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7129342 |
Infectious cDNA clone of GB virus B and uses thereof
The present invention relates to nucleic acid sequence which comprises the genome of an infectious GB virus B clone. The invention also relates to the use of the nucleic acid sequence of the...
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7129223 |
Inhibition of SARS-associated coronavirus (SCoV) infection and replication by RNA interference
The present invention relates to therapeutic agents useful for the treatment of Severe Acute Respiratory Syndrome (SARS) in humans. In particular, the present invention relates to RNA interference...
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7129337 |
Sequences of hepatitis C virus genotypes and their use as prophylactic, therapeutic and diagnostic agents
The present invention relates to new genomic nucleotide sequences and amino acid sequences corresponding to the coding region of these genomes. The invention relates to new HCV types and subtypes...
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7129041 |
Polymerase chain reaction assays for monitoring antiviral therapy and making therapeutic decisions in the treatment of acquired immunodeficiency syndrome
The present invention relates to methods of monitoring, via polymerase chain reaction, the clinical progression of human immunodeficiency virus infection and its response to antiretroviral therapy....
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7125705 |
Polynucleotides for use in recombinant adeno-associated virus virion production
Accessory functions capable of supporting efficient recombinant AAV (rAAV) virion production in a suitable host cell are provided. The accessory functions are in the form of one or more vectors...
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7125957 |
VPR mutant protein and its encoding gene having apoptosis-inducing action
An apoptosis inducing agent which comprises a protein as being Vpr protein encoded by vpr gene of HIV-1 wherein 15 amino acid residues from the C-terminal are deleted, and an apoptosis inducing...
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7125717 |
Metabolically activated recombinant viral vectors and methods for their preparation and use
Recombinant viral vectors, especially parvovirus vectors such as adeno-associated virus (AAV) vectors, capable of enhanced expression of heterologous sequences, and methods for their construction...
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7125712 |
Bovine immunodeficiency virus (BIV) based vectors
This invention pertains to BIV constructs encompassing BIV combination vectors, BIV vectors and BIV packaging vectors and particularly the invention pertains to a three vector system comprising: a)...
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7122180 |
DNA vectors containing mutated HIV proviruses
The present invention pertains to mutated, non-infectious HIV viral particles, vectors for production of such particles and vaccines employing such vectors. The non-infectious particles are...
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7122306 |
Sequences of hepatitis C virus genotypes and their use as therapeutic and diagnostic agents
The present application provides polynucleic acid sequences of 8 or more contiguous nucleotides selected from an HCV subtype 3 c genomic sequence selected from the region spanning positions 1 to...
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7119167 |
Fragment of L. lactis plasmid conferring antiphage activity and uses thereof
The present invention relates to a 2227-bp DNA fragment that confers antiphage activity. Two proteins encoded by this DNA sequence are responsible for the phage resistance phenotype. When...
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7118888 |
Gene expression vaccine
An effective prophylactic mucosal gene expression vaccine (GXV), made up of a cocktail of at least 4 different plasmid DNAs encoding corresponding RSV antigens, coacervated with chitosan to...
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7115363 |
Retrovirus capable of causing AIDS, means and methods for detecting it in vitro
The invention relates to a new class of retroviruses, designated by HIV-2, of which samples have been deposited to the ECACC under numbers 87.01.1001 and 87.01.1002 and to the NCIB under numbers...
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7115374 |
Compositions and methods for detecting West Nile virus
Compositions, methods and kits for detecting flavivirus nucleic acids. Particularly described are oligonucleotides that are useful as hybridization probes and amplification primers for detecting...
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7109029 |
Vector constructs
The present invention provides novel viral vectors and methods useful for the minimization of leaky gene expression, and, in particular, of nonspecific transcriptional read-through of genes. Such...
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RE39282 |
Nucleic acid derivatives
This invention relates to a methodology for assessing the sensitivity of an HIV-1 sample to zidovudine and to diagnostic assays for use in such assessment.
