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8895715 S100B mini-promoters  
Isolated polynucleotides comprising an S100B promoter are provided, where an S100B regulatory element is operably joined to an S100B basal promoter utilizing a non-native spacing between the...
8895524 Viral microRNA  
The present invention relates, in general, to micro RN As and, in particular, to viral microRNAs expressed by Herpes Simplex Vims 1 (HSV-1) or Herpes Simplex Virus 2 (HSV-2), to agents that inhibit...
8895305 Water deficit-inducible promoters  
Water deficit-inducible promoter sequences were identified that may be used to produce transgenic plants that are more tolerant to water deficit and related hyperosmotic stresses than control...
8895716 Viral promoter, truncations thereof, and methods of use  
The present disclosure provides compositions and methods for regulating expression of heterologous nucleotide sequences in a plant. Compositions include a novel nucleotide sequence for a promoter....
8889352 Conversion of alpha-hydroxyalkylated residues in biomolecules using methyltransferases  
The present invention relates to targeted conversion of alpha-hydroxyalkylated residues in biomolecules in the presence of a directing methyltransferase, namely to targeted removal of the...
8889356 CRISPR-Cas nickase systems, methods and compositions for sequence manipulation in eukaryotes  
The invention provides for systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are vectors and vector systems, some of which encode one...
8883993 Tetraselmis promoters and terminators for use in eukaryotic cells  
The present invention provides novel promoter and terminator sequences for use in gene expression in eukaryotic cells, such as algal cells. The invention further provides expression cassettes...
8883998 siRNA targeting myeloid differentiation primary response gene (88) (MYD88)  
Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene...
8883493 Adenoviral vector comprising herpes simplex virus type 1 thymidine kinase and a transgene for increasing the expression of the transgene  
Compositions and methods useful in transgene expression are provided. Herpes simplex virus type 1 thymidine kinase sequences (“TK sequences”) are used to enhance transgene expression in first gen...
8877916 Promoter, promoter control elements, and combinations, and uses thereof  
The present invention provides DNA molecules that constitute fragments of the genome of a plant, and polypeptides encoded thereby. The DNA molecules are useful for specifying a gene product in...
8877502 Plasmid curing  
The present invention relates to plasmid curing, and particularly to efficient and stress-free methods for displacing resident or endogenous plasmids from a host cell, such as a bacterium. The...
8878003 Storage-induced promoter  
A promoter with an organ-specific activity in plants. The promoter is characterized in that it exhibits greater activity in the storage organs of plants than in other organs of said plants and that...
8877503 Sulfonylurea-responsive repressor proteins  
Compositions and methods relating to the use of sulfonylurea-responsive repressors are provided. Compositions include polypeptides that specifically bind to an operator, wherein the specific...
8871919 RNAi therapeutic for treatment of Hepatitis C infection  
Small interfering RNAs (siRNAs) or small hairpin RNA (shRNAs) and compositions comprising same are provided that target human cyclophilin A (CyPA) to inhibit Hepatitis C (HCV) infection. Such siRNA...
8871445 CRISPR-Cas component systems, methods and compositions for sequence manipulation  
The invention provides for systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are vectors and vector systems, some of which encode one...
8871493 Transformation system in the field of filamentous fungal hosts  
A novel transformation system in the field of filamentous fungal hosts for expressing and secreting heterologous proteins or polypeptides is described. The invention also covers a process for...
8871729 Treatment of CNS conditions  
Methods and compositions for the treatment of pathologic conditions of the central nervous system (CNS) by means of intranasal administration of a composition that modulates, by means of RNA...
8865406 Engineering and optimization of improved systems, methods and enzyme compositions for sequence manipulation  
The invention provides for engineering and optimization of systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are compositions and...
8865674 Antisense modulation of GCGR expression  
Provided herein are methods, compounds, and compositions for reducing expression of GCGR mRNA and protein in an animal. Such methods, compounds, and compositions are useful to treat, prevent,...
8865669 DNA fragment and use thereof  
The invention relates to a DNA consisting of the nucleotide sequence shown in SEQ ID NO: 1, or a nucleotide sequence the same or substantially the same as a partial nucleotide sequence thereof...
8865881 Delivery of proteins using adeno-associated virus (AAV) vectors  
Disclosed herein are compositions, systems and methods for delivery of proteins of interest using adeno-associated virus (AAV) vectors.
8865883 Multiple exon skipping compositions for DMD  
Provided are antisense molecules capable of binding to a selected target site in the human dystrophin gene to induce exon skipping, and methods of use thereof to treat muscular dystrophy.
8865884 Antisense modulation of kinesin-like 1 expression  
Antisense compounds, compositions and methods are provided for modulating the expression of kinesin-like 1. The compositions comprise antisense compounds, particularly antisense oligonucleotides,...
8859514 Modulation of C-reactive protein expression  
Compounds, compositions and methods are provided for modulating the expression of C-reactive protein. The compositions comprise oligonucleotides, targeted to nucleic acid encoding C-reactive...
8859747 Promoters exhibiting endothelial cell specificity and methods of using same  
An isolated polynucleotide functional as a promoter in eukaryotic cells is disclosed. The isolated polynucleotide includes an endothelial specific enhancer element as detailed herein. Further...
8859515 Treatment of tumor necrosis factor receptor 2 (TNFR2) related diseases by inhibition of natural antisense transcript to TNFR2  
The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of Tumor Necrosis Factor Receptor 2 (TNFR2), in particular, by targeting natural...
