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7544473 |
Nucleic acid analysis using sequence tokens
The present invention provides methods and compositions for tagging nucleic acid sequence fragments, e.g., a set of nucleic acid sequence fragments from a single genome, with one or more unique...
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7541142 |
Pancreatic cancer genes
The present invention provides the art with the DNA coding sequences of polynucleotides that are up- or down-regulated in cancer and dysplasia. These polynucleotides and encoded proteins or...
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7541448 |
Oligonucleotides containing molecular rods
The invention is directed to an oligonucleotide comprising a molecular rod, wherein preferentially the molecular rod covalently connects the 3′ end of a first nucleotide residue with the 5′ end...
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7541148 |
Method for detecting base mutation
The present invention relates to methods for precisely and effectively detecting mutations of organism.
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7541447 |
Process for the preparation of an improved Brucella strain plasmid to develop the strain and the vaccine comprising the said strain
A Brucella bacterium is modified by partial or complete deletion of the pgm gene, rendering the bacterium incapable of synthesizing a key enzyme in the metabolism of bacterial sugars. A live...
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7541146 |
Biomolecule retaining material and methods for attaching biomolecules to a surface
The present invention provides a method and material for attachment of biomolecules onto the surface of a substrate, such as microwell plates, tubes, beads, microscope slides, silicon wafers or...
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7541444 |
Modified nucleotides
The invention provides modified nucleotide or nucleoside molecule comprising a purine or pyrimidine base and a ribose or deoxyribose sugar moiety having a removable 3′-OH blocking group...
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7541314 |
Microarray having a base cleavable sulfonyl linker
The present invention provides a microarray having base cleavable, sulfonyl-containing linkers and a process to make the microarray. Oligonucleotides of any sequence may be synthesized on the...
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7537898 |
Compositions and methods of selective nucleic acid isolation
The invention relates to methods for isolating and/or identifying nucleic acids. The invention also provides kits for isolating and/or identifying nucleic acids.
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7537888 |
Marker assisted selection of bovine for improved milk production using diacylglycerol acyltransferase gene DGAT1
The present invention provides a method of genotyping bovine for improved milk production traits by determining the DGAT1 genotypic state of said bovine, wherein the DGAT1 gene and polymorphisms...
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7538206 |
Comparative mycobacterial geneomics as a tool for identifying targets for the diagnosis, prophylaxis or treatment of mycobacterioses
The present invention is directed to a method of selection of purified nucleotidic sequences or polynucleotides encoding proteins or part of proteins carrying at least an essential function for the...
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7537892 |
Method and sequences for determinate nucleic acid hybridization
Provided are methods for using nucleic acid sequences having two or more degenerately pairing nucleotides, each degenerate nucleotide having a partially overlapping set of complementarity, to...
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7534878 |
Composition and methods of RNAi therapeutics for treatment of cancer and other neovascularization diseases
Compositions and methods are provided for treatment of diseases involving unwanted neovascularization (NV). The invention provides treatments that control NV through selective inhibition of...
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7534621 |
Method of producing probe medium and method of immobilizing probe using probe medium
When a probe medium is spotted on a substrate, a probe can be effectively and stably immobilized on the substrate. The probe medium includes a probe capable of specifically binding to a target...
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7534564 |
Methods and compositions for polypeptide engineering
Methods are provided for the evolution of proteins of industrial and pharmaceutical interest, including methods for effecting recombination and selection. Compositions produced by these methods are...
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7534854 |
Apparatus and method for oxidation and stabilization of polymeric materials
An apparatus for treating polymeric materials comprises a treatment chamber adapted to maintain a selected atmosphere; a means for supporting the polymeric material within the chamber; and, a...
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7534872 |
Compositions and methods for the use of FMOC derivatives in DNA/RNA synthesis
Methods of nucleic acid preparation are described, including preparation of mRNA, using FMOC derivatives to synthesize oligonucleotides in addition to applying FMOC protocols to various therapeutic...
