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7276333 |
Viral infection inhibitor targeting integrase N-terminal domain
The object of the present invention is to provide a screening method of a new integrase inhibitor being able to inhibit an HIV infection before the reverse transcription step and having a...
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7267942 |
Diagnostic assay for the human virus causing severe acute respiratory syndrome (SARS)
The present invention relates to a diagnostic assay for the virus causing Severe Acute Respiratory Syndrome (SARS) in humans (“hSARS virus”). In particular, the invention relates to a real-time...
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7262049 |
Pseudotyped lentiviral vectors and uses thereof
A vector system that will produce a pseudotyped lentiviral vector that can be used to deliver a desired gene is disclosed. The vector constructs that are described include a number of modifications...
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7262292 |
Oligonucleotides and methods for detecting hepatitis B viral nucleic acids
The present invention provides methods and compositions for determining the presence and/or amount of HBV nucleic acids in a test sample. In particular, substantially purified oligonucleotide...
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7259293 |
Expression of eukaryotic peptides in plant plastids
Constructs and methods are provided for expressing peptides derived from eukaryotic organisms in plant plastids. Constructs have a promoter functional in a plant plastid, a DNA sequence encoding a...
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7255986 |
Compositions for the diagnosis and treatment of epizootic catarrhal enteritis in ferrets
The present invention relates to the use of novel nucleotide sequences for the M and N region peptide of the ferret coronavirus and derivative products for the diagnosis and treatment of epizootic...
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7252991 |
Method for production of high titer virus and high efficiency retroviral mediated transduction of mammalian cells
The invention provides a novel retroviral packaging system, in which retroviral packaging plasmids and packagable vector transcripts are produced from high expression plasmids after stable or...
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7250296 |
Nucleotide sequences of 2S albumin gene and its promoter from grape and uses thereof
The subject invention pertains to the isolation of nucleotide sequences of the 2S albumin gene and its promoter from grape. Promoter sequences of the invention provide for seed-specific...
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7247439 |
Method of evaluating a patient antibody response to envelope proteins of a virus
The invention provides a method for identifying whether a compound inhibits entry of a virus into a cell which comprises: (a) obtaining nucleic acid encoding a viral envelope protein from a patient...
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7244617 |
Diminishing viral gene expression by promoter replacement
The present invention provides viral vectors that have been engineered to contain a synthetic promoter that controls at least one essential gene. The synthetic promoter is induced by a specific...
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7244434 |
Replicons of pestviruses that do not express C and or E1 protein and infectious viral particles containing same, that can be used in vaccines
The present invention provides new Pestiviral RNA genomes (replicons) that are able to replicate, and can be packaged into infectious viral particles in cells that complement the missing...
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7235356 |
Methods of evaluating cell surface receptor binding of a patient derived population of viral envelope protein constructs
The invention provides a method for identifying whether a compound inhibits entry of a virus into a cell which comprises: (a) obtaining nucleic acid encoding a viral envelope protein from a patient...
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7235394 |
Functional DNA clone for hepatitis C virus (HCV) and uses thereof
The present invention relates to the determination of an authentic HCV genome RNA sequences, to construction of infectious HCV DNA clones, and to use of the clones, or their derivatives, in...
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7235387 |
Method for mutation detection in HIV-1 using pol sequencing
The present invention relates to a method for mutation analysis of the HIV pol gene of HIV virions comprising amplifying virion RNA or DNA via nested PCR using outer primers as represented in SEQ...
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7220577 |
Modified AAV
Libraries of modified AAV cap genes are generated by synthesizing modified cap genes using degenerate oligonucleotides. Combinatorial libraries of virions composed of modified (e.g., chimeric),...
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7220852 |
Coronavirus isolated from humans
Disclosed herein is a newly isolated human coronavirus (SARS-CoV), the causative agent of severe acute respiratory syndrome (SARS). Also provided are the nucleic acid sequence of the SARS-CoV...
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7217812 |
Extraneous DNA sequence that facilitates hantavirus gene expression
In this application is described a protective DNA vaccines against infection with HFRS- and HPS-associated hantaviruses. The vaccines were constructed by subcloning cDNA representing the medium (M)...
