
Inhibition of Syk kinase expression
The present invention relates, in general, to Syk kinase and, in particular, to a method of inhibiting Syk kinase expression using small interfering RNA (siRNA).
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7173014 |
HIV-specific synthetic oligonucleotides and methods of their use
Disclosed are synthetic oligonucleotides having a nucleotide sequences specifically complementary to nucleotides 324 to 345 of a conserved gag region of the HIV-1 genome, the oligonucleotide...
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7173122 |
Antisense oligonucleotides to type I procollagen
The invention provides antisense DNA oligonucleotides which are effective in inhibiting the expression of a wild type COL1A1 gene.
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7160868 |
Nr-CAM gene, nucleic acids and nucleic acid products for therapeutic and diagnostic uses for tumors
The present invention relates to the identification of a novel role of Nr-CAM in cell transformation and aberrant cellular proliferation. In particular, the present invention relates to the altered...
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7150970 |
Methods of inhibiting VEGF-C
The present invention provides RNA molecules (e.g., antisense, RNAi, or siRNA) specific for VEGF-C, and further provides methods of reducing expression of VEGF-C in cells (e.g., cancer cells).
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7148014 |
Methods of inhibiting phagocytosis
The present invention relates, in general, to methods of treating diseases resulting from interactions between immune complexes and Fc receptors. In particular, the present invention relates to...
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7148202 |
Receptor-mediated gene delivery using bacteriophage vectors
Filamentous phage particles displaying a ligand on their surface are used to deliver a therapeutic gene to a cell. The ligand is a fusion protein with a phage capsid protein, covalently conjugated...
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7148342 |
Compositions and methods for sirna inhibition of angiogenesis
RNA interference using small interfering RNAs which are specific for the vascular endothelial growth factor (VEGF) gene and the VEGF receptor genes Flt-1 and Flk-1/KDR inhibit expression of these...
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7148204 |
Antisense modulation of bcl-x expression
Compositions and methods are provided for modulating the expression of bcl-x. Antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding bcl-x are preferred....
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7148205 |
Intravascular delivery of non-viral nucleic acid
Disclosed is a process for transfecting genetic material into a mammalian cell to alter endogenous properties of the cell. The process comprises designing a polynucleotide for transfection. Then...
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7148044 |
Nucleic acid enzyme for RNA cleavage
A method is described for cleaving a nucleic acid substrate with a nucleic acid enzyme at a cleavage site comprising mixing the substrate with the enzyme, wherein the substrate includes a 7...
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7144714 |
R2D2: an enzyme of RNA silencing
Methods for making siRNA comprise recombinantly coexpressing a Dicer protein with an R2D2 protein to form a complex comprising the R2D2 protein and the Dicer protein, and contacting the complex...
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7144999 |
Modulation of hypoxia-inducible factor 1 alpha expression
Compounds, compositions and methods are provided for modulating the expression of hypoxia-inducible factor 1 alpha. The compositions comprise oligonucleotides, targeted to nucleic acid encoding...
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7144869 |
Nucleic acid injected into hapatic vein lumen and delivered to primate liver
Processes are described for obtaining high levels of gene expression in primates after injection of nucleic acid to the liver via the lumen of the hepatic vein. The described process results in...
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7141665 |
Enzymatic DNA molecules
The present invention discloses deoxyribonucleic acid enzymes—catalytic or enzymatic DNA molecules—capable of cleaving nucleic acid sequences or molecules, particularly RNA, in a site-specific...
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7138383 |
Treating cancer using an oligonucleotide N3′->N5′ thiophosphoramidate
Oligonucleotides with a novel sugar-phosphate backbone containing at least one internucleoside 3′-NHP(O)(S − )O-5′ linkage, and methods of synthesizing and using the inventive...
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7138378 |
Genetic suppression and replacement
A strategy for suppressing specifically or partially specifically an endogenous gene and introducing a replacement gene, said strategy comprising the steps of:
1. providing suppressing nucleic...
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7138511 |
Nucleic acids, kits and methods for the diagnosis, prognosis and treatment of glaucoma and related disorders
In a preferred aspect of the invention, the upstream sequences of the TIGR protein encoding sequence can be used to diagnose a sensivity to steroids and a risk for glaucoma or ocular hypertensive...
