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7387877 |
Bio-sensor and bio-sensor reporting system
A biosensor unit that can be wall mounted in a location to perform testing of ambient air for bio-contaminants. This unit could contain an air filter for collecting contaminants and a...
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7387876 |
Amplification of trace amounts of nucleic acids
Methods of reducing background during amplification of small amounts of nucleic acids employ careful analysis of sources of low level contamination. Ultraviolet light can be used to reduce nucleic...
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7385049 |
Oligonucleotides and methods for detection of West Nile virus
The invention provides methods of detecting West Nile virus and oligonucleotide reagents derived from a West Nile virus consensus sequence that are useful in the methods of the invention.
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7384749 |
Electrodes linked via conductive oligomers to nucleic acids
The invention relates to nucleic acids covalently coupled to electrodes via conductive oligomers. More particularly, the invention is directed to the site-selective modification of nucleic acids...
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7384748 |
Compositions and methods for detecting and treating motor neuron disorders
The present invention relates to the NTE proteins and nucleic acids encoding the NTE proteins. The present invention further provides assays for the detection of NTE polymorphisms and mutations...
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7384746 |
Charge tags and the separation of nucleic acid molecules
The present invention relates to novel phosphoramidites, including positive and neutrally charged compounds. The present invention also provides charge tags for attachment to materials including...
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7384735 |
Retinoblastoma nucleic acids
This invention relates to nucleic acid, or fragments thereof, encoding the retinoblastoma polypeptide, the retinoblastoma polypeptide itself, methods of detecting a defective retinoblastoma gene in...
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7381819 |
Composition for treatment or prevention of endometrial cancer and method of preventing or treating endometrial cancer using the composition
Provided are a composition for the treatment or prevention of an endometrial cancer including a nuclear acid molecule inducing RNA interference against human syndecan-1 gene expression and a...
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7381818 |
Fluorescent probes containing 5′-minor groove binder, fluorophore and quenching moieties and methods of use thereof
Minor groove binder-oligonucleotide probes are provided along with methods for their use wherein the probes have an attached fluorophore which, in an unhybridized form exhibits very low background...
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7381808 |
Method and nucleic acids for the differentiation of prostate tumors
The present invention relates to chemically modified genomic sequences, to oligonucleotides and/or PNA-oligomers for detecting the cytosine methylation state of genomic DNA, as well as to a method...
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7381533 |
Electrodes linked via oligomers to nucleic acids
The invention relates to nucleic acids covalently coupled to electrodes via conductive oligomers. More particularly, the invention is directed to the site-selective modification of nucleic acids...
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7381532 |
Compositions and methods for the detection of a nucleic acid using a cleavage reaction
The invention relates to a method of generating a signal indicative of the presence of a target nucleic acid sequence in a sample, where the method includes forming a cleavage structure by...
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7381528 |
Methods for detection of mutations in myostatin variants
Methods for detecting allelic variants of the myostatin (growth and differentiation factor-8) gene are provided. Specifically provided are methods of identifying subjects having or having a...
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7381526 |
Assays for drug discovery based on microcompetition with a foreign polynucleotide
A recent discovery showed that microcompetition between a foreign polynucleotide and a cellular polynucleotide is a risk factor for some of the major chronic diseases. The invention uses this novel...
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7378517 |
UV excitable energy transfer reagents
Novel energy transfer dyes which can be used with shorter wavelength light sources are provided. These dyes include a donor dye with an absorption maxima at a wavelength between about 250 to 450 nm...
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7378485 |
Peptide nucleic acids with polyamide-containing backbones
A novel class of compounds, known as peptide nucleic acids, bind complementary ssDNA and RNA strands more strongly than a corresponding DNA. The peptide nucleic acids generally comprise ligands...
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7378236 |
Method for analyzing gene expression patterns
A method and device for detecting or monitoring the treatment status of a selected physiological state or disease condition. The device has a subarray of genes which show a statistically...
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7374945 |
Method for enhancing the association rates of polynucleotides
The present invention features a method and associated kit for increasing the association rate between polynucleotides having complementary, single-stranded regions, where the method includes...
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7374927 |
Methods of analysis of degraded nucleic acid samples
The invention provides arrays for analysis of compromised nucleic acid samples, for example, nucleic acids obtained from formalin fixed paraffin embedded samples and methods to analyzed these...
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7374882 |
Method for base sequencing and biologically active nucleic acids
Aptamers are nucleic acids and similar molecules, such as peptide-nucleic acids, that specifically bind to a ligand such as a protein or peptide. The present invention provides aptamers comprising...
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7374877 |
Amplification of HIV-1 gag sequences for detection of sequences associated with drug-resistance mutations
Sequences of nucleic acid oligonucleotides for amplifying different portions of gag and pol genes of HIV-1 and for detecting such amplified nucleic acid sequences are disclosed. Methods of...
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7371940 |
COT102 insecticidal cotton
The present application relates to an insect resistant transgenic cotton plant. In particular, it relates to a specific event, designated COT102. The application also relates to polynucleotides...
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7371851 |
Methods of cloning and producing fragment chains with readable information content
The present invention provides a method of attaching a fragment of a first nucleic acid molecule to a second nucleic acid molecule using adapters to mediate the binding particularly in methods of...
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7371850 |
Method and composition for reducing expression of ROCK-II
Methods and pharmaceutical compositions for treating, and delaying the onset of, viral infection, are provided.
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7371580 |
Use of unstructured nucleic acids in assaying nucleic acid molecules
The present invention provides a system and methods for assaying nucleic acid molecules with reduced levels of background signal and enhanced specificity and sensitivity. In particular, the present...
