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7585962 |
Multimerized enhancer domains for cell-specific expression
The invention features an enhancer cassette and methods of its use. The enhancer cassette has the formula [X−Y] n , wherein each X is independently a cell type-specific enhancer element; Y is...
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7585963 |
Chicken ovalbumin nucleotide sequence
The present invention provides isolated and recombinant avian nucleic acid molecules comprising at least one avian MAR and an avian nucleic acid sequence encoding an ovalbumin transcriptional...
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7585498 |
Regulation of adenovirus DNA packaging by IPTG
The present invention relates to recombinant Adenoviruses (Ad) which function as helper viruses to gutted Ad viruses lacking viral coding sequences. The recombinant Ad of the present invention...
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7582747 |
siRNA targeting inner centromere protein antigens (INCENP)
Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene...
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7582807 |
Regulation of gene expression using chromatin remodelling factors
The invention provides a method to regulate expression of a gene of interest in a plant comprising, introducing into the plant a first nucleotide sequence comprising, the gene of interest...
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7582746 |
siRNA targeting complement component 3 (C3)
Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene...
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7579516 |
Promoters functional in plant plastids
The present invention relates to isolated nucleic acid molecule comprising the untranslated region of SEQ ID NO: 1, 2 or 3. The invention also relates to chimeric genes comprising SEQ ID NO: 2...
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7579326 |
Gene switch systems employing regulators with decreased dimerization
Disclosed is a novel inducible expression system characterized by undetectable biological effect in the absence of an inducer, but which exhibits efficient inducibility in the presence of an inducer.
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7579330 |
Methods of treating various cancers using melanoma differentiation associated protein-7
This invention provides a method for reversing the cancerous phenotype of a cancer cell by introducing a nucleic acid having the melanoma differentiation associated gene (mda-7) into the cell under...
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7579327 |
Promoters exhibiting endothelial cell specificity and methods of using same
An isolated polynucleotide functional as a promoter in eukaryotic cells is disclosed. The isolated polynucleotide includes an endothelial specific enhancer element as detailed herein. Further...
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7579329 |
P450RAI-2 (P450 cytochrome 26B), encoding nucleic acid molecules and methods and uses thereof
The present invention provides a novel all-trans-RA inducible all-trans-RA metabolizing cytochrome P450, P450RAI-2, that is predominantly expressed in the brain, cerebellum in particular. It is...
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7579168 |
Human Dickkopf-related nucleic acid molecules
Novel Dkk and Dkk-related polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated, full-length Dkk and Dkk-related proteins, the invention further provides...
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7576196 |
siRNA targeting transducin (beta)-like 3 (TBL3)
Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene...
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7576195 |
Endosperm-specific plant promoter for cultivated plants
The invention provides an endosperm-specific plant promoter, as well as vectors, plant cells, and plant tissues comprising the endosperm-specific promoter. The invention also provides methods of...
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7575918 |
Tissue-specific and pathogen-specific ribozymes
The present invention relates to the discovery, identification and characterization of toxic agents which are lethal to pathogens and methods for targeting such toxic agents to a pathogen or...
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7572633 |
Use of the adenoviral E2 late promoter
The invention relates to a nucleic acid construct comprising an adenoviral E2 late promoter or a fragment thereof and a nucleic acid. The nucleic acid is selected from the group of transgenes,...
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7569659 |
Admixture comprising a target molecule and a nucleic acid mimic comprising sterically bulky substituents
The invention concerns compositions comprising a nucleic acid mimic. The compositions may be used in the diagnosis and treatment of diseases amenable through modulation of nucleic acids which...
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7569220 |
Compositions and methods for non-targeted activation of endogenous genes
The present invention is directed generally to activating gene expression or causing over-expression of a gene by recombination methods in situ. The invention also is directed generally to methods...
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7566700 |
Materials and methods for treatment of allergic disease
siRNA molecules are disclosed which target the transcription factor STAT6 and repress the expression of STAT6 mRNA, STAT6 protein and STAT6 function in lung cells. The use of STAT6 specific siRNA...
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7566563 |
Compositions and methods for manipulating carbon flux in cells
Nucleotide sequences and genetic constructs that can be used to regulate genes encoding enzymes that change carbon flux through metabolic pathways that lead to lactic acid or fumarate production in...
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7563944 |
Expression cassette for nucleic acids in plant tissue containing starch
The invention relates to methods for the transgenic expression of nucleic acid sequences predominantly in starch-comprising tissues of plants, preferably in fruits, roots, seeds or tubers, wherein...
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7561972 |
Synthetic nucleic acids for expression of encoded proteins
A method of designing a polynucleotide sequence encoding a polypeptide sequence of a predetermined polypeptide is provided. A frequency lookup table corresponding to an expression system is...
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7560622 |
Methods and compositions relating to the generation of partially transgenic organisms
The present invention provides methods of producing non-transgenic tissues or other agricultural products from a transgenic plant or other transgenic organism. Non-trausgenic organism parts, for...
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7560615 |
Root-specific, stimulant inducible promoter and its use
This invention relates to an isolated isoflavone synthase 1 (IFS1) promoter nucleic acid fragment. The invention also relates to the construction of chimeric genes comprising all or a portion of...
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7560626 |
Promoter sequence obtained from rice and methods of use
Methods are provided by which Oryza sativa plants and seeds thereof may be modified to express a coding region of interest using a promoter sequence operatively linked to the coding region. The...
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7560612 |
Early-inflorescence-preferred regulatory elements and uses thereof
The present invention provides compositions and methods for regulating expression of isolated nucleotide sequences in a plant. The compositions are novel nucleic acid sequences for regulatory...
