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9034837 |
Pharmaceutical compositions for treatment of HCV patients that are poor-responders to interferon
The present invention provides compositions and methods of treatment of HCV infected subjects that are not sensitive to interferon treatment. Further, compositions and methods are provided for... |
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9034581 |
Compositions and methods for detection of Staphylococcus aureus
The present invention relates to methods for the rapid detection of the presence or absence of Staphylococcus aureus in a biological or nonbiological sample. The present invention includes methods... |
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9029103 |
Methods for sequencing polynucleotides
Provided herein is a method for sequencing a polynucleotide molecules. The method includes the steps of providing a plurality of polynucleotide molecules attached to a surface, wherein a first... |
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9029083 |
Vitro evolution in microfluidic systems
The invention describes a method for isolating one or more genetic elements encoding a gene product having a desired activity, comprising the steps of: (a) compartmentalising genetic elements into... |
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9029084 |
Polynucleotide primers
A polynucleotide primer comprising at least the final six nucleotides of one of the following primer sequences, or a sequence complementary thereto: SEQ. ID NOS. 1 to 18, 21 to 45 or 74 to 77. |
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9023601 |
Microarray synthesis and assembly of gene-length polynucleotides
There is disclosed a process for in vitro synthesis and assembly of long, gene-length polynucleotides based upon assembly of multiple shorter oligonucleotides synthesized in situ on a microarray... |
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9024006 |
Mutation detection assay
A method of sample analysis is provided. In certain embodiments, the method involves: a) amplifying a product from a sample that comprises both wild type copies of a genomic locus and mutant... |
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9017938 |
Use of microrna-199b-5p in medical and diagnostic field
This invention concerns the use of MicroRNA-199b-5p in medical and diagnostic fields. Particularly, this invention concerns the use of the miR199b-5p in the anti-cancer therapy and as a... |
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9017947 |
Soybean event MON89788 and methods for detection thereof
The present invention provides for soybean plant and seed comprising transformation event MON89788 and DNA molecules unique to these events. The invention also provides methods for detecting the... |
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9017971 |
Means and methods for investigating nucleic acid sequences
The invention provides improved methods for investigating nucleic acid sequences, wherein at least one additional probe is used which is specific for a (pseudo)gene variant of a target nucleic acid. |
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9000142 |
Photocleavable sense-antisense complex
There is disclosed a photocleavable sense-antisense nucleobase polymer complex capable of modulating gene expression comprising an unnatural antisense nucleobase polymer that targets an mRNA, and... |
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8999634 |
Nucleic acid detection combining amplification with fragmentation
Provided herein are methods and compositions for detection of a nucleic acid target in a sample. The methods and compositions use primer directed amplification in conjunction with nucleic acid... |
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9000144 |
Identification of novel genes coding for small temporal RNAs
In Caenorhabditis elegans, lin-4 and let-7 encode 22- and 21-nucleotide RNAs, respectively, that function as key regulators of developmental timing. Because the appearance of these short RNAs is... |
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8993238 |
Brassica GAT event and compositions and methods for the identification and/or detection thereof
Compositions and methods related to transgenic glyphosate tolerant Brassica plants are provided. Specifically, the present invention provides Brassica plants having a DP-073496-4 event which... |
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8993271 |
Method of nucleic acid amplification
A nucleic acid molecule can be annealed to an appropriate immobilized primer. The primer can then be extended and the molecule and the primer can be separated from one another. The extended primer... |
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8987222 |
Single nucleotide polymorphism (SNP) targeting therapies for the treatment of huntington'S disease
The present invention relates to the discovery of (SNPs) significantly associated with Huntington's disease (HD). The present invention utilizes RNA silencing technology (e.g. RNAi) against such... |
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8986933 |
Selective detection of human rhinovirus
A process for detecting human rhinovirus nucleic acid in a biological sample, includes producing an amplification product by amplifying an human bocavirus nucleotide sequence using a forward... |
