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7390661 |
Artificial bidirectional promoter for activation of gene expression
A bidirectional module for activation of gene expression and regulation of transcription in both directions is disclosed. The bidirectional module comprises multiple cis regulatory DNA sequence...
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7390655 |
Promoter molecules for use in plants
The present invention provides DNA molecules isolated from corn and sorghum plants that are useful for expressing transgenes in plants. The present invention also provides expression constructs...
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7390639 |
Staphylococcal nuclease fusion proteins for the production of recombinant peptides
Peptides are produced as fusions with a suitable carrier protein. The carrier protein disclosed herein are adapted from the N-terminal domain of staphylococcus nuclease. This novel carrier...
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7390636 |
Method for construction and use of Kluyveromyces lactis promoter variants in K. lactis that substantially lack E. coli transcriptional capability
Methods and compositions are provided relating to production of recombinant protein in yeast. A modified P LAC4 is described where one or more mutations may be introduced into the Pribnow box-like...
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7388127 |
Multiple stress-inducible peroxidase promoter derived from Ipomoea batatas
The present invention relates to a multiple stress inducible promoter, more particularly to a multiple stress inducible peroxidase promoter derived by Ipomoea batatas , a expression vector for...
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7388091 |
Harvest-inducible genes from alfalfa (Medicago sativa) and methods of use thereof
The present invention relates to novel inducible genes from alfalfa. These genes are highly induced following mechanical harvesting or wounding of alfalfa. The genes are useful for inducible...
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7385105 |
Root active promoters and uses thereof
The present invention is directed to root active promoter sequences, polynucleotide constructs comprising the root active promoters and methods of identifying the root active promoters, or...
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7385048 |
Promoters and utilization thereof
The present invention relates to improved promoters and utilization thereof, in particular to promoters which are improved so as not to undergo methylation in the course of constructing...
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7384768 |
Nucleic acids and polypeptides specific for pathogenic strains of the Neisseria genus
The invention concerns nucleic acids coding for polypeptides specific of the Neisseria genus pathogenic strains, the corresponding polypeptides, and their diagnostic and therapeutic applications.
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7381813 |
Nucleic acids encoding estrogen receptor ligand binding domain variants
Mutants of steroid receptor ligand binding domains and synthetic ligands which have specific binding affinities for these receptors are provided. The use of these LBD-ligand combinations for...
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7381405 |
Methods of preparing lymphocytes that express interleukin-2 and their use in the treatment of cancer
The invention provides methods of preparing autologous T-lymphocytes for re-introduction into a patient having cancer, which method comprises obtaining peripheral blood mononuclear cells (PBMCs)...
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7378572 |
Constitutive expression cassettes for regulation of plant expression
The present invention relates to expression cassettes comprising transcription regulating sequences with constitutive expression profiles in plants obtainable from Arabidopsis thaliana genes...
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7378571 |
Promoter, promoter control elements, and combinations, and uses thereof
The present invention is directed to promoter sequences and promoter control elements, polynucleotide constructs comprising the promoters and control elements, and methods of identifying the...
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7378485 |
Peptide nucleic acids with polyamide-containing backbones
A novel class of compounds, known as peptide nucleic acids, bind complementary ssDNA and RNA strands more strongly than a corresponding DNA. The peptide nucleic acids generally comprise ligands...
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7378274 |
Regulatory nucleic acid for the ABC1 gene, molecules modifying its activity and therapeutic uses
The present invention concerns a nucleic acid which is capable of regulating the transcription of the ABC1 gene, which is a causal gene for pathologies linked to a dysfunctioning of cholesterol...
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7378273 |
Expression vectors
The present invention provides novel regulatory elements and vectors for the expression of one or more proteins in a host cell. The present invention also provides methods for expressing one or...
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7378256 |
Aspergillus niger promoter for expressing genes in host cells
The present invention relates to isolated promoter sequences, particularly a promoter isolated from Aspergillus niger designated herein as A4-L or A4 and DNA constructs and vectors including the...
