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7074898 |
Compositions and methods for therapy and diagnosis of prostate cancer
Compositions and methods for the therapy and diagnosis of cancer, such as prostate cancer, are disclosed. Compositions may comprise one or more prostate-specific proteins, immunogenic portions...
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7074602 |
Method for producing L-threonine
An L-threonine-producing Escherichia coli strain and a method for producing the same are provided. The Escherchia coli strain contains chromosomal DNA with inactivated metJ gene. Therefore,...
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7074590 |
Chimeric promoters
This invention provides novel chimeric promoter/enhancers. The chimeric promoter/enhancers are particularly suitable for directing gene expression in mammalian cells.
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7071321 |
Polynucleotides and polypeptides BASB033 from Neisseria meningitidis and their uses
The invention provides BASB033 polypeptides and polynucleotides encoding BASB033 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are diagnostic,...
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7071172 |
Secretion signal vectors
The present invention provides delivery vectors for transferring a nucleic acid sequence to a cell in vitro, ex vivo or in vivo. The delivery vector comprises a segment encoding a secretory signal...
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7071378 |
Plant seed endosperm specific promoter
The invention concerns promoter nucleotide sequences enabling expression of encoding sequences whereto they can be bound, which is specific of the endosperm region enclosing the embryo of seeds of...
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7071385 |
Promoter and intron from maize actin depolymerizing factor
The promoter from the maize actin depolymerizing factor gene is useful in controlling transgene expression in plants.
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7071171 |
Unique dendritic cell-associated c-type lectins, dectin-1 and dectin-2 compositions and uses thereof
Novel genes expressed selectively by long-term dendritic cell (DC) lines (XS series) from murine epidermis which retain important features of resident epidermal Langerhans cells (LC) are provided....
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7067644 |
Double transposition methods for manipulating nucleic acids
Methods are provided for manipulating nucleic acid to produce gene fusions, to delete or clone a portion of a chromosome, or to insert a sequence into a chromosome. The methods employ sequential...
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7067282 |
Compositions and methods using the yeast YLR110C promoter
The invention provides novel yeast promoters useful for controlling the expression of homologous and heterologous nucleic acid molecules in yeast cells. The yeast promoters are induced by a...
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7067649 |
Promoters exhibiting endothelial cell specificity and methods of using same
An isolated polynucleotide functional as a promoter in eukaryotic cells is disclosed. The isolated polynucleotide includes an endothelial specific enhancer element as detailed herein. Further...
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7067648 |
Regulatory sequences of the mouse villin gene—use in transgenesis
The invention relates to regulatory sequences of the mouse villin gene that efficiently drive transgenic expression in immature and differentiated epithelial cells of the intestine and uro-genital...
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7067643 |
Systems for the detection of target sequences
The present invention relates to means for cleaving a nucleic acid cleavage structure in a site-specific manner. Enzymes, including 5′ nucleases and 3′ exonucleases, are used to detect and...
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7063962 |
DNA sequences for regulating transcription
The invention relates to a DNA sequences for regulating transcription of a structural gene encoding a polypeptide in a eukaryotic host cell comprising (a) a first DNA sequence to which RNA...
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7060467 |
Recombinant proteins containing repeating units
Methods for the production of recombinant proteins containing repeating units are disclosed. Also disclosed are methods for the production of degenerate polynucleotides encoding said recombinant...
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7060459 |
TNF-inducible promoters and methods for using
The present invention provides isolated TNF-inducible promoter sequences, expression vectors containing such promoter sequences, host cells transfected with such expression vectors, as well as...
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7060690 |
Methods and compositions for treating a cell-proliferative disorder using CRE decoy oligomers, BCL-2 antisense oligomers, and hybrid oligomers thereof
The present invention is directed to hybrid oligomers comprising a cyclic AMP response element (CRE) sequence and a sequence that hybridizes to a bcl-2 pre-mRNA or mRNA, and pharmaceutical...
