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7449188 |
Recombinant oligometric protein complexes with enhanced immunogenic potential
The present invention relates to a chimeric protein comprising an antigen and an oligomerisation domain. The present invention relates further to recombinant oligomeric protein complexes comprising...
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7442525 |
Method for expressing HIV polypeptides
Polynucleotide sequences are provided for the diagnosis of the presence of retroviral infection in a human host associated with lymphadenopathy syndrome and/or acquired immune deficiency syndrome,...
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7439058 |
HBV/HCV virus-like particle
Chimeric antigens derived from hepatitis B virus (HBV) and hepatitis C virus (HCV) are described which form virus-like particles when co-expressed with an excess of hepatitis B virus surface...
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7439347 |
Hepatitis C virus non-structural NS3/4A fusion gene
Disclosed herein is the discovery of a novel hepatitis C virus (HCV) isolated from a human patient. Embodiments of the invention include HCV peptides, nucleic acids encoding said HCV peptides,...
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7423138 |
Compositions and methods for treating papillomavirus-infected cells
By virtue of the present invention, there is provided methods and compositions for interfering with the proliferation of cells infected and/or transformed by papillomaviruses. The processes and...
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7419829 |
Vector system
The present invention provides a vector system comprising a mutated post-transcriptional regulatory element. In particular, the present invention relates to a mutated WPRE sequence that can...
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7417136 |
Nucleic acid vaccines for prevention of flavivirus infection
The invention encompasses nucleic acid molecules containing transcription units which encode the flavivirus M and E protein antigens. The flaviviruses include Japanese encephalitis virus,...
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7408053 |
Recombinant DNA constructs for GAG polypeptides and polypeptides produced thereby
Polynucleotide sequences are provided for the diagnosis of the presence of retroviral infection in a human host associated with lymphadenopathy syndrome and/or acquired immune deficiency syndrome,...
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7407758 |
HCV variants
HCV variants are described. The variants include polynucleotides comprising non-naturally occurring HCV sequences and HCV variants that have a transfection efficiency and ability to survive...
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7407802 |
Vectors and cells for preparing immunoprotective compositions derived from transgenic plants
The inventions is drawn towards vectors and methods useful for preparing genetically transformed plant cells that express immunogens from pathogenic organisms which are used to produce...
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7393831 |
Peptide compositions and their use against HCV
The invention relates to novel peptide compositions. In particular, the invention relates to a peptide composition comprising at least two peptides which are selected from among the following...
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7381817 |
LTR region of MSRV-1 and the proteins it encodes, and probes and methods for detecting MSRV-1 retrovirus
The invention relates to: a nucleotide fragment of an MSRV-1 LTR-RU5 region, comprising a nucleotide sequence encoding the expression of a protein, wherein the protein comprises a peptide sequence...
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7378515 |
Synthetic gagpol genes and their uses
The present invention relates to synthetic gag and gagpol genes optimized for high level expression via codon optimization and the uses thereof for the efficient generation of vector particles. The...
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7375202 |
Human virus causing severe acute respiratory syndrome (SARS) and uses thereof
The present invention relates to an isolated novel virus causing Severe Acute Respiratory Syndrome (SARS) in humans (“hSARS virus”). The hSARS virus is identified to be morphologically and...
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7371846 |
CD4-independent HIV envelope proteins as vaccines and therapeutics
The invention relates to novel CD4-independent HIV Envelope proteins and uses therefor.
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7371525 |
Compositions and methods for diagnosing and treating severe acute respiratory syndrome (SARS)
The present invention relates to the fields of immunochemistry and pharmacology. Methods and compositions are described for the diagnosis and treatment of SARS CoV infection. More specifically, the...
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7368557 |
Polynucleotides encoding porcine transmissible gastroenteritis virus
The present invention relates to methods of preparing a DNA comprising steps, wherein (a) a DNA comprising a full length copy of the genomic RNA (gRNA) or an RNA virus; or (b) a DNA comprising one...
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7361747 |
Isolation and characterization of the precursor virus of human SARS virus: SARS-associated corona virus-like virus
The present invention relates to isolation and characterization of a class of isolated novel viruses which is the precursor of the virus causing Severe Acute Respiratory Syndrome (SARS) in humans...
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7355033 |
Screening for West Nile Virus antiviral therapy
The instant invention provides stable and novel lineage I WNV reverse genetics systems, and methods for making the reverse genetics systems, specifically, a fully-infectious lineage I WNV cDNA or...
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7351877 |
Lambda integrase mediated recombination in plants
The present disclosure provides methods for obtaining the targeted integration of a DNA molecule into the genome of a host cell using a recombinase. The methods disclosed herein can be used with a...
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7348423 |
Nucleic acids encoding fusion peptides
A process is disclosed for the production of an antifusogenic peptide by producing a fusion peptide of a length of about 14 to 70 amino acids in a prokaryotic host cell, comprising the steps, under...
