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7034010 |
Use of recombinant gene delivery vectors for treating or preventing lysosomal storage disorders
Gene delivery vectors, such as, for example, recombinant FIV vectors, and methods of using such vectors are provided for use in treating or preventing retinal diseases of the eye and diseases of...
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7033827 |
Prostate-specific polynucleotide compositions
Compositions and methods for the therapy and diagnosis of cancer, particularly prostate cancer, are disclosed. Illustrative compositions comprise one or more prostate-specific polypeptides,...
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7033799 |
Haemophilus adherence and penetration proteins
Haemophilus adhesion and penetration proteins, nucleic acids, vaccines and monoclonal antibodies are provided.
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7033826 |
Recombinant adenoviruses, use thereof for preparing AAVS, complementary cell line, and pharmaceutical compositions containing said adenoviruses
A recombinant adenovirus in which the expression of a nucleic acid sequence coding for at least one homologous or heterologous gene of viral origin is placed under the control of an inducible...
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7030099 |
Tumor specific promoters of the midkine gene that allow for selective expression in P53-inactivated cells
A DNA comprising a 609 bp base sequence from −559 to +50 when the first base sequence of exon 1 of the midkine gene, a human retinoic acid-responsive growth/differentiation factor was set as +1,...
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7029910 |
Immunoglobulin control region
This invention relates to a control region in human immunoglobulins, to parts thereof and to their use.
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7029881 |
Methods for constructing DNA library and support carrying DNA library immobilized thereon
Method and apparatus for constructing a cDNA library by hybridizing mRNA with oligo (dT) on a support and treating with a reverse transcriptase to immobilized complementary DNA, or for constructing...
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7030236 |
Antisense oligonucleotides tarageting folate receptor alpha, and the use thereof
The invention relates to treatment of cancers and cancerous cells which over-express α folate receptor (FRα) compared to the normal cells of the same tissue. The invention is directed to...
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7026527 |
Plant methionine synthase gene and methods for increasing the methionine content of the seeds of plants
This invention relates to a nucleic acid fragment encoding a plant 5-methyltetra-hydropteroyltriglutamate-homocysteine methyltransferase or methionine synthase. The invention also includes chimeric...
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7026301 |
Method of orally treating inflammatory skin conditions with prodrugs of 5-fluorouracil
The present invention relates to the treatment of inflammatory skin conditions, including psoriasis, with a prodrug of 5-fluorouracil. The invention relates to methods for treatment of psoriasis...
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7022525 |
Process of making a compound by forming a polymer from a template drug
A method of forming polymers in the presence of nucleic acid using template polymerization. Also, a method of having the polymerization occur in heterophase systems. These methods can be used for...
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7022481 |
Methods of using glucan synthase pathway reporter genes to screen for antifungal compounds
The present invention relates to methods of using nucleotide sequences from the promoter region of at least one of seven S. cerevisiae genes whose expression is an indicator of the inhibition or...
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7024312 |
Methods for making character strings, polynucleotides and polypeptides having desired characteristics
“In silico” nucleic acid recombination methods, related integrated systems utilizing genetic operators and libraries made by in silico shuffling methods are provided.
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7022827 |
Xylanase, microorganisms producing it, DNA molecules, methods for preparing this xylanase and uses of the latter
The invention relates to an isolated and purified culture of Bacillus sp. strain 720/1 (LMG P-14798); to xylanases obtained from this strain and xylanases obtained from derivatives and mutants of...
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7022327 |
Recombinant birnavirus vaccine
The present invention provides a birnavirus mutant which is suited as vaccine candidate in eradication control programmes. The mutant is not able to produce a native VP5 protein, and this feature...
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7018810 |
Chordin-like molecules and uses thereof
The present invention provides Chordin-Like (CHL) polypeptides and nucleic acid molecules encoding the same. The invention also provides selective binding agents, vectors, host cells, and methods...
