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8785411 HIV DNA vaccine methods of use  
The present invention is directed to a DNA vaccine for immunization against HIV. The invention comprises a DNA molecule that has a sequence encoding a plurality of viral proteins capable of...
8785613 P. pastoris pastoris promoters, and the use thereof to direct expression of proteins in yeast, preferably using a haploid mating strategy  
Novel promoters which are derived from P. pastoris pastoris which are inducible or repressible under specific growth conditions are provided. These promoters are useful for regulating the...
8785617 Oligomeric compounds for the modulation of HIF-1A expression  
Oligonucleotides directed against the hypoxia-inducible factor-1α (HIF-1α) gene are provided for modulating the expression of HIF-1α. The compositions comprise oligonucleotides, particularly an...
8785612 Sugarcane bacilliform viral (SCBV) enhancer and its use in plant functional genomics  
Identification of new enhancer sequence has significant utility in the plant functional genomics. The sugarcane bacilliform badnavirus (SCBV) transcriptional enhancer has been identified. This...
8785611 Compositions and methods related to mRNA translational enhancer elements  
Provided are mRNA translational enhancer elements (TEEs), e.g., SEQ ID NOs:1-35. Also provided are translational enhancer polynucleotides that comprise one or more of the specific TEEs exemplified...
8778900 Modulation of eIF4E-BP1 expression  
Compounds, compositions and methods are provided for modulating the expression of eIF4E-BP1. The compositions comprise oligonucleotides, targeted to nucleic acid encoding eIF4E-BP1. Methods of...
8779116 SiRNA-mediated gene silencing  
The present invention is directed to small interfering RNA molecules (siRNA) targeted against an allele of interest, and methods of using these siRNA molecules.
8778903 MicroRNA-10 antagonists and MicroRNA-10 targets for use in the treatment of a glioma  
The present invention embraces microRNA-antagonists and activators of homeobox D10 protein; Zinc finger, MYND domain containing 11 protein; or RB1-inducible coiled-coil 1 protein for use in...
8778672 Somatic ovule specific promoter and methods of use  
Compositions and methods for regulating expression of heterologous nucleotide sequences in a plant are provided. Compositions include nucleotide sequences for an Arabidopsis thaliana nucellar...
8772464 Aptamer regulated nucleic acids and uses thereof  
The invention relates to aptamer-regulated, ligand-responsive nucleic acids, or “ampliSwitches,” and uses thereof. Particular embodiments include a ligand-responsive nucleic acid that comprises a p...
8772575 Nucleic acids useful in the manufacture of oil  
Novel gene sequences from microalgae are disclosed, as well as novel gene sequences useful in the manufacture of triglyceride oils. Also disclosed are sequences and vectors that allow microalgae to...
8772465 IRES functioning in plant  
It is intended to provide for a polycistronic expression pattern in a plant used as a host. The present invention provides a polynucleotide which comprises the following DNA (a) or (b) and...
8772260 Methods for inhibiting expression of connective tissue growth factor  
This invention provides compounds which comprise modified oligonucleotides capable of inhibitory expression of connective tissue factor and composition containing same as well as methods of...
8772466 Zea mays NFB2 promoter  
The present invention provides non-coding regulatory element polynucleotide molecules isolated from the transcription factor Nuclear Factor B (NFB2) gene of Zea mays and useful for expressing...
8771984 Selection of host cells expressing protein at high levels  
The invention provides a DNA molecule comprising a multicistronic transcription unit coding for i) a selectable marker polypeptide functional in a eukaryotic host cell, and for ii) a polypeptide of...
8771945 CRISPR-Cas systems and methods for altering expression of gene products  
The invention provides for systems, methods, and compositions for altering expression of target gene sequences and related gene products. Provided are vectors and vector systems, some of which...
8765929 Promoter for use in transformation of algae  
The objective of the present invention is to provide a transformation method that is applicable to a wide variety of species of algae with high efficiency. The promoter of the present invention is...
8765140 DNA vaccine compositions with HIV/SIV gene modifications  
The present invention is directed to a DNA vaccine for immunization against HIV. The invention comprises a DNA molecule that has a sequence encoding a plurality of viral proteins capable of...
8766037 Drought responsive expression of genes from the Zea mays Rab17 promoter  
The present invention relates generally to the drought-specific expression of a nucleotide sequence of interest in one or more cells of a plant. In some particular embodiments, the present...
8759506 Expression enhancing intron sequences  
The invention relates to methods for the identification and use of introns with gene expression enhancing properties. The teaching of this invention enables the identification of introns causing...
8759088 Lactococcus promoters and uses thereof  
The invention is in the field of molecular biology, and relates to recombinant engineering and protein expression. More in particular, the invention relates to nucleic acids for recombinant...
8759612 Soybean promoters LTP2 and flower-preferred expression thereof in transgenic plants  
The invention relates to gene expression regulatory sequences from soybean, specifically to the promoters of a soybean lipid transfer protein LTP2 and fragments thereof and their use in promoting...
8759507 Modulation of exon recognition in pre-mRNA by interfering RNA structure  
The invention provides a method for generating an oligonucleotide with which an exon may be skipped in a pre-mRNA and thus excluded from a produced mRNA thereof. Further provided are methods for...
8759002 Gene dosage analysis  
The present invention relates to methods of detecting the presence of a genetic polymorphism within two or more closely linked, homologous genes, for example α-thalassemia, in a sample using ...
8754200 MEG1 endosperm-specific promoters and genes  
The present invention relates to promoters that enable gene expression which is both specific to the endosperm and early during the development of the endosperm, as well as nucleic acid molecules...
