Matches 1 - 46 out of 46
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7402574 Antisense composition and method for treating cancer  
A method and composition for treating colorectal cancer is disclosed. The method involves administering to a subject, a therapeutically effective amount of a morpholino antisense compound (i)...
7399853 Modulation of glucagon receptor expression  
Compounds, compositions and methods are provided for modulating the expression of glucagon receptor. The compositions comprise oligonucleotides, targeted to nucleic acid encoding glucagon receptor....
7399586 Modulation of biological signal transduction by RNA interference  
Compositions and methods relating to small interfering RNA (siRNA) polynucleotides are provided as pertains to modulation of biological signal transduction. Shown are siRNA polynucleotides that...
7396922 Regulation of hypoxia-inducible gene expression with antisense Inhibitory PAS domain protein  
A pharmaceutical composition comprises the sequence of SEQ ID NO:s 3-5 or pharmaceutically equivalent sequences. Methods employing the pharmaceutical compositions include treatments to increase...
7393951 Antisense oligonucleotide having anticancerous activity  
An antisense oligonucleotide having anti-carcinogenicity, for example, an inhibitory action on growth of cancer cells and a therapeutic or prophylactic action on cancer and the like, as well as an...
7393950 Antisense oligonucleotides targeted to human CDC45  
Antisense oligonucleotides that inhibit expression of human replication-initiation protein as well as methods of preventing or treating hyperproliferative conditions using said oligonucleotides are...
7393949 Human immunodeficiency virus (HIV) nucleotide sequences  
Polynucleotide sequences are provided for the diagnosis of the presence of retroviral infection in a human host associated with lymphadenopathy syndrome and/or acquired immune deficiency syndrome,...
7390792 MicroRNA1 therapies  
Delta protein expression in a cell is reduced by introducing miR-1 into the cell, and detecting a resultant reduction of Delta protein expression in the cell.
7381819 Composition for treatment or prevention of endometrial cancer and method of preventing or treating endometrial cancer using the composition  
Provided are a composition for the treatment or prevention of an endometrial cancer including a nuclear acid molecule inducing RNA interference against human syndecan-1 gene expression and a...
7381708 Suppression of eIF5A1 expression by the use of antisense oligonucleotides for the prevention of retinal cell death in the glaucomatous eye  
The present invention provides methods for preventing retinal ganglion cell death in the glaucomatous eye and methods for suppressing apoptosis-specific eIF5A1 expression through the use of...
7378275 Canine IL-13 receptor alpha-1 subunit nucleic acid molecules  
The invention relates to canine immunoglobulin G (IgG) and canine interleukin-13 receptors (IL-13R) as well as fusion proteins containing canine IgG and/or canine IL-13R. In particular, the present...
7378243 Nucleic acid cloning  
The present invention provides an improved system for linking nucleic acids to one another. In particular, the present invention provides techniques for producing DNA product molecules that may be...
7375212 Modulation of Aurora B expression  
Compounds, compositions and methods are provided for modulating the expression of Aurora B. The compositions comprise oligonucleotides, targeted to nucleic acid encoding Aurora B. Methods of using...
7371850 Method and composition for reducing expression of ROCK-II  
Methods and pharmaceutical compositions for treating, and delaying the onset of, viral infection, are provided.
7371735 Inhibitor oligonucleotides and their use for specific repression of a gene  
A method of treating a disease resulting from the expression of a harmful gene is described. The method includes the step of administering a therapeutically effective amount of a pharmaceutical...
7368561 Isolation of antisense oligonucleotides  
The present invention relates to a method of isolating fully thioated single stranded antisense oligonucleotides from a biological solution, which method comprises the steps of contacting the...
7368559 FcγRIIA-specific nucleic acid interference  
The present invention provides methods and compositions for attenuating expression of FcγRIIA. In general, the described methodology involves the use of RNAi constructs that are targeted to a...
7368436 TRPM-2 antisense therapy  
It has been determined that antisense therapy which reduces the expression of TRPM- 2 provides therapeutic benefits in the treatment of cancer, particularly prostate and renal cell cancers....
7365058 MicroRNA and methods for inhibiting same  
The invention relates to isolated DNA or RNA molecules comprising at least ten contiguous bases having a sequence in a pancreatic islet microRNA. In another embodiment, the invention relates to...
7361752 RNAi modulation of MLL-AF4 and uses thereof  
The invention relates to compositions and methods for modulating the expression of the MLL-AF4 fusion gene, and more particularly to the downregulation of MLL-AF4 by chemically modified...
7358418 Isoforms of eIF-5A: senescence-induced eLF5A; wounding-induced eIF-4A; growth eIF-5A; and DHS  
The present invention relates to unique isoforms of eukaryotic initiation Factor 5A (“eIF-5A”): senescence-induced eIF-5A; wounding-induced eIF-5A; and growth eIF-5A, as well as polynucleotides...
7358223 Biodegradable cationic polymers  
Polymers comprising a polyethylenimine, a biodegradable group, and a relatively hydrophobic group are useful for the delivery of bioactive agents to cells.
7355056 Transfection agents  
The present invention provides compounds, compositions and methods that enhance the transfer of an agent into a cell. The agents can include polypeptides, polynucleotides such as genes and...
7355035 Catalytic molecules  
The present invention relates to DNAzymes which are targeted against mRNA molecules encoding EGR-1 (also known as Egr-1 and NGFI-A). The present invention also relates to compositions including...
