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7312035 |
Methods of genetic analysis of yeast
Arrays of oligonucleotide probes which are complementary to a plurality of S. cerevisisae and S. pombe genes are disclosed. The arrays may be used to measure the expression levels of a...
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7309573 |
Methods for detection of a nucleic acid by sequential amplification
The invention relates to methods and compositions for detecting a target nucleic acid. The methods include subjecting a target, template, cleavage agent, polymerase and first, second and third...
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7306913 |
Genetic polymorphisms associated with coronary stenosis, methods of detection and uses thereof
The present invention is based on the discovery of genetic polymorphisms that are associated with coronary stenosis. In particular, the present invention relates to nucleic acid molecules...
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7307069 |
Antisense oligonucleotide modulation of STAT3 expression
Compounds, compositions and methods are provided for inhibiting the expression of human STAT3. The compositions comprise antisense oligonucleotides targeted to nucleic acids encoding STAT3. Methods...
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7306915 |
Probe set for detection of target substance and detection method using the same
A probe set is described that includes a first probe having a target-binding substance and a base sequence X1, a second probe having a base sequence X2c and a base sequence X1c hybridizable with...
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7306918 |
Determination of the number of tandem repeat nucleotides using encoded probe-displaying beads
This invention provides compositions and methods for genetic testing of an organism and for correlating the results of the genetic testing with a unique marker that unambiguously identifies the...
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7306910 |
Breast cancer prognostics
A method of providing a prognosis of breast cancer is conducted by analyzing the expression of a group of genes. Gene expresson profiles in a variety of medium such as microarrays are included as...
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7308364 |
Diagnosis of multiple myeloma on gene expression profiling
Gene expression profiling between normal B cells/plasma cells and multiple myeloma cells revealed four distinct subgroups of multiple myeloma plasma cells that have significant correlation with...
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7304041 |
Modulators of coagulation factors
The invention provides improved nucleic acid ligands that inhibit coagulation and improved modulators of the nucleic acids to provide ideal modulators of coagulation. These improved nucleic acids...
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7303870 |
Method of detecting microorganisms
The present invention relates generally to a method for detecting, enumerating and/or identifying microorganisms in a sample. More particularly, the present invention provides a method for...
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7303895 |
Choline transport like (CTL) membrane proteins involved in choline transport
The invention concerns the identification of a novel family of CTL (Choline Transporter Like) genes, in particular hCTL1 and hCTL2, involved in the metabolism and/or transport of choline in cells...
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7303879 |
Determination of SNP allelic frequencies using temperature gradient electrophoresis
A method for determining a frequency of single nucleotide polymorphism (SNP) within genomic DNA includes providing genomic DNA of each of a plurality of different organisms. The genomic DNA of each...
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7303880 |
Microdissection-based methods for determining genomic features of single chromosomes
The present provides a microdissection-based method for identifying a genomic feature present within a visible chromosome region. The method includes steps of: (a) micro-dissecting a single copy of...
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7300788 |
Method for genotyping polymorphisms in humans
The invention provides nucleic acid sequences that are complementary, in one embodiment, to a wide variety of human polymorphisms. The invention provides the sequences in such a way as to make them...
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7301015 |
Genotyping kit for diagnosis of human papilloma virus infection
The present invention relates to a genotyping kit for diagnosis of detecting the human papillomavirus (HPV) infection, probes for genotyping the HPV, and DNA chips including the probes. Also, the...
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7300758 |
Nucleic acid underexpressed in esophageal tumor
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid...
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7300755 |
Methods for haplotyping genomic DNA
The present invention provides a novel method for specifically isolating and separating large segments of genomic DNA that can subsequently be used to determine a genomic haplotype. The invention...
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7300752 |
Compositions and methods for determining canine gender
The present invention provides methods to determine gender of a canine subject, that include contacting a nucleic acid sample from the canine subject with at least one probe or primer specific for...
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7297518 |
Methods and apparatus for analyzing polynucleotide sequences by asynchronous base extension
The invention provides methods and apparatus for analyzing polynucleotide sequences by asynchronous base extension. Some applications of the invention utilize total internal reflection fluorescence...
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7297490 |
Authentication of biologic materials using DNA-DNA hybridization on a solid support
Provided are a method for preparing an array for authenticating biological samples and a method for authenticating the biological samples based on analysis of variable sequences of ribosomal RNA...
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7297785 |
Unique chromosomal sequence of Bacillus anthracis and methods of making and using thereof including real-time PCR assays
Disclosed herein are nucleic acid molecules having sequences that are unique to Bacillus anthracis and method of making and using thereof. Also disclosed are kits comprising the nucleic acid...
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7297484 |
Characterization of single stranded nucleic acids by melting analysis of secondary structure using double strand-specific nucleic acid dye
A novel method for characterizing nucleic acids. A nucleic acid is combined with a double stranded nucleic acid-specific dye to form a detectable complex between the dye and one or more double...
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7297494 |
Activatable probes and methods for in vivo gene detection
Probes for detecting a target polynucleotide are provided. One aspect provides a molecular beacon probe set wherein the donor molecular beacon comprises a quantum dot and an acceptor molecular...
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RE39920 |
Methods for detection of nucleic acid sequences in urine
Described are non-invasive methods of detecting the presence of specific nucleic acid sequences as well as nucleic acid modifications and alterations by analyzing urine samples for the presence of...
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7294465 |
Polycystic kidney disease PKD2 gene and uses thereof
The present invention provides a purified and isolated wild type PKD2 gene, as well as mutated forms of this gene. The present invention also provides one or more single-stranded nucleic acid...
