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7635565 |
Analyzing blood type with identification of patient by genotyping
This invention provides compositions and methods for genetic testing of an organism and for correlating the results of the genetic testing with a unique marker that unambiguously identifies the...
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7635566 |
Methods and compositions for isolating nucleic acid sequence variants
The invention is drawn to isolating sequence variants of a genetic locus of interest using a modified iterative primer extension method. The nucleic acids analyzed are generally single stranded and...
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7636637 |
Variable length probe selection
The present invention provides novel method for increasing the efficiency and accuracy of high-throughput mutation mapping and genome resequencing by using a variable length probe selection...
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7635578 |
Massive parallel method for decoding DNA and RNA
This invention provides methods for attaching a nucleic acid to a solid surface and for sequencing nucleic acid by detecting the identity of each nucleotide analogue after the nucleotide analogue...
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7635558 |
Method for analyzing nucleic acid and use thereof for evaluating the degree of mRNA editing of the serotonin 5-HT2C receptor
The invention concerns a method for analyzing nucleic acids using a small-size probe array comprising deoxyinostines (dI) instead of deoxyguanogines (dG). The invention also concerns such probe...
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7635799 |
Corn event 3272 and methods for detection thereof
A novel transgenic corn event designated 3272, is disclosed. The invention relates to DNA sequences of the recombinant constructs inserted into the corn genome that resulted in the 3272 event and...
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7635769 |
Oligoribonucleotide derivatives for specific inhibition of gene expression
The present invention relates to oligoribonucleotide derivatives which have a 2′5′-linked oligoribonucleotide residue without a 5′-phosphate residue on the 3′ end and to the use thereof for...
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7632642 |
Primers, probes and methods for nucleic acid amplification
Homogenous detection during or following PCR amplification, preferably LATE-PCR, utilizing fluorescent DNA dye and indirectly excitable labeled primers and probes, improves reproducibility and...
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7632932 |
Oligonucleotides comprising a ligand tethered to a modified or non-natural nucleobase
One aspect of the present invention relates to a double-stranded oligonucleotide comprising at least one ligand tethered to an altered or non-natural nucleobase. In certain embodiments, the...
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7632931 |
Endogeneous nucleic acid fragment associated with an autoimmune disease, labeling method and reagent
The invention concerns an endogenic nucleic fragment, such as an isolated retrovirus, integrated in the human DNA genome, the fragment being characterized in that it comprises, or consists of, at...
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7632934 |
Oligonucleotides for amplifying Trichomonas vaginalis-derived nucleic acid
Oligonucleotides useful for determining the presence of Trichomonas vaginalis in a test sample. The oligonucleotides may be incorporated into detection probes, helper probes, capture probes and...
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7632639 |
Signal amplification method for detecting mutated gene
There is provided a signal amplification method for detecting a mutated gene, which can increase the detection sensitivity of mutated genes on a DNA chip according to the PALSAR method, can...
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7629448 |
Compositions for detection and analysis of polynucleotides using light harvesting multichromophores
Methods, compositions and articles of manufacture for assaying a sample for a target polynucleotide are provided. A sample suspected of containing the target polynucleotide is contacted with a...
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7630837 |
Real-time gene quantification with internal standards
The present invention is directed to a nucleic acid quantification kit and method for determining the initial concentration or mass fraction of a target nucleic acid present in a sample....
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7629324 |
Antisense oligonucleotides for treating atopic diseases and neoplastic cell proliferation
The present invention relates to the use of antisense oligonucleotides directed against specific nucleic acid sequences coding for receptors, alone or in combination, in order to inhibit the...
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7629118 |
Method of testing wheat
A method of testing the presence/absence of wheat in a food by performing PCR with the use of primers which have been designed on the basis of data obtained from a part of a gene of wheat. This...
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7629164 |
Methods for genotyping polymorphisms in humans
The invention provides nucleic acid sequences that are complementary, in one embodiment, to a collection of human single nucleotide polymorphisms. The invention provides the sequences in such a way...
