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8435783 |
Plant artificial chromosome platforms via telomere truncation
The invention provides engineered plant minichromosomes generated by telomere mediated truncation of native chromosomes. These minichromosomes are faithfully transmitted from one generation to the...
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8436162 |
Arabidopsis derived promoters for regulation of plant expression
The instant invention is directed to a constitutive promoter for use in plants. The plant genus from which the promoter is derived is Arabidopsis. The invention encompasses the isolated promoter,...
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8435960 |
Devices for improved wound management
The present invention provides devices and compositions for the management of infection of topical lesions, each of the devices and compositions containing protonated/acidified nucleic acids either...
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8436160 |
Isolated DNA fragment of the SPARC human promoter and its use for driving the expression of an heterologous gene in tumor cells
An isolated DNA sequence corresponding to a region of the SPARC gene human promoter from base pair −513 to base pair +35 capable of driving the expression of a heterologous gene of interest, that c...
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8436161 |
Chimeric promoters comprising a rice actin 1 promoter and 35S enhancer for use in plants
The present invention provides polynucleotide molecules useful for expressing transgenes in plants. More particularly, the present invention provides chimeric promoters comprising rice actin 1...
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8431392 |
Shortened Alk1 regulatory fragment
Regulatory elements for controlling expression of transgenes in angiogenic tissue are provided. One embodiment provides an isolated nucleic acid having at least 80%, 85%, 90%, 95%, 97%, 99% or 100%...
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8426675 |
Methods for producing microRNAs
The invention relates to recombinant vectors for inducible and/or tissue specific expression of double-stranded RNA molecules that interfere with the expression of a target gene. In certain...
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8426577 |
Promoter and a production method for L-lysine using the same
Disclosed are a nucleic acid molecule of Corynebacterium glutamicum origin, having an improved promoter activity, which is operably linked to operon encoding aspartate kinase and aspartate...
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8426580 |
Microbacterial peptide deformylase
The present invention relates to the design of the Antisense-oligonucleotide complementary to the specific region of peptide deformylase gene from Mycobacterium tuberculosis. The use of this...
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8426374 |
Method for modifying myostatin expression
A method comprising inhibiting myostatin expression or activity to increase muscle mass. Still further, methods for locally inhibiting myostatin expression or activity to reduce fibrosis are...
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8426576 |
Arabidopsis derived promoters for regulation of plant expression
The instant invention is directed to a constitutive promoter for use in plants. The plant genus from which the promoter is derived is Arabidopsis. The invention encompasses the isolated promoter,...
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8426579 |
SiRNA targeting myeloid differentiation primary response gene (88) (MYD88)
Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene...
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8426195 |
Promoter nucleic acid molecule derived from corynebacterium glutamicum, recombinant vector comprising the promoter, host cell comprising the recombinant vector and method of expressing gene using the host cell
Provided are a novel promoter nucleic acid molecule having a nucleotide sequence of SEQ ID NO: 1 or 2 derived from Corynebacterium glutamicum, a recombinant vector comprising the promoter, a host...
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8420617 |
Multiantivirus compound, composition and method for treatment of virus diseases
A method for obtaining a new antiviral compound with multiple action against many viruses, comprising modified highly purified yeast RNA, a pharmaceutical composition comprising such RNA, and a...
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8420075 |
Ex vivo and in vivo expression of the thrombomodulin gene for the treatment of cardiovascular and peripheral vascular diseases
The present invention relates to methods and compositions for treatment of cardiovascular and peripheral vascular diseases using ex vivo and in vivo gene delivery technologies. One aspect of the...
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8420792 |
Suppressor tRNA transcription in vertebrate cells
This invention provides compositions and methods for producing translational components that expand the number of genetically encoded amino acids in vertebrate cells. The components include...
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8420797 |
Ubiquitin promoter and methods of use
The present invention provides compositions and methods for regulating expression of heterologous nucleotide sequences in a plant. Compositions are novel nucleotide sequences for a constitutive...
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8420388 |
Gene of porcine beta casein, a promoter of the same and the use thereof
The present invention provides a porcine beta-casein gene, a porcine beta-casein gene promoter, an expression vector comprising the same promoter, and a method for the production of a target...
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8420888 |
Chloroplast transit peptides for efficient targeting of DMO and uses thereof
The invention provides for identification and use of certain chloroplast transit peptides for efficient processing and localization of dicamba monooxygenase (DMO) enzyme in transgenic plants....
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8420796 |
Constitutive promoters from poplar and uses thereof
The present invention relates to nucleic acid molecules corresponding to regulatory portions of genes whose expression is constitutive. The invention also relates to compositions and methods of...
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8415155 |
Cardiomyocyte production
Methods and composition for the production of cardiomyocytes from differentiation of pluripotent stem cells are provided. For example, in certain aspects methods including differentiating...
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8415461 |
Amphiphilic substances and functionalized lipid vesicles including the same
An amphiphilic substance includes a hydrophobic group, and a polynucleotide group attached to the hydrophobic group. The polynucleotide group includes a first polynucleotide segment and a second...
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8415465 |
Compositions and their uses directed to huntingtin
Disclosed herein are compounds, compositions and methods for modulating the expression of huntingtin in a cell, tissue or animal. Further provided are methods of slowing or preventing Huntington's...
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8415466 |
Duplex oligonucleotides with enhanced functionality in gene regulation
Disclosed are methods of enhancing functionality of duplex oligonucleotides and compositions made by the methods. The duplex oligonucleotides include siRNAs, miRNA mimics, and piRNA mimics which...
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8415148 |
Expression system
The present invention relates generally to methods and compositions for expression of polypeptides or delivery of interfering RNAs in various cell types.
