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6977176 |
Plasmid maintenance system for antigen delivery
The present invention relates generally to a Plasmid Maintenance System for the stabilization of expression plasmids encoding foreign antigens, and methods for making and using the Plasmid...
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6977165 |
Sequence specific recombinase-based methods for producing intron containing vectors and compositions for use in practicing the same
Methods are provided for producing a vector that includes at least one splicable intron. In the subject methods, intron containing vectors are produced from donor and acceptor vectors that each...
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6977157 |
Clock gene promoter
The present invention discloses a Period2 gene promoter, a construct containing the promoter and a reporter gene, a cell containing the construct, a transgenic animal harboring the construct, and a...
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6974689 |
Nucleic acid encoding PRO211 polypeptides
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid...
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6974671 |
Methods for indentifying compounds that modulate gluconeogenesis through the binding of CREB to the PGC-1 promoter
In accordance with the present invention, it has been discovered that CREB regulates hepatic gluconeogenesis via the co-activator, PGC-1. PGC-1 potentiated glucocorticoid induction of the gene for...
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6974867 |
Compositions and methods for treating neoplastic disease using chemotherapy and radiation sensitizers
Inhibitors of KIAA0175 are provided that reduce the expression or biological activities of KIAA0175, p53 and/or p21 in a mammalian cell. KIAA0175 inhibitors include anti-sense molecules, ribozymes,...
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6972328 |
Non-aggregating non-quenching oligomer comprising nucelotide analogs, method of synthesis and use thereof
The invention provides compositions and methods for improved hybridization analysis utilizing DNA, RNA, PNA and chimeric oligomers in which one or more purine bases are substituted by a...
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6969784 |
Genetic engineering of plants through manipulation of lignin biosynthesis
The invention pertains to the genetically down regulating a lignin pathway p-coumarate Co-enzyme A ligase (CCL) in trees.
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6967089 |
Delivery system for porcine somatotropin
An expression construct is disclosed which is useful for delivering mature somatotropin to a host. Mature somatotropin is operably linked to an insulin secretory signal. Host cells comprising the...
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6964845 |
Thermostable phage lambda operator mutants for regulating gene expression
The present invention concerns a method for selecting New P R or P L operator sequences from lambdoid phages which have different thermostability compared to the wild-type sequence with regard to...
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6965025 |
Antisense modulation of connective tissue growth factor expression
Antisense compounds, compositions and methods are provided for modulating the expression of connective tissue growth factor. The compositions comprise antisense compounds, particularly antisense...
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6962805 |
Method of constructing amino acid producing bacterial strains, and method of preparing amino acids by fermentation with the constructed amino acid producing bacterial strains
A method of producing coryneform bacteria having improved amino acid or nucleic acid productivity comprising the steps of introducing a mutation in a promoter sequence of amino acid- or nucleic...
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6963021 |
Chimeric expression promoters originating from commelina yellow mottle virus and cassava vein mosaic virus
The present invention relates to a chimeric expression promoter comprising at least one nucleic acid sequence derived from a first plant promoter containing a plant vascular expression promoter...
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6962785 |
Antibacterial and antiviral agents and methods of screening for the same
A method of screening for compounds useful for inhibiting retrovirus propagation in a host for the retrovirus, wherein the retrovirus primes reverse transcription in the host by binding of a...
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6962990 |
Fusobacterium nucleic acids, plasmids and vectors
The invention provides origin of replication sequences and replication genes and proteins for a plasmid functional in Fusobacterium (e.g., F. nucleatum ) and related species. Provided by the...
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6960656 |
Nucleic acid encoding DS-CAM proteins and products related thereto
In accordance with the present invention, there are provided Down Syndrome-Cell Adhesion Molecule (DS-CAM) proteins. Nucleic acid sequences encoding such proteins and assays employing same are also...
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6958235 |
Recombinant protein containing a C-terminal fragment of plasmodium MSP-1
The invention relates to a recombinant protein fabricated in a baculovirus system, of which the essential constitutive polypeptide sequence is that of a C-terminal fragment of 19 kilodalton (p19)...
