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8809289 Double-stranded nucleic acid molecule, cancer cell proliferation inhibitor and pharmaceutical agent suitable for prevention or treatment of cancer  
A double-stranded nucleic acid molecule including (a) a sense strand which includes a nucleotide sequence corresponding to a target sequence indicated by any one of SEQ ID Nos.: 1 to 21, and (b) an...
8809628 S-adenosylmethionine synthetase expression elements identified from Arabidopsis thaliana  
The present invention provides non-coding regulatory element polynucleotide molecules isolated from the S-adenosyl methionine synthetase (SAMS3) gene of Arabidopsis thaliana and useful for...
8809017 IRES mediated multicistronic vectors  
This invention relates to nucleic acid molecules comprising at least one nucleic acid sequence encoding for a peptide or protein of interest, at least one nucleic acid sequence encoding for a...
8809626 Trichome specific promoters  
Trichome specific plant promoters are provided herein. Also provided are transgenic cells and organisms, especially plant cell and plants, comprising an trichome specific promoter and methods for...
8802921 Engineered landing pads for gene targeting in plants  
A method for producing a transgenic plant includes providing a nucleic acid molecule comprising at least two regions of nucleic acid sequence that lack sequence homology with genomic DNA of the...
8802928 Plants having enhanced yield-related traits and/or increased abiotic stress resistance, and a method for making the same  
The present invention relates generally to the field of molecular biology and concerns a method for enhancing various economically important yield-related traits in plants. More specifically, the...
8802648 Repressor on IFN-λ promoter and siRNA against ZEB1 and BLIMP-1 to increase IFN-λ gene activity  
The present invention is directed to the identification of a novel repressor located between ˜1.2 kb to ˜1.6 kb from the translation start site of the IFN-λ1 promoter. The present invention pr...
8802645 Molecule for treating an inflammatory disorder  
The invention provides two types of oligonucleotides for treating an inflammatory disorder: an oligonucleotide which is able of altering the splicing of a pre-mRNA encoding a C5 in order to...
8802080 Raav expression systems for genetic modification of specific capsid proteins  
Disclosed are improved recombinant adeno-associated viral (rAAV) vectors having mutations in one or more capsid proteins. Exemplary vectors are provided that have altered affinity for heparin or...
8795675 Allergy inhibitor compositions and kits and methods of using the same  
Compositions, methods, and kits for inhibiting an allergic response against an allergenic protein are disclosed. Compositions, methods and kits for inhibiting an allergic response against an a flea...
8796440 Promote system for regulatable gene expression in mammalian cells  
The present invention is directed to a bidirectional human cytomegalovirus (hCMV) promoter that can be used to promote transcription on both strands of a double stranded DNA molecule. When used as...
8796444 Methods and compositions for the specific inhibition of gene expression by double-stranded RNA  
The invention is directed to compositions and methods for selectively reducing the expression of a gene product from a desired target gene in a cell, as well as for treating diseases caused by the...
8796507 MEG1 endosperm-specific promoters and genes  
The present invention relates to promoters that enable gene expression which is both specific to the endosperm and early during the development of the endosperm, as well as nucleic acid molecules...
8795965 CRISPR-Cas component systems, methods and compositions for sequence manipulation  
The invention provides for systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are vectors and vector systems, some of which encode one...
8790896 Method for increasing protein expression in cells  
The present invention relates to a method for increasing the expression of a protein in cells, preferably in eukaryotic cells, by reducing the number of RNase L cleavage sites in the coding and/or...
8791248 Nuclear reprogramming factor comprising miRNA and a protein factor  
A method of preparing induced pluripotent stem cells, comprising a nuclear reprogramming step with a nuclear reprogramming factor in the presence of miRNA, wherein said miRNA has a property of...
8791330 Expression regulatory elements  
The present invention relates generally to an expression regulatory element operable in plants which includes oil palm, and in particular to an expression regulatory element operable selectively in...
8790900 Microorganisms having enhanced sucrose mutase activity  
The invention relates to the biotechnological production of isomaltulose and isomaltulose-containing compositions and improved means, therefore particularly microbial cells.
8790636 Human skin equivalents expressing exogenous polypeptides  
The present invention relates generally to compositions for wound closure. More specifically, the present invention provides human skin equivalents engineered to express exogenous polypeptides...
8791325 Chloroplast transit peptides for efficient targeting of DMO and uses thereof  
The invention provides for identification and use of certain chloroplast transit peptides for efficient processing and localization of dicamba monooxygenase (DMO) enzyme in transgenic plants....
8785411 HIV DNA vaccine methods of use  
The present invention is directed to a DNA vaccine for immunization against HIV. The invention comprises a DNA molecule that has a sequence encoding a plurality of viral proteins capable of...
8785613 P. pastoris pastoris promoters, and the use thereof to direct expression of proteins in yeast, preferably using a haploid mating strategy  
Novel promoters which are derived from P. pastoris pastoris which are inducible or repressible under specific growth conditions are provided. These promoters are useful for regulating the...
8785617 Oligomeric compounds for the modulation of HIF-1A expression  
Oligonucleotides directed against the hypoxia-inducible factor-1α (HIF-1α) gene are provided for modulating the expression of HIF-1α. The compositions comprise oligonucleotides, particularly an...
8785612 Sugarcane bacilliform viral (SCBV) enhancer and its use in plant functional genomics  
Identification of new enhancer sequence has significant utility in the plant functional genomics. The sugarcane bacilliform badnavirus (SCBV) transcriptional enhancer has been identified. This...