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7211379 |
Prevention of myocarditis, abortion and intrauterine infection associated with porcine circovirus-2
Provided is a method for reducing viral load of porcine circovirus type 2 (PCV-2) in a pig by inducing an immune response against PCV-2 through the administration of an immunogenic composition...
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7211659 |
Polynucleotides encoding antigenic HIV type C polypeptides, polypeptides and uses thereof
The present invention relates to polynucleotides encoding immunogenic HIV polypeptides. Uses of the polynucleotides in applications including immunization, generation of packaging cell lines, and...
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7208161 |
Production of attenuated parainfluenza virus vaccines from cloned nucleotide sequences
Isolated polynucleotide molecules provide recombinant PIV genomes and antigenomes for production of recombinant PIV vaccines. The recombinant genome or antigenome can be expressed with a...
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7205101 |
Human immunodeficiency virus (HIV) nucleotide sequences, recombinant polypeptides, and applications thereof
Polynucleotide sequences are provided for the diagnosis of the presence of retroviral infection in a human host associated with lymphadenopathy syndrome and/or acquired immune deficiency syndrome,...
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7201909 |
Cold-adapted equine influenza viruses
The present invention provides experimentally-generated cold-adapted equine influenza viruses, and reassortant influenza A viruses comprising at least one genome segment of such an equine influenza...
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7201907 |
Attenuated human-bovine chimeric parainfluenza virus(PIV) vaccines
Chimeric human-bovine parainfluenza viruses (PIVs) are infectious and attenuated in humans and other mammals and useful individually or in combination in vaccine formulations for eliciting an...
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7202329 |
Tsg101-GAGp6 interaction and use thereof
Isolated protein complexes are provided comprising Tsg101 and HIV GAGp6. The protein complexes are useful in screening assays for selecting compounds effective in modulating the Tsg101-HIV GAGp6...
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7198793 |
Bovine immunodeficiency virus (BIV) based vectors
This invention pertains to BIV constructs encompassing BIV combination vectors, BIV vectors and BIV packaging vectors and particularly the invention pertains to a three vector system comprising: a)...
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7196188 |
Methods and compositions for screening of human borna disease virus
Human Borna disease virus (BDV) nucleic acids and polypeptides are described from three psychiatric patients. The human BDV-derived nucleic acids and polypeptides are useful in both DNA- and...
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7192593 |
Use of recombinant parainfluenza viruses (PIVs) as vectors to protect against infection and disease caused by PIV and other human pathogens
Chimeric parainfluenza viruses (PIVs) incorporate a PIV vector genome or antigenome and one or more antigenic determinant(s) of a heterologous PIV or non-PIV pathogen. These chimeric viruses are...
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7189401 |
Live attenuated viruses for use as vectors or vaccines
The present invention provides modified viral genomes for use as vaccines or vectors, which are improved in their ability to retain attenuating mutations. The genomes are from viruses that...
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7189561 |
Production of adenovirus vectors with reduced levels of replication competent adenovirus contamination
Methods, cells and recombinant adenoviral vectors are disclosed that permit the production of recombinant adenoviral vector stocks with reduced levels of contamination by replication competent...
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7183047 |
Reporter gene construct for the detection of HIV Rev and HIV Tat
The present invention relates to a reporter gene construct for the detection of the HIV Rev and HIV Tat proteins. Furthermore, the invention relates to a functionality test method for Rev and Rev...
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7183404 |
Vaccine against ISA virus
The invention relates to vaccine against infectious salmon anaemia (ISA) virus, DNA sequences endocing immunogenic proteins from ISA virus, diagnostic kit for detection of ISA specific nucleic acid...
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7179457 |
Modified nodavirus RNA for gene delivery
The invention provides a nodavirus RNA1 molecule modified to include a heterologous insertion which is downstream of its replicase ORF and, preferably, its B2 ORF. The insertion preferably...
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7179600 |
Oligonucleotide chip composition and a method for analyzing a hepatitis C virus genotype using the composition
The present invention discloses a method for analyzing a HCV genotype by extracting RNA from plasma and serum, performing C-type hepatitis virus (HCV) RT-PCR and then making them react on an...
