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7579451 |
Oligonucleotides comprising a modified or non-natural nucleobase
One aspect of the present invention relates to a double-stranded oligonucleotide comprising at least one non-natural nucleobase. In certain embodiments, the non-natural nucleobase is difluorotolyl,...
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7575867 |
Use of mass labelled probes to detect target nucleic acids using mass spectrometry
The invention relates to the use of mass labelled probes to characterize nucleic acids by mass spectrometry. Thus the invention provides methods of detecting the presence of a target nucleic acid...
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7575862 |
Assay systems, kits and methods for detecting microorganisms
The present invention relates to an assay system, kits and methods for detecting microorgansims (especially for M. tuberculosis ) of suspected patient. The present invention also relates to an...
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7575902 |
Universal bases for nucleic acid analyses, methods for using universal bases, and kits comprising universal bases
Compounds, methods and kits for making and analyzing primer extension products incorporating one or more universal bases are described, including methods and kits for nucleic acid sequencing and...
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7575868 |
Methods for assessing efficacy of chemotherapeutic agents
Methods are provided for accurately predicting efficacy of chemotherapeutic agents. Methods of the invention increase the positive predictive value of chemosensitivity assays by assessing both the...
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7576194 |
UspA2 nucleic acid of moraxella catarrhalis
The present invention discloses the existence of two novel proteins UspA1 and UspA2, and their respective genes uspA1 and uspA2. Each protein encompasses a region that is conserved between the two...
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7575913 |
Chlamydia trachomatis genomic sequence and polypeptides, fragments thereof and uses thereof, in particular for the diagnosis, prevention and treatment of infection
The subject of the invention is the genomic sequence and the nucleotide sequences encoding polypeptides of Chlamydia trachomatis , such as cellular envelope polypeptides, which are secreted or...
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7572584 |
Species-specific primer sets and identification of species-specific DNA sequences using genome fragment enrichment
Targeted sequencing of genetic regions that differ between two DNA preparations uses genomic fragment enrichment. This method can be used to study genetic variation among closely related species...
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7572582 |
Oligonucleotide analogues
The present invention relates to novel bicyclic and tricyclic nucleoside and nucleotide analogues as well as to oligonucleotides comprising such elements. The nucleotide analogues, LNAs (Locked...
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7572588 |
Modified probe molecules having self-complementary regions
The present invention concerns oligonucleotides containing one or more modified nucleotides which increase the binding affinity of the oligonucleotides to target nucleic acids having a...
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7572586 |
Identifying susceptibility to cardiac hypertrophy
This document provides methods and materials related to identifying, assessing, and predicting hypertrophic cardiomyopathy (HCM) in mammals. For example, methods and materials for using mutations...
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7569684 |
siRNA targeting gremlin
Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene...
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7569659 |
Admixture comprising a target molecule and a nucleic acid mimic comprising sterically bulky substituents
The invention concerns compositions comprising a nucleic acid mimic. The compositions may be used in the diagnosis and treatment of diseases amenable through modulation of nucleic acids which...
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7569344 |
Detection of human papilloma virus in papanicolaou (Pap) smears
Methods and reagents for detecting high-risk human papilloma virus (HPV) DNA types in cells on a Pap smear that indicates the patient is at higher risk for cancer are described. The method uses...
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7569683 |
UspA2 nucleic acid of Moraxella catarrhalis
The present invention discloses the existence of two novel proteins UspA1 and UspA2, and their respective genes uspA1 and uspA2. Each protein encompasses a region that is conserved between the two...
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7566538 |
Sequencing by incorporation
Nucleotides and nucleotide analogs are used in various sequencing by incorporation/sequencing by synthesis methods. Nucleotide analogs comprising 3′-blocking groups are used to provide reversible...
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7566773 |
Photolabile compound and substrate for oligomer probe array with the same
Provided is a substrate for an oligomer probe array to which a photolabile material having an acetylene derivative is directly attached or attached via a linker.
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7566536 |
WNT-regulated cytokine-like polypeptide and nucleic acids encoding same
The present invention provides novel polypeptides, termed FCTRX polypeptides, as well as polynucleotides encoding FCTRX polypeptides and antibodies that immunospecifically bind to an FCTRX or a...
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7566775 |
N8- and C8-linked purine bases and structurally related heterocycles as universal nucleosides used for oligonucleotides hybridization
The present invention is directed to a nucleic acid binding compound comprising N 8 - or C 8 -linked purine bases or structurally related heterocycles, a compound useful for the preparation of such...
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7566420 |
Methods, kits and compositions pertaining to combination oligomers and libraries for their preparation
This invention pertains to the field of combination oligomers, including the block synthesis of combination oligomers in the absence of a template, as well as related methods, kits, libraries and...
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7563944 |
Expression cassette for nucleic acids in plant tissue containing starch
The invention relates to methods for the transgenic expression of nucleic acid sequences predominantly in starch-comprising tissues of plants, preferably in fruits, roots, seeds or tubers, wherein...
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7563579 |
Method for detecting a structured target
The present invention concerns oligonucleotides containing one or more modified nucleotides which increase the binding affinity of the oligonucleotides to target nucleic acids having a...
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7563569 |
Optimization of gene expression analysis using immobilized capture probes
Disclosed are methods of multiplexed analysis of oligonucleotides in a sample, including: methods of probe and target “engineering”, as well as methods of assay signal analysis relating to the...
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7563880 |
Compositions and methods for the therapy and diagnosis of breast cancer
Compositions and methods for the therapy and diagnosis of cancer, particularly breast cancer, are disclosed. Illustrative compositions comprise one or more breast tumor polypeptides, immunogenic...
