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7115369 |
Functional nucleic acid probes and uses thereof
The present invention provides functional nucleic acid probes, and methods of using functional nucleic acid probes, for binding a target to carry out a desired function. The probes have at least...
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7115420 |
Promoters and utilization thereof
The present invention relates to improved promoters and utilization thereof, in particular to promoters which are improved so as not to undergo methylation in the course of constructing...
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7115733 |
Rubisco promoters and uses thereof
The present invention is related to a family of novel spatiotemporally active Rubisco promoters (SEQ ID NO: 1, 2, 3) obtainable from light grown Brassica seedlings. Furthermore the invention is...
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7112434 |
Vector system for selection of genes encoding secreted proteins and membrane-bound proteins
The subject invention concerns novel vectors for the rapid and robust selection for cDNA sequences that encode secreted or membrane-bound proteins. The invention also pertains to methods for...
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7112723 |
Globulin 2 regulatory region and method of using same
A globulin-2 regulatory region is shown, which provides improved seed preferred, and particularly embryo preferred expression in plants. Methods of use are also shown in preferentially expressing a...
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7112725 |
Plants having high plant map values
The present invention relates to novel plant expression constructs. More specifically the present invention provides DNA constructs comprising 5′ regulatory sequences for modulating the...
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7109001 |
COBRA gene and uses thereof
A method by which many plants control organ shape is by regulated, differential cellular expansion. A gene involved in regulating the expansion of plants cells, such as Arabidopsis thaliana root...
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7109321 |
DNA fragment directing gene expression predominant in flower organ
An object of the present invention is to provide a novel DNA sequence having a flower organ-specific promoter activity which makes it possible to express a foreign gene specifically in pistil or...
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7109179 |
Methods and compositions comprising DNA damaging agents and p53
The present invention relates to the use of tumor suppressor genes in combination with a DNA damaging agent or factor for use in killing cells, and in particular cancerous cells. A tumor suppressor...
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7109033 |
Stress-regulated genes of plants, transgenic plants containing same, and methods of use
Clusters of plant genes that are regulated in response to one or more stress conditions are provided, as are isolated plant stress-regulated genes, including portions thereof comprising a coding...
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7109029 |
Vector constructs
The present invention provides novel viral vectors and methods useful for the minimization of leaky gene expression, and, in particular, of nonspecific transcriptional read-through of genes. Such...
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7105316 |
Neisseria lactoferrin binding protein
LbpB polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing LbpB polypeptides and...
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7101990 |
Bax-responsive genes for drug target identification in yeast and fungi
The use of nucleic acids and polypeptides which are involved in a pathway eventually leading to programmed cell death of yeast or fungi for the preparation of a medicament for treating diseases...
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7101541 |
Utilization of non-viral sequences for minus-strand DNA transfer and gene reconstitution
A retroviral vector for gene reconstitution is provided that includes a 3′ portion of a heterologous nucleic acid sequence 5′ of a first att site and a 5′ portion of the heterologous nucleic...
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7098005 |
Natural promoters for gene expression in C1 metabolizing bacteria
Genes have been identified in the Methylomonas genome that are responsive to various metabolic and growth conditions. The identified responsiveness of these genes allows for the use of their...
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7098382 |
Promoter having specific activity to pistil tissue and use of the same
A novel promoter is provided which has an expression activity specific to any pistil tissue. The promoter has any one of the DNA sequence from position 1 to 2595 of SEQ ID NO. 1, the DNA sequence...
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7098190 |
Formulations comprising antisense nucleotides to connexins
A therapeutic and/or cosmetic formulation comprising at least one anti-sense polynucleotide to a connexin protein together with a pharmaceutically acceptable carrier or vehicle is useful in site...
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7098324 |
Chitinase encoding DNA molecules from cotton expressed preferentially in secondary walled cells during secondary wall deposition and a corresponding promoter
The present invention relates to isolated nucleic acid molecules encoding endogenous cotton chitinases and corresponding promoters, which are preferentially expressed in secondary walled cells...
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7098025 |
Human peroxisome proliferator activated receptor gamma (pparγ) gene regulatory sequences and uses therefor
This invention relates to the isolation and cloning of the promoter and other control regions of human PPARγ gene. It provides a method for identifying and screening for agents useful for the...
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7094398 |
Recombinant adenoviral vectors expressing chimeric fiber proteins for cell specific infection and genome integration
The present invention provides for novel chimeric Ad-vectors carrying transgene, or portions of transgenes for stable and efficient gene transfer into diverse cell types or tissues in a CAR- and/or...
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7094577 |
Insulin and albumin fusion protein
Biologically active polypeptides comprising a therapeutically active polypeptide fused to human serum albumin or a variant thereof, methods for the preparation thereof, nucleotide sequences...
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7094893 |
Nucleic acid fragments for the identification of bacteria in industrial wastewater bioreactors
Unique bacterial strains and identifying 16S rDNA sequences have been isolated from activated wastewater sludge. The 16S rDNA sequences are diagnostic for organisms which are key to the health of...
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7094947 |
Animals with high histamine productivity
The invention of the present patent application provides, a histamine-hyperproductive animal, which is a non-human animal or progeny thereof obtained by ontogenesis of totipotent cell transfected...
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7094573 |
Modified shine-dalgarno sequences and methods of use thereof
Novel Shine-Dalgarno (ribosome binding site) sequences, vectors containing such sequences, and host cells transformed with these vectors are provided. Methods of use of such sequences, vectors, and...
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7094604 |
Production of pseudotyped recombinant AAV virions
Vectors that encode Adeno-Associated Virus (AAV) Rep and Cap proteins of different serotypes and Adenovirus transcription products that provide helper functions were used to produce pseudotyped...