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7629151 |
Method and apparatus for the automated generation of nucleic acid ligands
The present invention includes a method and device for performing automated SELEX. The steps of the SELEX process are performed at one or more work stations on a work surface by a robotic...
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7625706 |
Methods and apparatus for characterizing polynucleotides
Systems and methods for analysis of polymers, e.g., polynucleotides, are provided. The systems are capable of analyzing a polymer at a specified rate. One such analysis system includes a structure...
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7625705 |
Methods and compositions for detection of a target nucleic acid sequence utilizing a probe with a 3′ flap
The invention provides compositions, kits and methods of generating a signal indicative of the presence of a target nucleic acid sequence in a sample by forming a cleavage structure. The cleavage...
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7625699 |
Genetic polymorphisms associated with coronary stenosis, methods of detection and uses thereof
The present invention is based on the discovery of genetic polymorphisms that are associated with coronary stenosis. In particular, the present invention relates to nucleic acid molecules...
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7625750 |
Compositions for DNA mediated gene silencing
DNA compositions that mediate gene silencing via RNA interference are provided. The DNA compositions include an RNA polymerase III promoter, which drives expression of a nucleotide sequence...
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7625698 |
DNA markers for meat tenderness
A method for assessing the tenderness of meat from an animal, comprising the step of testing the animal for the presence or absence of a genetic marker selected from the group consisting of:
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7625704 |
Methods and compositions for identifying bacteria associated with bacteria vaginosis
The present invention provides methods and compositions for identifying bacteria associated with bacterial vaginosis and diagnosing bacterial vaginosis in a subject.
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7622279 |
Photocleavable fluorescent nucleotides for DNA sequencing on chip constructed by site-specific coupling chemistry
This invention provides a method for determining the sequence of a DNA or an RNA, wherein (i) about 1000 or fewer copies of the DNA or RNA are bound to a solid substrate via 1,3-dipolar...
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7622281 |
Methods and compositions for clonal amplification of nucleic acid
Described herein are methods and compositions relating to amplifying nucleic acid. In certain embodiments, the invention provides methods for labeling and amplifying a nucleic acid molecule.
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RE41005 |
Beads bound to a solid support and to nucleic acids
Novel compositions comprised of at least one bead conjugated to a solid support and further conjugated to at least one nucleic acid and preferred methods for making the novel compositions are...
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7619079 |
Db, the receptor for leptin, nucleic acids encoding the receptor, and uses thereof
The present invention relates to identification of a receptor for a satiety factor, which is involved in body weight homeostasis. Mutations in this receptor are associated with obese phenotypes. In...
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7619080 |
Oligonucleotides of a chicken leukemia inhibitory factor (LIF) gene
The present invention is to provide a chicken LIF gene. Based on this genetic information, LIF protein derived from the chicken can be stably supplied and it solves the problems of the creation of...
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7618777 |
Composition and method for array hybridization
The present disclosure relates to a system, composition, and method for hybridizing a microarray. The composition includes a superwetting agent. The method includes contacting the microarray with...
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7618780 |
Use of mass labelled probes to detect target nucleic acids using mass spectrometry
The invention relates to the use of mass labelled probes to characterize nucleic acids by mass spectrometry. Thus the invention provides methods of detecting the presence of a target nucleic acid...
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7615618 |
Oligonucleotides comprising a non-phosphate backbone linkage
One aspect of the present invention relates to a ribonucleoside substituted with a phosphonamidite group at the 3′-position. In certain embodiments, the phosphonamidite is an alkyl...
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7615625 |
In vitro amplification of nucleic acid molecules via circular replicons
Methods and compositions suitable for accomplishing the in vitro amplification of nucleic acid molecules via enzymatic means are provided. The preferred means employ circular rather than linear...
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7615627 |
RNA interference mediated inhibition of aurorakinase B and its combinations as anticancer therapy
This invention relates to the use of short nucleic acid molecules that modulate Aurora-B kinase (AurkB) expression. The invention includes compounds, compositions and methods useful for the...