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8409795 |
Selex and photoSELEX
The present disclosure describes improved SELEX methods for generating nucleic acid ligands that are capable of binding to target molecules and improved photoSELEX methods for generating...
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8410259 |
Recombinant expression vector elements (REVES) for enhancing expression of recombinant proteins in host cells
Compositions and methods comprising recombinant expression vector elements (rEVEs) to enhance the level of expression of recombinant proteins are described. Other compositions and methods for...
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8410074 |
Modulation of eIF4E expression
Oligomeric compounds, compositions and methods are provided for modulating the expression of eIF4E. The antisense compounds may be single- or double-stranded and are targeted to nucleic acid...
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8410073 |
Methods and compositions for prevention or treatment of RSV infection
Methods and compositions are provided for the prevention or treatment of RSV infection in a human. The methods include administering one or more doses of a composition comprising an siRNA. The dose...
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8404657 |
Means and methods for treating or preventing brain tumors based on the nuclear receptor tailless (Tlx)
The present invention relates to the use of an inhibitor of tailless gene expression or tailless protein activity for the preparation of a pharmaceutical composition for treating or preventing the...
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8404827 |
Environmental stress-inducible 996 promoter isolated from rice and uses thereof
The present invention relates to environmental stress-inducible 996 promoter isolated from rice, a recombinant plant expression vector comprising said promoter, a method of producing a target...
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8404931 |
Use of multiple transformation enhancer sequences to improve plant transformation efficiency
The present invention relates to methods and compositions for improving the efficiency of Agrobacterium- and Rhizobium-mediated plant cell transformation by use of additional transformation...
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8399246 |
Baculovirus expression vector and method therewith for generating immunogenicity in a host
A baculovirus expression vector achieves dual functions of (1) subunit vaccine by displaying the influenza surface protein for humoral immune responses; and (2) DNA vaccine by expressing influenza...
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8399424 |
Method for controlling the amount of gene product, and agent for controlling the amount of gene product
The invention relates to a method of intracellularly controlling amounts of gene products, which can increase an amount of gene product intracellularly, comprising a step of introducing into the...
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8394947 |
Positionally modified siRNA constructs
The present invention provides oligomeric compounds having sufficient complementarity to hybridize to a nucleic acid target and methods for their use in modulating gene expression. In one...
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8395024 |
Stress-inducible plant promoters
The present invention discloses and claims stress-inducible plant promoters, DNA constructs with such promoters, transgenic plants containing such promoters and DNA constructs, isolated DNAs...
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8395022 |
Viral promoter, truncations thereof, and methods of use
The present disclosure provides compositions and methods for regulating expression of heterologous nucleotide sequences in a plant. Compositions include a novel nucleotide sequence for a promoter....
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8389711 |
Pharmaceutical composition for treatment of cancer and asthma
Provided is a pharmaceutical composition for treating cancer and asthma. The object can be solved by a pharmaceutical composition comprising a siRNA molecule that directs cleavage of mRNA of mucin...
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8389710 |
Therapeutic nucleic acid-3′-conjugates
Methods are described for improvement of the serum half life of therapeutic nucleic acids by 3′ conjugation to useful target proteins, or other large molecules with useful function. In one e...
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8389214 |
Glucose transport mutants for production of biomaterial
A method is disclosed for restoring a Glu+ phenotype to a PTS−/Glu− bacterial cell which was originally capable of utilizing a phosphotransferase transport system (PTS) for carbohydrate tra...
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8389806 |
Vascular-preferred promoters
The present invention relates to the regulation of polynucleotide transcription and/or expression. In particular, this invention relates to polynucleotide regulatory sequences isolated from...
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8389238 |
Long-term in vivo transgene expression
Efficient and prolonged hCFTR expression is one of the major obstacles for cystic fibrosis lung therapy. hCFTR mRNA expression levels depend on eukaryotic expression cassette components,...
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8389795 |
Vectors and methods for the mutagenesis of mammalian genes
Disclosed herein are methods for mutagenizing a mammalian gene, the methods involving introducing into a mammalian cell a retroviral vector which includes a splice acceptor sequence, a...
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8389493 |
Microsphere-based composition for preventing and/or reversing new-onset autoimmune diabetes
AS-oligonucleotides are delivered in microsphere form in order to induce dendritic cell tolerance, particularly in the non-obese-diabetic (NOD) mouse model. The microspheres incorporate antisense...
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8389805 |
Promoter, promoter control elements, and combinations, and uses thereof
The present invention is directed to promoter sequences and promoter control elements, polynucleotide constructs comprising the promoters and control elements, and methods of identifying the...
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8383364 |
Inducible expression systems
Provided is an rtTA and single chain rtTA variants and uses thereof for inducible expression of a nucleic acid of interest. Nucleic acid molecules comprising an improved rtTA and/or sc rtTA...
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8383803 |
PITX3 expression promoters
Isolated polynucleotides comprising a PITX3 promoter are provided, where a PITX3 regulatory element is operably joined to a PITX3 basal promoter utilizing a non-native spacing between the promoter...
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8383336 |
Antisense formulation
A room temperature stable and minimal aggregate liquid formulation comprises an oligonucleotide comprising Seq ID No. 1: or comprising a variant oligonucleotide in which no more than 3...
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8383599 |
Methods and compositions for RNA interference
The present invention provides methods for attenuating gene expression in a cell using gene-targeted double stranded RNA (dsRNA). The dsRNA contains a nucleotide sequence that hybridizes under...
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8383398 |
Expression vector
A conventional shuttle vector constructed by fusing an E. coli-derived plasmid and a transformant-derived plasmid functions in both E. coli and the transformant bacterium, and there exists no...
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