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7329797 |
Modulating plant carbon levels
Methods and materials for modulating (e.g., increasing or decreasing) carbon levels in plants are disclosed. For example, nucleic acids encoding carbon-modulating polypeptides are disclosed as well...
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7323622 |
Stem-regulated, plant defense promoter and uses thereof in tissue-specific expression in monocots
The invention is directed to isolated promoters from stem-regulated, defense-inducible genes, such as OMT promoters. The promoters are useful in expression cassettes and expression vectors for the...
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7323319 |
RNA containing coenzymes, biotin, or fluorophores, and methods for their preparation and use
Materials and methods for incorporating adenosine derivatives into the 5′ end of transcribed RNA are disclosed. Adenosine derivatives include naturally occurring compounds such as Coenzyme A,...
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7323619 |
Method for producing transgenic birds and fish
The present invention relates to methods for producing transgenic animals, particularly transgenic birds and fish, using retroviral constructs engineered to carry the transgene(s) of interest.
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7321031 |
Seed preferred regulatory elements
The present invention provides compositions for regulating expression of isolated nucleotide sequences in a plant. The compositions are novel nucleic acid sequences for seed-preferred regulatory...
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7320964 |
Modulation of expression of STAT-1 dependent genes
The invention relates to decoy oligonucleotides and antisense oligonucleotides comprising a nucleic acid sequence according to SEQ ID NO: 1 to 43, in addition to the use of said nucleotides as...
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7320890 |
Soluble steroidal peptides for nucleic acid delivery
Amphiphilic lipopeptide compositions for gene delivery are disclosed. An illustrative amphiphilic lipopeptide composition includes a human protamine 2 peptide conjugated to a hydrophobic moiety....
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7321030 |
Tumor-specific promotor and use thereof
A promoter domain of 1816 bp or 441 bp in the upstream side of exon 1B of IAI.3B gene has a specifically high promoter activity in ovarian cancer cells. An adenovirus having this promoter domain...
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7319020 |
Method for carrying out the controlled post-harvest production of proteins in host organisms
The invention relates to a method of obtaining a desired protein from a transgenic host organism, the gene coding for this protein being not expressed until the host organism has been harvested and...
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7319033 |
Adenovirus vectors specific for cells expressing androgen receptor and methods of use thereof
Replication-competent adenovirus vectors specific for cells which allow a probasin transcriptional response element (PB-TRE) to function, such as cells which express the androgen receptor (AR), and...
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7316925 |
Codon optimized synthetic plasmids
One aspect of the current invention is an optimized synthetic mammalian expression plasmid (e.g. pAV0201). This new plasmid comprise a therapeutic element, and a replication element. The...
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7316900 |
Methylated nucleotide regulation of gene expression
The present invention provides a method of regulating the expression of the urokinase type plasminogen activator (“uPA”) gene in a mammalian cell comprising the steps of: identifying a target...
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7316914 |
Methods and materials relating to gene expression
An expression cassette for expressing a nucleic acid of interest derived from the regulatory region of the methylenomycin gene cluster of the SCP1 plasmid of Streptomyces coelicolor A3(2), and...
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7317137 |
Promoter sequences providing male tissue-preferred expression in plants
Promoter sequences and their essential regions are identified which provide for male tissue-preferred expression. The nucleotide sequences are useful in mediating male fertility in plants.
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7314757 |
Drought inducible promoters and uses thereof
The present invention is directed to drought responsive promoter sequences, polynucleotide constructs comprising the drought responsive promoters and methods of identifying the drought responsive...
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7314926 |
Antiproliferative activity of g-rich oligonucleotides and method of using same to bind to nucleolin
The present invention provides a method for inhibiting the proliferation of malignant and/or hyperplastic cells in a subject by administering to the subject a therapeutically effective amount of a...
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7314734 |
Muteins of placental growth factor type 1, preparation method and application thereof
The present invention relates to chemically stable muteins of type 1 Placental Growth Factor (PLGF-1) bearing the substitution or elimination of a cysteine residue from the wild type protein amino...
