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8183359 Kits for amplifying DNA  
Kits for amplifying DNA which include a priming oligonucleotide that hybridizes to a 3′-end of a DNA target sequence, a displacer oligonucleotide that hybridizes to a target nucleic acid c...
8183355 Method for the synthesis of oligonucleotide derivatives  
Method for the synthesis of nucleotide derivatives wherein molecules of interest are grafted on the oligonucleotide with the help of a “click chemistry” reaction between an azide function on the...
8183360 Population scale HLA-typing and uses thereof  
The present invention provides a portable system for real-time population-scale HLA genotyping and/or allelotyping in a field environment and methods of such population-scale HLA genotyping. The...
8178297 Method of detecting canine exercise-induced collapse  
The present invention relates to diagnosing Canine Exercise-Induced Collapse (EIC).
8178659 Targets for the identification of antibiotics that are not susceptible to antibiotic resistance  
To identify conserved and variable regions of the 16 S rRNA, an instant evolution experiment was performed on the entire 16 S rRNA. Analysis of these mutants identified regions that are required...
8173764 Solubilization and targeted delivery of drugs with self-assembling amphiphilic polymers  
There are provided amphiphilic biodegradable copolymers comprising a hydrophilic backbone with pendant aliphatic groups as the hydrophobic component. The polymers form nanoscale molecular...
8173795 Methods and compositions for identifying and characterizing hepatitis C  
The invention provides novel methods and compositions for amplifying portions of the HCV genome. The nucleic acid sequences set forth as SEQ ID NOS:1-64 derived from HCV cDNA and functional...
8168773 Methods for monitoring multiple gene expression  
The present invention relates to methods for monitoring differential expression of a plurality of genes in a first Bacillus cell relative to expression of the same genes in one or more second...
8168387 Oligonucleotides, use thereof, detecting method and kit for diagnosing the presence of H5 and N1 genes of the Influenza A virus  
The present invention relates to a double pair of oligonucleotides for amplifying two target sequences located, respectively, in the H5 and N1 genes of the genome of the Influenza A virus, said...
8168381 Template directed split and mix systhesis of small molecule libraries  
The present invention provides a method for combining the advantages of encoded molecule fragments made by split and mix synthesis with the advantages of template directed synthesis of molecules....
8168390 Method and apparatus for diagnosing age-related macular degeneration  
Disclosed is a method for identifying an individual who has an altered risk for developing age-related macular degeneration comprising detecting an insertion/deletion polymorphism in the ARMS2 gene.
8163485 Differential enzymatic fragmentation  
The present invention provides methods for detecting the presence of methylation at a locus within a population of nucleic acids.
8163524 Comparative analysis of extracellular RNA species  
The invention provides methods for detecting tumor-associated RNA in plasma, serum, and other bodily fluids. In particular, the invention provides methods for detecting translocated gene RNA,...
8163896 Bioinformatically detectable group of novel regulatory genes and uses thereof  
The present invention relates to a first group of novel genes, here identified as genomic address messenger or GAM genes, and a second group of novel operon-like genes, here identified as genomic...
8163484 Light emission modifiers and their uses in nucleic acid detection, amplification and analysis  
The present invention relates to methods and reagents for modifying the emission of light from labeled nucleic acids for the purpose of real time detection, analysis, and quantitation of nucleic...
8163897 5-bromo-2′-deoxy-uridine labeled nucleotide triphosphates and nucleic acid probes and methods of making and using the same  
5-bromo-2′-deoxy-uridine (BrdU) labeled nucleotide triphosphates and nucleic acid probes are described herein. The BrdU labeled nucleotide triphosphates include a linker between the nucleotide t...
8163483 Compositions and methods for spinocerebellar ataxia  
Mutations in the KCNC3 (Kv3.3) voltage-gated potassium channel gene result in spinocerebellar ataxia.
8163486 Probe, probe set, probe carrier, and testing method  
A probe, a set of probes, and a probe carrier on which the probe or the set of probes is immobilized, are provided for classification of fungus species. The probe or the set of probes is capable of...
8163480 Nucleic acid size detection method  
The present invention provides methods of determining the size of a particular nucleic acid segment of interest in a sample of nucleic acids through fragmentation of DNA, size fractionation, an...
8163711 Compositions and methods for inhibiting expression of the HAMP gene  
The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of the HAMP gene (HAMP gene), comprising an antisense strand having a nucleotide sequence which is...
8163477 Nuclease-based method for detecting and quantitating oligonucleotides  
A method for quantitating an oligonucleotide in a sample of bodily fluid and/or extract is provided. The method provides for the detection and/or localization of oligonucleotides, including...
8158344 Methods and compositions for correlating genetic markers with multiple sclerosis  
The present invention provides, in certain aspects, a method of identifying a subject as having an increased risk of developing multiple sclerosis, comprising detecting in the subject the presence...
8158353 Species-specific and quantitative detection of CNS tissue in meat and meat products  
The present invention concerns a method for the species-specific and quantitative detection of CNS tissue in meat and meat products of the ruminant species bovine, ovine and caprine or porcine by a...
8158345 Labeled oligonucleotide  
The present invention relates to a labeled oligonucleotide comprising a first nucleotide segment and a second nucleotide segment, complementary to a target sequence, a fluorophore, a quencher and...
8158766 Genes with ES cell-specific expression  
The present invention relates to a probe for selecting ES cells, which characteristically contains one of DNAs having base sequences depicted in SEQ ID Nos; 1, 2, 3, 4, 5, 6, 7 and 8, or DNAs...
