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7604996 |
Compositions and methods for preparing oligonucleotide solutions
The present invention is directed to methods and compositions for generating a pool of oligonucleotides. The invention finds use in preparing a population or subpopulations of oligonucleotides in...
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7605243 |
Compounds and methods for labeling oligonucleotides
The invention provides a novel method of labeling oligonucleotides, with reporter moieties, including but not limited to, quenchers, fluorophores, biotin, digoxigenin, peptides and proteins. In...
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7601532 |
Microarray for predicting the prognosis of neuroblastoma and method for predicting the prognosis of neuroblastoma
A microarray for predicting the prognosis of neuroblastoma, wherein the microarray has 25 to 45 probes related to good prognosis, which are hybridized to a gene transcript whose expression is...
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7601503 |
Detection of negatively charged polymers using water-soluble, cationic, polythiophene derivatives
Novel methods allowing for the simple optical and electrochemical detection of double-stranded oligonucleotides are disclosed. The methods are rapid, selective and versatile. Advantageously, they...
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7601531 |
Chlamydia pneumoniae polynucleotides and uses thereof
The subject of the invention is the genomic sequence and the nucleotide sequences encoding polypeptides of Chlamydia pneumoniae , such as cellular envelope polypeptides, which are secreted or...
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7601831 |
Methods, kits and assay system for detecting drug-resistant mycobacterium tuberculosis
The present invention relates to methods, kits and assay system for detecting drug-resistant Mycobacterium tuberculosis of suspected patient. The system of the present invention largely reduces...
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7601498 |
Methods of using dyes in association with nucleic acid staining or detection and associated technology
Methods of using dyes and associated technology are provided. A dye, such as a monomeric dye or a dimeric dye, may be used in a nucleic acid gel staining application and/or a nucleic acid detection...
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7601493 |
Methods and apparatus for screening and detecting multiple genetic mutations
An assay system and methods are described where patient samples containing genomic DNA are analyzed for the presence of known genetic polymorphisms using a universal reporter strategy. In a...
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7601822 |
Molecular identification of bacteria of genus Streptococcus and related genera
The invention concerns a method for detecting by molecular identification a bacterium of one of the species of genus Streptococcus and four related genera Enterococcus, Gemella, Abiotrophia and...
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7598034 |
Method of identifying hairpin DNA probes by partial fold analysis
Method of identifying molecular beacons in which a secondary structure prediction algorithm is employed to identify oligonucleotide sequences within a target gene having the requisite hairpin...
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RE40929 |
Chromosome-specific staining to detect genetic rearrangements associated with chromosome 3 and/or chromosome 17
Methods and compositions for staining based upon nucleic acid sequence that employ nudeic nucleic acid probes are provided. Said methods produce staining patterns that can be tailored for...
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7598057 |
Use of cytokine receptors as biomarkers and therapeutic targets in human cancer
Nucleic acids encoding erythropoietin receptor isoforms are described, as well as the encoded isoforms, methods of detecting the same, and methods of screening for and treating cancer.
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7598035 |
Method and compositions for ordering restriction fragments
The invention provides a method for constructing a high resolution physical map of a polynucleotide. In accordance with the invention, nucleotide sequences are determined at the ends of restriction...
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7598038 |
Method for estimating end use qualities of wheat at growth stage
The invention provides a means for estimating the end use qualities of wheat flour that will be obtained in the future from the harvested wheat at an early stage before maturation of the wheat...
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7595164 |
Compositions and methods to detect Candida albicans nucleic acid
Compositions are disclosed as nucleic acid sequences that may be used as amplification oligomers, including primers, capture probes for sample preparation, and detection probes specific for ...
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7595385 |
Polymorphisms in the region of the human hemochromatosis gene
Polymorphic sites in the region surrounding the HH gene are provided. These polymorphisms are useful as surrogate markers in diagnostic assays for hemochromatosis.
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7595155 |
Multiplex detection probes
The present invention comprises detection probes utilizing vesicles or soluble bodies to retain multiple mass tag molecules. The detection probes may be used to simultaneously assay a plurality of...