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7378244 |
Telomerase promoters sequences for screening telomerase modulators
Telomerase reverse transcriptase is part of the telomerase complex responsible for maintaining telomere length and increasing the replicative capacity of progenitor cells. Telomerase activity is...
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7375212 |
Modulation of Aurora B expression
Compounds, compositions and methods are provided for modulating the expression of Aurora B. The compositions comprise oligonucleotides, targeted to nucleic acid encoding Aurora B. Methods of using...
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7375209 |
Expression cassettes for seed-preferential expression in plants
The present invention relates to expression cassettes comprising transcription regulating sequences with seed-preferential or seed-specific expression profiles in plants obtainable from ...
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7375198 |
Modified nucleic acid probes
Oligonucleotide analogue arrays attached to solid substrates and methods related to the use thereof are provided. The oligonucleotide analogues hybridize to nucleic acids with either higher or...
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7371928 |
Plant seed-specific expression promoter derived from sesame and seed-specific expression vector comprising the promoter
Provided are a seed-specific expression promoter derived from sesame microsomal oleic acid desaturase (Si-FAD2) gene, an intron for expression enhancement, a seed-specific expression vector...
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7371925 |
Cytokinin oxidase promoter from maize
The present invention provides compositions and methods for regulating expression of nucleotide sequences in a plant. Compositions may comprise a novel nucleic acid sequence for a promoter with...
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7371848 |
Chimeric promoters comprising a caulimovirus promoter enhancer for use in plants
The present invention provides polynucleotide molecules useful for expressing transgenes in plants. More particularly, the present invention provides chimeric promoters comprising a Cauliflower...
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7371847 |
Yeast-origin promoter and vector and expression system using the same
The present invention provides a DNA fragment having a cold-inducible promoter function of yeast, which has high activity in a low temperature range, by identifying a DNA fragment, which exists in...
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7371734 |
Oligonucleotide compositions and their use for the modulation of immune responses
The present invention relates to 3′-OH, 5′-OH polynucleotide sequence compositions and methods for activating an immune response in an individual, and more preferably, for activating antigen...
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7371570 |
Cell-specific adenovirus vector comprising EBV-specific promoter
Replication-competent adenoviral vectors comprising an EBV-specific transcriptional regulatory element (TRE) operably linked to a gene required for adenovirus replication are provided. By providing...
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7365241 |
Seed specific USP promoters for expressing genes in plants
The present invention relates to the field of plant genetic engineering. More specifically, the present invention relates to seed specific gene expression. The present invention provides promoters...
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7365186 |
Vascular-preferred promoter sequences and uses thereof
Plant polynucleotide promoter sequences are provided, together with DNA constructs comprising the inventive polynucleotide. Methods for using the inventive constructs for regulating gene expression...
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7365185 |
Genomic plant sequences and uses thereof
The present invention discloses rice genomic promoter sequences. The promoters are particularly suited for use in rice and other cereal crops. Methods of modifying, producing, and using the...
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7365177 |
Recombinant plasmid expressing two fluorescence genes
Recombinant plasmids comprising (a) a ubiquitous promoter, (b) one fluorescent gene, the gene being operably liked to and inserted downstream of the ubiquitous promoter, (c) a skin-specific or...
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7364847 |
Nucleic acid participating in the formation of presenilin-2-gene exon 5-defective splicing variant
The present invention provides a means for treatment and/or prevention of a disease caused by aberrant splicing, a neurodegenerative disease represented by Alzheimer's disease, or the like. The...
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7364727 |
Metastatic colon cancer specific promoter and uses thereof
Colon cancer specific promoter sequences and adenovirus vehicles are provided. By providing for transcriptional initiating regulation dependent upon transcription factors that are only active in...