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7534568 |
Methods for detection of a target nucleic acid by forming a cleavage structure with a cleavage resistant probe
The invention relates to compositions and methods for generating a signal indicative of the presence of a target nucleic acid in a sample utilizing a cleavage resistant probe.
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7534587 |
Microsatellite markers for plants of the genus Triticeae and use thereof
The invention relates to novel microsatellite markers for wheats ( Triticum aestivum ) and closely related species (Genus Triticeae ) and to the use of said markers for the genetic analysis of...
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7531726 |
Controlled alignment of nanobarcodes encoding specific information for scanning probe microscopy (SPM) reading
The methods, apparatus and compositions disclosed herein concern the detection, identification and/or sequencing of biomolecules, such as nucleic acids or proteins. In certain embodiments of the...
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7527925 |
Purified pol DNA, a recombinant DNA construct for expression of HIV pol polypeptide sequences and a cell containing such construct
Polynucleotide sequences are provided for the diagnosis of the presence of retroviral infection in a human host associated with lymphadenopathy syndrome and/or acquired immune deficiency syndrome,...
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7527931 |
Identification of a gene associated with spinocerebellar ataxia type 5 and methods of use
The present invention provides methods that include analyzing an SCA5 polynucleotide, and determining whether the SCA5 polynucleotide includes a mutation. The methods may be used to identify a...
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7524632 |
Species identification by melting analysis of secondary structure of single stranded nucleic acids
Methods of identifying the type of a cell are provided, the methods comprising determining the T m profile of a sample rRNA or fragment thereof from the cell using a double stranded nucleic...
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7524948 |
Expression cassettes for vascular tissue-preferential expression in plants
The present invention relates to expression cassettes comprising transcription regulating sequences with vascular tissue-preferential or vascular tissue-specific expression profiles in plants...
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7524942 |
Labeled nucleotide composition
Embodiments of labeled nucleotide compositions are described. Methods are described in which a sample containing RNA is contacted with an enzyme having an RNA ligation activity in the presence of a...
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7524827 |
Methods and compositions for the inhibition of gene expression
The present invention relates to methods and compositions for the inhibition of gene expression. In particular, the present invention provides oligonucleotide-based therapeutics for the inhibition...
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7521213 |
Sample processing for nucleic acid amplification
Methods are described for the processing of biological samples for direct use in nucleic acid amplification without extracting or isolating the nucleic acids from the sample. In preferred...
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7521184 |
Detection and quantitation of nucleic acid molecules in biological samples
The present invention concerns processes for the detection and quantitation of nucleic acid molecules, polynucleotides, and/or oligonucleotides in a sample using hybridizationdetection assays,...
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7517684 |
Nucleic acid and amino acid sequences relating to Pseudomonas aeruginosa for diagnostics and therapeutics
The invention provides isolated polypeptide and nucleic acid sequences derived from Pseudomonas aeruginosa that are useful in diagnosis and therapy of pathological conditions; antibodies against...
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7517977 |
Reagents and methods for improving reproducibility and reducing mispriming in PCR amplification
An additive for preventing mispriming in polymerase chain reaction (PCR) amplifications and assays comprising a hairpin oligonucleotide having a stem duplex greater than six nucleotides in length...
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7517864 |
RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfering nucleic acid (siNA)
This invention relates to compounds, compositions, and methods useful for modulating VEGF and/or VEGFR gene expression using short interfering nucleic acid (siNA) molecules. This invention also...
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7517645 |
Detection of high grade dysplasia in cervical cells
Methods of using probes and probe sets for the detection of high grade dysplasia and carcinoma in cervical cells are described. Methods of the invention include hybridizing one or more chromosomal...
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7517650 |
Method of diagnosing breast cancer and compositions therefor
A method of diagnosing breast cancer in an individual aged younger than 41 or older than 54 is provided. The method comprises obtaining a nucleic acid from the individual and determining a...