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7105655 |
Stabilization of envelope glycoprotein trimers by disulfide bonds introduced into a gp41 glycoprotein ectodomain
The present application is directed to stabilized envelope glycoprotein trimers. The trimers are stabilized by introducing disulfide bonds at certain sites in the gp41 ectodomain. DNA molecules...
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7105346 |
Packaging systems for human recombinant adenovirus to be used in gene therapy
Presented are ways to address the problem of replication competent adenovirus in adenoviral production for use with, for example, gene therapy. Packaging cells having no overlapping sequences with...
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7105345 |
Adeno-associated virus serotype 1 nucleic acid sequences, vectors and host cells containing same
The nucleic acid sequences of adeno-associated virus (AAV) serotype 1 are provided, as are vectors and host cells containing these sequences and functional fragments thereof. Also provided are...
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7101685 |
Recombinant Sendai virus
A method for generating Sendai virus particles by transfecting the Sendai virus genome to a host expressing all genes for the initial viral replication has been developed, enabling the genetic...
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7097970 |
Methods of evaluating viral entry inhibitors using patient derived envelope protein constructs
The invention provides a method for identifying whether a compound inhibits entry of a virus into a cell which comprises: (a) obtaining nucleic acid encoding a viral envelope protein from a patient...
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7094411 |
Avirulent, immunogenic flavivirus chimeras
Chimeric flaviviruses that are avirulent and immunogenic are provided. The chimeric viruses are constructed to contain amino acid mutations in the nonstructural proteins of a flavivirus. Chimeric...
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7094604 |
Production of pseudotyped recombinant AAV virions
Vectors that encode Adeno-Associated Virus (AAV) Rep and Cap proteins of different serotypes and Adenovirus transcription products that provide helper functions were used to produce pseudotyped...
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7094408 |
Immunogenicity using a combination of DNA and vaccinia virus vector vaccines
This invention relates to improved methods of inducing an immune response for the prevention or treatment of HIV-1 infection by using a nucleic acid vaccine in conjunction with a recombinant viral...
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7094953 |
Plant retroelements and methods related thereto
The present invention provides nucleic acids, as well as vectors, cells, and plants (including plant parts, seeds, and embryos) containing the nucleic acids. In particular, molecular tools are...
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7090852 |
Venezuelan equine encephalitis virus replicon encoding marburg virus proteins
Using the MBGV GP, NP, and virion proteins, a method and composition for use in inducing an immune response which is protective against infection with MBGV in nonhuman primates is described.
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7087811 |
Enhanced protein production in higher plants by N-terminal fusion of a ubiquitin or a cucumber mosaic virus coat protein peptide
Methods are disclosed for enhancing protein production. One method comprises preparing a vector by inserting a gene encoding ubiquitin in front of a gene encoding a protein of interest and...
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7084266 |
Cloned genome of infectious hepatitus C virus of genotype 2A and uses thereof
The present invention discloses nucleic acid sequence which encodes infectious hepatitis C virus of strain HC-J6 CH , gentotype 2a, and the use of the sequence, and polypeptides encoded by all or...
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7084264 |
Viral sequences
An isolated nucleic acid comprising the nucleotide sequence of SEQ ID NO:1, or the full complementary sequence thereof. Presence of said nucleic acid in a subject predisposes the subject to an...
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7078388 |
DNA vaccines for farm animals, in particular bovines and porcines
DNA vaccine against a pathogen affecting farm animals, in particular bovines or porcines, comprising a plasmid containing a nucleotide sequence encoding an immunogen of a pathogen of the animal...
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7078215 |
HCV NS2/3 fragments and uses thereof
Truncated HCV NS2/3 can be produced recombinantly and renatured into functional enzyme, useful in assays for modulators of activity and HCV function.
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7074410 |
Modified HCV peptide vaccines
Provided are an isolated peptide having the amino acid sequence DLMGYIPAV (SEQ ID NO: 1), an isolated HCV core polypeptide comprising an L→A substitution at amino acid position 139, an isolated...
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7071322 |
HIV envelope polynucleotides and immunogenic composition
Oligonucleotide sequences encoding gp120 polypeptides from breakthrough isolates of vaccine trials using MN-rgp120 and the encoded gp120 polypeptides are provided. Use of the gp120 polypeptides...
