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8183359 |
Kits for amplifying DNA
Kits for amplifying DNA which include a priming oligonucleotide that hybridizes to a 3′-end of a DNA target sequence, a displacer oligonucleotide that hybridizes to a target nucleic acid c...
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8183355 |
Method for the synthesis of oligonucleotide derivatives
Method for the synthesis of nucleotide derivatives wherein molecules of interest are grafted on the oligonucleotide with the help of a “click chemistry” reaction between an azide function on the...
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8183360 |
Population scale HLA-typing and uses thereof
The present invention provides a portable system for real-time population-scale HLA genotyping and/or allelotyping in a field environment and methods of such population-scale HLA genotyping. The...
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8178297 |
Method of detecting canine exercise-induced collapse
The present invention relates to diagnosing Canine Exercise-Induced Collapse (EIC).
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8178659 |
Targets for the identification of antibiotics that are not susceptible to antibiotic resistance
To identify conserved and variable regions of the 16 S rRNA, an instant evolution experiment was performed on the entire 16 S rRNA. Analysis of these mutants identified regions that are required...
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8173764 |
Solubilization and targeted delivery of drugs with self-assembling amphiphilic polymers
There are provided amphiphilic biodegradable copolymers comprising a hydrophilic backbone with pendant aliphatic groups as the hydrophobic component. The polymers form nanoscale molecular...
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8173795 |
Methods and compositions for identifying and characterizing hepatitis C
The invention provides novel methods and compositions for amplifying portions of the HCV genome. The nucleic acid sequences set forth as SEQ ID NOS:1-64 derived from HCV cDNA and functional...
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8168773 |
Methods for monitoring multiple gene expression
The present invention relates to methods for monitoring differential expression of a plurality of genes in a first Bacillus cell relative to expression of the same genes in one or more second...
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8168387 |
Oligonucleotides, use thereof, detecting method and kit for diagnosing the presence of H5 and N1 genes of the Influenza A virus
The present invention relates to a double pair of oligonucleotides for amplifying two target sequences located, respectively, in the H5 and N1 genes of the genome of the Influenza A virus, said...
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8168381 |
Template directed split and mix systhesis of small molecule libraries
The present invention provides a method for combining the advantages of encoded molecule fragments made by split and mix synthesis with the advantages of template directed synthesis of molecules....
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8168390 |
Method and apparatus for diagnosing age-related macular degeneration
Disclosed is a method for identifying an individual who has an altered risk for developing age-related macular degeneration comprising detecting an insertion/deletion polymorphism in the ARMS2 gene.
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8163485 |
Differential enzymatic fragmentation
The present invention provides methods for detecting the presence of methylation at a locus within a population of nucleic acids.
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8163524 |
Comparative analysis of extracellular RNA species
The invention provides methods for detecting tumor-associated RNA in plasma, serum, and other bodily fluids. In particular, the invention provides methods for detecting translocated gene RNA,...
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8163896 |
Bioinformatically detectable group of novel regulatory genes and uses thereof
The present invention relates to a first group of novel genes, here identified as genomic address messenger or GAM genes, and a second group of novel operon-like genes, here identified as genomic...
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8163484 |
Light emission modifiers and their uses in nucleic acid detection, amplification and analysis
The present invention relates to methods and reagents for modifying the emission of light from labeled nucleic acids for the purpose of real time detection, analysis, and quantitation of nucleic...
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8163897 |
5-bromo-2′-deoxy-uridine labeled nucleotide triphosphates and nucleic acid probes and methods of making and using the same
5-bromo-2′-deoxy-uridine (BrdU) labeled nucleotide triphosphates and nucleic acid probes are described herein. The BrdU labeled nucleotide triphosphates include a linker between the nucleotide t...
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8163483 |
Compositions and methods for spinocerebellar ataxia
Mutations in the KCNC3 (Kv3.3) voltage-gated potassium channel gene result in spinocerebellar ataxia.
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8163486 |
Probe, probe set, probe carrier, and testing method
A probe, a set of probes, and a probe carrier on which the probe or the set of probes is immobilized, are provided for classification of fungus species. The probe or the set of probes is capable of...
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8163480 |
Nucleic acid size detection method
The present invention provides methods of determining the size of a particular nucleic acid segment of interest in a sample of nucleic acids through fragmentation of DNA, size fractionation, an...
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8163711 |
Compositions and methods for inhibiting expression of the HAMP gene
The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of the HAMP gene (HAMP gene), comprising an antisense strand having a nucleotide sequence which is...
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8163477 |
Nuclease-based method for detecting and quantitating oligonucleotides
A method for quantitating an oligonucleotide in a sample of bodily fluid and/or extract is provided. The method provides for the detection and/or localization of oligonucleotides, including...
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8158344 |
Methods and compositions for correlating genetic markers with multiple sclerosis
The present invention provides, in certain aspects, a method of identifying a subject as having an increased risk of developing multiple sclerosis, comprising detecting in the subject the presence...
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8158353 |
Species-specific and quantitative detection of CNS tissue in meat and meat products
The present invention concerns a method for the species-specific and quantitative detection of CNS tissue in meat and meat products of the ruminant species bovine, ovine and caprine or porcine by a...
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8158345 |
Labeled oligonucleotide
The present invention relates to a labeled oligonucleotide comprising a first nucleotide segment and a second nucleotide segment, complementary to a target sequence, a fluorophore, a quencher and...
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8158766 |
Genes with ES cell-specific expression
The present invention relates to a probe for selecting ES cells, which characteristically contains one of DNAs having base sequences depicted in SEQ ID Nos; 1, 2, 3, 4, 5, 6, 7 and 8, or DNAs...
