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8940502 Nucleic acid constructs and methods of making protein  
The present invention relates to methods for producing a polypeptide, comprising: (a) cultivating a fungal host cell in a medium conducive for the production of the polypeptide, wherein the fungal...
8940962 Chimeric promoter comprising FMV enhancer and HSP81-2 promoter and plants transformed therewith  
The present invention provides novel promoters for use in plants. Specifically, the present invention provides novel chimeric promoters comprising combinations of plant viral enhancer elements and...
8940479 Methods for modulating de novo hepatic lipogenesis by modulating XBP-1 activity  
The invention provides methods and compositions for modulating the expression, processing, post-translational modification, stability and/or activity of XBP-1 protein, or a protein in a signal...
8936937 System for expression of genes in plants from a virus-based expression vector  
Modified expression vectors, including Tobacco Mosaic Virus (TMV) expression vectors, methods for modifying such vectors, and uses of the same are disclosed.
8933049 Repressor on IFN-λ promoter and siRNA against ZEB1 and BLIMP-1 to increase IFN-λ gene activity  
The present invention is directed to the identification of a novel repressor located between ˜1.2 kb to ˜1.6 kb from the translation start site of the IFN-λ1 promoter. The present invention pr...
8932814 CRISPR-Cas nickase systems, methods and compositions for sequence manipulation in eukaryotes  
The invention provides for systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are vectors and vector systems, some of which encode one...
8933302 Jatropha curcas curcin genes, tissue-specific promoters and generation of curcin-deficient transgenic Jatropha plants  
The present invention relates to the isolation of Jatropha curcas curcin genes and tissue-specific promoters and to the production of curcin-deficient Jatropha plants. More specifically, the...
8933215 Interfering RNA molecules  
The present invention is related to a ribonucleic acid comprising a double stranded structure whereby the double-stranded structure comprises a first strand and a second strand, whereby the first...
8927269 Avian adenoassociated virus and uses thereof  
The present invention provides an Avian adeno-associated virus (AAAV) virus and vectors and particles derived therefrom. In addition, the present invention provides methods of delivering a nucleic...
8927807 Nitrate-responsive promoter  
The present invention provides methods for screening for nitrate-regulated promoter and enhancer elements in plant cells. The present invention also provides expression cassettes that contain...
8927702 Solanum bulbocastanum polyubiquitin Bul409 promoter and uses thereof  
The present invention relates to isolated Solanum Bulbocastanum Bul409 promoter sequences and uses thereof. An exemplary embodiment provides an isolated plant Bul409 promoter comprising a nucleic...
8927704 Sense oligonucleotide capable of controlling the expression of iNOS and composition comprising the same  
The invention relates to sense oligonucleotide having a sequence complementary to a single-stranded RNA (antisense transcript) having a sequence complementary to mRNA of iNOS gene in order to...
8927515 Methods and compositions for the specific inhibition of androgen receptor by double-stranded RNA  
This invention relates to compounds, compositions, and methods useful for reducing AR target RNA and protein levels via use of dsRNAs, e.g., Dicer substrate siRNA (DsiRNA) agents.
8927519 Methods for producing interfering RNA molecules in mammalian cells and therapeutic uses for such molecules  
Methods for producing interfering RNA molecules in mammalian cells are provided. Therapeutic uses for the expressed molecules, including inhibiting expression of HIV, are also provided.
8927703 Compositions, kits and related methods for the detection and/or monitoring of Pseudomonas aeruginosa  
The present invention provides compositions, methods and kits for the species-specific detection of Pseudomonas aeruginosa.
8927245 Ligation method employing eukaryotic tRNA ligase  
Provided herein is a method of preparing an RNA sample comprising: a) obtaining an RNA sample comprising: i. long RNA molecules that may be unfragmented or fragmented to contain 5′-OH group and a 2...
8921333 Therapeutic agent for tumor  
The present invention provides a therapeutic agent for a tumor, particularly a therapeutic agent for drug-resistant cancer, an agent for suppression or prophylaxis of tumor metastasis, and an agent...
8921656 Solanum bulbocastanum polyubiquitin Bul427 promoter and uses thereof  
The present invention relates to isolated Solanum Bulbocastanum Bul427 promoter sequences and uses thereof. An exemplary embodiment provides an isolated plant Bul427 promoter comprising a nucleic...
8921100 Use of the adenoviral E2 late promoter  
The invention relates to a nucleic acid construct comprising an adenoviral E2 late promoter or a fragment thereof and a nucleic acid. The nucleic acid is selected from the group of transgenes,...
8921538 Control of gene expression in plants  
The invention provides the isolated promoter polynucleotide sequence of SEQ ID NO: 1 from perennial ryegrass (Lolium perenne L.), and fragments and variants thereof. The invention also provides...
8921657 Expression cassettes for endosperm-specific expression in plants  
The present invention relates to an expression cassette for regulating seed-specific expression of a polynucleotide of interest, said expression cassette comprising a transcription regulating...
8921331 Methods for slowing familial ALS disease progression  
Methods for slowing disease progression in an individual suffering from familial ALS are provided. Also provided are methods of increasing the survival time of an individual suffering from familial...
8921056 Compositions for diagnosis and therapy of diseases associated with aberrant expression of futrins (R-Spondins) and/or Wnt  
The present invention relates to a composition useful for the diagnosis of diseases associated with aberrant expression of the genes encoding the secreted proteins Futrin 1, 2, 3 and/or...
8916377 Root-preferred promoter and methods of use  
The present invention provides compositions and methods for regulating expression of heterologous nucleotide sequences in a plant. Compositions include a novel nucleotide sequence for a promoter...
