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9040776 Genes regulating plant branching, promotors, genetic constructs containing same and uses thereof  
The invention relates to genes coding for TCP family transcription factors and having a biological role in the development of axillary buds and branch growth. Furthermore, the invention relates to...
9029339 Impaired wound healing compositions and methods  
Connexin modulation for the treatment of wounds that do not heal at expected rates, including delayed healing wounds, incompletely healing wounds, and chronic wounds, and associated methods,...
9029523 Promoter, promoter control elements, and combinations, and uses thereof  
The present invention provides DNA molecules that constitute fragments of the genome of a plant, and polypeptides encoded thereby. The DNA molecules are useful for specifying a gene product in...
9024005 Nucleic acid complexes  
The present invention relates to complexes of transcription factor decoys, their delivery to bacteria and their formulation. In particular, the present invention resides in an antibacterial complex...
9018365 Methods and compositions for tagging and identifying polynucleotides  
The invention provides methods and compositions for attaching oligonucleotide tags to polynucleotides for the purpose of carrying out analytical assays in parallel and for decoding the...
9018002 Method to trigger RNA interference  
A method to generate siRNAs in vivo is described, as are constructs and compositions useful in the method. The method does not depend on the use of DNA or synthetic constructs that contain inverted...
9017938 Use of microrna-199b-5p in medical and diagnostic field  
This invention concerns the use of MicroRNA-199b-5p in medical and diagnostic fields. Particularly, this invention concerns the use of the miR199b-5p in the anti-cancer therapy and as a...
9018182 Tumor specific promoter and oncolytic virus vector comprising the same  
Provided are tumor-specific promoters, oncolytic virus vectors and a pharmaceutical composition comprising the virus vector. The virus vector comprising the novel tumor-specific promoter shows...
9012720 Compositions and methods for modifying gene expression using the promoter of ubiquitin conjugating protein coding gene of soybean plants  
A polynucleotide isolated from soybean plants capable of initiating transcription and with sequence identity to SEQ ID No. 1 is provided. In some aspects, the polynucleotide has sequence identity...
9012721 Transgenic plants with improved growth and nitrogen use efficiency  
The invention relates to transgenic plants with improved growth and nitrogen use efficiency expressing nitrate transporter gene, methods of making such plants and methods for improving growth and...
9012617 Detection reagents for tyrosine kinase activity and methods of use thereof  
Dual colored fluorescent indicators of specific tyrosine kinase activity and methods of use thereof are disclosed.
9006518 F-box protein targeted plant oil production  
Disclosed are genetic constructs, transgenic plant cells and transgenic plants, as well as associated methods, for increasing oil production in a plant using F-box gene sequences.
9006413 PCP2 mini-promoters  
Isolated polynucleotides comprising a PCP2 mini-promoter are provided. The mini-promoter may be operably linked to an expressible sequence, e.g. reporter genes, genes encoding a polypeptide of...
9006412 Expression vector for pseudonocardia autotrophica  
An expression vector capable of expressing a foreign gene in Pseudonocardia autotrophica; a transformant of Pseudonocardia autotrophica produced by using the expression vector; a method for...
9005935 Methods and compositions for DNA fragmentation and tagging by transposases  
The present invention provides new compositions for transposase-mediated fragmenting and tagging DNA targets. The invention relates to the surprising discovery that use of manganese ions (Mn2+) in...
9006515 Pollen preferred promoters and methods of use  
Compositions and methods for regulating expression of heterologous nucleotide sequences in a plant are provided. Compositions include nucleotide sequences encompasses a strong pollen preferred...
8999667 Selection of host cells expressing protein at high levels  
The invention provides a DNA molecule comprising a multicistronic transcription unit coding for i) a polypeptide of interest, and for ii) a selectable marker polypeptide functional in a eukaryotic...
8999673 Method for specifically producing a joined DNA fragment comprising a sequence derived from a target gene  
Provided is a method for selectively obtaining, for a given target gene, a “joined DNA fragment” wherein just a target gene fragment is joined with desired other DNA fragments, regardless of whe...
8999641 Engineering and optimization of systems, methods and compositions for sequence manipulation with functional domains  
The invention provides for engineering and optimization of systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are vectors and vector...
8993233 Engineering and optimization of systems, methods and compositions for sequence manipulation with functional domains  
The invention provides for engineering and optimization of systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are vectors and vector...
8993837 Chimeric promoters and methods of use  
Compositions and methods comprising promoters from the 4-hydroxyphenylpyruvate dioxygenase (HPPD) gene and active variants and fragments thereof, as well as chimeric promoters employing regulatory...
8993238 Brassica GAT event and compositions and methods for the identification and/or detection thereof  
Compositions and methods related to transgenic glyphosate tolerant Brassica plants are provided. Specifically, the present invention provides Brassica plants having a DP-073496-4 event which...
8993836 Plant promoters and uses thereof  
The invention concerns tools, methods and compositions for modifying plants and/or protein expression in plants. The invention concerns in particular transcriptional promoters enabling specific...
8993861 Soybean promoters SC194 and flower-preferred expression thereof in transgenic plants  
The promoters of a soybean SC194 polypeptide and fragments thereof and their use in promoting the expression of one or more heterologous nucleic acid fragments in plants are described.
8993840 Sucrose transporter genes for increasing plant seed lipids  
This invention relates to polynucleotide sequences encoding SUT2 or SUT4 sucrose transporter genes. Methods for increasing seed oil content and evaluating increased oil content in a plant seed are...