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7294489 |
Nucleic acid amplification and detection of Mycobacterium species
Oligonucleotides used to prime in vitro nucleic acid amplification of 16S rRNA sequences or DNA encoding 16S rRNA sequences for many species within the genus Mycobacterium are disclosed. Kits...
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7294466 |
Multiplexed detection of biological agents
Described are methods, kits and systems for multiplexed detection of biological agents in a sample, e.g., multiplexed detection of e.g., bacteria, viruses, and biological toxins. The method...
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7294488 |
Amplification-hybridisation method for detecting and typing human papillomavirus
The present invention provides amplification and hybridisation method for detecting and typing human papillomavirus (HPV), and the primers and hybridisation probes used in the method. The invention...
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7294709 |
Detection of Giardia
Oligonucleotide molecules for the detection of Giardia lamblia ( G. lamblia which molecules hybridise under medium to high stringency conditions to unique 18S rDNA/rRNA sequences of G. lamblia,...
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7294487 |
Combinatorial oligonucleotide PCR: a method for rapid, global expression analysis
The present invention relates to a method for the detection of gene expression and analysis of both known and unknown genes. The invention is a highly sensitive, rapid and cost-effective means of...
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7294461 |
Methods and compositions for transcription-based nucleic acid amplification
Methods for isothermal exponential amplification of a target polynucleotide are disclosed. The methods employ two transcription modules, the first module providing linear amplification resulting in...
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7291457 |
Electrochemical detection of mismatch nucleic acids
A method and system for specifically detecting perfectly matched probe-target hybrids by annealing a hairpin-based probe to a nucleic acid target under conditions favoring the formation of...
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7291461 |
Methods for identifying small molecules that modulate premature translation termination and nonsense mRNA decay
The present invention relates to methods for identifying compounds that modulate premature translation termination and/or nonsense-mediated mRNA decay by screening and identifying compounds that...
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7291452 |
Erythrovirus and its applications
The invention concerns nucleic acids derived from human V9 erythrovirus, fragments thereof, encoded polypeptides, and applications as diagnostic reagents and as immunogenic agents.
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7291462 |
TADG-15: an extracellular serine protease overexpressed in carcinomas
The present invention provides DNA encoding a TADG-15 protein as well as a TADG-15 protein. Also provided is a vector capable of expressing the DNA of the present invention adapted for expression...
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7291469 |
Mutant met and uses therefor
The present invention provides compositions and methods for detecting mutations in the proto-oncogene Met.
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7288641 |
Sulfotransferase 1E1 sequence variants
Isolated sulfotransferase nucleic acid molecules that include a nucleotide sequence variant and nucleotides flanking the sequence variant are described, as well as sulfotransferase allozymes....
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7288531 |
Potent inhibition of influenza virus by specifically designed short interfering RNA
This patent application discloses siRNA sequences against the constant region of the influenza virus nucleoprotein gene comprising:
Sense strand: 5′ UGAAGGAUCUUAUUUCUUCdTdT 3′ (SEQ ID NO: 1)...
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7288642 |
Sulfotransferase 2B1 pharmacogenetics
Isolated sulfotransferase nucleic acid molecules that include a nucleotide sequence variant and nucleotides flanking the sequence variant are described, as are sulfotransferase allozymes. Methods...
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7288374 |
Process for the detection of oxidative stress and kit for its implementation
The present invention relates to a process for detecting oxidative stress in a sample and to a kit for this implementation. According to one embodiment the present invention provides a method for...
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7285648 |
IL-1 delta DNA and polypeptides
DNA encoding IL-1 delta polypeptides and methods for using the DNA and encoded polypeptides are disclosed.
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7285288 |
Inhibition of Bcl-2 protein expression by liposomal antisense oligodeoxynucleotides
The present invention provides novel compositions and methods for use in the treatment of Bcl-2-associated diseases like cancer, specifically, in the treatment of follicular lymphoma (FL). The...
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7285388 |
Methods for identification of alport syndrome
Animals with mutations in COL4a4 present with autosomal recessive Alport Syndrome (ARAS). Through sequencing of COL4a4, the mutation causative for ARAS in the English Cocker Spaniel (ECS) has been...
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7285242 |
Biochemical analysis unit and biochemical analyzing method using the same
A biochemical analysis unit includes a substrate made of a material capable of attenuating radiation energy and/or light energy and formed with a plurality of holes, and a plurality of absorptive...
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7285401 |
Method and reagents for detecting nucleic acid sequences
The present invention is directed to a method for detecting an amplification product. Amplification is accomplished through the use of a plurality of detection probes. The present invention is also...
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7282328 |
Helicase dependent amplification of nucleic acids
Methods and a kit are provided for selectively and exponentially amplifying nucleic acids and include the use of a helicase preparation and a DNA polymerase such that the amplification can be...
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7282330 |
Methods and apparati using single polymer analysis
The invention relates to methods for analyzing and characterizing single polymers such as nucleic acid molecules. In preferred embodiments, the single molecules are analyzed using single molecule...
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7282333 |
Methods and compositions for nucleic acid analysis
The present invention relates to improved methods and composition for nucleic acid analysis. In particular, the present invention provides improved methods and compositions for carrying out nucleic...
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7282355 |
Nucleic acid detection method
Disclosed are methods for detecting a target nucleic acid molecule having a known sequence among a plurality of nucleic acid molecules. The method includes hybridizing two oligonucleotides to...
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7282331 |
Method for improved specificity in probe based assays
Disclosed are compositions and methods for analyzing a target sequence in a sample. Generally, the method includes use of at least one pair of probes (Probe A and Probe B). In one embodiment, Probe...
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