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7615350 |
Methods for haplotyping genomic DNA
The present invention provides a novel method for specifically isolating and separating large segments of genomic DNA that can subsequently be used to determine a genomic haplotype. The invention...
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7615343 |
Electrical readout of the binding of analyte molecules to probe molecules
The invention relates to the detection of the binding of analyte molecules, for example biopolymer molecules, to immobilized capture substance molecules. The invention consists in using...
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7615347 |
Method for trapping nucleic acids using divalent metal ions
A method for trapping nucleic acids on a surface of a solid phase substrate, which comprises the step of contacting a sample containing nucleic acids and having a pH of 12 or higher with the...
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7615341 |
Disease susceptibility gene for rheumatoid arthritis, protein thereof, evaluation method and evaluation kit for evaluating onset possibility of rheumatoid arthritis by using those, and remedy and curing medicine for rheumatoid arthritis
An gene was identified as a RA disease susceptibility gene on Human Chromosome 8, the gene coding a protein that has an amino acid sequence shown in SEQ. ID NO. 1 and that has such mutation that...
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7615342 |
ACTN3 genotype screen for athletic performance
The present invention concerns novel methods of selecting or matching a sport or sporting event to an individual (e.g. a sprint/power sport or an endurance sport) and predicting athletic...
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7615621 |
High lysine maize compositions and methods for detection thereof
Disclosed herein are assays for detecting the presence of a lysine-increasing transgenic event based on the DNA sequence of the exogenous DNA construct inserted into the maize genome and of genomic...
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7615348 |
Electrochemical method to measure DNA attachment to an electrode surface in the presence of molecular oxygen
The present disclosure provides methods and compositions for conducting an assay to detect a polynucleotide. In particular, ruthenium complexes having reduction potentials that do not coincide with...
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7611838 |
Biologically-active DNA-binding sites and related methods
The invention relates to the identification of biologically-active DNA-binding sites to which a protein of interest binds in a cell. The invention also relates to the identification of agents and...
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7611841 |
Method for detecting methylation of promoter using restriction enzyme and DNA chip
A method for detecting the methylation of promoters using HpaII, a methylation-sensitive restriction enzyme. In such method, DNAs, derived from clinical samples or subjects to be diagnosed, are cut...
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7611871 |
Method for the specific determination of DNA sequences by means of parallel amplification
The invention concerns a general method for the specific determination of DNA sequences by means of parallel amplification through nested polymerase chain reaction in a combined...
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7611869 |
Multiplexed methylation detection methods
The present invention is directed to sensitive and accurate multiplexed assays for target analyte detection and detection of methylation in nucleic acid samples.
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7611892 |
Prostate-specific or testis-specific nucleic acid molecules, polypeptides, and diagnostic and therapeutic methods
The invention provides novel STAMP2 nucleic acid molecules, polypeptides, antibodies, and modulatory compounds for use in methods of diagnosing, treating, and preventing diseases and conditions of...
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7612187 |
2-azapurine compounds and their uses
Within oligonucleotides 2-azapurine and especially 2-azaadenine bases form specifically base pairs with guanine. This base pair is of analogous stability as an adenine-thymine but less stable than...
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7611870 |
Methods for identifying cancer risk
The present invention provides methods and kits for identifying an increased risk of developing cancer in a subject. The methods include analyzing a first biological sample, such as a blood sample,...
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7608393 |
Methods of predicting a benefit of antioxidant therapy for prevention of cardiovascular disease in hyperglycemic patients
A method of determining a potential of a diabetic patient to benefit from anti oxidant therapy for treatment of a vascular complication, the method comprising determining a haptoglobin phenotype of...
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7608401 |
Mutations in the ferroportin 1 gene associated with hereditary haemochromatosis
The present invention relates to mutations in the gene coding for ferroportin 1 associated with hereditary haemochromatosis and methods for the diagnosis of hereditary haemochromatosis based on the...
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