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7067247 |
Hepatitis B virus surface protein
We isolated and characterized a new surface mutant of the hepatitis B virus surface antigen (HBsAg). The mutant was isolated from a symptomatic patient with Down's syndrome who was found to be...
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7049428 |
HCV variants
HCV variants are described. The variants include polynucleotides comprising non-naturally occurring HCV sequences and HCV variants that have a transfection efficiency and ability to survive...
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7045344 |
Adenoviral vector and methods for making and using the same
In vitro methods for making a recombinant adenoviral genome, as well as kits for practicing the same and the recombinant adenovirus vectors produced thereby, are provided. In the subject methods,...
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7045335 |
Alphavirus replicon vector systems
The present invention provides compositions useful in and methods for producing populations of infectious, replication-defective alphavirus replicon particles that contain no replication-competent...
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7045685 |
Insect viruses and their uses in protecting plants
The present invention relates to an isolated small RNA virus capable of infecting insect species including Heliothis species, and to the nucleotide sequences and proteins encoded thereby. The...
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7041442 |
Peptides for vaccinating against human CMV
The present invention relates to peptides or peptide derivatives of the 65 kD lower matrix phoshpoprotein of human cytomegalovirus. The peptides disclosed are useful for determining whether...
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7041813 |
Canine herpes virus alpha transinducing factor nucleic acid molecules
The present invention includes novel recombinant canine herpes virus (CHV) and novel recombinant CHV genomes, and particularly to those CHV and CHV genomes that contain heterologous nucleic acid...
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7037509 |
Immunologically significant herpes simplex virus antigens and methods for using same
The invention provides HSV antigens that are useful for the prevention and treatment of HSV infection. Disclosed herein are epitopes confirmed to be recognized by T-cells derived from herpetic...
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7037508 |
Pestivirus mutants and vaccines containing the same
The present invention is directed to attenuated pestivirus mutants, which have a reduced ability to replicate as exhibited by a small plaque size. The mutations are in the 5′ nontranslated region...
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7037716 |
Packaging systems for human recombinant adenovirus to be used in gene therapy
The invention provides improved methods and products based on adenoviral materials which can advantageously be used in gene therapy. In one aspect, an adenoviral vector is provided having no...
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7037712 |
DNA encoding ovine adenovirus (OAV287) and its use as a viral vector
A genome of an ovine adenovirus designated OAV287 is isolated from sheep and sequenced. Portions of the genome not essential for maintenance or viability of the virus can be deleted or altered. A...
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7038035 |
Vaccine-induced hepatitis B viral strain and uses thereof
This invention provides an isolated strain of Hepatitis B virus designated Human Hepatitis B Virus Surface Antigen-'Ś-145 Singapore Strain (Glycine to Arginine) which constituent viral genome is...
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7034141 |
Packaging of positive-strand RNA virus replicon particles
The invention generally relates to recombinant polynucleotides, positive-strand RNA virus (psRNAV) recombinant expression vectors, and packaging systems. The packaging systems are based on the...
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7033751 |
Antigenic fragment of human T-lymphotropic virus
Antigenic fragments of human T-lymphotropic virus (HTLV), their fusion proteins with glutathione S-tranferase (GST) or thioredoxin (Thio), and a process for producing the fusion proteins thereof....
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7033835 |
Production of peptides in plants as viral coat protein fusions
The present invention relates to foreign peptide sequences fused to recombinant plant viral structural proteins and a method of their production. Fusion proteins are economically synthesized in...
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7033826 |
Recombinant adenoviruses, use thereof for preparing AAVS, complementary cell line, and pharmaceutical compositions containing said adenoviruses
A recombinant adenovirus in which the expression of a nucleic acid sequence coding for at least one homologous or heterologous gene of viral origin is placed under the control of an inducible...
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7026112 |
Oligonucleotides for the amplification and detection of Epstein Barr Virus (EBV) nucleic acid
The present invention is concerned with oligonucleotides that can be used as in the amplification and detection of Epstein Barr Virus (EBV) nucleic acid, in particular RNA-specific sequences....
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