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6958433 |
Transgenic mice overexpressing aspartyl protease 2 (ASP2)
The present invention provides a recombinant DNA construct comprising a coding sequence encoding human ASP2 and a brain-specific calcium calmodulin kinase promoter sequence which is operably linked...
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6958434 |
OsCc1 promoter and methods of transforming monocot plants using the same
The present invention relates to a process for varying a trait of monocot plants, wherein the process comprises the step of transforming a monocot plant with a recombinant plasmid containing an...
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6955902 |
High throughput DNA sequencing vector
High throughput DNA sequencing vectors for generating nested deletions using enzymatic techniques and/or transposition-based techniques are disclosed. Methods of constructing contigs of long DNA...
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6953687 |
Vectors for delivering viral and oncogenic inhibitors
Cell transformation vectors for inhibiting HIV and tumor growth are provided. Optionally, the vectors encode RNAses such as EDN. Cells transduced by the vectors and methods of transforming cells...
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6953848 |
Gene promoter sequences and uses thereof
This invention is directed to a DNA sequence encoding the Capsicum annuum (bell pepper) capsanthin-capsorubin synthase gene promoter, its use for driving expression of foreign genes in transgenic...
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6953688 |
Vector for screening for modulators of IgE synthesis, secretion and switch rearrangement
The invention relates to methods and compositions useful in screening for modulators of IgE synthesis, secretion and switch rearrangement.
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6951969 |
Nucleic acid molecules which code for enzymes derived from wheat and which are involved in the synthesis of starch
Nucleic acid molecules are described which encode enzymes involved in starch synthasis in plants. These enzymes are wheat isoamylases. The invention furthermore relates to vectors and host cells...
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6949694 |
Methods and means for modification of plant characteristics
The invention discloses nucleic acid encoding an FY polypeptide with the sequence shown in Annex 2. Also provided are vectors, host cells and plants. Methods of the invention include the use of...
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6949693 |
Promoters for gene expression in caryopses of plants
The present invention relates to promoters which permit a caryopsis-specific expression or suppression of genes in genetically modified plants, to methods for the tissue-specific gene expression or...
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6949637 |
Methods for diagnosis, prediction and treatment of asthma and other inflammatory conditions based on eotaxin coding sequence polymorphism
Methods and compositions for diagnosing and treating asthma are provided. The methods involve the discovery of a correlation between an eotaxin gene polymorphism and the ocurrence of asthma.
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6949696 |
Chimeric figwort mosaic virus-elongation factor 1 α promoters and methods of using them
The present invention relates to novel plant expression constructs. More specifically the present invention provides DNA constructs comprising 5′ regulatory sequences for modulating the...
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6949379 |
Aptamer-mediated regulation of gene expression
This invention provides methods of regulating gene expression. An aptamer is positioned in a nucleic acid molecule along with a sequence encoding a transcriptional regulatory polypeptide. The...
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6946126 |
Replicating adenovirus vectors
The present invention provides replicating [100K−] adenovirus vectors that have an impairment in 100K activity. In particular preferred embodiments, the impairment is the result of a deletion in...
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6943012 |
Helper dependent adenoviral vector system and methods for using the same
A helper dependent adenoviral vector system is provided. The subject helper dependent adenoviral vector system is made up of: (1) a “gutless” adenoviral vector that include cis-acting human...
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6943026 |
Antitumour vector constructs and methods
Compositions for targeting expression of a gene such as an antitumor gene may contain a first nucleic acid construct in which expression of a first gene is controlled by a first promoter whose...
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6943246 |
3′terminal sequence of hepatitis C virus genome and diagnostic and therapeutic uses thereof
The invention relates to the discovery of a novel RNA sequence at the 3′ terminal sequence of hepatitis C virus (HCV) genome RNA. Included in the invention are the 3′ sequence, its complement,...
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6943011 |
Localization and characterization of the Wilms' tumor gene
The Wilms' tumor gene associated with 11p3 locus on the human chromosome, as well as a method of analyzing cells for the gene is described and characterized. The gene encodes a transcription unit...