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7561973 |
Methods for determining properties that affect an expression property value of polynucleotides in an expression system
A method of determining a property that affects expression of polynucleotides in an expression system. A plurality of polynucleotides, each encoding a polypeptide sequence, is constructed. An amino...
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7557268 |
Promoter for expression of a gene and response to infection or wounding
Promoters which increase the pathogen-inducibility of genes in plants, preferably in sugar beets, rape, potatoes, corn, soybeans, wheat, rice, rye, barley, cotton and sunflower. The promoters are...
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7557264 |
Gossypium hirsutum tissue-specific promoters and their use
The present invention relates to an isolated DNA molecule selected from the group: a promoter-effective DNA molecule of Gossypium which is operable in embryonic seed tissues and a...
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7556944 |
Methods and compositions for use in preparing siRNAs
Methods and compositions for producing siRNAs, e.g., in the form of a d-siRNA composition, from dsRNAs are provided. In the subject methods, a dsRNA is contacted with a composition that includes an...
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7557203 |
Expression cassettes for the bi-directional transgenic expression of nucleic acids in plants
The invention relates to transgenic expression cassettes for expressing two nucleic acid sequences in a plant cell comprising at least one regulatory sequence selected from the group consisting of
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7553637 |
Oxa1p enhanced protein secretion
The present invention provides methods and compositions for the efficient and enhanced secretion of a protein of interest from a host cell. In specific, proteins are secreted through the...
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7553667 |
Regulation of gene expression using chromatin remodelling factors
The invention provides a method to regulate expression of a gene of interest in a plant comprising, introducing into the plant a first nucleotide sequence comprising, the gene of interest...
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7550579 |
Pericarp-preferred regulatory element
The present invention provides compositions and methods for regulating expression of heterologous nucleotide sequences in a plant. Compositions are novel nucleotide sequences for a...
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7550578 |
Rice promoters for regulation of plant expression
The present invention provides promoters from plants capable of driving gene expression in plant cells. The promoters vary in strength and in tissue specificity, and can be used to facilitate the...
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7550577 |
Regulation of expression of high-affinity immunoglobulin E (IgE) receptor β-chain
The present invention provides a polynucleotide comprising all or a part of the nucleotide sequence identified as SEQ ID NO:1 that regulates transcription of the human high-affinity IgE receptor...
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7547774 |
RCc3 regulatory elements for use in plants
The present invention provides polynucleotide molecules isolated from Oryza sativa and useful for expressing transgenes in plants. The present invention also provides DNA constructs containing...
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7544857 |
Brachytic2 (Br2) promoter from maize and methods of use
The invention relates to the regulation of gene expression, particularly to methods and compositions for regulating gene expression in plants. Expression cassettes comprising a polynucleotide...
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7544486 |
Nell peptide expression systems and bone formation activity of nell peptide
The invention generally relates to a bone growth factor, and more particularly to compositions including NELL1, articles of manufacture including NELL1 and methods of using NELL1 to induce bone...
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7541447 |
Process for the preparation of an improved Brucella strain plasmid to develop the strain and the vaccine comprising the said strain
A Brucella bacterium is modified by partial or complete deletion of the pgm gene, rendering the bacterium incapable of synthesizing a key enzyme in the metabolism of bacterial sugars. A live...
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7541452 |
Rice regulatory sequences for gene expression in defined wheat tissue
The abundance of the 96 most abundant EST cluster sequences in a wheat lemma/palea cDNA library was investigated in a range of cDNA libraries made from various wheat tissues. 30 cDNA sequences...
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7541446 |
Tet repressor-based transcriptional regulatory proteins
The present invention provides a panel of transcriptional activator fusion proteins which comprises both tetracycline controlled transactivator proteins and reverse tetracycline transactivator...
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7541179 |
Vector encoding human globin gene and use thereof in treatment of hemoglobinopathies
Recombinant lentiviral vectors having a region encoding a functional β-globin gene; and large portions of the β-globin locus control regions which include DNase I hypersensitive sites HS2, HS3...
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7541344 |
Modulation of survivin expression
Compounds and compositions are provided for modulating the expression of survivin. The compounds, exemplified by those acting through an RNAi antisense mechanism of action, include double-stranded...
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7538259 |
Moss expressing promoting regions
Disclosed are isolated nucleic acid molecules encoding wild type nucleus derived moss expression promoting regions (MEPRs) as well as a method for producing recombinant polypeptides using such MEPRs.
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7538210 |
Sucrose-inducible promoter from sweetpotato
Disclosed herein are a novel sucrose-inducible promoter sequence and a 5′ untranslated region which are derived from sweetpotato ADP-glucose pyrophosphorlyase gene (ibAGP1) (SEQ ID NO: 1). Also...
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7538261 |
Maize promoter active in silks, stalk nodes, roots and leaf sheaths
The present disclosure provides compositions and methods for regulating expression of heterologous nucleotide sequences in a plant. Compositions include a novel nucleotide sequence for a...
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7534602 |
Promoters and usage thereof
Promoters and usage thereof. Two promoters, acuF and hsp promoters, comprise the nucleotide sequences of SEQ ID NO: 1 and 2, respectively.
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7534932 |
Root-specific phosphate transporter promoters
The current invention provides plant promoter sequences. Compositions comprising the promoter sequence are described, as are methods for the expression of transgenes in plants comprising the use of...
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7531321 |
Fibroblast growth factor-like molecules and uses thereof
The present invention provides Fibroblast Growth Factor-Like (FGF-L) polypeptides and nucleic acid molecules encoding the same. The invention also provides selective binding agents, vectors, host...
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