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8182996 |
Compositions and methods for detecting Klebsiella pneumoniae
Four highly conserved genes, encoding translation elongation factor Tu, translation elongation factor G, the catalytic subunit of proton-translocating ATPase and the RecA recombinase, are used to...
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8182993 |
Methods and processes for calling bases in sequence by incorporation methods
Computer implemented methods, and systems performing such methods for processing signal data from analytical operations and systems, and particularly in processing signal data from...
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8182992 |
Compositions for use in identification of adventitious viruses
The present invention provides compositions, kits and methods for rapid identification and quantification of adventitious contaminant viruses by molecular mass and base composition analysis.
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8183360 |
Population scale HLA-typing and uses thereof
The present invention provides a portable system for real-time population-scale HLA genotyping and/or allelotyping in a field environment and methods of such population-scale HLA genotyping. The...
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8183363 |
Antisense oligonucleotide modulation of STAT3 expression
Compounds, compositions and methods are provided for inhibiting the expression of human STAT3. The compositions comprise antisense oligonucleotides targeted to nucleic acids encoding STAT3. Methods...
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8183221 |
Suppression of SCN9A gene expression and/or function for the treatment of pain
Disclosed herein are methods, sequences and nucleic acid molecules used to treat pain. Specifically, the methods and sequences include locally administering molecules that suppress the expression...
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8183222 |
Method to inhibit cell growth using oligonucleotides
Described are methods for treating hyperproliferative disorders, including cancers, by administering to the affected mammal (e.g., human) an effective amount of a composition comprising one or more...
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8178505 |
Method of predicting and reducing risk of metastasis of breast cancer to lung
A signature for breast cancer tissue derived from a patient is established that is indicative of the virulence and risk of lung metastasis by determining the expression levels to define a sample...
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8168773 |
Methods for monitoring multiple gene expression
The present invention relates to methods for monitoring differential expression of a plurality of genes in a first Bacillus cell relative to expression of the same genes in one or more second...
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8168409 |
Compositions and methods relating to anti-IGF-1 receptor antibodies
The present invention provides compositions and methods relating to or derived from anti-IGF-1R antibodies. In particular embodiments, the invention provides fully human, humanized, or chimeric...
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8168410 |
Anti-IGF-IR antibodies and uses thereof
The present invention relates to novel antibodies capable of binding specifically to the human insulin-like growth factor I receptor IGF-IR and/or capable of specifically inhibiting the tyrosine...
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8163524 |
Comparative analysis of extracellular RNA species
The invention provides methods for detecting tumor-associated RNA in plasma, serum, and other bodily fluids. In particular, the invention provides methods for detecting translocated gene RNA,...
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8163895 |
Compositions for use in identification of orthopoxviruses
Oligonucleotide primers and compositions and kits containing the same for rapid identification of orthopoxviruses by amplification of a segment of viral nucleic acid followed by molecular mass...
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8163711 |
Compositions and methods for inhibiting expression of the HAMP gene
The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of the HAMP gene (HAMP gene), comprising an antisense strand having a nucleotide sequence which is...
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8158352 |
Screening of a novel hepatic syndrome and its uses
The invention concerns methods of screening for a hepatic syndrome occurring in the young adult and associating cholesterol biliary microlithiasis, intrahepatic cholestasis and several mutations of...
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8158350 |
Probe, probe set, probe-immobilized carrier, and genetic testing method
A nucleic acid probe for classification of pathogenic bacterial species is capable of collectively detecting bacterial strains of the same species and differentially detecting them from other...
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8158772 |
Oligonucleotide sequences that identify species of animal
Methods for identifying animal species involving amplifying a DNA fragment by PCR using a DNA in a sample as a template and animal-specific DNA sequences as a primer pair, the animal-specific DNA...