8987434 Hybrid caulimovirus promoters and constructs thereof  
The present invention relates to novel hybrid promoters comprising a caulimovirus promoter operably linked to one or more of an EF1α, Act8, Act2 or Act11 promoter. The present invention also ...
8980858 Treatment of methionine sulfoxide reductase a (MSRA) related diseases by inhibition of natural antisense transcript to MSRA  
The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of Methionine Sulfoxide Reductase A (MSRA), in particular, by targeting natural antisense...
8980860 Treatment of discs large homolog (DLG) related diseases by inhibition of natural antisense transcript to DLG  
The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of Discs large homolog (DLG), in particular, by targeting natural antisense...
8980862 Defibrotide for use in prophylaxis and/or treatment of Graft versus Host Disease (GVHD)  
Defibrotide for use in prophylaxis and/or treatment of Graft versus Host Disease (GVHD) in humans is disclosed, preferably in hematopoietic stem cell transplantation (HSCT), more preferably...
8980556 High resolution melting analysis as a prescreening tool  
Compositions and methods for determining an increased likelihood of a response to a targeted treatment of a cancer disease including isolating genomic DNA from a patient sample, amplifying a...
8980853 Compositions and methods for modulation of SMN2 splicing in a subject  
Disclosed herein are compounds, compositions and methods for modulating splicing of SMN2 mRNA in a subject. Also provided are uses of disclosed compounds and compositions in the manufacture of a...
8975023 Method for controlling the amount of gene product, and agent for controlling the amount of gene product  
The invention relates to a method of intracellularly controlling amounts of gene products, which can increase an amount of gene product intracellularly, comprising a step of introducing into the...
8975472 Compositions and methods for altering alpha- and beta-tocotrienol content using multiple transgenes  
Preparation and use of isolated nucleic acids useful in altering the oil phenotype of plants are described. Isolated nucleic acids and their encoded polypeptides are described that alter the...
8975391 Regulatory elements  
The invention concerns novel regulatory elements as well as related vectors and cells. Furthermore, it relates to methods of improving expression of polypeptides from nucleic acids such as cloned...
8969539 Expression vectors  
This present invention provides an expression vector system that uses alternative RNA processing to express in a single cell a polypeptide in both membrane-bound and soluble forms. By incorporating...
8969316 Compounds and methods for modulating expression of DGAT2  
The present disclosure describes short antisense compounds, including such compounds comprising chemically-modified high-affinity monomers 8-16 monomers in length. Certain such short antisense...
8962916 Viral promoter, truncations thereof, and methods of use  
The present disclosure provides compositions and methods for regulating expression of heterologous nucleotide sequences in a plant. Compositions include a novel nucleotide sequence for a promoter....
8962586 Treatment of pyrroline-5-carboxylate reductase 1 (PYCR1) related diseases by inhibition of natural antisense transcript to PYCR1  
The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of Pyrroline-5-carboxylate reductase 1 (PYCR1), in particular, by targeting natural...
8956829 Human recombinant growth and differentiaton factor-5 (rhGDF-5)  
Expression vector systems are provided for increased production of a recombinant GDF-5 (rhGDF-5) protein. Also provided are transformed host cells that were engineered to produce and express high...
8957038 Treatment of neurological disorders  
This invention provides treatment compositions as well as systems and methods of determining and administering an effective amount of treatment for a neurological disorder. The treatment...
8957044 Systemic gene replacement therapy for treatment of X-linked myotubular myopathy (XLMTM)  
The present invention provides compositions and methods for treating a myopathy. In certain embodiments, the invention provides compositions and methods for treating, improving muscle function, and...
8957196 Vector and expression cell line for mass production of recombinant protein and a process of producing recombinant protein using same  
Disclosed herein is an inducible high-expression cassette comprising a dihydrofolate reductase (DHFR) promoter from which GC-rich repeat sequences are partially or entirely removed, the cassette...
8952215 Antibody-producing transgenic silkworms and methods for producing the same  
The present inventors produced transgenic silkworms which comprise a promoter of a DNA encoding a protein specifically expressed in the silk gland and a DNA encoding a recombinant antibody whose...
8952216 Plant promoter operable in basal endosperm transfer layer of endosperm and uses thereof  
The present invention provides an isolated promoter or an active fragment or derivative thereof capable of conferring selective expression on a gene to which it is operably connected in the...
8951984 Oligonucleotides for modulation of target RNA activity  
The present invention relates to oligonucleotides for modulation of target RNA activity. Thus, the invention provides oligonucleotides that bind to microRNA binding sites of target RNA. The...
8951745 Compositions for diagnosis and therapy of diseases associated with aberrant expression of futrins (R-Spondins) and/or Wnt  
The present invention relates to a composition useful for the diagnosis of diseases associated with aberrant expression of the genes encoding the secreted proteins Futrin 1, 2, 3 and/or 4...
8951790 Mammalian expression vector pUHAB  
The present invention relates to the construction and utilization of a new mammalian expression vector that contains a unique multiple cloning site (MCS), designated pUHAB. The pUHAB vector...
8952145 Compositions and their uses directed to huntingtin  
Disclosed herein are compounds, compositions and methods for modulating the expression of huntingtin in a cell, tissue or animal. Further provided are methods of slowing or preventing Huntington's...
8951981 Treatment of paraoxonase 1 (PON1) related diseases by inhibition of natural antisense transcript to PON1  
The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of Paraoxonase 1(PON1), in particular, by targeting natural antisense polynucleotides of...
8945884 Methods and compositions for synthesis of nucleic acid molecules using multiplerecognition sites  
The present invention provides compositions and methods for recombinational cloning. The compositions include vectors having multiple recombination sites and/or multiple topoisomerase recognition...