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7595162 |
Methods of labeling polynucleotides with energy transfer dyes
Novel linkers for linking a donor dye to an acceptor dye in an energy transfer fluorescent dye are provided. These linkers faciliate the efficient transfer of energy between a donor and acceptor...
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7595161 |
Efficacy of calcimimetic agents
A method of assessing the efficacy of a calcimimetic drug to treat hyperparathyroidism in a subject may include determining which alleles for a calcium-sensitive receptor (CaSR) gene the subject...
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7592135 |
High resolution typing system for pathogenic Mycobacterium tuberculosum
MLVA methods for strain discrimination among Mycobacterium tuberculosum strains are disclosed. Nine VNTR loci have been identified from genomic sequences of Mycobacterium tuberculosum strains...
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7592446 |
Synthesis of selenium-derivatized nucleosides, nucleotides, phosphoramidites, triphosphates and nucleic acids
The present invention provides selenium derivatives of nucleosides, nucleoside phosphoramidites, nucleotides, nucleotide triphosphates, oligonucleotides, polynucleotides, and larger nucleic acids...
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7592137 |
Genetic testing kits and a method of bladder cancer
A deletion in the end region of the long arm of a Chromosome 9 is efficiently detected. A genetic testing kit of bladder cancer according to the present invention includes a primer allowing for...
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7592441 |
Liver cancer-related nucleic acids
Described herein are novel polynucleotides associated with liver cancer. The polynucleotides are miRNAs, miRNA precursors, and associated nucleic acids. Methods and compositions are described that...
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7592435 |
Modified nucleosides and nucleotides and uses thereof
The invention is directed to modified guanine-containing nucleosides and nucleotides and uses thereof. More specifically, the invention relates to modified fluorescently labelled guanine-containing...
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7592318 |
88kDa tumorigenic growth factor and antagonists
This invention relates to products and methods for treating cancer and for diagnosing tumorigenicity and other diseases associated with alteration in GP88 expression or action. Antagonists to an 88...
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7589189 |
Inhibition of the expression of huntingtin gene
It is intended to provide methods for suppressing the huntington gene expression by using a double-stranded RNA (dsRNA), huntington gene expression inhibitors to suppress the huntington gene...
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7588921 |
Messenger RNA profiling: body fluid identification using multiplex real time-polymerase chain reaction (q-PCR)
This invention relates to a ribonucleic acid (RNA) based assay system for body fluid identification, and in particular to a novel, multiplex, parallel assay system based on messenger RNA expressed...
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7588896 |
Methods, compositions, and kits for forming self-complementary polynucleotides
The present teachings generally relate to methods, kits, and compositions for detecting target polynucleotide sequences. The teachings also relate to ligation and amplification reactions that...
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7588894 |
Use of ID4 for diagnosis and treatment of cancer
Methods for diagnosis and treatment of cancer using ID4 are disclosed. Specifically, epigenetic inactivation of ID4 in colorectal carcinomas and breast correlates with poor differentiation and...
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7588941 |
Dispersion of carbon nanotubes by nucleic acids
Nucleic acid molecules in a stabilized solution such as single stranded DNA and RNA were able to disperse high concentration of bundled carbon nanotubes into aqueous solution.
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7585849 |
Position dependent recognition of GNN nucleotide triplets by zinc fingers
The specificity of binding of a zinc finger to a triplet or quadruplet nucleotide target subsite depends upon the location of the zinc finger in a multifinger protein and, hence, upon the location...
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7585966 |
Inhibitory polynucleotides directed against the RNA component of telomerase
This invention provides inhibitory polynucleotides, such as antisense molecules, directed against accessible regions in the telomerase ribonucleoprotein. The polynucleotides are useful for...
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7585624 |
Detection of the energy of photons from biological assays
A cryogenic detector is used for detection in a biological assay.