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8153777 |
Modulation of toll-like receptor 5 expression by antisense oligonucleotides
Antisense oligonucleotide compounds, compositions and methods are provided for down regulating the expression of TLR5. The compositions comprise antisense oligonucleotides targeted to nucleic acids...
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8153401 |
Method for direct amplification from crude nucleic acid samples
The present teachings relate to improved methods, kits, and reaction mixtures for amplifying nucleic acids. In some embodiments a novel direct buffer formulation is provided which allows for the...
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8153602 |
Composition and methods for the pulmonary delivery of nucleic acids
The present invention relates to compositions and methods for the pulmonary delivery of nucleic acids, particularly oligonucleotides. In one preferred embodiment, the compositions and methods of...
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8153375 |
Compositions and methods for nucleic acid sequencing
Compositions and methods for nucleic acid sequencing include template constructs that comprise double stranded portions in a partially or completely contiguous constructs, to provide for redundant...
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8148073 |
Probe, probe set, probe-immobilized carrier, and genetic testing method
A nucleic acid probe for classification of pathogenic bacterial species is capable of collectively detecting bacterial strains of the same species and differentially detecting them from other...
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8148063 |
Probe, probe set, probe-immobilized carrier, and genetic testing method
A nucleic acid probe for classification of pathogenic bacterial species is capable of collectively detecting bacterial strains of the same species and differentially detecting them from other...
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8148064 |
Labelled nucleotides
Nucleosides and nucleotides are disclosed that are linked to detectable labels via a cleavable linker group.
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8143007 |
Nested primer sets for amplifying mouse immunoglobulin variable gene segments
The present invention provides oligonucleotides for detection of rearrangement of immunoglobulin genes for identifying clonality of cells, cancer cells, hypermutation in immunoglobulin gene,...
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8143008 |
Method of nucleic acid amplification
A nucleic acid molecule can be annealed to an appropriate immobilized primer. The primer can then be extended and the molecule and the primer can be separated from one another. The extended primer...
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8143001 |
Methods for analysis of nucleic acid methylation status and methods for fragmentation, labeling and immobilization of nucleic acids
The invention relates to methods for analysis of nucleic acid methylation status, and fragmentation and/or labeling and/or immobilization of nucleic acids. More particularly, the invention relates...
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8137914 |
Variants of alpha-fetoprotein coding and expression sequences
The invention discloses the sequences of variant forms of alpha-fetoprotein transcripts that have been identified in human hemopoietic progenitors but not in differentiated mature cells. The...
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8137907 |
Orthotopic and genetically tractable non-human animal model for liver cancer and the uses thereof
This invention provides a genetically tractable in situ non-human animal model for hepatocellular carcinoma. The model is useful, inter alia, in understanding the molecular mechanisms of liver...
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8138328 |
Modulation of apolipoprotein (A) expression
Compounds, compositions and methods are provided for modulating the expression of apolipoprotein(a). The compositions comprise oligonucleotides, targeted to nucleic acid encoding apolipoprotein(a)....
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8137906 |
Method for the synthesis of DNA fragments
The invention relates to a method that can be carried out in parallel and automated for the production of any nucleic acid, comprising the following steps: a) coupling an oligonucleotide to a solid...
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8133668 |
Probe, probe set, probe-immobilized carrier, and genetic testing method
A nucleic acid probe for classification of pathogenic bacterial species is capable of collectively detecting bacterial strains of the same species and differentially detecting them from other...
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8133669 |
Chemically modified nucleoside 5′-triphosphates for thermally initiated amplification of nucleic acid
Provided herein are methods and compositions for nucleic acid replication. These methods involve the use of 3′-substituted nucleoside 5′-triphosphates or 3′-substituted terminated primers in nucle...
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8133677 |
Method for measuring the number of oral Lactobacillus, and a PCR primers-probe set used for the same
There is provided a real-time PCR assay capable of measuring the number of lactobacillus present in an oral cavity, in a short time. The object can be solved by a method for measuring the number of...