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7138376 |
Methods and compositions for treating hepatitis C virus using 4'-modified nucleosides
A compound, method and composition for treating a host infected with a hepatitis C viral comprising administering an effective hepatitis C treatment amount of a described 4′-disubstituted...
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7138517 |
Sugar modified oligonucleotides
Compositions and methods are provided for the treatment and diagnosis of diseases amenable to modulation of the production of selected proteins. In accordance with preferred embodiments,...
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7138380 |
Transgenic animals and cell lines for screening drugs effective for the treatment or prevention of Alzheimer's disease
Disclosed are transgenic animals and transfected cell lines expressing a protein associated with Alzheimer's Disease, neuroectodermal tumors, malignant astrocytomas, and glioblastomas. Also...
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7138235 |
Nucleic acid molecules comprising the promoter for PCA3, and uses thereof
This invention describes the cloning and characterization of the promoter region for the PCA3 dd3 gene. This region regulates the PCA3 dd3 gene expression by a unique prostate specific...
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7138505 |
Factor VIII:C nucleic acid molecules
Methods and compositions are provided for recombinant DNA production of Factor VIIIC and truncated derivatives thereof. Based on amino acid sequences, probes are developed for isolating messenger...
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7132529 |
Antisense modulation of stearoyl-CoA desaturase expression
Antisense compounds, compositions and methods are provided for modulating the expression of stearoyl-CoA desaturase. The compositions comprise antisense compounds, particularly antisense...
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7132530 |
Antisense modulation of superoxide dismutase 1, soluble expression
Antisense compounds, compositions and methods are provided for modulating the expression of superoxide dismutase 1, soluble. The compositions comprise antisense compounds, particularly antisense...
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7129223 |
Inhibition of SARS-associated coronavirus (SCoV) infection and replication by RNA interference
The present invention relates to therapeutic agents useful for the treatment of Severe Acute Respiratory Syndrome (SARS) in humans. In particular, the present invention relates to RNA interference...
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7122527 |
Use of antisense oligonucleotides to inhibit the expression of human Akt-1
New antisense oligonucleotide compounds inhibit expression of Akt-1 and also induce cytotoxicity in several cancer cell lines.
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7119184 |
Oligonucleotides having A-DNA form and B-DNA form conformational geometry
Modified oligonucleotides containing both A-form conformation geometry and B-from conformation geometry nucleotides are disclosed. The B-form geometry allows the oligonucleotide to serve as...
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7115580 |
Antisense modulation of B7 protein expression
Compositions and methods for the diagnosis, prevention and treatment of immune states and disorders amenable to treatment through modulation of T cell activation are provided. In accordance with...
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7115579 |
Modulation of oligonucleotide CpG-mediated immune stimulation by positional modification of nucleosides
The invention provides methods for modulating the immune response caused by CpG dinucleotide-containing compounds. The methods according to the invention enables both decreasing the...
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7115583 |
Microbubble compositions and methods for oligonucleotide delivery
The invention relates to a new and improved pharmaceutical composition and method for delivery of therapeutic agents. The methods and composition of the invention can be used with several...
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7112420 |
Lymphoma associated molecules and uses therefor
The invention provides isolated nucleic acids molecules, designated BBAP nucleic acid molecules, which encode proteins that interact with or bind to BAL molecules, which are differentially...
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7112718 |
Transgenic plants synthesizing high amylose starch
Transgenic plant cells and plants are described which synthesize a starch which is modified in comparison with corresponding wild type plant cells and plants. The plant cells and plants described...
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7105495 |
Modulation of oligonucleotide CpG-mediated immune stimulation by positional modification of nucleosides
The invention provides methods for modulating the immune response caused by CpG dinucleotide-containing compounds. The methods according to the invention enables both decreasing the...
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7105657 |
Compositions and methods for inhibiting pancreatic cancer metastasis
Methods are provided for the inhibition of metastasis of cancer cells expressing MUC4, metastatic pancreatic cancer cells.
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7101995 |
Compositions and processes using siRNA, amphipathic compounds and polycations
Described is a deliverable composition with low toxicity comprising an amphipathic compound, a polycation, and a siRNA. The composition may be used in the process of delivering a siRNA to an animal...
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7101712 |
Plant protein with repeated WD40 motifs, nucleic acid coding for said protein, and uses thereof
Isolated or purified nucleic acids, such as SEQ ID NO: 1, encoding a plant protein with repeated WD-40 motifs or fragments of such a protein that regulate plant differentiation or endoreplication....
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