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7585649 |
Modified oligonucleotides and applications thereof
Disclosed, among other things, are primers containing certain modified nucleobases in the 3′ terminal region of the primers that provide reduced formation of primer-dimers during amplification...
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7585632 |
Compositions and methods for the detection of a nucleic acid using a cleavage reaction
The invention relates to compositions and methods for generating a signal indicative of the presence of a target nucleic acid in a sample utilizing a primer-probe duplex.
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7585968 |
Compositions and their uses directed to thymus and activation-regulated chemokine (TARC)
Disclosed herein are compounds, compositions and methods for modulating the expression of TARC in a cell, tissue or animal. Also provided are methods of target validation. Also provided are uses of...
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7585630 |
Genetic variants in the TCF7L2 gene as diagnostic markers for risk of type 2 diabetes mellitus
Polymorphisms in the gene TCF7L2 are shown by association analysis to be a susceptibility gene for type II diabetes. Methods of diagnosis of susceptibility to diabetes, of decreased susceptibility...
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7585629 |
Compositions and methods for spinocerebellar ataxia
The autosomal dominant spinocerebellar ataxias (SCAs) represent a growing and heterogeneous clinical phenotype with ongoing discovery of causative etiologies. Methods: The authors collected DNA and...
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7585631 |
Method for obtaining purified RNA from viable oocysts
The present invention describes novel oligonucleotides targeted to nucleic acid sequences derived from Crytosporidium organisms, and Crytosporidium parvum organisms in particular, which are...
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7585964 |
Methods of analyzing chromosomal translocations using fluorescence in situ hybridization (FISH)
Probes and methods of using the probes to detect chromosomal rearrangements and/or deletions are provided. The methods utilize probes that are free of repeat sequences to provide greater...
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7585965 |
Metallic object with a nucleic acid coating and derivatives thereof and method for producing said object
A metallic object has a coating made of a thin metal oxide layer and nucleic acids or nucleic acid derivatives bonded thereto. The nucleic acid compounds have 5′-terminal or 3′-terminal...
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7582421 |
Methods for determination of single nucleic acid polymorphisms using a bioelectronic microchip
This application includes methods for detecting single nucleotide polymorphisms (SNPs) in a sample using an electronically addressable microchip having a plurality of test sites. A sample nucleic...
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7582420 |
Multiplex nucleic acid reactions
The invention is directed to a variety of multiplexing methods used to amplify and/or genotype a variety of samples simultaneously.
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7582427 |
Method of estimating drug metabolic activity by analyzing mutations in glucuronosyl transferase gene
An object of this invention is to provide a method for assaying, predicting or assessing drug metabolism by effectively detecting (a) mutation(s) in a gene coding for UGT. A gene coding for UGT...
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7582740 |
Methods and kits for detecting SARS-associated coronavirus
The present invention provides a synthetic nucleic acid sequence comprising 10-30 nucleotides of the N gene region and/or the 3′ non-coding region of the SARS-associated coronavirus genome, and a...
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7582470 |
Device for amplifying and detecting a target nucleic acid
Compositions, methods and devices for detecting nucleic acids. The invention particularly regards composite arrays of immobilized amplification primers and hybridization probes. Also disclosed are...
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7582615 |
Antisense antiviral compound and method for treating arenavirus infection
The invention provides antisense antiviral compounds and methods of their use and production in inhibition of growth of viruses of the Arenaviridae family and in the treatment of a viral infection....
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7579146 |
Nucleic acid cloning
The present invention provides an improved system for linking nucleic acids to one another. In particular, the present invention provides techniques for producing DNA product molecules that may be...
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7579454 |
Method for detecting gram-positive bacteria
The present invention relates to a method for detecting and/or identifying Gram-positive bacteria with high GC content, in particular mycobacteria. The method comprises a nucleic acid amplification...
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7579155 |
Method for identifying the sequence of one or more variant nucleotides in a nucleic acid molecule
The invention relates to methods for identifying the sequence of one or more variant nucleotides in nucleic acid molecules. The method involves cleaving a double-stranded nucleic acid molecule...
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