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7169396 |
Reference clones and sequences for non-subtype B isolates of human immunodeficiency virus type 1
The nucleotide sequences of the genomes of eleven molecular clones for non-subtype B isolates of human immunodeficiency virus type 1 are disclosed. The invention relates to the nucleic acids and...
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7169551 |
Methods of evaluating viral entry inhibitors using patient derived envelope protein constructs
The invention provides a method for identifying whether a compound inhibits entry of a virus into a cell which comprises: (a) obtaining nucleic acid encoding a viral envelope protein from a patient...
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7169585 |
Papillomavirus vaccine
A method of providing papillomavirus like particles which may be used for diagnostic purposes or for incorporation in a vaccine for use in relation to infections causd by papillomavirus. The method...
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7164056 |
Gene targeting using replicating DNA molecules
The invention provides novel methods of gene targeting using replication in order to increase the efficiency of targeted genetic modification in an eukaryotic organism. Included are vectors,...
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7157225 |
Nucleotide sequences of HIV-1 type (or subtype) O retrovirus antigens
An HIV-1 type (or subtype) O retrovirus protein, or a natural or synthetic polypeptide or peptide including at least a part of said protein, which is capable of being recognised by antibodies...
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7150874 |
Vector for integration of heterologous sequences into poxviral genomes
A new DNA vector is disclosed comprising a nucleic acid sequence useful for inserting heterologous sequences into the genome of poxviruses by homologous recombination. Also disclosed are...
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7151172 |
Attenuated vif DNA immunization cassettes for genetic vaccines
The present invention is directed to nucleic acid molecules encoding attenuated, non-functional virion infectivity factor (vif) proteins. The nucleic acid molecules of the invention are inserted...
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7148341 |
AAV DNA comprising helper virus sequences
The present invention relates to an AAV DNA having helper virus sequences which are necessary for developing AAV viral particles, a system containing such a DNA and the use of both.
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7147848 |
Recombinant poliovirus for the treatment of cancer
The present invention is directed to non-pathogenic, oncolytic, recombinant polioviruses for the treatment of various forms of malignant tumors. The recombinant polioviruses of the invention are...
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7141405 |
Chimeric GB virus B (GBV-B)
The present invention relates generally to the fields of biochemistry, molecular biology, and virology. More particularly, it relates to the identification of GB virus B (GBV-B)/HCV chimeras. The...
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7138231 |
Means and methods for monitoring protease inhibitor antiretroviral therapy and guiding therapeutic decisions in the treatment of HIV/AIDS
This invention relates to antiviral drug susceptibility and resistance tests to be used in identifying effective drug regimens for the treatment of human immunodeficiency virus (HIV) infection and...
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7138515 |
Translational activity-promoting higher-order structure
The present invention was conceived from the findings; that a specific higher-order structure can be formed in CrP-like viruses; that linkage of a gene reading frame downstream in the higher-order...
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7138376 |
Methods and compositions for treating hepatitis C virus using 4'-modified nucleosides
A compound, method and composition for treating a host infected with a hepatitis C viral comprising administering an effective hepatitis C treatment amount of a described 4′-disubstituted...
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7138252 |
Molecular antigen arrays
The present invention provides a composition comprising an AP205 virus like particle (VLP) and an antigen. The invention also provides a process for producing an antigen or antigenic determinant...
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7135561 |
Infectious bovine viral diarrhea virus clone
The invention belongs to the field of animal health and in particular Bovine Viral Diarrhea Virus (BVDV). The invention provides infectious BVDV clones and methods to produce said BVDV clones. The...
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7135187 |
System for production of helper dependent adenovirus vectors based on use of endonucleases
The present invention relates to methods for efficient and reliable construction of adenovirus vectors which contain and express foreign DNA and are useful for gene transfer into mammalian cells,...
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7132106 |
Infectious cDNA clone of North American porcine reproductive and respiratory syndrome (PRRS) virus and uses thereof
The invention provides isolated polynucleotide molecules, including plasmids; viral vectors; and transfected host cells that comprise a DNA sequence encoding an infectious RNA sequence encoding a...
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