8916174 HIV DNA vaccine regulated by a caev-derived promoter  
The present invention is directed to a DNA vaccine for immunization against HIV. The invention comprises a DNA molecule that has a sequence encoding a plurality of viral proteins capable of...
8916534 Methods of inducing insulin production  
The present invention provides a method of inducing insulin production in a cell by up-regulating a target gene involved in insulin production in said cell using an saRNA (short activating...
8912161 MicroRNA compounds and methods for modulating miR-21 activity  
Described herein are compositions and methods for the inhibition of miR-21 activity. The compositions have certain nucleoside modification patterns that yield potent inhibitors of miR-21 activity....
8912315 Purkinje cell-tropic viral vector  
The present invention relates to a Purkinje cell-tropic viral vector in which a modified L7 promoter and a therapeutic gene are operably linked to a virus-based plasmid vector.
8912155 Method for analyzing secretome, biomarker for lung cancer metastasis, and siRNA compound for inhibiting lung cancer metastasis  
A method for analyzing secretome, a biomarker for lung cancer metastasis, and a siRNA compound for inhibiting lung cancer metastasis are disclosed. The method for analyzing secretome of the present...
8907073 Nucleic acids encoding FOXD3 promoter and methods to isolate FOXD3 expressing cells  
DNA enhancer sequences are provided for use in constructs to identify early stage embryonic cells. The enhancer sequences can be used in parallel with short-hairpin RNA in a vector construct for...
8907076 Mycobacterial peptide deformylase  
The present invention relates to the design of the Antisense-oligonucleotide complementary to the specific region of peptide deformylase gene from Mycobacterium tuberculosis. The use of this...
8906607 Method for modulating double-strand break-induced homologous recombination  
The present invention concerns a method for modulating double-strand break-induced homologous recombination through the identification of effectors that modulate said double-strand break-induced...
8907074 Laticiferous tissue-specific SRPP promoter from Hevea brasiliensis and uses thereof  
A laticiferous tissue-specific SRPP (small rubber particle-associated protein) promoter derived from Hevea brasiliensis, consists of nucleotide sequence of SEQ ID NO: 1. A recombinant plant...
8901098 Antisense modulation of GCCR expression  
Provided herein are methods, compounds, and compositions for reducing expression of GCCR mRNA and protein in an animal. Such methods, compounds, and compositions are useful to treat, prevent,...
8901374 Fatty acid dehydratases and uses thereof  
The invention provides isolated nucleic acid molecules which encode novel fatty acid dehydratase family members. The invention also provides recombinant expression vectors containing dehydratase...
8900849 Oxygen-regulated microorganisms  
The present invention relates to novel strains of microorganisms with oxygen-regulated metabolism. The microorganisms have higher growth rates and are more efficient than parental strains. The...
8895715 S100B mini-promoters  
Isolated polynucleotides comprising an S100B promoter are provided, where an S100B regulatory element is operably joined to an S100B basal promoter utilizing a non-native spacing between the...
8895524 Viral microRNA  
The present invention relates, in general, to micro RN As and, in particular, to viral microRNAs expressed by Herpes Simplex Vims 1 (HSV-1) or Herpes Simplex Virus 2 (HSV-2), to agents that inhibit...
8895305 Water deficit-inducible promoters  
Water deficit-inducible promoter sequences were identified that may be used to produce transgenic plants that are more tolerant to water deficit and related hyperosmotic stresses than control...
8895716 Viral promoter, truncations thereof, and methods of use  
The present disclosure provides compositions and methods for regulating expression of heterologous nucleotide sequences in a plant. Compositions include a novel nucleotide sequence for a promoter....
8889352 Conversion of alpha-hydroxyalkylated residues in biomolecules using methyltransferases  
The present invention relates to targeted conversion of alpha-hydroxyalkylated residues in biomolecules in the presence of a directing methyltransferase, namely to targeted removal of the...
8889356 CRISPR-Cas nickase systems, methods and compositions for sequence manipulation in eukaryotes  
The invention provides for systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are vectors and vector systems, some of which encode one...
8883993 Tetraselmis promoters and terminators for use in eukaryotic cells  
The present invention provides novel promoter and terminator sequences for use in gene expression in eukaryotic cells, such as algal cells. The invention further provides expression cassettes...
8883998 siRNA targeting myeloid differentiation primary response gene (88) (MYD88)  
Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene...
8883493 Adenoviral vector comprising herpes simplex virus type 1 thymidine kinase and a transgene for increasing the expression of the transgene  
Compositions and methods useful in transgene expression are provided. Herpes simplex virus type 1 thymidine kinase sequences (“TK sequences”) are used to enhance transgene expression in first gen...
8877916 Promoter, promoter control elements, and combinations, and uses thereof  
The present invention provides DNA molecules that constitute fragments of the genome of a plant, and polypeptides encoded thereby. The DNA molecules are useful for specifying a gene product in...
8877502 Plasmid curing  
The present invention relates to plasmid curing, and particularly to efficient and stress-free methods for displacing resident or endogenous plasmids from a host cell, such as a bacterium. The...
8878003 Storage-induced promoter  
A promoter with an organ-specific activity in plants. The promoter is characterized in that it exhibits greater activity in the storage organs of plants than in other organs of said plants and that...
8877503 Sulfonylurea-responsive repressor proteins  
Compositions and methods relating to the use of sulfonylurea-responsive repressors are provided. Compositions include polypeptides that specifically bind to an operator, wherein the specific...
8871919 RNAi therapeutic for treatment of Hepatitis C infection  
Small interfering RNAs (siRNAs) or small hairpin RNA (shRNAs) and compositions comprising same are provided that target human cyclophilin A (CyPA) to inhibit Hepatitis C (HCV) infection. Such siRNA...