8753847 Selection and enrichment of proteins using in vitro compartmentalization  
Compositions and methods are provided for selection and enrichment of a target gene from a library of polynucleotide sequences such as might be formed from a genome or by random mutagenesis of a...
8754198 Modified food grade microorganism for treatment of inflammatory bowel disease  
The present invention relates to microorganisms that express, or have attached to their surface, a TNFα binding polypeptide. Peptides expressed or attached on the surface of microorganism are more ...
8742089 Methods and compositions for expressing negative-sense viral RNA in canine cells  
The present invention provides novel canine pol I regulatory nucleic acid sequences useful for the expression of nucleic acid sequences in canine cells such as MDCK cells. The invention further...
8741634 Soybean transcription terminators and use in expression of transgenic genes in plants  
Five novel plant transcription terminators MYB2, KTI1, PIP1, EF1A2, and MTH1 are isolated from soybean and their functions in the regulation of RNA transcription and processing in plants are...
8742203 Chemically Inducible Expression of Biosynthetic Pathways  
Methods and constructs for the introduction of multiple genes encoding enzymes in a multi-enzyme biosynthetic pathway are provided. In one embodiment, the constructs contain two or more...
8735062 Chemiluminescence proximity nucleic acid assay  
This invention relates to the detection and quantitation of target nucleic acids in a heterogeneous mixture in a sample and the methods of use thereof. The detection system includes a...
8735562 Isolated fungal promoters and gene transcription terminators and methods of protein and chemical production in a fungus  
The present invention encompasses isolated gene regulatory elements and gene transcription terminators that are differentially expressed in a native fungus exhibiting a first morphology relative to...
8735147 Polynucleotides encoding cyclotides having nematocidal activity  
The invention provides novel cyclotide polypeptides, and variants and fragments thereof, obtained from Butterfly pea and having pesticidal activity against nematodes. Particular embodiments of the...
8735364 Antisense modulation of apolipoprotein B expression  
Antisense compounds, compositions and methods are provided for modulating the expression of apolipoprotein B. The compositions comprise antisense compounds, particularly antisense oligonucleotides,...
8735563 Polynucleotides having promoter activity  
The present invention relates to isolated polynucleotides having promoter activity the juse of the isolated polynucleotides for the procuction of a polypeptide. The invention also relates to...
8735365 Targeting PAX2 for the induction of DEFB1-mediated tumor immunity and cancer therapy  
Provided is a method of treating cancer in a subject by inhibiting expression of PAX2. An example of a cancer treated by the present method is prostate cancer. In the cancer treatment methods...
8735655 DNA molecules from maize and methods of use thereof  
The present invention relates to DNA polynucleotides for regulating gene expression in plants. In particular, the invention relates to 5′ regulatory sequences isolated from Zea mays that are u...
8735159 PEF-TS expression units  
The present invention relates to the use of nucleic acid sequences for regulating the transcription and expression of genes, the novel promoters and expression units themselves, methods for...
8728760 Microcin H47 plasmid selection system  
The present invention relates generally to stabilized expression plasmid systems. The stabilized expression plasmid systems comprise an expression vector that includes a plasmid maintenance system...
8729339 Gene silencing  
The invention provides methods and compositions useful in target sequence suppression and target sequence validation. The invention provides polynucleotide constructs useful for gene silencing, as...
8729041 Compositions and methods for treating hepatic neoplasia  
The present invention provides compositions and methods featuring miR-26 microRNA polynucleotides for the diagnosis, treatment or prevention of hepatic neoplasia.
8729340 Solanum lycopersicum histidine decarboxylase gene-derived fruit-specific expression promoter and uses thereof  
The present invention relates to a Solanum lycopersicum histidine decarboxylase-2 (SlHD-2) gene-derived fruit-specific expression promoter, to a 5′ untranslated region (5′-UTR), to a (5′UTR), —spec...
8722873 Modulation of stat5 expression  
Compounds, compositions and methods are provided for modulating the expression of STAT5. The compositions comprise oligonucleotides, targeted to nucleic acid encoding STAT5. Methods of using these...
8722867 Gene therapy vectors and cytosine deaminases  
This disclosure provides modified cytosine deaminases (CDs). The disclosure further relates to cells and vector expressing or comprising such modified CDs and methods of using such modified CDs in...
8722640 Stabilized STAT3 decoy oligonucleotides and uses therefor  
The present invention is based, at least in part, on novel, unimolecular STAT3 oligonucleotide decoys exhibiting increased in vivo stability as compared to previously known decoys which are...
8722642 Multiantivirus compound, composition and method for treatment of virus diseases  
A method for obtaining a new antiviral compound with multiple action against many viruses, comprising modified highly purified yeast RNA, a pharmaceutical composition comprising such RNA, and a...
8716463 Method for the producing alpha-1, 6-branched alpha-1, 4-glucans from sucrose  
Nucleic acid molecules which encode a branching enzyme from a bacterium of the genus Neisseria, vectors, host cell, plant cells and plants containing said nucleic acid molecules as well as starch...
8716021 Use of replicators to prevent gene silencing  
Regulatory elements, specifically replicators and transgene constructs containing replicator nucleic acid sequences, are disclosed herein. Methods of using replicators and transgene constructs...
8715968 Methods and reagents for modulating cholesterol levels  
The invention features ABC1 nucleic acids and polypeptides for the diagnosis and treatment of abnormal cholesterol regulation. The invention also features methods for identifying compounds for...
8716255 Microrna compositions and methods for the treatment of myelogenous leukemia  
The invention provides methods, uses, kits and compositions comprising a therapeutically effective amount of the microRNA miR-223 for treating myelogenous leukemia in a subject in need of such...