8859229 Transient transfection with RNA  
A method of mRNA production for use in transfection is provided, that involves in vitro transcription of PCR generated templates. This RNA can efficiently transfect different kinds of cells. This...
8859745 Promoters exhibiting endothelial cell specificity and methods of using same  
An isolated polynucleotide functional as a promoter in eukaryotic cells is disclosed. The isolated polynucleotide includes an endothelial specific enhancer element as detailed herein. Further...
8859746 Genome wide identification and characterization of gene expression regulatory elements in Zea mays for use in plants  
The present invention provides non-coding regulatory element polynucleotide molecules isolated from the lipid transfer protein (LTP) gene of Oryza sativa and useful for expressing transgenes in...
8853383 Promoters from Brassica napus for seed specific gene expression  
The present invention is concerned with means and methods for allowing tissue specific and, in particular, seed specific expression of genes. The present invention, accordingly, relates to a...
8852942 Cineraria-derived chromosomal DNA involved in synthesis of flavonoid, and use thereof  
Presently provided are a cineraria-derived polynucleotide which can act as a promoter for a coding region of flavonoid 3′,5′-hydroxylase (F3′5′H and a F3′5′H gene construct which carries the...
8853377 mRNA for use in treatment of human genetic diseases  
Compositions for modulating the expression of a protein in a target cell comprising at least one RNA molecule which comprises at least one modification conferring stability to the RNA, as well as...
8847015 Rice promoters  
The invention provides several promoters isolated from Oryza sativa, which promoters are capable of driving and/or regulating the expression of an operably linked nucleic acid in a plant. The...
8847016 Rice promoters  
The invention provides several promoters isolated from Oryza sativa, which promoters are capable of driving and/or regulating the expression of an operably linked nucleic acid in a plant. The...
8846369 Cyanobacterium sp. host cell and vector for production of chemical compounds in cyanobacterial cultures  
A cyanobacterial host cell, Cyanobacterium sp., that harbors at least one recombinant gene for the production of a chemical compounds is provided, as well as vectors derived from an endogenous...
8846401 Promoters exhibiting endothelial cell specificity and methods of using same  
An isolated polynucleotide functional as a promoter in eukaryotic cells is disclosed. The isolated polynucleotide includes an endothelial specific enhancer element as detailed herein. Further...
8846343 High-expression promoter derived from Kluyveromyces marxianus  
Provided is a novel high-expression promoter, namely a GAL1 promoter, derived from Kluyveromyces marxianus. Also provided are the following, characterized by the use of the provided high-expression...
8846385 Method and means for producing high titer, safe recombinant lentivirus vectors  
Lentiviral vectors modified at the 5′ LTR or both the 5′ and 3′ LTR's are useful in the production of recombinant lentivirus vectors. Such vectors can be produced in the absence of a funct...
8846892 Chimeric plant promoters and their uses in plants  
The present invention provides novel promoters for use in plants. Specifically, the present invention provides novel chimeric promoters comprising combinations of plant enhancer elements and plant...
8841432 Shuttle vectors for mycobacteria-escherichia coli and uses thereof  
The present disclosure provides a DNA molecule capable of replication in Mycobacteria having a nucleic acid sequence as disclosed in SEQ ID NO: 1, a shuttle vector constructed using it and a...
8841270 Use of inhibitors of Zdhhc2 activity for modulation of adipogenesis  
The present invention concerns Zdhhc2, a new target involved in adipogenesis modulation. Using a siRNA approach, the inventors demonstrated that decrease in Zdhhc2 activity in adipose tissue...
8841089 Polynucleotides for enhancing expression of a polynucleotide of interest  
The present invention relates to polynucleotides comprising a first nucleic acid sequence for a chromatin element, which is capable of enhancing expression, and at least one second nucleic acid...
8841436 Screening, diagnosing, treating and prognosis of pathophysiologic status by RNA regulation  
A relationship between cancer and ribonucleic acid (RNA) regulation is described by determining intracellular levels of niRN A regulators. Generally, mRNA levels are decreased in cancer cells that...
8841434 Isolated rice LP2 promoters and uses thereof  
The present invention relates to isolated rice LP2 promoter sequences and uses thereof.
8841512 Flax (Linum usitatissimum L.) seed-specific promotors  
The present invention is directed to promoters of flax conlinin and ω-3 desaturase genes. The promoters guide high levels of the expression exclusively in flax developing seeds. This specific ...
8841430 Use of regulatory sequences for specific, transient expression in neuronal determined cells  
The present invention relates to the use of regulatory sequences for mediating specific, early transient expression in proliverative neuronal determined cells. Furthermore, the uses of recombinant...
8835621 Synthetic 5'UTRs, expression vectors, and methods for increasing transgene expression  
The present invention provides synthetic 5′UTRs comprising a first polynucleotide fragment and a second polynucleotide fragment, wherein the first polynucleotide fragment comprises at least one s...
8835622 Expression cassettes for seed-specific expression in plants  
The present invention relates to materials and methods for the expression of a gene of interest specifically in seeds of plants, even more specifically in oilseed plants. In particular, the...
8828959 Antisense oligonucleotides capable of inhibiting the formation of capillary tubes by endothelial cells  
A pharmaceutical composition that blocks angiogenesis comprising as active agent at least one substance selected from the group consisting of (i) a nucleic acid molecule of a gene coding for...
8829177 Enhanced engineered native promoters and uses thereof  
We describe methods and DNA constructs/engineered mammalian promoters to enhance native promoter activity while retaining inherent regulation by inserting multi-copy response elements (REs) into...