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7514414 |
Suppressors of CpG oligonucleotides and methods of use
The present disclosure relates to oligodeoxynucleotides that suppress an immune response. Methods are disclosed for preventing or treating an immune-mediated disorder, such as, but not limited to,...
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7514211 |
Genomic DNAs participating in rheumatoid arthritis, method of diagnosing the same, method of judging onset risk and diagnostic kit for detecting the same
A genomic DNA involved in rheumatoid arthritis, a method of diagnosing rheumatoid arthritis or a method of judging onset risk of rheumatoid arthritis, and a diagnostic kit for diagnosing rheumatoid...
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7514549 |
Tumor inhibition by modulating sprouty expression or activity
Methods are provided for identifying compounds that decrease the expression or activity of an overexpressed Sprouty protein in certain cancers. Such compounds can be useful for treating cancers in...
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7514551 |
Multisignal labeling reagents, and processes and uses therefor
The present invention provides multisignal labeling reagents and these are useful in a number of biochemical applications, including the manufacture of biomolecular probes and their use in...
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7514220 |
Kits for detection of nucleic acids using invasive cleavage structures and flap endonucleases
The present invention relates to means for the detection and characterization of nucleic acid sequences, as well as variations in nucleic acid sequences. The present invention also relates to...
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7514415 |
Method of treating inflammatory arthropathies with suppressors of CpG oligonucleotides
The present disclosure relates to oligodeoxynucleotides that suppress an immune response. Methods are disclosed for preventing or treating inflammatory arthropathies by administering a...
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7510834 |
Gene mapping method using microsatellite genetic polymorphism markers
The present invention provides a gene mapping method which involves analysis of a DNA sample from a test subject and from a control subject for the presence of an allelic form of a plurality of...
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7510833 |
Method for examining obesity or leanness
In the examination of obesity or leanness, the examination is based on the expression level of the MCP-1 gene or the MCP-1 protein in a tissue or cell analyte, or on the polymorphism in the gene....
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7510835 |
Methods for identifying risk of breast cancer and treatments thereof
Provided herein are methods for identifying risk of breast cancer in a subject and/or a subject at risk of breast cancer, reagents and kits for carrying out the methods, methods for identifying...
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7507810 |
Compositions and their uses directed to IL-4R alpha
Disclosed herein are compounds, compositions and methods for modulating the expression of IL-4R alpha in a cell, tissue or animal. Also provided are methods of target validation. Also provided are...
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7507531 |
Use of 5-lipoxygenase activating protein (FLAP) gene to assess susceptibility for myocardial infarction
Linkage of Myocardial Infarction (MI) to a locus on chromosome 13q12-13 is disclosed. In particular, the FLAP gene within this locus is shown by association analysis to be a susceptibility gene for...
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7507539 |
Substractive single label comparative hybridization
Provided are methods of determining differences between nucleic acids in a test sample and a reference sample. In certain embodiments the methods are used for detecting and mapping chromosomal or...
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7507535 |
Strong PCR primers and primer cocktails
The invention disclosed relates to a PCR primer pair for amplication of chaperonin-60 (cpn60) targets having high G+C content and to a PCR primer “cocktail” to improve the representation of...
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7507808 |
Modulation of endothelial lipase expression
Compounds, compositions and methods are provided for modulating the expression of endothelial lipase. The compositions comprise oligonucleotides, targeted to nucleic acid encoding endothelial...
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7507811 |
siRNA targeting KRAS
Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rationale design, one can maximize the generation of an effective gene...
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7504385 |
si-RNA-mediated gene silencing technology to inhibit tyrosinase and reduce pigmentation
The present invention describes compositions and methods for treating, preventing and improving hyperpigmentation, or other unwanted pigmentation of the skin, or other unwanted skin condition, such...
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7504490 |
Nucleic acid and amino acid sequences relating to Apergillus fumigatus for diagnostics and therapeutics
The invention provides isolated polypeptide and nucleic acid sequences derived from Aspergillus fumigatus that are useful in diagnosis and therapy of pathological conditions; antibodies against...
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