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6500615 |
Identifying antisense oligonucleotide binding
A method for identifying an antisense oligonucleotide capable of binding to a target mRNA, which comprises contacting the target mRNA with each member of an oligonucleotide library separately under...
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6501007 |
Method of dwarfing plants
A method of dwarfing plants comprises controlling the expression of the genes involved in the dwarfism of the plants is provided. A molecule to be utilized for dwarfing plants is also provided. A...
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6498035 |
Antisense modulation of MEKK3 expression
Antisense compounds, compositions and methods are provided for modulating the expression of MEKK3. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted...
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6498147 |
Suppression of nuclear factor-&kgr b dependent processes using oligonucleotides
Antisense oligonucleotides which hybridize with nuclear factor- κ B(NF- κ B) mRNA and methods of using these oligonucleotides.
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6498033 |
Lentiviral vectors
The present invention provides a conditionally replicating viral vector, methods of making, modifying, propagating and selectively packaging, and using such a vector, isolated molecules of...
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6495318 |
Method and kits for preparing multicomponent nucleic acid constructs
The invention provides a highly efficient, rapid, and cost effective method of linking nucleic acid components in a predetermined order to produce a nucleic acid multicomponent construct. The...
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6495672 |
Oligonucleotides including 2-aminopyridine and 2-pyridone C-nucleoside units
The present invention provides 2-aminopyridine and 2-pyridone C-nucleosides and oligonucleotides containing the subject nucleosides. The nucleosides are useful in the preparation of the subject...
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6495675 |
Pharmaceutical composition for treating or preventing influenza, and novel capped oligonucleotide
A pharmaceutical composition comprising a capped oligonucleotide capable of binding to a PB2 protein of an influenza virus RNA polymerase, and a pharmaceutically acceptable carrier or dilute, said...
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6492173 |
Antisense inhibition of cyclin D2 expression
Antisense compounds, compositions and methods are provided for modulating the expression of Cyclin D2. The compositions comprise antisense compounds, particularly antisense oligonucleotides,...
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6492512 |
Method and reagent for treatment of lung cancer and other malignancies caused by the deregulation of L-MYC gene expression
An enzymatic RNA molecule which cleaves mRNA associated with development or maintenance of lung cancer.
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6492172 |
Antisense modulation of GU protein expression
Antisense compounds, compositions and methods are provided for modulating the expression of GU Protein. The compositions comprise antisense compounds, particularly antisense oligonucleotides,...
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6492170 |
Antisense modulation of caspase 9 expression
Antisense compounds, compositions and methods are provided for modulating the expression of caspase 9. The compositions comprise antisense compounds, particularly antisense oligonucleotides,...
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6492171 |
Antisense modulation of TERT expression
Antisense compounds, compositions and methods are provided for modulating the expression of TERT. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to...
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6489307 |
Antisense compositions targeted to β1-adrenoceptor-specific mRNA and methods of use
Disclosed are antisense oligonucleotide, polynucleotide, and peptide nucleic acid compounds that specifically bind to mammalian mRNA encoding a β 1 -adrenoceptor polypeptide and that are useful in...
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6489464 |
Branched oligonucleotides as pathogen-inhibitory agents
Novel antisense oligonucleotides are disclosed. The present oligonucleotides have increased resistance to nuclease attack and manifest increased efficacy in combating pathogenic infections. The...
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6489538 |
Method for regulation of plant lignin composition
A method is disclosed for the regulation of lignin composition in plant tissue. Plants are transformed with a gene encoding an active F5H gene. The expression of the F5H gene results in increased...
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6485974 |
Antisense modulation of PTPN2 expression
Antisense compounds, compositions and methods are provided for modulating the expression of PTPN2. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted...
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6485936 |
Heat shock transcription factor-binding protein
To provide a heat shock transcription factor (HSF) 2 binding factor, which can be involved in the transcriptional regulation of HSP70.2 playing an essential role in spermatogenesis; a DNA encoding...
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6485973 |
Oligonucleotides specific for the marORAB operon
Disclosed are synthetic oligonucleotides complementary to a transcript of the marORAB operon which inhibit expression of a gene in the operon. Also disclosed are methods of reducing bacterial...
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6483009 |
Antisense intron inhibition of starch branching enzyme expression
A method for affecting enzymatic activity in a starch producing organism is described. The method comprises expressing in the organism: (a) a first nucleotide which comprises, partially or...
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6482644 |
Antisense modulation of dual specific phosphatase 8 expression
Antisense compounds, compositions and methods are provided for modulating the expression of Dual specific phosphatase 8. The compositions comprise antisense compounds, particularly antisense...
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6482803 |
Modification of mutated P53 gene in tumors by retroviral delivery of ribozyme A
The present invention discloses expression constructs and methods for employing them that result in the modulation of abnormal oncogene and tumor suppressor genes in a novel approach to cancer...
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6479465 |
Methods of treating colitis using STAT-4 anti-sense oligonucleotides
The present invention provides a method of treating or preventing the inflammatory response of an inflammatory bowel disease in a subject, comprising administering to the subject an amount of a...
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6479732 |
cDNA of 4-coumarate: coenzyme a ligase and process for modifying lignin in plants
The object of the present invention is to provide a transformed plant that produces woody raw materials having improved pulp cooking property and that has a growth characteristics equal to that of...
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6475795 |
Use of hyaluronan in gene therapy
A method of treating a human suffering a disease or condition caused by a gene, cDNA or RNA-DNA oligonucleotide or RNA-DNA oligonucleotide hybrids or messenger RNA implicated in a disease or...