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8158346 |
Labelled nucleotides
Nucleosides and nucleotides are disclosed that are linked to detectable labels via a cleavable linker group.
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8153366 |
Methods and compositions for predicting drug responses
The present invention relates to methods and compositions for predicting drug responses. In particular, the present invention provides methods and compositions for determining individualized...
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8153371 |
Probe, probe set, probe carrier, and testing method
A probe, a set of probes, and a probe carrier on which the probe or the set of probes is immobilized, are provided for classification of fungus species. The probe or the set of probes is capable of...
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8153401 |
Method for direct amplification from crude nucleic acid samples
The present teachings relate to improved methods, kits, and reaction mixtures for amplifying nucleic acids. In some embodiments a novel direct buffer formulation is provided which allows for the...
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8153365 |
Oligonucleotide analogues
The present invention relates to novel bicyclic and tricyclic nucleoside and nucleotide analogues as well as to oligonucleotides comprising such elements. The nucleotide analogues, LNAs (Locked...
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8153773 |
Synthesis and use of anti-reverse phosphorothioate analogs of the messenger RNA cap
New RNA cap analogs are disclosed containing one or more phosphorothioates groups. The analogs also contain modifications at the 2′-O position of 7-methylguanosine that prevent them from being i...
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8153375 |
Compositions and methods for nucleic acid sequencing
Compositions and methods for nucleic acid sequencing include template constructs that comprise double stranded portions in a partially or completely contiguous constructs, to provide for redundant...
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8153361 |
Dynamic and combinatorial synthesis of polymerase primers
This invention relates to the field of nucleic acid chemistry, more specifically to compositions of matter that are nucleic acid analogs, and processes that use them. Still more specifically, these...
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8148511 |
Methods and compositions for the detection and quantification of E. coli and Enterococcus
The present invention is drawn to methods and compositions for the rapid assessment of fecal indicator bacteria in a sample. Provided herein are novel primer and probe compositions for use in...
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8148515 |
Detection using a dye and a dye modifier
The present invention relates to dyes in general. The present invention provides a wide range of dyes and kits containing the same, which are applicable for labeling a variety of biomolecules such...
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8148066 |
Method of nucleic acid hybridization
The present invention relates to a nucleic acid hybridization method and in particular to a method using a microfluidic chip-based hybridization device with modified procedures which shows the...
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8148075 |
Methods for producing nucleic acid hybridization probes that amplify hybridization signal by promoting network formation
This invention describes methods for the generation of nucleic acid probes that improve the sensitivity of hybridization assays. The sensitivity increase results from structural modifications of...
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8148064 |
Labelled nucleotides
Nucleosides and nucleotides are disclosed that are linked to detectable labels via a cleavable linker group.
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8145433 |
High-resolution melting analysis
The present invention relates to methods and systems for the analysis of the dissociation behavior of nucleic acids and the identification of nucleic acids. In one aspect, methods and systems are...
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8143008 |
Method of nucleic acid amplification
A nucleic acid molecule can be annealed to an appropriate immobilized primer. The primer can then be extended and the molecule and the primer can be separated from one another. The extended primer...
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8143001 |
Methods for analysis of nucleic acid methylation status and methods for fragmentation, labeling and immobilization of nucleic acids
The invention relates to methods for analysis of nucleic acid methylation status, and fragmentation and/or labeling and/or immobilization of nucleic acids. More particularly, the invention relates...
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8143384 |
Mutation of PRPS1 gene causing CMTX5 disease and the use thereof
Disclosed is a gene mutation associated with peripheral neuropathy associated with sensorineural hearing loss and optic neuropathy. More specifically, disclosed are: a polynucleotide comprising a...
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8143388 |
Method and test kit for quantitative determination of polynucleotides in a mixture
The invention relates to a method and test kit for quantitative determination of the amounts or relative proportions of polynucleotides in a mixture. The invention enables assessment of dynamic...
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8143000 |
Mutation within the connexin 26 gene responsible for prelingual non-syndromic deafness and method of detection
A purified polynucleotide having a chain of nucleotides corresponding to a mutated sequence, which in a wild form encodes a polypeptide implicated in hereditary sensory defect, wherein said mutated...
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8137915 |
Genes involved in intestinal inflammatory diseases and use thereof
The invention concerns genes involved in inflammatory and/or immune diseases and some cancers, in particular intestinal cryptogenic inflammatory diseases, and proteins coded by these genes. The...
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8137912 |
Methods for the diagnosis of fetal abnormalities
The present invention relates to methods for detecting, enriching, and analyzing rare cells that are present in the blood, e.g. fetal cells. The invention further features methods of analyzing rare...
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8138326 |
Method and kit for quantitative and qualitative determination of human papillomavirus
The present invention relates to a method and kit for quantitative and qualitative determination of human papillomavirus, HPV, in a sample. More precisely, for quantitative and qualitative...
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8137916 |
Susceptibility gene for alzheimer's disease
The invention relates to genetic screens for susceptibility to Alzheimer's disease. In particular, the invention provides genetic screens based on genotyping of the p21E2c31 C/A polymorphism and/or...
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8137913 |
Methods for nucleic acid manipulation
A method for replicating and amplifying a target nucleic acid sequence is described. A method of the invention involves the formation of a recombination intermediate without the prior denaturing of...
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8137906 |
Method for the synthesis of DNA fragments
The invention relates to a method that can be carried out in parallel and automated for the production of any nucleic acid, comprising the following steps: a) coupling an oligonucleotide to a solid...
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