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7060815 |
Isolated and purified nucleic acids comprising a gene and a regulatory region for the gene expression of the same
An isolated and purified nucleic acid comprising a gene specifically expressed in hop lupulin glands. Hops are dioecious, and only female plants bear cones, the lupulin glands of which contain...
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7060433 |
Methods and compositions for screening using diphtheria toxin constructs
The invention relates to methods and compositions utilizing diphtheria toxin for screening purposes. The invention is particularly useful in screening for modulators of IgE synthesis, secretion and...
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7056701 |
Hormone and albumin fusion protein
Biologically active polypeptides comprising a therapeutically active polypeptide fused to human serum albumin or a variant thereof, methods for the preparation thereof, nucleotide sequences...
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7056728 |
Compositions and methods for use thereof in modifying the genomes of microorganisms
The present invention relates to bacterial luciferase transposon cassettes suitable for conferring bioluminescence properties on a Gram-positive bacteria, Gram-negative bacteria, and other...
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7056743 |
MtHP promoter element
The invention provides MtHP promoter sequences capable of functioning as a strong plant promoter. Compositions comprising these sequences described, as are transgenic cells transformed with such...
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7056733 |
Nucleic acids encoding Sarcocystis neurona antigen and uses thereof
The present invention provides novel isolated nucleic acids encoding antigenic proteins derived from Sarcocystis neurona , or unique fragments thereof. In particular, the invention provides novel...
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7057086 |
Therapeutic methods employing PAI-1 inhibitors and transgenic non-human animal for screening candidate PAI-1 inhibitors
A method of testing a candidate composition for PAI-1 inhibition activity is disclosed. The method includes the steps of obtaining a transgenic non-human warm blooded vertebrate animal having...
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7052837 |
Histoplasma capsulatum catalase sequences and their use in the detection of Histoplamsa capsulatum and histoplasmosis
The present invention describes Histoplasmosis capsulatum catalase A and catalase P nucleic acid and protein sequences as reagents for the detection of H. capsulatum infection. Specifically,...
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7052860 |
Identification of Actinobacillus actinomycetemcomitans antigens for use in the diagnosis, treatment, and monitoring of periodontal diseases
Antibodies, polypeptides, and polynucleotides are provided for the detection, prevention, amelioration and treatment of diseases caused by Actinobacillus actinomycetemcomitans.
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7053205 |
Cassava vein mosaic virus promoter nucleic acid sequences and expression vectors
The invention relates to compositions useful for the production of transgenic plants. In particular, the invention relates to Cassava vein mosaic virus (CsVMV) promoter sequences and expression...
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7052834 |
Tumor suppressor protein involved in death signaling, and diagnostics, therapeutics, and screening based on this protein
The present invention relates to identification of tumor suppressor activity of a protein, caspase-8 (CASP8), and to related diagnostic and therapeutic compositions and methods. The discovery of...
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7053268 |
Promoter
A promoter is described. The promoter comprises a nucleotide sequence corresponding to that shown as SEQ ID No. 1 or a variant, homologue or derivative thereof.
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7053265 |
Application of bi-directional promoters for modification of gene expression
The present invention provides a novel bi-directional promoter. The present invention further provides methods of producing proteins of interest and methods of controlling gene expression using the...
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RE39114 |
Expression of sucrose phosphorylase in plants
Introducing sucrose phosphorylase activity into plants by transformation with a gene for the enzyme increases the rate of sucrose hydrolysis, leading to increased starch, oil, and/protein levels....
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7049102 |
Multi-gene expression profile
This invention relates to the use of promoters for ribonucleic acid amplification and other genetic manipulations. Processes are provided wherein complementary deoxyribonucleic acid (cDNA) is...
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7048931 |
Compositions and methods for the therapy and diagnosis of prostate cancer
Compositions and methods for the therapy and diagnosis of cancer, such as prostate cancer, are disclosed. Compositions may comprise one or more prostate-specific proteins, immunogenic portions...