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6475998 |
Methods and compositions for the treatment of injury to the central nervous system
The invention provides methods and pharmaceutical compositions thereof for treating injury to the central nervous system (CNS). The method includes administering to the CNS of a patient suffering...
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6475797 |
Antisense modulation of SR-CYP expression
Antisense compounds, compositions and methods are provided for modulating the expression of SR-cyp. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted...
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6472521 |
Oligonucleotides for the inhibition of human eg5 expression
The present invention relates to an oligonucleotide or a derivative thereof which has a sequence that corresponds to a particular fragment of a nucleic acid sequence which encodes human eg5 or a...
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6471968 |
Multifunctional nanodevice platform
The present invention relates to novel therapeutic and diagnostic arrays. More particularly, the present invention is directed to dendrimer based multifunctional compositions and systems for use in...
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6468983 |
RNase L activators and antisense oligonucleotides effective to treat telomerase-expressing malignancies
The present invention relates to chimeric molecules comprising an oligonucleotide complementary to a region of the ribonucleotide component of telomerase attached to an activator of RNase L...
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6468795 |
Antisense modulation of Apaf-1 expression
Antisense compounds, compositions and methods are provided for modulating the expression of Apaf-1. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted...
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6468796 |
Antisense modulation of bifunctional apoptosis regulator expression
Antisense compounds, compositions and methods are provided for modulating the expression of bifunctional apoptosis regulator. The compositions comprise antisense compounds, particularly antisense...
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6465187 |
Method of treatment
A method of treatment of mast cell mediated inflammatory disorders in mammals comprising regulating the longevity and activity of activated mast cells by inhibiting the expression and/or function...
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6465219 |
Polynucleotide pools enriched in either high-abundance or low-abundance sequences
This invention provides novel methods for producing a plurality of polynucleotides prepared from a polynucleotide sample and the plurality of polynucleotides so produced. The plurality of...
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6465439 |
Pharmaceutical compositions
A pharmaceutical composition is disclosed comprising (A) and oligonucleotide having 5 to 50 nucleotide units, which is specifically hybridizable with DNA or RNA derived from a protein kinase C...
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6462179 |
Phenyldiboronic acid reagents and complexes
Reagents suitable for the modification of a bioactive species for the purpose of incorporating one or more phenyldiboronic acid (PDBA) moieties for subsequent conjugation to a different (or the...
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6461815 |
Antibacterial agents and methods of screening for the same
Methods of inhibiting microbial propagation, and screening for compounds that inhibit microbial propagation, are described. A method of inhibiting microbial propagation comprises inhibiting...
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6458567 |
Hepatitis C Virus ribozymes
This invention provides ribozymes useful to treat or prevent Hepatitis C Virus (“HCV”) infection or disease in an organism or subject, as well as methods of treating an HCV infection or...
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6458590 |
Methods and compositions for treatment of restenosis
The present invention provides sequences capable of inhibiting osteopontin (OPN) expression. In particular, the sequences provided herein are antisense osteopontin oligonucleotide sequences. The...
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6458591 |
Antisense modulation of phosphorylase kinase Alpha 2 expression
Antisense compounds, compositions and methods are provided for modulating the expression of Phosphorylase kinase alpha 2. The compositions comprise antisense compounds, particularly antisense...
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6455307 |
Antisense modulation of casein kinase 2-alpha prime expression
Antisense compounds, compositions and methods are provided for modulating the expression of Casein kinase 2-alpha prime. The compositions comprise antisense compounds, particularly antisense...
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6455689 |
Antisense-oligonucleotides for transforming growth factor-β (TGF-β)
Antisense-oligonucleotides or effective derivatives thereof hybridizing with an area of a gene coding for transforming growth factor-β (TGF-β) comprising the following nucleic acid sequences...
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6455495 |
Methods and compositions for delivery of therapeutic agents to bone tissue employing conjugates of negatively charged peptide oligomers with therapeutic agents
The invention provides conjugates of negatively charged peptide oligomers with therapeutic agents, moieties capable of recruiting endogenous bone-affecting agents, or imaging agents, useful for...
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6455308 |
Antisense modulation of serum amyloid A4 expression
Antisense compounds, compositions and methods are provided for modulating the expression of serum amyloid A4. The compositions comprise antisense compounds, particularly antisense oligonucleotides,...
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6451991 |
Sugar-modified gapped oligonucleotides
Oligonucleotides are provided which have increased nuclease resistance, substituent groups for increasing binding affinity to complementary nucleic acid strand, and subsequences of...
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6451602 |
Antisense modulation of PARP expression
Antisense compounds, compositions and methods are provided for modulating the expression of human PARP. The compositions comprise antisense compounds, particularly antisense oligonucleotides,...
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6451538 |
Antisense modulation of CHK2 expression
Antisense compounds, compositions and methods are provided for modulating the expression of CHK2. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to...
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6451603 |
Ribozyme nucleic acids and methods of use thereof for controlling viral pathogens
The invention consists of a non-naturally occurring nucleic acid molecule capable of blocking or interfering with a replicative intermediate of a virus, a virusoid, or a viroid. The nucleic acid...
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6451992 |
Antithrobin nucleotides and proteins from horn fly
Compositions and methods for preventing hematophagous infestation of cattle are provided, directed at isolated proteins with antithrombin activity and nucleotide sequences encoding the proteins....
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6451540 |
2′-O-alkylthioalkyl and 2′-C-alkythioalkyl containing nucleic acids
A compound having the formula: wherein, R1 represents 2′-O-alkylthioalkyl or 2′-C-alkylthioalkyl; X represents a base or H; Y represents a phosphorus-containing group; and R2 represents H,...
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