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7312202 |
Rationally designed and chemically synthesized promoter for genetic vaccine and gene therapy
The present invention relates to chemically synthesized promoters that circumvent the disadvantages of the universal CMV promoter/enhancer elements. The promoter may be used in a variety of...
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7312324 |
Regulatory elements for delivery to the liver
The invention is directed to novel combinations of liver specific enhancers and promoter elements for achieving persistent transgene expression in the liver. The liver specific enhancer elements...
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7312376 |
Regulatory regions from Papaveraceae
Regulatory regions suitable for regulating expression of a heterologous nucleic acid are described, as well as nucleic acid constructs that include these regulatory regions. Also disclosed are...
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7312322 |
Genetic sequences encoding steroid and juvenile hormone receptor polypeptides and insecticidal modalities therefor
The present invention provides isolated nucleic acid molecules encoding polypeptides comprising functional steroid hormone and juvenile hormone receptors, in particular isolated nucleic acid...
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7312325 |
RNA aptamers and methods for identifying the same
RNA aptamers and methods for identifying the same are disclosed. The RNA aptamers selectively bind coagulation factors, E2F family members, Ang1 or Ang2, and therapeutic and other uses for the RNA...
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7312075 |
Trap vectors and gene trapping by using the same
A trap vector containing a loxP sequence composed of inverted repeat sequence 1, a spacer sequence and inverted repeat sequence 2 in this order, the loxP sequence being a mutant loxP wherein a part...
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7312375 |
Plant reproduction polynucleotides and methods of use
This invention relates to an isolated nucleic acid fragment encoding a reproduction protein. The invention also relates to the construction of a chimeric gene encoding all or a portion of the...
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7309786 |
Oligonucleotide antagonist for human tumor necrosis factor α (TNF-α)
The present invention relates to a group of new oligonucleotides sequences with human tumor necrosis factor α (TNF-α) inhibiting activity, which includes DNA sequences and RNA sequences. These...
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7301014 |
Nucleic acid molecule encoding a novel estrogen receptor beta variant
This invention relates to an isolated nucleotide fragment of a novel estrogen receptor, in particular, a novel ERβ variant protein and isolated nucleic acid fragment comprising the coding regions...
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7297535 |
Use of the human LRP/MVP promotor for a vector that can be induced by therapy
Embodiments of the invention relate to a vector system that allows one to induce expression of therapeutically relevant genes in mammalian cells. Such a vector system may be useful for medicine and...
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7297786 |
RNA interference in respiratory epitheial cells
The present invention is directed to small interfering RNA molecules targeted against a gene of interest in respiratory epithelial cells, and methods of using these RNA molecules.
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7297839 |
Promoters functional in plant plastids
The present invention relates to isolated nucleic acid molecule comprising the untranslated region of SEQ ID NO:2, which is functional as a promoter in plant plastids. The invention also relates to...
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7297536 |
Inducible protein expression system
Inducible gene expression systems and a method thereof. A first inducible gene expression system includes a first vector comprising at least one retroviral promoter and at least one factor to...
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7294712 |
Nucleotide sequences coding for variable regions of β chains of human T lymphocyte receptors, corresponding peptide segments and the diagnostic and therapeutic uses
The present invention relates to new nucleotide sequences coding for variable regions of β chains of human T lymphocyte receptors, corresponding peptide segments and the diagnostic and therapeutic...
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7294760 |
Plant promoters for use in early seed development
The present invention relates to DNA molecules that encode transcription regulatory regions. Furthermore, this present invention relates to nucleotide sequences encoding transcription regulatory...
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7294463 |
Method of screening for compounds that modulate activity of a regulatory sequence of the β-2 subunit of a neuronal nicotinic acetylcholine receptor
Several genes encoding subunits of the neuronal nicotinic acetylcholine receptors have been cloned and regulatory elements involved in the transcription of the ∝:2 and ∝:7-subunit genes have...