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7560256 |
Automated process for detecting the presence of a target nucleic acid in a sample
An automated process for detecting the presence of a target nucleic acid in a sample. The process includes separating the target nucleic acid from other material present in the sample at a first...
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7560254 |
Allele specific primer extension
A method of characterizing a nucleic acid sample is provided that includes the steps of: (a) conducting a DNA polymerase reaction that includes the reaction of a template, an allele specific...
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7560230 |
Method for determining susceptibility of tumor to treatment with anti-neoplastic agent
The level of one or more glucose transporters in a sample containing cancer cells is measured and compared to a reference value to determine whether the cancer is susceptible to treatment with an...
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7556923 |
Hybridization and mismatch discrimination using oligonucleotides conjugated to minor groove binders
Conjugates between a minor groove binding molecule, such as the trimer of 1,2-dihydro-(3H)-pyrrolo[3,2-e]indole-7-carboxylate (CDPI 3 ), and an oligonucleotide form unusually stable hybrids with...
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7557204 |
CUDR as biomarker for cancer progression and therapeutic response
Disclosed is a novel human gene designated CUDR. Provides is also a CUDR gene as a biomarker in the diagnosis of human cancers and a cancer therapy.
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7553659 |
CHD5 encoding nucleic acids, polypeptides, antibodies and methods of use thereof
Nucleic acid sequences encoding chromodomain helicase DNA-binding (CHD) proteins, CHD proteins, and antibodies thereto and methods of use thereof are disclosed.
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7553644 |
Detection and treatment of polycystic kidney disease
Compositions useful for examining the PKD1 gene are provided. In addition, methods for detecting mutations of the PKD1 gene, which can be associated with autosomal dominant polycystic kidney...
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7553943 |
Polynucleotide arrays
The invention provides a hairpin polynucleotide, having a loop and a stem region, characterised in that a sulfur-based nucleophile is attached to an internal nucleotide in the hairpin through a...
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7553624 |
Method of analyzing physiological function of target substance
The present invention provides a method of analyzing the physiological function of a target substance by inactivating the physiological function of the target substance, comprising the steps of:...
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7553955 |
Molecular beacons, methods and kits for detecting DNA damage response
This invention relates to embodiment to a molecular beacon, methods and kits for the detection of expression of p21(Waf1/Cip1), in response to chemotherapy. Specifically, the introduction of a...
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7553643 |
Method for amplifying target nucleic acid sequences using a primer comprising an AP endonuclease-cleavable linker
The present invention provides a novel method for nucleic acid amplification. The method includes contacting the sample with at least one forward primer and at least one reverse primer, an AP...
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7553949 |
Reversible terminator nucleotides and methods of use
Disclosed herein a reversible terminator nucleotides and methods of use.
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7550582 |
Polyamide nucleic acid derivatives and agents, and processes for preparing them
The present invention relates to PNA derivatives which carry, at the C terminus, or at both the C and N termini of the PNA backbone, one or more phosphoryl radicals. The phosphoryl radicals carry,...
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7550261 |
Method of screening for drug hypersensitivity reaction
Methods of assessing the risk of clinical signs of hypersensitivity reaction to nucleoside antiviral compounds, including abacavir, are described. The methods include genotyping subjects for...
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7550571 |
Lafora's disease gene
A novel gene (EPM2A) that is deleted or mutated in people with Lafora's disease is described. The EPM2A gene encodes a protein having an active catalytic site of a protein tyrosine phosphatase....
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7550276 |
Method of detecting nucleic acid
The present invention relates to a method of detecting or quantifying a target nucleic acid present in a specimen. The present invention provides a method of detecting or quantifying a target...
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7547513 |
Mutants of deoxycytidine kinase having extended enzymatic activity
The invention relates to a method for artificial in vivo evolution of proteins, said method making it possible to bring about the evolution of a protein X by complementation of a relative protein...
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7547775 |
Parallel preparation of high fidelity probes in an array format
The present invention provides massively parallel oligonucleotide synthesis and purification for applications that utilize large collections of defined high-fidelity oligonucleotides (e.g., from...
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7547511 |
Antisense inhibition of laminin-8 expression to inhibit human gliomas
Using gene array technology, we observed that an increase of the α4 chain-containing Laminin-8 correlated with poor prognosis for patients with brain gliomas. We established that inhibition of...
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7544473 |
Nucleic acid analysis using sequence tokens
The present invention provides methods and compositions for tagging nucleic acid sequence fragments, e.g., a set of nucleic acid sequence fragments from a single genome, with one or more unique...
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7541142 |
Pancreatic cancer genes
The present invention provides the art with the DNA coding sequences of polynucleotides that are up- or down-regulated in cancer and dysplasia. These polynucleotides and encoded proteins or...
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7541448 |
Oligonucleotides containing molecular rods
The invention is directed to an oligonucleotide comprising a molecular rod, wherein preferentially the molecular rod covalently connects the 3′ end of a first nucleotide residue with the 5′ end...
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7541148 |
Method for detecting base mutation
The present invention relates to methods for precisely and effectively detecting mutations of organism.
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7541447 |
Process for the preparation of an improved Brucella strain plasmid to develop the strain and the vaccine comprising the said strain
A Brucella bacterium is modified by partial or complete deletion of the pgm gene, rendering the bacterium incapable of synthesizing a key enzyme in the metabolism of bacterial sugars. A live...
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7541146 |
Biomolecule retaining material and methods for attaching biomolecules to a surface
The present invention provides a method and material for attachment of biomolecules onto the surface of a substrate, such as microwell plates, tubes, beads, microscope slides, silicon wafers or...
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7541444 |
Modified nucleotides
The invention provides modified nucleotide or nucleoside molecule comprising a purine or pyrimidine base and a ribose or deoxyribose sugar moiety having a removable 3′-OH blocking group...
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