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8697440 Compositions and methods for producing gamma-carboxylated proteins  
The present invention relates to methods and tools for producing large quantities of gamma-carboxylated protein comprising: (i) culturing a cell adapted to express a protein which requires...
8697858 Antisense antiviral compound and method for treating influenza viral infection  
The present invention relates to antisense antiviral compounds and methods of their use and production in inhibition of growth of viruses of the Orthomyxoviridae family and in the treatment of a...
8697947 Plants having increased yield-related traits and a method for making the same  
The present invention relates generally to the field of molecular biology and concerns a method for increasing various plant yield-related traits by modulating expression in a plant of a nucleic...
8697857 Soybean EF1A2 promoter and its use in constitutive expression of transgenic genes in plants  
The promoter of a soybean translation elongation factor EF1 alpha, a polypeptide that promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis,...
8697087 Influenza vaccines including combinations of particulate adjuvants and immunopotentiators  
Influenza vaccines containing insoluble particulate adjuvants have been found to elicit an IgG response that is primarily a TH2 response (IgG1). This response can be shifted towards a TH1 response...
8697949 Temporal regulation of gene expression by MicroRNAs  
This invention provides molecular constructs and methods for the temporally specific control of gene expression in plants or in plant pests or pathogens. More specifically, this invention provides...
8697359 CRISPR-Cas systems and methods for altering expression of gene products  
The invention provides for systems, methods, and compositions for altering expression of target gene sequences and related gene products. Provided are vectors and vector systems, some of which...
8691505 Promoter for use in transformation of algae  
The problem to be solved by the present invention is to provide a highly-efficient transformation technology, specifically, a highly-efficient promoter used for transforming algae, a vector...
8691786 Methods and compositions for the specific inhibition of gene expression by double-stranded RNA  
The invention is directed to compositions and methods for selectively reducing the expression of a gene product from a desired target gene in a cell, as well as for treating diseases caused by the...
8691962 Peroxidase gene nematode inducible promotors and methods of use  
The invention provides isolated plant gene promoters and regulatory elements that are root specific and/or induced by plant parasitic nematodes. The promoters of the invention are useful for...
8691965 Oligonucleotides for modulating target RNA activity  
The present invention relates to oligonucleotides for modulation of target RNA activity. Thus, the invention provides oligonucleotides that bind to microRNA binding sites of target RNA. The...
8692071 Drought responsive promoters HVA22e and PLDdelta identified from Arabidopsis thaliana  
The present invention provides non-coding regulatory element polynucleotide molecules isolated from the At.PLDĪ“ gene or the At.HVA22e gene of Arabidopsis thaliana and useful for expressing ...
8691564 Female specific insect expression system  
The present invention provides an insect expression system that may be used to provide biological control of pest insects and control transmission of infectious diseases transmitted to the human...
8692069 Environmental stress-inducible 557 promoter isolated from rice and uses thereof  
The present invention relates to environmental stress-inducible 557 promoter isolated from rice, a recombinant plant expression vector comprising the promoter, a method of producing a target...
8691784 MCP-1 binding nucleic acids  
The present invention is related to a nucleic acid, preferably binding to MCP-1, selected from the group consisting of Type 1A nucleic acids, type 1B nucleic acids, Type 2 nucleic acids, Type 3...
8686221 Plants having improved growth characteristics under reduced nutrient availability and a method for making the same  
The present invention relates generally to the field of molecular biology and concerns a method for improving plant growth characteristics relative to wild type plants. More specifically, the...
8686127 Apoptosis inducer  
This invention relates to an agent, a composition and a product comprising at least one apoptosis-inducing substance, and at least one substance which inhibits expression and/or activity of an...
8685940 Impaired wound healing compositions and treatments  
Connexin modulation for the treatment of wounds that do not heal at expected rates, including delayed healing wounds, incompletely healing wounds, and chronic wounds, and associated methods,...
8685937 Nucleic acid aptamers  
The present invention relates to optimized aptamers and methods of using these aptamers.
8685720 Engineered cellular pathways for programmed autoregulation of differentiation  
The present invention provides compositions and methods for programming mammalian cells to perform desired functions. In particular, the present invention provides compositions and methods for...
8686125 Chimeric promoters comprising MYB10 repeat element and methods for regulating plant gene expression  
The invention provides a method for producing a chimeric promoter polynucleotide capable of controlling transcription of an operably linked polynucleotide in a plant cell or plant, wherein the...
8679790 Leader sequence to boost gene expression  
The invention provides compositions and methods for enhanced gene expression. The invention provides a composition comprising a 28-codon leader sequence operably linked to a desired gene which...
8680368 Method of expression of foreign gene in plant induced by chemical substance  
There is provided an expression method of a target foreign gene in a plant induced by a chemical substance, which comprises a step of activating with copper ions a transcription factor encoded by a...
8680256 Methods for producing inducible and/or repressible expression active linear RNA interference cassettes and inducible and/or repressible expression active linear gene cassettes and their uses  
The present invention relates to a (first) method for producing inducible and/or repressible expression active linear RNA interference constructs comprising a PCR amplification of a source...
8679829 Archaeon expression system  
The present invention relates to a sulfolobus expression vector comprising: (a) sulfolobus origin of replication; (b) the genes encoding the structural proteins and the site-specific integrase of...
8680258 Use of microRNAs to control virus helper nucleic acids  
Provided herein are helper nucleic acids comprising at least one microRNA target sequence of an endogenous, cellular microRNA and a nucleic acid encoding a viral protein, wherein the microRNA...