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7371533 |
Methods for separation of polymeric compounds
Recently two techniques using free solution electrophoresis to separate charged-uncharged polymer conjugates have proven successful: End Labeled Free Solution Electrophoresis (ELFSE) for DNA...
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7371532 |
Method and apparatus for determining base sequence of nucleic acid molecule
Disclosed herein is a method and apparatus for determining the base sequence of a nucleic acid molecule by cleaving a nucleic acid molecule of interest while controlling the cleavage site,...
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7368559 |
FcγRIIA-specific nucleic acid interference
The present invention provides methods and compositions for attenuating expression of FcγRIIA. In general, the described methodology involves the use of RNAi constructs that are targeted to a...
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7368558 |
PRO357 nucleic acids
The present invention is directed to secreted and transmembrane polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising...
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7368549 |
Tm leveling compositions
Modified oligonucleotides are provided containing bases selected from unsubstituted and 3-substituted pyrazolo[3,4-d]pyrimidines and 5-substituted pyrimidines, and optionally have attached minor...
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7368547 |
Use of novel virulence-specific genes as targets for diagnosis and potential control of virulent strains of Listeria monocytogenes
A method for identifying virulent strains of L. monocytogenes that includes the use of primers or probes in a PCR assay or hybridization technique that employs primers or probes, which are...
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7368245 |
Method and probes for the detection of chromosome aberrations
A novel method for detecting chromosome aberrations is disclosed. More specifically, chromosome aberrations are detected by in situ hybridisation using at least two sets of hybridisation probes, at...
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7368243 |
Detection of nucleic acids to assess risk for bovine spongiform encephalopathy
The present invention provides a method of detecting abnormal serum nucleic acid profiles to assess the risk of a transmissible spongiform encephalopathy, e.g., BSE.
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7368242 |
Method and kits for multiplex hybridization assays
The invention provides a method for genotyping interfering polymorphic loci in a target polynucleotide, such as a strand of genomic DNA, in a multiplex hybridization-based assay. The invention also...
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7368241 |
Cotton event PV-GHBK04 (757) and compositions and methods for detection thereof
The present invention provides a cotton event PV-GHBK04 (757), a cotton plant that contains PV-GHBK04 (757) DNA molecules and its progeny thereof, and methods for producing cotton event PV-GHBK04...
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7368239 |
Method and materials for polyamine catalyzed bisulfite conversion of cytosine to uracil
The invention provides methods and materials for conversion of cytosine to uracil. In some embodiments, a nucleic acid, such as gDNA, is reacted with bisulfite and a polyamine catalyst, such as a...
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7365187 |
DNA amplification method and kit therefor
In a method for amplifying a DNA, comprising performing PCR using a sense primer and an antisense primer, PCR is performed in the presence of an additional sense primer comprising the sense primer...
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7365179 |
Multiplexed analytical platform
The invention provides a system and reagents for carrying out multiplexed analytical measurements using the hybridization of oligonucleotide tags to addressable solid phase supports to obtain...
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7364855 |
Methods and kits for methylation detection
Ligation-based methods and kits are disclosed for determining the degree of methylation of one or more target nucleotides. In certain embodiments, the methylation status of one or more target...
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7364852 |
Short GCG expansions in the PAB II gene for oculopharyngeal muscular dystrophy and diagnostic thereof
The present invention relates to a human PAB II gene containing transcribed polymorphic GCG repeat, which comprises a sequence as set forth in SEQ ID NO:3, which includes introns and flanking...
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7364849 |
Treatment of substrates for immobilizing biomolecules
A method of treating a substrate for immobilizing a biomolecule and substrates produced by the method are disclosed. The method includes contacting at least a portion of a substrate with a reducing...
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7364844 |
Use of the Krit1 gene in the field of angiogenesis
The invention concerns a method for diagnosing cavernous angiomas for detecting mutations in the Krit1 gene. More particularly, said detection is performed by using nucleotide sequences. The...
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7361511 |
Compositions, kits, and methods for identification, assessment, prevention, and therapy of cervical cancer
The invention relates to nucleic acid molecules and proteins associated with cervical cancer including pre-malignant conditions such as dysplasia. Compositions, kits, and methods for detecting,...
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7361489 |
Nucleic acid amplification methods
The present invention relates to assays and kits for carrying out said assays for the rapid, automated detection of infectious pathogenic agents and normal and abnormal genes. The present invention...
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7361488 |
Nucleic acid detection methods using universal priming
The present invention is directed to providing sensitive and accurate assays for gene detection, genome-wide gene expression profiling and alternative splice monitoring with a minimum or absence of...
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7361471 |
Nucleic acid archiving
This invention is directed to a process for tightly binding nucleic acid to solid phase and corresponding processes for the utilization thereof. Nucleic acid is bound to solid phase matrices...
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7361470 |
Electrocatalytic nucleic acid hybridization detection
The detection of specific DNA sequences using electrochemical readout would permit the rapid and inexpensive detection and identification of bacterial pathogens and the analysis of human genes. A...
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7361469 |
Dual labeled fluorescent probes
The present invention relates to probes useful for the detection and measurement of target nucleic acids, as well as compositions and kits containing such probes. The probes of the present...
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7361468 |
Methods for genotyping polymorphisms in humans
Methods, kits and arrays of nucleic acid probes for genotyping large numbers of human SNPs in parallel are provided. A set of more than 100,000 human SNPs, known to be biallelic in at least two...
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7361460 |
Approach to molecular diagnosis of human papillomavirus-related diseases
The present invention relates to an accurate, sensitive, and efficient sequential or concurrently sequential method for molecular diagnosis of human papillomavirus (HPV)-based disease, where the...
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