8158346 Labelled nucleotides  
Nucleosides and nucleotides are disclosed that are linked to detectable labels via a cleavable linker group.
8153366 Methods and compositions for predicting drug responses  
The present invention relates to methods and compositions for predicting drug responses. In particular, the present invention provides methods and compositions for determining individualized...
8153371 Probe, probe set, probe carrier, and testing method  
A probe, a set of probes, and a probe carrier on which the probe or the set of probes is immobilized, are provided for classification of fungus species. The probe or the set of probes is capable of...
8153401 Method for direct amplification from crude nucleic acid samples  
The present teachings relate to improved methods, kits, and reaction mixtures for amplifying nucleic acids. In some embodiments a novel direct buffer formulation is provided which allows for the...
8153365 Oligonucleotide analogues  
The present invention relates to novel bicyclic and tricyclic nucleoside and nucleotide analogues as well as to oligonucleotides comprising such elements. The nucleotide analogues, LNAs (Locked...
8153773 Synthesis and use of anti-reverse phosphorothioate analogs of the messenger RNA cap  
New RNA cap analogs are disclosed containing one or more phosphorothioates groups. The analogs also contain modifications at the 2′-O position of 7-methylguanosine that prevent them from being i...
8153375 Compositions and methods for nucleic acid sequencing  
Compositions and methods for nucleic acid sequencing include template constructs that comprise double stranded portions in a partially or completely contiguous constructs, to provide for redundant...
8153361 Dynamic and combinatorial synthesis of polymerase primers  
This invention relates to the field of nucleic acid chemistry, more specifically to compositions of matter that are nucleic acid analogs, and processes that use them. Still more specifically, these...
8148511 Methods and compositions for the detection and quantification of E. coli and Enterococcus  
The present invention is drawn to methods and compositions for the rapid assessment of fecal indicator bacteria in a sample. Provided herein are novel primer and probe compositions for use in...
8148515 Detection using a dye and a dye modifier  
The present invention relates to dyes in general. The present invention provides a wide range of dyes and kits containing the same, which are applicable for labeling a variety of biomolecules such...
8148066 Method of nucleic acid hybridization  
The present invention relates to a nucleic acid hybridization method and in particular to a method using a microfluidic chip-based hybridization device with modified procedures which shows the...
8148075 Methods for producing nucleic acid hybridization probes that amplify hybridization signal by promoting network formation  
This invention describes methods for the generation of nucleic acid probes that improve the sensitivity of hybridization assays. The sensitivity increase results from structural modifications of...
8148064 Labelled nucleotides  
Nucleosides and nucleotides are disclosed that are linked to detectable labels via a cleavable linker group.
8145433 High-resolution melting analysis  
The present invention relates to methods and systems for the analysis of the dissociation behavior of nucleic acids and the identification of nucleic acids. In one aspect, methods and systems are...
8143008 Method of nucleic acid amplification  
A nucleic acid molecule can be annealed to an appropriate immobilized primer. The primer can then be extended and the molecule and the primer can be separated from one another. The extended primer...
8143001 Methods for analysis of nucleic acid methylation status and methods for fragmentation, labeling and immobilization of nucleic acids  
The invention relates to methods for analysis of nucleic acid methylation status, and fragmentation and/or labeling and/or immobilization of nucleic acids. More particularly, the invention relates...
8143384 Mutation of PRPS1 gene causing CMTX5 disease and the use thereof  
Disclosed is a gene mutation associated with peripheral neuropathy associated with sensorineural hearing loss and optic neuropathy. More specifically, disclosed are: a polynucleotide comprising a...
8143388 Method and test kit for quantitative determination of polynucleotides in a mixture  
The invention relates to a method and test kit for quantitative determination of the amounts or relative proportions of polynucleotides in a mixture. The invention enables assessment of dynamic...
8143000 Mutation within the connexin 26 gene responsible for prelingual non-syndromic deafness and method of detection  
A purified polynucleotide having a chain of nucleotides corresponding to a mutated sequence, which in a wild form encodes a polypeptide implicated in hereditary sensory defect, wherein said mutated...
8137915 Genes involved in intestinal inflammatory diseases and use thereof  
The invention concerns genes involved in inflammatory and/or immune diseases and some cancers, in particular intestinal cryptogenic inflammatory diseases, and proteins coded by these genes. The...
8137912 Methods for the diagnosis of fetal abnormalities  
The present invention relates to methods for detecting, enriching, and analyzing rare cells that are present in the blood, e.g. fetal cells. The invention further features methods of analyzing rare...
8138326 Method and kit for quantitative and qualitative determination of human papillomavirus  
The present invention relates to a method and kit for quantitative and qualitative determination of human papillomavirus, HPV, in a sample. More precisely, for quantitative and qualitative...
8137916 Susceptibility gene for alzheimer's disease  
The invention relates to genetic screens for susceptibility to Alzheimer's disease. In particular, the invention provides genetic screens based on genotyping of the p21E2c31 C/A polymorphism and/or...
8137913 Methods for nucleic acid manipulation  
A method for replicating and amplifying a target nucleic acid sequence is described. A method of the invention involves the formation of a recombination intermediate without the prior denaturing of...
8137906 Method for the synthesis of DNA fragments  
The invention relates to a method that can be carried out in parallel and automated for the production of any nucleic acid, comprising the following steps: a) coupling an oligonucleotide to a solid...