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8865406 Engineering and optimization of improved systems, methods and enzyme compositions for sequence manipulation  
The invention provides for engineering and optimization of systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are compositions and...
8865674 Antisense modulation of GCGR expression  
Provided herein are methods, compounds, and compositions for reducing expression of GCGR mRNA and protein in an animal. Such methods, compounds, and compositions are useful to treat, prevent,...
8865669 DNA fragment and use thereof  
The invention relates to a DNA consisting of the nucleotide sequence shown in SEQ ID NO: 1, or a nucleotide sequence the same or substantially the same as a partial nucleotide sequence thereof...
8865881 Delivery of proteins using adeno-associated virus (AAV) vectors  
Disclosed herein are compositions, systems and methods for delivery of proteins of interest using adeno-associated virus (AAV) vectors.
8865883 Multiple exon skipping compositions for DMD  
Provided are antisense molecules capable of binding to a selected target site in the human dystrophin gene to induce exon skipping, and methods of use thereof to treat muscular dystrophy.
8865884 Antisense modulation of kinesin-like 1 expression  
Antisense compounds, compositions and methods are provided for modulating the expression of kinesin-like 1. The compositions comprise antisense compounds, particularly antisense oligonucleotides,...
8859514 Modulation of C-reactive protein expression  
Compounds, compositions and methods are provided for modulating the expression of C-reactive protein. The compositions comprise oligonucleotides, targeted to nucleic acid encoding C-reactive...
8859747 Promoters exhibiting endothelial cell specificity and methods of using same  
An isolated polynucleotide functional as a promoter in eukaryotic cells is disclosed. The isolated polynucleotide includes an endothelial specific enhancer element as detailed herein. Further...
8859515 Treatment of tumor necrosis factor receptor 2 (TNFR2) related diseases by inhibition of natural antisense transcript to TNFR2  
The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of Tumor Necrosis Factor Receptor 2 (TNFR2), in particular, by targeting natural...
8859229 Transient transfection with RNA  
A method of mRNA production for use in transfection is provided, that involves in vitro transcription of PCR generated templates. This RNA can efficiently transfect different kinds of cells. This...
8859745 Promoters exhibiting endothelial cell specificity and methods of using same  
An isolated polynucleotide functional as a promoter in eukaryotic cells is disclosed. The isolated polynucleotide includes an endothelial specific enhancer element as detailed herein. Further...
8859746 Genome wide identification and characterization of gene expression regulatory elements in Zea mays for use in plants  
The present invention provides non-coding regulatory element polynucleotide molecules isolated from the lipid transfer protein (LTP) gene of Oryza sativa and useful for expressing transgenes in...
8853383 Promoters from Brassica napus for seed specific gene expression  
The present invention is concerned with means and methods for allowing tissue specific and, in particular, seed specific expression of genes. The present invention, accordingly, relates to a...
8852942 Cineraria-derived chromosomal DNA involved in synthesis of flavonoid, and use thereof  
Presently provided are a cineraria-derived polynucleotide which can act as a promoter for a coding region of flavonoid 3′,5′-hydroxylase (F3′5′H and a F3′5′H gene construct which carries the...
8853377 mRNA for use in treatment of human genetic diseases  
Compositions for modulating the expression of a protein in a target cell comprising at least one RNA molecule which comprises at least one modification conferring stability to the RNA, as well as...
8847015 Rice promoters  
The invention provides several promoters isolated from Oryza sativa, which promoters are capable of driving and/or regulating the expression of an operably linked nucleic acid in a plant. The...
8847016 Rice promoters  
The invention provides several promoters isolated from Oryza sativa, which promoters are capable of driving and/or regulating the expression of an operably linked nucleic acid in a plant. The...
8846369 Cyanobacterium sp. host cell and vector for production of chemical compounds in cyanobacterial cultures  
A cyanobacterial host cell, Cyanobacterium sp., that harbors at least one recombinant gene for the production of a chemical compounds is provided, as well as vectors derived from an endogenous...
8846401 Promoters exhibiting endothelial cell specificity and methods of using same  
An isolated polynucleotide functional as a promoter in eukaryotic cells is disclosed. The isolated polynucleotide includes an endothelial specific enhancer element as detailed herein. Further...
8846343 High-expression promoter derived from Kluyveromyces marxianus  
Provided is a novel high-expression promoter, namely a GAL1 promoter, derived from Kluyveromyces marxianus. Also provided are the following, characterized by the use of the provided high-expression...
8846385 Method and means for producing high titer, safe recombinant lentivirus vectors  
Lentiviral vectors modified at the 5′ LTR or both the 5′ and 3′ LTR's are useful in the production of recombinant lentivirus vectors. Such vectors can be produced in the absence of a funct...
8846892 Chimeric plant promoters and their uses in plants  
The present invention provides novel promoters for use in plants. Specifically, the present invention provides novel chimeric promoters comprising combinations of plant enhancer elements and plant...
8841432 Shuttle vectors for mycobacteria-escherichia coli and uses thereof  
The present disclosure provides a DNA molecule capable of replication in Mycobacteria having a nucleic acid sequence as disclosed in SEQ ID NO: 1, a shuttle vector constructed using it and a...
8841270 Use of inhibitors of Zdhhc2 activity for modulation of adipogenesis  
The present invention concerns Zdhhc2, a new target involved in adipogenesis modulation. Using a siRNA approach, the inventors demonstrated that decrease in Zdhhc2 activity in adipose tissue...
8841089 Polynucleotides for enhancing expression of a polynucleotide of interest  
The present invention relates to polynucleotides comprising a first nucleic acid sequence for a chromatin element, which is capable of enhancing expression, and at least one second nucleic acid...