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7358419 |
Enhanced silk exsertion under stress
The invention provides methods for enhancing maize silk exsertion under stress conditions and compositions relating to such methods, including nucleic acids and proteins. The invention further...
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7358353 |
Nucleic acid and corresponding protein named 158P1D7 useful in the treatment and detection of bladder and other cancers
A novel gene (designated 158P1D7) and its encoded protein are described. While 158P1D7 exhibits tissue specific expression in normal adult tissue, it is aberrantly expressed in multiple cancers...
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7355096 |
Ryegrass pollen-specific promoters and expression constructs
The present invention relates to a nucleic acid molecule capable of modifying pollen-specific expression, constructs including the molecule and methods of using the molecule.
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7354909 |
Method for rapid generation of mature dendritic cells
Novel methods for rapidly generating dendritic cells are disclosed herein. The methods include contacting a dendritic cell precursor with a D ODN to generate a mature dendritic cell. In one...
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7354390 |
Seed coat specific nucleotide sequence encoding peroxidase
A novel seed coat specific peroxidase genomic sequence is characterized and presented. The seed coat peroxidase is translated as a 352 amino acid precursor protein of 38 kDa comprising a 26 amino...
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7351879 |
Compositions and methods for modulating plant development
The present invention provides compositions and methods for modulating plant development by modulating the expression or activity of plant polycomb genes including FIE and MEA.
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7351818 |
Method to improve translation of polypeptides by using untranslated regions from heat-shock proteins
Untranslated regions associated with the heat shock response can be used to obtain increased efficiency of translation of polypeptides that are not necessarily normally associated with the heat...
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7351813 |
Liver-specific gene expression cassettes, and methods of use
In one aspect, the present invention provides nucleic acid expression cassettes that are predominantly expressed in the mammalian liver. The present invention also provides vectors comprising a...
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7351550 |
Exoenzyme toxin of Aeromonas salmonicida, and uses thereof
A protein toxin named Aeromonas salmonicida exoenzyme T (AcxT), which belongs to the family of ADP-ribosylating toxins, is disclosed as is a Calcium (or other cation concentration) dependent...
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7351535 |
Compositions and methods for increasing cholesterol efflux and raising HDL using ATP binding cassette transporter protein ABC1
The present invention relates to novel ABC1 polypeptides and nucleic acid molecules encoding the same. The invention also relates to recombinant vectors, host cells, and compositions comprising...
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7348471 |
Rice glutelin gene promoters
A nucleic acid containing a glutelin gene promoter. Disclosed are transformed plant cells and transgenic plants containing a nucleic acid that includes the promoter operably linked to a sequence...
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7348468 |
Wuschel (wus) gene homologs
This invention relates to an isolated nucleic acid fragment encoding a WUS protein. The invention also relates to the construction of a chimeric gene encoding all or a portion of the WUS protein,...
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7348156 |
7B2 knockout transgenic animals as models of endocrine disease
In general, the invention features methods and uses for transposon-mediated gene targeting which greatly enhance the insertion and detection of desired genes in genomic exons by homologous...
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7345216 |
Expression cassettes for meristem-preferential expression in plants
The present invention relates to expression cassettes comprising transcription regulating sequences with meristem-preferential or meristem-specific expression profiles in plants obtainable from ...
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7344888 |
Blueberry red ringspot virus, sequences, promoters, and uses thereof
A nucleic acid sequence of the blueberry red ringspot virus is disclosed. Also disclosed are putative promoter regions of the sequence and promoter regions capable of directing transgene expression...
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7344838 |
Gene encoding brain specific membrane protein
A novel gene apparently encoding a transmembrane glycoprotein has been successfully isolated by constructing a cDNA library of 4 kb or above in size from mRNA expressed in human adult brain and...
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7342147 |
Expression cassettes for root-preferential expression in plants
The present invention relates to expression cassettes comprising transcription regulating sequences with root-preferential or root-specific expression profiles in plants obtainable from ...
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