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7094953 |
Plant retroelements and methods related thereto
The present invention provides nucleic acids, as well as vectors, cells, and plants (including plant parts, seeds, and embryos) containing the nucleic acids. In particular, molecular tools are...
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7091029 |
High titer recombinant AAV production
The invention includes methods and compositions for the production of high titer recombinant adeno-associated virus (rAAV). The disclosed rAAV are useful in gene therapy applications. Methods are...
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7091003 |
Polypeptides having phospholipase B activity and nucleic acids encoding same
The present invention relates to isolated polypeptides having phospholipase B activity and isolated nucleic acid sequences encoding the polypeptides. The invention also relates to nucleic acid...
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7090994 |
Methods of screening for introduction of DNA into a target cell
The present invention provides methods of introducing a polynucleotide into a target cell, wherein the method employs a light generating protein coding sequence acting as a reporter. An important...
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7091315 |
Protein HDPBQ71
The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells,...
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7091039 |
Kunitz domain polypeptide zkun6
Proteinase inhibitors comprising a Kunitz domain are disclosed. The Kunitz domain comprises a sequence of amino acid residues as shown in SEQ ID NO:3, wherein the sequence is at least 80% identical...
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7091040 |
P450/acetaminophen genetically directed enzyme prodrug therapy (GDEPT)
The invention hereindescribed relates to a form of cancer therapy which exploits the cytotoxic properties of acetaminophen when converted to NABQI by the metabolic activity of tumour cell specific...
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7087737 |
Pro1278 nucleic acids
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid...
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7087410 |
Systems for expression of heterologous proteins in M. capsulatus
The present invention relates to an expression system for the expression of proteins and peptides in a methanotrophic bacterium, preferable the M. capsulatus . Further, the invention relates to...
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7084267 |
Promoter regions of the mouse and human telomerase RNA component genes
The present invention relates to the identification of the genomic promoter region of the human and mouse telomerase RNA gene. Telomerase activity is necessary for the unrestricted proliferative...
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7081242 |
Methods of treating lupus based on antibody affinity and screening methods and compositions for use thereof
The invention provides methods identifying individuals suitable for treatment for lupus and methods of monitoring treatment, based on measuring antibody affinities, as well as of treating lupus...
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7081359 |
Recombinant bacillus proteases and uses thereof
The present invention provides genetically engineered Bacillus strains that can secrete large amount of Bacillus proteases in the extracellular culture medium. More particularly, this invention...
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7081354 |
Interleukin and albumin fusion protein
Biologically active polypeptides comprising a therapeutically active polypeptide fused to human serum albumin or a variant thereof, methods for the preparation thereof, nucleotide sequences...
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7081565 |
Plant seed specific promoters
The present invention relates to novel seed specific promoter regions. The present invention further provide methods of producing proteins and other products of interest and methods of controlling...
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7081566 |
Seed preferred regulatory elements
The present invention provides compositions and methods for regulating expression of isolated nucleotide sequences in a plant. The compositions are novel nucleic acid sequences for seed-preferred...
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7078193 |
Pathogenic Escherichia coli associated protein espA
The present invention provides a polypeptide, called EspA, which is secreted by pathogenic E. coli , such as the enteropathogenic (EPEC) and enterohemorrhagic (EHEC) E. coli . The invention also...
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7078234 |
Maize embryo-specific promoter compositions and methods for use thereof
This invention provides an embryo specific promoter, e.g. derived from the 5′ regulatory region of an emb5 gene. Compositions comprising this promoter include DNA constructs useful for plant...
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7078587 |
Tapetum-specific promoters
The present invention relates to nucleic acid sequences encoding tapetum specific promoters, for use in Artificial Male Sterility systems in plants. In particular, the promoters may be the pMAC2...
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7078501 |
Topoisomerase linker-mediated amplification methods
A Vaccinia topoisomerase-adapted linker, which contains an oligonucleotide primer binding site of known sequence, useful for specifically joining the linker to the end of a polynucleotide of...
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7078589 |
Isolated nematode regulated gene promoter and use thereof
The present invention relates to nematode-regulated promoter and polypeptide-encoding nucleotide sequences and their use in creating or enhancing nematode-resistance in plants. Nucleic acid...
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7078190 |
Compositions and methods utilizing the yeast ZE01 promoter
The invention provides novel yeast promoters useful for controlling the expression of homologous and heterologous nucleic acid molecules in yeast cells. The yeast promoters are induced by a...
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7078390 |
Ribozymes to growth factor originating in human platelet
A ribozyme comprising the following nucleotide sequence (SEQ ID NO:14) (I):
3′-GUGCCCCA GUACGGUG-5′ A C A UGA G AGU N 3 N 1 N 2
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7078593 |
Sequence regulating the anther-specific expression of a gene and its use in the production of androsterile plants and hybrid seeds
The regulatory sequence is useful for the specific expression in anther of a nucleotide sequence of interest, for example, a sequence whose controlled expression under the regulatory sequence...
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7078387 |
Efficient and stable in vivo gene transfer to cardiomyocytes using recombinant adeno-associated virus vectors
This invention relates to the use of recombinant adeno-associated virus (rAAV) vectors to transduce cardiomyocytes in vivo by infusing the rAAV into a coronary artery or coronary sinus. rAAV...
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7074400 |
Regulatory constructs comprising intron 3 of prostate specific membrane antigen gene
The invention provides regulatory constructs comprising intron 3 of the prostate specific membrane antigen gene (PSMA). An isolated nucleic acid molecule encoding the partial sequence of intron 3...
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