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8133986 |
Methylated CpG island amplification (MCA)
The present invention provides a method for identifying a methylated CpG containing nucleic acid by contacting a nucleic acid with a methylation sensitive restriction endonuclease that cleaves...
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8129109 |
Probe, probe set, probe-immobilized carrier, and genetic testing method
A nucleic acid probe for classification of pathogenic bacterial species is capable of collectively detecting bacterial strains of the same species and differentially detecting them from other...
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8129120 |
Methods for genetic analysis of DNA to detect sequence variances
Methods for determining genotypes and haplotypes of genes are described. Also described are single nucleotide polymorphisms and haplotypes in the ApoE gene and methods of using that information.
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8129110 |
Probe, probe set, probe-immobilized carrier, and genetic testing method
A nucleic acid probe for classification of pathogenic bacterial species is capable of collectively detecting bacterial strains of the same species and differentially detecting them from other...
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8129108 |
Probe, probe set, probe-immobilized carrier, and genetic testing method
A nucleic acid probe for classification of pathogenic bacterial species is capable of collectively detecting bacterial strains of the same species and differentially detecting them from other...
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8124754 |
Double-stranded nucleic acid molecule cancer cell proliferation inhibitor and pharmaceutical agent suitable for prevention or treatment of uterine cancer, breast cancer, and bladder cancer
A double-stranded nucleic acid molecule for suppressing the expression of at least one of COX7RP and Efp genes which includes (a) a sense strand which includes a nucleotide sequence corresponding...
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8124747 |
HCV clade and prototype sequences thereof
The current invention relates to a previously unrecognized clade of HCV genotypes as well as to diagnostic, prophylactic and therapeutic applications of nucleic acids, proteins, and antibodies to...
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8119790 |
Antisense oligonucleotides for treating allergy and neoplastic cell proliferation
Antisense oligonucleotides for treating and/or preventing at least one of asthma, allergy, hypereosinophilia, general inflammation and cancer are provided. The oligonucleotides are directed against...
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8119336 |
Compositions for use in identification of alphaviruses
The present invention provides oligonucleotide primers and compositions and kits containing the same for rapid identification of alphaviruses by amplification of a segment of viral nucleic acid...
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8119400 |
Methods of inhibiting smooth muscle cell migration and proliferation
In particular embodiments, the present invention provides methods of inhibiting smooth muscle cell responses and methods of treating or preventing vascular proliferative disease caused by smooth...
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8119349 |
Methods and materials for detecting mutations in quasispecies having length polymorphisms
The present invention is directed to a method for detecting the presence or absence of a mutation of interest in the nucleic acid of a pathogen, wherein the mutation of interest is located adjacent...
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8114599 |
Compositions and methods for free-solution conjugate nucleic acid analysis
The present invention provides compositions and methods for performing free-solution conjugate analysis of nucleic acid molecules. For example, the present invention provides multiplexed...
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8114978 |
Methods for genotyping selected polymorphism
Methods for genotyping polymorphisms using a locus specific primer that is complementary to a region near a selected polymorphism are described. Methods for synthesizing pools of locus specific...
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8114601 |
Highly conserved genes and their use to generate probes and primers for detection of microorganisms
Four highly conserved genes, encoding translation elongation factor Tu, translation elongation factor G, the catalytic subunit of proton-translocating ATPase and the RecA recombinase, are used to...
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8114590 |
Diagnosis and treatment of chronic lymphocytic leukemia (CLL)
The present invention provides diagnostic methods and kits for diagnosis of chronic lymphocytic leukemia (CLL) by determining expression levels of isoforms of cyclic nucleotide phosphodiesterases...
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8110359 |
PCR method for identifiying a serotype of Klebsiella pneumoniae by using cps region primers and application thereof
The present invention relates to a method of identifying a serotype of Klebsiella pneumoniae, in particular to a method using specific polymerase chain reaction (PCR) primer sets designed according...
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