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7049429 |
Mutations of the 5′ region of the human 5-HT1A gene
Clinical response to antidepressant compounds correlates with a selective down-regulation of presynaptic 5-HT1A receptors in serotonergic raphe neurons. Thus regulation of the 5-HT1A receptor gene...
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7045293 |
Alteration of sequence of a target molecule
Method for splicing a target nucleic acid molecule with a separate nucleic acid molecule. Such splicing generally causes production of a chimeric protein with advantageous features over that...
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7045616 |
Transgenic animals and cell lines for screening drugs effective for the treatment or prevention of Alzheimer's disease
Disclosed are transgenic animals and transfected cell lines expressing a protein associated with Alzheimer's Disease, neuroectodermal tumors, malignant astrocytomas, and glioblastomas. Also...
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7045315 |
Methods for modulating expression of exogenous genes in mammalian systems
In accordance with the present invention, there are provided various methods for modulating the expression of an exogenous gene in an isolated cell and in a mammalian subject employing modified...
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7045294 |
Promoter sequences
The present invention relates an isolated human Site-1 Protease promoter region. The invention also relates to screening methods for agents decreasing the expression of Site-1 protease and thereby...
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7045284 |
Method for selective inactivation of viral replication
Method for screening for an antiviral agent, by determining whether a potential agent interacts with a virus or cellular component which allows or prevents preferential translation of a virus RNA...
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7045357 |
Efficiency agrobacterium-mediated plant transformation method
The present invention relates to a rapid transformation and regeneration system for plants. In particular, the invention relates to a plant tissue preparation system. The transformation method is...
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7041815 |
Sporamin promoter and uses thereof
The invention features sporamin promoters, including the promoter of the Ipomoea batatas sporamin A gene. The promoter directs gene expression in tubers and responds in aerial structures to...
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7041477 |
Production of heterologous proteins from Zygosaccharomyces bailii
The invention refers to the production of recombinant gene products from cultures of the yeast Zygosaccharomyces bailii strains transformed with expression vectors bearing the gene coding for...
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7041478 |
G-CSF and albumin fusion protein
Biologically active polypeptides comprising a therapeutically active polypeptide fused to human serum albumin or a variant thereof, methods for the preparation thereof, nucleotide sequences...
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7041653 |
Gene transcription and ionizing radiation: methods and compositions
The present invention provides a DNA molecule comprising a radiation responsive enhancer-promoter operatively linked to an encoding region that encodes at least one polypeptide. An encoding region...
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7037715 |
Multimerized DBH enhancer domains
The invention features an enhancer cassette having the formula [X-Y] n , wherein each X is independently a noradrenergic cell-specific enhancer derived from a DBH gene; Y is absent or is a mono or...
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7037647 |
Prostate-specific membrane antigen and uses thereof
This invention provides an isolated mammalian nucleic acid molecule encoding an alternatively spliced prostate-specific membrane (PSM′) antigen. This invention provides an isolated nucleic acid...
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7037716 |
Packaging systems for human recombinant adenovirus to be used in gene therapy
The invention provides improved methods and products based on adenoviral materials which can advantageously be used in gene therapy. In one aspect, an adenoviral vector is provided having no...
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7034010 |
Use of recombinant gene delivery vectors for treating or preventing lysosomal storage disorders
Gene delivery vectors, such as, for example, recombinant FIV vectors, and methods of using such vectors are provided for use in treating or preventing retinal diseases of the eye and diseases of...
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7033827 |
Prostate-specific polynucleotide compositions
Compositions and methods for the therapy and diagnosis of cancer, particularly prostate cancer, are disclosed. Illustrative compositions comprise one or more prostate-specific polypeptides,...
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7033799 |
Haemophilus adherence and penetration proteins
Haemophilus adhesion and penetration proteins, nucleic acids, vaccines and monoclonal antibodies are provided.
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