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6943018 |
Transgenic expression from a SOCS-3 promoter in vertebrate cells
Disclosed is a transgenic vertebrate cell containing a nucleic acid construct comprising a murine SOCS-3 promoter, or an operative fragment thereof, or an operative derivative of either of these.
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6943242 |
Design of artificial genes for use as controls in gene expression analysis systems
Method of producing controls for use in gene expression analysis systems such as macroarrays, real-time PCR, northern blots, SAGE and microarrays. The controls are generated either from near-random...
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6939711 |
Control of gene expression in plants by receptor mediated transactivation in the presence of a chemical ligand
The present invention is drawn to a method of controlling gene expression in plants. Specifically, the method comprises obtaining a transgenic plant comprising at least two receptor expression...
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6939690 |
Polynucleotides encoding motilin homologs
The present invention is directed to polynucleotides, polypeptides and peptide fragments thereof, and uses thereof for a novel cDNA sequence which has homology to motilin. Tissue distribution of...
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6939958 |
Regulatory region of a lipid transfer protein (LtpW1) from aleuron tissue of wheat
This invention is directed to a regulatory region obtained from a wheat aleurone gene LtpW1. This regulatory region, truncated derivatives, mutations, or deletions of this regulatory region, can be...
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6936466 |
Transcriptionally-activated AAV inverted terminal repeats (ITRs) for use with recombinant AAV vectors
This invention provides transcriptionally-activated AAV ITRs (inverted terminal repeats) which are small and transcriptionally active and uses thereof to optimize the expression of relatively large...
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6936708 |
Expression of Alfin 1 and methods for producing transgenic plants having increased root growth and root specific gene activation
Alfin1 cDNA encodes a putative transcription factor associated with salt tolerance in alfalfa ( Medicago sativa L). The recombinant protein binds DNA in a sequence specific manner, including...
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6933378 |
Methods for coexpression of more than one gene in eukaryotic cells
A primary object of this invention is to provide a method which will enable to coexpress simultaneously two (or more) desired genes in plant, animal or yeast cells, in transgenic plants and...
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6933146 |
Methods and means for producing efficient silencing construct using recombinational cloning
Methods and vectors and kits are provided for producing chimeric nucleic acid constructs capable of producing dsRNA for silencing target nucleic acid sequences of interest using recombinational...
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6933374 |
Farnesyl pyrophosphate synthase protein, nucleic acid and promoter region thereof
The promoter region of the farnesyl pyrophosphate synthase gene that was expressed in the hop luplin gland in a specific manner was elucidated based on the genomic DNA of the hop farnesyl...
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6930095 |
Hepatitis C virus constructs characterized by high efficiency replication
The present invention relates to recombinant hepatitis C virus (HCV)-derived nucleic acids and to stable rapidly growing cell clones derived from human hepatoma Huh-7 cell line and supporting high...
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6929948 |
Lineage specific cells and progenitor cells
A method for generating a culture that is purified or enriched in respect of cells of a selected lineage is described in which selectable marker, which is differentially expressed in cells of the...
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6930182 |
Composition and methods of using the Mirabilis mosaic caulimovirus sub-genomic transcript (Sgt) promoter for plant genetic engineering
The isolation of and methods of using a sub-genomic transcript (Sgt) promoter from Mirabilis mosaic virus (MMV) are described. A 333 bp MMV Sgt promoter fragment (sequence−306 to +27 from the...
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6927026 |
Orotidine-5′-phosphate decarboxylase-gene, gene construct containing said gene and the utilization thereof
The invention relates to an orotidine-5′-phosphate decarboxylase gene having the sequence of SEQ ID NO: 1 or its homologs, to a gene construct comprising this gene or its homologs, and to its...
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6927321 |
Arcelin-5 promoter and uses thereof
The present invention discloses Arcelin promoters capable of transcribing a heterologous nucleic acid sequence at high levels in plants. The promoters are particularly suited for use in soybean...
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6924125 |
Expression of heterologous multi-domain proteins in yeast
This invention demonstrates the utility of a yeast expression system for the expression of functional heterologous multi-domain proteins in yeast. The yeast expression system allows for the...
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