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7291605 |
Methods of treating various cancers using melanoma differentiation associated protein-7
This invention provides a method for reversing the cancerous phenotype of a cancer cell by introducing a nucleic acid having the melanoma differentiation associated gene (mda-7) into the cell under...
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7291765 |
PM29 and LEA3 promoters and use in expression of transgenic genes in plants
The promoters of a soybean seed maturation protein PM29 and a soybean late-embryogenesis abundant protein LEA3 and fragments thereof and their use in promoting the expression of one or more...
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7291725 |
Sos1 inhibitors
Inhibitors of human Sos1, including antisense oligonucleotides, methods, and compositions specific for human Sos1, are provided. Methods of using the compositions for modulating Sos1 expression and...
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7288530 |
Antisense modulation of survivin expression
Antisense compounds, compositions and methods are provided for modulating the expression of Survivin. The compositions comprise antisense compounds, particularly antisense oligonucleotides,...
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7285657 |
Rubisco small subunit promotes from Brassica rapa and uses thereof
The present invention is related to a family of novel spatiotemporally active Rubisco promoters (SEQ ID NO: 1, 2, 3) obtainable from light grown Brassica seedlings. Furthermore the invention is...
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7285265 |
Stable adenoviral vectors and methods for propagation thereof
The present invention provides methods and means to increase the stability and/or the packaging capacity of recombinant adenoviruses, by overexpression of pIX in an adenoviral packaging cell, by...
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7285399 |
Compositions and methods using the yeast YMR107W promoter
The invention provides novel yeast promoters useful for controlling the expression of homologous and heterologous nucleic acid molecules in yeast cells. The yeast promoters are induced by a...
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7285656 |
Root-specific conifer gene promoter and its use
There is provided an isolated polynucleotide sequence useful as a promoter in plant root tissue. The sequence is derived from the promoter for the Western white pine gene PR10. The sequence...
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7282351 |
Prostatic growth factor
The present invention relates to human PGF polypeptides and DNA (RNA) encoding such polypeptides. Also provided is a procedure for producing such polypeptides by recombinant techniques, and...
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7279617 |
Promoter, promoter control elements, and combinations, and uses thereof
The present invention is directed to nitrogen responsive promoter sequences and promoter control elements, polynucleotide constructs comprising the nitrogen responsive promoters and control...
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7279168 |
Recombinant virus expressing foreign DNA encoding feline CD86 and uses thereof
The present invention involves a recombinant virus which comprises at least one foreign nucleic acid inserted within a non-essential region of the viral genome of a virus, wherein each such foreign...
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7279568 |
Highly efficient eukaryotic expression vector comprising an exogenous transcription regulatory element
The present invention relates to a highly efficient eukaryotic expression vector containing an exogenous transcription regulatory element which comprises a promoter/enhancer and the nucleotide...
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7279616 |
Method for improving corn starch extractability
The present invention relates to the transformation of maize with a grain softness-enhancing gene for improving starch extractability. The invention more precisely concerns the reduction of wet...
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7276596 |
Promoter from maize invertase inhibitor gene
The present invention provides compositions and methods for regulating expression of heterologous nucleotide sequences in a plant. Compositions include a novel nucleotide sequence for a...
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7276335 |
Designing compounds specifically inhibiting ribonucleic acid function
A method for designing compounds specifically targeting RNA sequences, based on the discovery of short, specific sequences within RNA that are critical to function, using modeling of the compound...
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7276595 |
DNA sequence encoding a retinoic acid regulated protein
The present invention concerns a novel retinoic acid regulated gene whose expression product displays useful morphogenic/mitogenic properties. The present invention further concerns an isolated...
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7276370 |
Rf2a and rf2b transcription factors
A method of activating the rice tungro bacilliform virus (RTBV) promoter in vivo is disclosed. The RTBV promoter is activated by exposure to at least one protein selected from the group consisting...
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