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8987435 |
Oligomeric compounds and methods
The present invention provides oligomeric compounds and uses thereof. In certain embodiments, such oligomeric compounds are useful as antisense compounds. Certain such antisense compounds are... |
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8980556 |
High resolution melting analysis as a prescreening tool
Compositions and methods for determining an increased likelihood of a response to a targeted treatment of a cancer disease including isolating genomic DNA from a patient sample, amplifying a... |
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8980584 |
System and methods for nucleic acid sequencing of single molecules by polymerase synthesis
This invention relates to improved methods for sequencing and genotyping nucleic acid in a single molecule configuration. The method involves single molecule detection of fluorescent labeled PPi... |
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8980562 |
Method of simultaneous detection and typing of human papilloma viruses
The invention relates to a method of detecting HPV and determining HPV type. |
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8980545 |
Divergent picornavirus: cosavirus
Presented herein is the discovery of a new human picornavirus, Cosavirus (previously termed Dekavirus), methods of detecting the Cosavirus and diagnosing Cosavirus infection, methods of treating... |
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8975237 |
Treatment of fibrotic conditions
Treatment of fibrosis and fibrotic diseases, disorders, and conditions, and associated methods, compositions, formulations and articles. |
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8975024 |
Methods for sequencing polynucleotides
The invention relates to methods and systems for sequencing and constructing a high resolution physical map of a polynucleotide. In accordance with the invention, nucleotide sequences are... |
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8969047 |
Solid support assay systems and methods utilizing non-standard bases
Solid support assays using non-standard bases are described. A capture oligonucleotide comprising a molecular recognition sequence is attached to a solid support and hybridized with a target. In... |
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8969006 |
***WITHDRAWN PATENT AS PER THE LATEST USPTO WITHDRAWN LIST***
Soybean event MON89788 and methods for detection thereof
The present invention provides for soybean plant and seed comprising transformation event MON89788 and DNA molecules unique to these events. The invention also provides methods for detecting the... |
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8962278 |
Compositions and methods for production of immunoglobulins
Provided are oligonucleotides for isolating human antibody cDNAs from cells or cell lines, such as hybridomas. The invention also provides cDNAs that encode at least one provided CDR of a heavy... |
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8962238 |
Nucleic acid enzymes and complexes and methods for their use
The present invention relates to methods that utilize multi-component nucleic acid complex (MNA complex) cascades. The MNA complexes may have cleavage or ligase activity. Further, the invention... |
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8956818 |
Proteoglycan splice variants as therapeutics and diagnostics for amyloid diseases
The identification of novel Syndecan-2 splice variants and their use in the diagnosis and therapeutic intervention of Alzheimer's disease and other amyloid diseases. In addition the use of new... |
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8945850 |
Detection, identification and differentiation of Staphylococcus using a hybridization assay
The present invention relates to a method for the specific detection and/or identification of Staphylococcus species, in particular Staphylococcus aureus, using new nucleic acid sequences derived... |
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8945833 |
Method for determining drug resistance mutations in any of the non-structural protein regions NS3 to NS5B of hepatitis C virus (HCV) for genotypes 1 to 6
The present invention relates to a method for determining drug resistance mutations in any of the non-structural protein regions NS3 to NS5B of Hepatitis C Virus (HCV) for genotypes 1 to 6, more... |
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8940486 |
Oligonucleotides and methods for detecting KRAS and PIK3CA mutations
Provided are oligonucleotides that are capable of detecting KRAS and PIK3CA mutations in both cancer patients and healthy individuals with high specificity in kPCR assays. When the... |
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8936906 |
Potentiator of activity of anti-cancer agent and use thereof, and biomarker for prediction of prognosis in cancer patient and use thereof
Disclosed is a means for improving the clinical outcomes of cancer therapy. Specifically disclosed is an activity potentiator comprising a compound capable of inhibiting the expression of RFP (RET... |
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8936912 |