8841436 Screening, diagnosing, treating and prognosis of pathophysiologic status by RNA regulation  
A relationship between cancer and ribonucleic acid (RNA) regulation is described by determining intracellular levels of niRN A regulators. Generally, mRNA levels are decreased in cancer cells that...
8841434 Isolated rice LP2 promoters and uses thereof  
The present invention relates to isolated rice LP2 promoter sequences and uses thereof.
8841512 Flax (Linum usitatissimum L.) seed-specific promotors  
The present invention is directed to promoters of flax conlinin and ω-3 desaturase genes. The promoters guide high levels of the expression exclusively in flax developing seeds. This specific ...
8841430 Use of regulatory sequences for specific, transient expression in neuronal determined cells  
The present invention relates to the use of regulatory sequences for mediating specific, early transient expression in proliverative neuronal determined cells. Furthermore, the uses of recombinant...
8835621 Synthetic 5'UTRs, expression vectors, and methods for increasing transgene expression  
The present invention provides synthetic 5′UTRs comprising a first polynucleotide fragment and a second polynucleotide fragment, wherein the first polynucleotide fragment comprises at least one s...
8835622 Expression cassettes for seed-specific expression in plants  
The present invention relates to materials and methods for the expression of a gene of interest specifically in seeds of plants, even more specifically in oilseed plants. In particular, the...
8828959 Antisense oligonucleotides capable of inhibiting the formation of capillary tubes by endothelial cells  
A pharmaceutical composition that blocks angiogenesis comprising as active agent at least one substance selected from the group consisting of (i) a nucleic acid molecule of a gene coding for...
8829177 Enhanced engineered native promoters and uses thereof  
We describe methods and DNA constructs/engineered mammalian promoters to enhance native promoter activity while retaining inherent regulation by inserting multi-copy response elements (REs) into...
8829176 Beta-actin and RPS21 promoters and uses thereof  
The invention relates to isolation of novel β-actin and ribosomal protein S21 (rpS21) promoters and uses thereof. In particular, this invention features nucleotide sequences for rodent β-actin p...
8828962 SiRNA compositions and methods for potently inhibiting viral infection  
No antiviral regimen has been consistently successful in treating H5N1 virus infection. We demonstrate that a group of highly effective siRNAs targeting different H5N1 viral genes shares a unique...
8828658 Spatio-temporal control of protein interactions using phytochromes  
The invention provides methods, materials and systems of regulating association between proteins of interest using light. In an aspect, the invention takes advantage of the ability of phytochromes...
8829173 Recombinant vectors  
This disclosure provides recombinant replication competent retroviral vectors having increased stability. The disclosure further relates compositions and uses of such vectors in the treatment of...
8828961 Methods and compositions to protect aquatic invertebrates from disease  
Compositions and methods of protecting aquatic invertebrates from disease is shown. In one embodiment, dsRNA or antisense RNA to a nucleic acid molecule of the disease-causing microorganism is...
8829272 Specific expression using transcriptional control sequences in plants  
The present invention relates generally to methods and transcriptional control sequences suitable for effecting expression of a nucleotide sequence of interest in a plant. More particularly, the...
8822427 Methods and compositions to protect aquatic invertebrates from disease  
Compositions and methods of protecting aquatic invertebrates from disease is shown. In one embodiment, dsRNA or antisense RNA to a nucleic acid molecule of the disease-causing microorganism is...
8822759 GL9 transcriptional control sequences  
The present invention relates to transcriptional control sequences derived from GL9 genes, wherein the transcriptional control sequences direct specific or preferential expression of an operably...
8822666 Hybrid caulimovirus promoters and constructs thereof  
The present invention relates to novel hybrid promoters comprising a caulimovirus promoter operably linked to one or more of an EF1α, Act8, Act2 or Act11 promoter. The present invention also ...
8816059 Method for predicting and detecting tumor metastasis  
The invention provides a method of determining the prognosis of cancer in a subject. The method comprises (a) obtaining a sample from the subject, (b) analyzing the sample for the expression level...
8816153 Recombinant DNA constructs employing site-specific recombination  
Recombinant DNA constructs, for use in plants and plant cells, have site-specific recombination sites that allow assessing phenotypes and modes of action by over expression or suppression of...
8815568 Enhanced gene expression in algae  
The invention provides eukaryotic unicellular algae engineered to express a nucleosome alteration protein fused to a protein with affinity to the DNA binding site acting in coordination. An example...
8816056 Modulation of signal transducer and activator of transcription 3 (STAT3)expression  
Disclosed herein are antisense compounds and methods for decreasing STAT3 mRNA and protein expression. Such methods, compounds, and compositions are useful to treat, prevent, or ameliorate...
8816152 Regulatory polynucleotides and uses thereof  
The present disclosure provides compositions and methods for regulating expression of transcribable polynucleotides in plant cells, plant tissues, and plants. Compositions include regulatory...
8815779 Transcription biomarkers of biological responses and methods  
This invention provides transcription regulatory control sequences, the activity of which function as biomarkers for a variety of biological responses. This invention also provides expression...
8815819 Anti-connexin compounds targeted to connexins and methods of use thereof  
Methods and compositions for modulating the activities of connexins are provided, including, for example, for use in post-surgical, trauma, or tissue engineering applications. These compounds and...
8816060 Anti-microRNA oligonucleotide molecules  
The invention relates to isolated anti-microRNA molecules. In another embodiment, the invention relates to an isolated microRNA molecule. In yet another embodiment, the invention provides a method...