8785611 Compositions and methods related to mRNA translational enhancer elements  
Provided are mRNA translational enhancer elements (TEEs), e.g., SEQ ID NOs:1-35. Also provided are translational enhancer polynucleotides that comprise one or more of the specific TEEs exemplified...
8778900 Modulation of eIF4E-BP1 expression  
Compounds, compositions and methods are provided for modulating the expression of eIF4E-BP1. The compositions comprise oligonucleotides, targeted to nucleic acid encoding eIF4E-BP1. Methods of...
8779116 SiRNA-mediated gene silencing  
The present invention is directed to small interfering RNA molecules (siRNA) targeted against an allele of interest, and methods of using these siRNA molecules.
8778903 MicroRNA-10 antagonists and MicroRNA-10 targets for use in the treatment of a glioma  
The present invention embraces microRNA-antagonists and activators of homeobox D10 protein; Zinc finger, MYND domain containing 11 protein; or RB1-inducible coiled-coil 1 protein for use in...
8778672 Somatic ovule specific promoter and methods of use  
Compositions and methods for regulating expression of heterologous nucleotide sequences in a plant are provided. Compositions include nucleotide sequences for an Arabidopsis thaliana nucellar...
8772464 Aptamer regulated nucleic acids and uses thereof  
The invention relates to aptamer-regulated, ligand-responsive nucleic acids, or “ampliSwitches,” and uses thereof. Particular embodiments include a ligand-responsive nucleic acid that comprises a p...
8772575 Nucleic acids useful in the manufacture of oil  
Novel gene sequences from microalgae are disclosed, as well as novel gene sequences useful in the manufacture of triglyceride oils. Also disclosed are sequences and vectors that allow microalgae to...
8772465 IRES functioning in plant  
It is intended to provide for a polycistronic expression pattern in a plant used as a host. The present invention provides a polynucleotide which comprises the following DNA (a) or (b) and...
8772260 Methods for inhibiting expression of connective tissue growth factor  
This invention provides compounds which comprise modified oligonucleotides capable of inhibitory expression of connective tissue factor and composition containing same as well as methods of...
8772466 Zea mays NFB2 promoter  
The present invention provides non-coding regulatory element polynucleotide molecules isolated from the transcription factor Nuclear Factor B (NFB2) gene of Zea mays and useful for expressing...
8771984 Selection of host cells expressing protein at high levels  
The invention provides a DNA molecule comprising a multicistronic transcription unit coding for i) a selectable marker polypeptide functional in a eukaryotic host cell, and for ii) a polypeptide of...
8771945 CRISPR-Cas systems and methods for altering expression of gene products  
The invention provides for systems, methods, and compositions for altering expression of target gene sequences and related gene products. Provided are vectors and vector systems, some of which...
8765929 Promoter for use in transformation of algae  
The objective of the present invention is to provide a transformation method that is applicable to a wide variety of species of algae with high efficiency. The promoter of the present invention is...
8765140 DNA vaccine compositions with HIV/SIV gene modifications  
The present invention is directed to a DNA vaccine for immunization against HIV. The invention comprises a DNA molecule that has a sequence encoding a plurality of viral proteins capable of...
8766037 Drought responsive expression of genes from the Zea mays Rab17 promoter  
The present invention relates generally to the drought-specific expression of a nucleotide sequence of interest in one or more cells of a plant. In some particular embodiments, the present...
8759506 Expression enhancing intron sequences  
The invention relates to methods for the identification and use of introns with gene expression enhancing properties. The teaching of this invention enables the identification of introns causing...
8759088 Lactococcus promoters and uses thereof  
The invention is in the field of molecular biology, and relates to recombinant engineering and protein expression. More in particular, the invention relates to nucleic acids for recombinant...
8759612 Soybean promoters LTP2 and flower-preferred expression thereof in transgenic plants  
The invention relates to gene expression regulatory sequences from soybean, specifically to the promoters of a soybean lipid transfer protein LTP2 and fragments thereof and their use in promoting...
8759507 Modulation of exon recognition in pre-mRNA by interfering RNA structure  
The invention provides a method for generating an oligonucleotide with which an exon may be skipped in a pre-mRNA and thus excluded from a produced mRNA thereof. Further provided are methods for...
8759002 Gene dosage analysis  
The present invention relates to methods of detecting the presence of a genetic polymorphism within two or more closely linked, homologous genes, for example α-thalassemia, in a sample using ...
8754200 MEG1 endosperm-specific promoters and genes  
The present invention relates to promoters that enable gene expression which is both specific to the endosperm and early during the development of the endosperm, as well as nucleic acid molecules...
8753847 Selection and enrichment of proteins using in vitro compartmentalization  
Compositions and methods are provided for selection and enrichment of a target gene from a library of polynucleotide sequences such as might be formed from a genome or by random mutagenesis of a...
8754198 Modified food grade microorganism for treatment of inflammatory bowel disease  
The present invention relates to microorganisms that express, or have attached to their surface, a TNFα binding polypeptide. Peptides expressed or attached on the surface of microorganism are more ...
8742089 Methods and compositions for expressing negative-sense viral RNA in canine cells  
The present invention provides novel canine pol I regulatory nucleic acid sequences useful for the expression of nucleic acid sequences in canine cells such as MDCK cells. The invention further...
8741634 Soybean transcription terminators and use in expression of transgenic genes in plants  
Five novel plant transcription terminators MYB2, KTI1, PIP1, EF1A2, and MTH1 are isolated from soybean and their functions in the regulation of RNA transcription and processing in plants are...
8742203 Chemically Inducible Expression of Biosynthetic Pathways  
Methods and constructs for the introduction of multiple genes encoding enzymes in a multi-enzyme biosynthetic pathway are provided. In one embodiment, the constructs contain two or more...