8674084 Protein expression system  
The inventions is based on an expression enhancer sequence derived from the RNA-2 genome segment of a bipartite RNA virus, in which a target initiation site in the RNA-2 genome segment has been...
8673875 Method for treating atherosclerosis  
The invention provides a method for treating atherosclerosis in a subject in need thereof, including administering an effective amount of microRNA-195 to the subject in need thereof. The...
8673871 Compounds and methods for modulating expression ApoB  
The present disclosure describes short antisense compounds, including such compounds comprising chemically-modified high-affinity monomers 8-16 monomers in length. Certain such short antisense...
8673631 Chimeric regulatory sequences comprising introns for plant gene expression  
The present invention relates to a method of using a dicot intron or elements thereof to enhance transgene expression in plants. The present invention also provides constructs, transgenic plants...
8674180 Nucleic acids useful in the manufacture of oil  
Novel gene sequences from microalgae are disclosed, as well as novel gene sequences useful in the manufacture of triglyceride oils. Also disclosed are sequences and vectors that allow microalgae to...
8669108 Gene expression control in plants  
The invention provides the isolated promoter polynucleotide sequence of SEQ ID NO:1, and fragments and variants thereof. The invention also provides constructs, plant cells and plants genetically...
8669051 Substitution mutant receptors and their use in a nuclear receptor-based inducible gene expression system  
This invention relates to the field of biotechnology or genetic engineering. Specifically, this invention relates to the field of gene expression. More specifically, this invention relates to novel...
8664188 siRNA compositions and methods for potently inhibiting viral infection  
No antiviral regimen has been consistently successful in treating H5N1 virus infection. We demonstrate that a group of highly effective siRNAs targeting different H5N1 viral genes shares a unique...
8664189 RNA interference in skin indications  
The present invention relates to RNAi constructs with improved tissue and cellular uptake characteristics and methods of use of these compounds in dermal applications.
8663657 Nucleic acid constructs  
A nucleic acid construct comprising a chimeric promoter sequence and a cloning site for insertion of a coding sequence in operable linkage with the chimeric promoter, wherein the chimeric promoter...
8658778 hTMC promoter and vectors for the tumor-selective and high-efficient expression of cancer therapeutic genes  
Promoters that include a tissue-selective promoter sequence and a second promoter sequence operatively coupled to the tissue-selective promoter sequence, wherein the second promoter sequence...
8658155 Compositions and methods relating to non-human animals modified to promote production of selected gametes  
Methods and compositions for producing selected non-human mammalian germ cells and gametes and for making non-human animals using the produced germ cells and gametes are provided by the present...
8658779 Perilla-derived promoter functioning in petals  
A transcriptional regulatory region of perilla anthocyanin 3-acyltransferase is useful for altering the flower color of plants.
8658363 Cell, method, and assay kit for measuring level of aryl hydrocarbon receptor transcriptional activation  
According to one embodiment, a cell for measuring a level of Ah receptor transcriptional activation is provided. The cell is derived from a neural cell. The cell contains a chromosome into which a...
8653249 Expression vector for mass production of foreign gene-derived protein using animal cell and use thereof  
The present inventors successfully constructed expression vectors that enable high-level production of foreign gene-derived proteins in mammalian host cells, which comprise a translation-impaired...
8648228 MSCA1 nucleotide sequences impacting plant male fertility and method of using same  
Nucleotide sequences of a Msca1 gene, critical to male fertility in plants are described, with DNA molecule and amino acid sequences set forth. Promoter sequences and their essential regions are...
8648229 Plant seed active transcriptional control sequences  
The present invention relates generally to transcriptional control sequences for effecting expression of a nucleotide sequence of interest in a plant. More particularly, the present invention...
8648230 Regulatory regions preferentially expressing in non-pollen plant tissue  
Regulatory regions are shown which regulate expression of an operably linked heterologous nucleic acid molecule in plants. Promoters are described which express at lower levels in pollen cells that...
8648051 Antiproliferative activity of G-rich oligonucleotides and method of using same to bind to nucleolin  
The present invention provides a method for inhibiting the proliferation of malignant and/or hyperplastic cells in a subject by administering to the subject a therapeutically effective amount of a...
8648184 Recombinant vectors carrying zearalenone-inducible promoter and methods for producing proteins and detecting zearalenone using them  
The present invention relates to a zearalenone-inducible promoter originated from Gibberella zeae, recombinant vectors comprising the promoters, methods of producing proteins and detecting plants...
8648186 Antisense oligonucleotides (ODN) against SMAD7 and uses thereof in medical field  
The invention relates to antisense oligonucleotidic sequences (ODN) against Smad7 suitably modified, and their uses in medical field as therapeutic biological agents, in particular in the treatment...
8648183 Modified promoter  
It is intended to provide base sequences participating in the regulation of the expression of a promoter. It is also intended to modify a promoter based on the base sequence data to give a modified...
RE44760 Antisense modulation of apolipoprotein B-expression  
Antisense compounds, compositions and methods are provided for modulating the expression of apolipoprotein B. The compositions comprise antisense compounds, particularly antisense oligonucleotides,...
8642840 Nitrogen-efficient monocot plants  
Methods of increasing nitrogen utilization efficiency in monocot plants through genetic modification to increase the levels of alanine aminotransferase expression and plants produced there from are...