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7018984 |
Methods and compositions for controlling translation of HCV proteins
Embodiments of the present invention feature methods and compositions for controlling the translation of viral peptides and proteins from viral nucleic acid, with particular applications to...
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7019126 |
Transgenic plants producing a PAP II protein
Disclosed are recombinant plant cells, plant cell parts, plant parts and transgenic plants containing a DNA molecule comprising a sequence encoding a Pokeweed Antiviral Protein (PAP) II protein....
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7019122 |
Unusual retrotransposon from the yeast Candida albicans
TCa2 is a Tyl/copia retrotransposon from the pathogenic yeast Candida albicans . In contrast to other retrotransposons it can appear as an abundant, extrachromosomal double-stranded DNA molecule,...
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7012173 |
Promoter system and production and use of the same
The present invention relates to nucleic acids coding for promoters, which are both tapetum-specific and pollen-specific, as well as the use thereof for producing male sterile plants.
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7011973 |
Regulatory sequences capable of conferring expression of a heterologous DNA sequence in endothelial cells in vivo and uses thereof
Described are recombinant DNA molecules comprising the regulatory sequences of an intron of the Endothelial Growth Factor (VFGF) receptor-2 gene (Flk-1) or of a gene homologous to the Flk-1 gene,...
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7008764 |
Optimization of cells for endogenous gene activation
The invention concerns a process for optimizing the gene expression in cells. A first aspect concerns a process for changing the expression of a nucleic acid sequence which is present endogenously...
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7009045 |
Transformation systems for flavinogenic yeast
This invention is directed to the transformation of the flavinogenic yeasts, Pichia guilliermondii and Candida famata , and mutants thereof, by electroporation (electrotransformation) and by...
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7005275 |
Inducible alphaviral gene expression system
The present invention provides novel expression vectors which permit tight regulation of gene expression in eucaryotic cells. More specifically, the invention provides DNA vectors comprising...
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7005562 |
SAR and pathogen-inducible promoter
The Arabidopsis NI16 gene was isolated in a yeast 2-hybrid screen via its interaction with the NIM1 protein and encodes a protein involved in the regulation of SAR gene expression in plants. NI16...
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7002004 |
Biomolecule and/or cellular arrays on metal surfaces
Disclosed is a process to construct multi-component biomolecule or cellular arrays suitable for use in SPR imaging studies of large molecule, cellular/molecular, and cell/cell interactions. Also...
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7001890 |
Pharmaceutical compositions comprising a polynucleotide and optionally an antigen especially for vaccination
The present invention relates to pharmaceutical compositions comprising at least one fragment of a polynucleotide, preferably at least one antigen, and optionally a pharmaceutically acceptable...
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7001760 |
Hepatitis B virus vectors for gene therapy
The present invention relates to novel hepatitis B virus vectors for use in gene therapy which can deliver therapeutic genes to liver cells. The invention also provides methods for the production...
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7002003 |
Method for the inhibition of function of STAT transcription factors
There is provided a method of modulating the function of transcription factor by administering an effective amount of an oligonucleotide containing optimal nucleotide binding sites for the...
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7001764 |
Compositions comprising tissue specific adenoviral vectors
Compositions comprising host cell specific adenovirus vehicles are provided for transfecting target host cells. The compositions comprise replication competent adenovirus having an adenovirus gene...
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6998263 |
Methods of preparing and using a viral vector library
The present invention provides a library of viral vectors, wherein each member comprises a first heterologous DNA encoding a first gene product and a second heterologous DNA encoding a second gene...
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6998478 |
Isolation and characterization of a fiber-specific β-tubulin promoter from cotton
The present invention relates to a cotton β-tubulin gene CFTUB2, and active fragments thereof. These promoters show strong fiber-specific activity.
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6998477 |
Nucleic acid fragment, recombinant vector containing the same and method of promoting the expression of structural genes by using the same
A novel nucleic acid fragment which has an high activity to promote expression of a structural gene located downstream thereof, and a method for promoting expression of the structural gene located...