7351535 Compositions and methods for increasing cholesterol efflux and raising HDL using ATP binding cassette transporter protein ABC1  
The present invention relates to novel ABC1 polypeptides and nucleic acid molecules encoding the same. The invention also relates to recombinant vectors, host cells, and compositions comprising...
7351532 DNA sequence analysis  
There is disclosed a method for determining the identity of one or more mutations or single nucleotide polymorphisms (SNPs) in a genome, comprising: a contacting a sample genome, under conditions...
7349808 System and method for tracking and controlling infections  
The present invention is a system and method for performing real-time infection control over a computer network. The method comprises obtaining a sample of a microorganism at a health care...
7348314 Compositions and methods for inhibiting viral replication  
The present invention relates to a double-stranded ribonucleic acid (dsRNA) having a nucleotide sequence which is less that 30 nucleotides in length and which is substantially identical to at least...
7345027 Compositions and methods for siRNA inhibition of angiogenesis  
RNA interference using small interfering RNAs which are specific for the vascular endothelial growth factor (VEGF) gene and the VEGF receptor genes Flt-1 and Flk-1/KDR inhibit expression of these...
7345025 Methods for genetic modification of hematopoietic progenitor cells and uses of the modified cells  
Described are compositions and methods relating to gene therapy, particularly as applied to hematopoietic progenitor (HP) cells, to transduced cells and methods of obtaining them, and to methods of...
7342111 Adeno-associated virus-delivered ribozyme compositions and methods of use  
Provided are methods for the identification of novel genes involved in a variety of cellular processes, including retinal degeneration, retinal disease, cancer, memory and learning, amylotropic...
7339051 Compositions and methods for the treatment of severe acute respiratory syndrome (SARS)  
The present invention provides design and synthesis of oligomeric compounds and compositions that can be administered to reduce the activity of SARS virus in vivo or in vitro, to prevent or treat...
7335764 Antisense modulation of acyl CoA cholesterol acyltransferase-2 expression  
Antisense compounds, compositions and methods are provided for modulating the expression of acyl CoA cholesterol acyltransferase-2. The compositions comprise antisense compounds, particularly...
7335763 Herpesvirus ribozymes and vectors  
Hammerhead ribozymes that target components critical to HSV replication (ICP4, UL20, UL30, and UL54) were synthesized and shown to efficiently cleave target RNA encoding a portion of these...
7335750 Hybrid compositions for intracellular targeting  
Hybrid compounds comprising a first domain and a second domain are provided. The first domain and the second domain are preferably covalently linked, and the first domain comprises a domain which...
7332335 Decreasing cell proliferation by decreasing levels of PP5  
The invention provides a method of increasing expression of p21 WAF1/Cip 1 in cells to decrease proliferation of the cells, the method comprising decreasing levels of PP5 protein in the cells. The...
7329741 Polynucleotides that hybridize to DP-75 and their use  
The present invention is a novel nucleic acid sequence which hybridizes to SEQ ID NO:6 or fragments thereof under stringent conditions, or fragments thereof. The invention also includes diagnostic...
7329649 Combinatorial methods for inducing cancer cell death  
The present invention relates to methods and compositions for inhibiting proliferation and inducing cell death in a population of cancer cells by (i) increasing the amount of the differentiation...
7326783 Pharmaceutical composition comprising antisense-nucleic acid for prevention and/or treatment of neuronal injury, degeneration and cell death and for the treatment of neoplasms  
A pharmaceutical composition comprising an effective amount of a compound which is capable from preventing and treating neuronal injury, degeneration, cell death and/or neoplasms in which...
7323560 Plastidic phosphoglucomutase genes  
An isolated nucleic acid fragment encoding a plastidic phosphoglucomutase protein is disclosed. Also disclosed is the construction of a chimeric gene encoding all or a substantial portion of the...
7323319 RNA containing coenzymes, biotin, or fluorophores, and methods for their preparation and use  
Materials and methods for incorporating adenosine derivatives into the 5′ end of transcribed RNA are disclosed. Adenosine derivatives include naturally occurring compounds such as Coenzyme A,...
7320965 Compositions and methods for inhibiting expression of Huntingtin gene  
The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of the Huntingtin gene (HD gene), comprising an antisense strand having a nucleotide sequence which...
7319145 Methylenetetrahydrofolate reductase inhibitors and use thereof  
The present invention provides methylenetetrahydrofolate reductase (MTHFR) inhibitors for use in selective inhibition of cancer cell growth in a mammal. These inhibitors can be a small molecule, an...
7314927 Regulation of bcl-2 gene expression  
The present invention provides novel anticode oligomers and methods of using them for controlling the growth of cancer cells expressing the bcl-2 gene.
6008200 ***WITHDRAWN PATENT AS PER THE LATEST USPTO WITHDRAWN LIST***
Immunomodulatory oligonucleotides  
Oligonucleotides containing unthylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response in a subject are disclosed. Also disclosed are therapies...
5998385 ***WITHDRAWN PATENT AS PER THE LATEST USPTO WITHDRAWN LIST***
Antisense oligonucleotide modulation of raf gene expression  
Oligonucleotides are provided which are targeted to nucleic acids encoding human c-raf and capable of inhibiting raf expression. The oligonucleotides contain a methoxyethoxy (2'-O--CH 2 CH 2 OCH...
Matches 1 - 46 out of 46