Method for multiplexed nucleic acid patch polymerase chain reaction
The invention encompasses a method for amplifying at least two different nucleic acid sequences. In particular, the method encompasses a multiplexed nucleic acid patch polymerase chain reaction. |
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8936920 |
Primers for detecting plasmodium
The present invention provides an easy and rapid method for detecting/identifying the presence or absence of specific Plasmodium parasites and four species of malaria parasites in a human... |
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8937171 |
Nucleic-acid-responsive gel, method for producing same, and use of same
The present invention provides a nucleic-acid-responsive gel which allows (i) a larger volumetric change through structural design, (ii) adjustment of its recognition ability to recognize a... |
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8932832 |
Methods and compositions related thereto for detecting and identifying distinct species of nucleic acids from causative agents
Methods are described herein for detecting and identifying distinct species of nucleic acids, in a single container, for example, from a certain genus of infectious agents or otherwise causative... |
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8927703 |
Compositions, kits and related methods for the detection and/or monitoring of Pseudomonas aeruginosa
The present invention provides compositions, methods and kits for the species-specific detection of Pseudomonas aeruginosa. |
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8927217 |
Detection of hepatotoxic cyanobacteria
The present invention relates to methods and kits for the detection of toxic cyanobacteria, in particular of hepatotoxin-producing cyanobacteria. |
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8927701 |
HPIV-2 variants and their medical applications
A variant phylogenetic group of HPIV-2, more particularly a novel variant phylogenetic sub-group of HPIV-2, and a means for diagnosing HPIV-2 which take into account this novel group and this... |
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8921334 |
Treatment of nuclear respiratory factor 1 (NRF1) related diseases by inhibition of natural antisense transcript to NRF1
The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of Nuclear Respiratory Factor 1 (NRF1), in particular, by targeting natural antisense... |
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8921046 |
Nucleic acid sequence analysis
Provided are methods for sequencing a nucleic acid with a sequencing enzyme, e.g., a polymerase or exonuclease. The sequencing enzyme can optionally be exchanged with a second sequencing enzyme,... |
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8916362 |
Devices comprising a polynucleotide to extend single stranded target molecules
A polynucleotide device is provided that adds one or more bases to a single stranded polynucleotide. Methods of using the device are provided, comprising contacting a single stranded target... |
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8912154 |
Antisense compositions and methods of making and using same
The present invention provides pharmaceutical formulations for oral administration of antisense oligonucleotides, such as antisense oligonucleotides against SMAD7. The pharmaceutical formulations... |
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8911947 |
DNA fragment used as attached to 5′ end of primer used in nucleic acid amplification reaction and use of DNA fragment
A method is provided which enables quick, convenient, inexpensive, and high sensitivity confirmation of nucleic acid amplification after a nucleic acid amplification reaction. The DNA fragment in... |
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8906614 |
Labeled reactants and their uses
Labeled reactant compositions, and particularly labeled nucleic acid reaction compositions, that include structural components that maintain potentially damaging labeling components sufficiently... |
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8906876 |
Methods for controlling pests using RNAi
The present invention concerns methods for controlling insect infestation via RNAi-mediated gene silencing, whereby the intact insect cell(s) are contacted with a double-stranded RNA from outside... |
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8901287 |
Detection of nucleic acids by target-specific hybrid capture method
Target-specific hybrid capture (TSHC) provides a nucleic acid detection method that is not only rapid and sensitive, but is also highly specific and capable of discriminating highly homologous... |
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8901285 |
Polynucleotide primers
A polynucleotide comprising at least the final six nucleotides of one of the following primer sequences, or a sequence complementary thereto: SEQ. ID NOS. 3 to 16, 18, 20 to 33, 35 or 37 to 39. A... |
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8900627 |
Compositions for the in vivo delivery of RNAi agents
This application describes emulsion formulations containing neutral phospholipids for delivering RNAi, anti-miRNA, or aptamer agents in vivo. The application also relates to methods of making the... |