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6998472 |
Obesity gene
The invention describes a previously unknown gene, termed 5′OT-EST, which is responsible for inducing an obesity and/or infertility phenotype in transgenic animals, and transgenic animals...
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6995249 |
Nucleic acid capable of binding specifically to Ras target protein
A novel nucleic acid (aptamer) which binds specifically to the target protein of Ras, more particularly, a novel RNA aptamer which binds specifically to Raf-1; a method for screening an RNA capable...
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6995008 |
Coordinate in vivo gene expression
Nucleic acids, including DNA constructs and RNA transcripts, capable of inducing coordinate expression of two to three cistrons upon direct introduction into animal tissues, are bi- or...
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6995256 |
Isolation and characterization of a fiber-specific actin promoter from cotton
The present invention relates to the cotton actin gene CFACT1, and the fiber-specific promoter thereof. These promoters show strong fiber-specific activity.
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6994999 |
Isolated DNA molecule comprising the promoter sequence of a bovine myostatin gene
The present invention relates to a novel promoter sequence which encodes an isolated DNA molecule comprising the polynucleotide sequence of SEQ ID NO: 1 and which encodes the promoter region of the...
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6992237 |
Regulated expression of genes in plant seeds
This invention relates generally to the field of plant molecular biology. More specifically, this invention relates to methods and reagents for the temporal and/or spatial expression of genes that...
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6989270 |
Using polyamide nucleic acid oligomers to engender a biological response
The invention involves methods and materials for extracellularly administering PNA oligomers to living cells. Specifically, the invention provides methods and materials of treating living cells...
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6987179 |
Constitutive plant promoters
The invention describes new promoters built from elements from a set of promoters which have a complementary expression pattern.
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6986988 |
Method for enrichment of natural antisense messenger RNA
A method for enrichment of natural antisense mRNA which involves hybridization of cDNA obtained from sense RNA with cDNA obtained from antisense RNA, followed by DNA polymerase treatment of the...
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6987006 |
Erythropoietin and albumin fusion protein, nucleic acids, and methods thereof
Biologically active polypeptides comprising a therapeutically active polypeptide fused to human serum albumin or a variant thereof, methods for the preparation thereof, nucleotide sequences...
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6984518 |
DNA construct comprising an FGF1B promoter region operably linked to an SV40 large T antigen encoding sequence
A transgenic, non-human mammal useful for assessing the effect of candidate chemotherapeutic drugs on the growth of brain tumors in vivo is provided. Incorporated into the genome of the transgenic...
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6984517 |
AAV5 vector and uses thereof
The present invention provides an adeno-associated virus 5 (AAV5) virus and vectors and particles derived therefrom. In addition, the present invention provides methods of delivering a nucleic acid...
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6984379 |
Gene therapy by administration of genetically engineered CD34+ cells obtained from cord blood
A method of providing a therapeutic effect in a human patient which comprises administering to the patient CD34+ cells obtained from cord blood. The CD34+ cells have been engineered with at least...
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6979568 |
Vector for the expression of two foreign genes
A vector expressing two foreign genes by using RRE sequence and controlling the ratio of the expression doses of these genes owing to the modification is provided. This vector, which can be...
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6977325 |
Plant promoter sequences and methods of use for same
The invention discloses novel promoter sequences capable of expressing genes in plant cells. The promoters include engineered versions of the maize ubiquitin promoter to increase expression levels...
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6977176 |
Plasmid maintenance system for antigen delivery
The present invention relates generally to a Plasmid Maintenance System for the stabilization of expression plasmids encoding foreign antigens, and methods for making and using the Plasmid...
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6977165 |
Sequence specific recombinase-based methods for producing intron containing vectors and compositions for use in practicing the same
Methods are provided for producing a vector that includes at least one splicable intron. In the subject methods, intron containing vectors are produced from donor and acceptor vectors that each...
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