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7344722 |
Cold-adapted influenza virus
The cold-adapted master strain A/Ann Arbor/6/60 7PI (H2N2) and progenitor wild type E2(3) viral strains have been deposited and their genomic sequences identified. Seven nucleotide differences were...
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7341726 |
Modified HCV peptide immunogens
Provided are an isolated peptide having the amino acid sequence DLMGYIPAV (SEQ ID NO: 1), an isolated HCV core polypeptide comprising an L→A substitution at amino acid position 139, an isolated...
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7338759 |
HCV variants
HCV variants are described. The variants include polynucleotides comprising non-naturally occurring HCV sequences and HCV variants that have a transfection efficiency and ability to survive...
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7329732 |
HCV RNA-dependent RNA polymerase
The present invention features NS5B polypeptides from different clinically important HCV genotypes. The polypeptides can be used individually, or as part of a panel of RNA-dependent RNA...
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7326417 |
IGF-1 as feline vaccine adjuvant, in particular against feline retroviruses
The invention relates to feline IGF-1, to the nucleotide sequence encoding this protein and to the use of IGF-1 as adjuvant for the vaccination of cats, in particular against the feline...
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7320857 |
Characterization of the earliest stages of the severe acute respiratory syndrome (SARS) virus and uses thereof
Severe Acute Respiratory Syndrome (“SARS”) is a human respiratory disease of recent origin, widespread infectivity, recurring incidence, and significant mortality. Although there is abundant...
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7320795 |
Rodent hepatitis B virus core proteins as vaccine platforms and methods of use thereof
The present invention relates to hepatitis virus core proteins and nucleic acids. In particular, the present invention provides compositions and methods comprising recombinant hepatitis virus core...
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7319144 |
Polynucleotides encoding a multiple epitope fusion antigen for use in an HCV antigen/antibody combination assay
The invention relates to a method of detecting HCV infection in a biological sample, the method comprising providing an immunoassay solid support, comprising an HCV anti-core antibody, an antigen...
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7318927 |
Recombinant poxvirus for chimeric proteins of the human immunodeficiency virus
The invention relates to HIV chimeric gene formed by the union of fragments of different genes of said virus, wherein said fragments contains epitopes for cytotoxic T cells (CTL) or HIV-1 auxiliary...
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7319033 |
Adenovirus vectors specific for cells expressing androgen receptor and methods of use thereof
Replication-competent adenovirus vectors specific for cells which allow a probasin transcriptional response element (PB-TRE) to function, such as cells which express the androgen receptor (AR), and...
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7317142 |
Immunization of fish with plant-expressed recombinant proteins
Plants are produced that express an amino acid sequence that, when administered to a fish, produce an antigenic or immune response in the fish. The amino acid sequence in one embodiment is an...
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7314868 |
Compositions and methods for elimination of unwanted cells
Disclosed are compositions comprising a recombinant nucleic acid vector including a nucleotide sequence encoding a syncytium-inducing polypeptide expressible on a eukaryotic cell surface, and a...
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7314627 |
Cationic lipid-mediated enhancement of nucleic acid immunization of cats
The present invention relates to a method to introduce a nucleic acid molecule into a felid by administration of a nucleic acid-cationic lipid complex composition. The method includes the step of...
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7314925 |
Constructs and methods for expression of recombinant HCV envelope proteins
The current invention relates to vectors and methods for efficient expression of HCV envelope proteins in eukaryotic cells. More particularly said vectors comprise the coding sequence for an avian...
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7314710 |
Method for replicating the hepatitis C virus
The invention concerns the use of cells capable of carrying out a process of prenylation of proteins coded by the hepatitis C virus (HCV) genome, such as prenylation of the NS5A protein, for...
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7314631 |
Use of recombinant live-attenuated parainfluenza virus (PIV) as a vector to protect against disease caused by PIV and respiratory syncytial virus (RSV)
Chimeric parainfluenza viruses (PIVs) are provided that incorporate a PIV vector genome or antigenome and one or more antigenic determinant(s) of a heterologous PIV or non-PIV pathogen. These...
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7312080 |
Plant resistance to insect pests mediated by viral proteins
The invention involves combining a peptide toxin effective against insects, including but not limited to thrips, leaf hoppers, and beetles, with a transport peptide capable of facilitating transfer...
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7297784 |
DNA encoding T-1249 and other viral fusion inhibitor peptides useful for treating aids
The present invention relates to enhancer peptide sequences originally derived from various retroviral envelope (gp41) protein sequences that enhance the pharmacokinetic properties of any core...
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7297536 |
Inducible protein expression system
Inducible gene expression systems and a method thereof. A first inducible gene expression system includes a first vector comprising at least one retroviral promoter and at least one factor to...
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7294758 |
Materials and methods for producing geminivirus resistant plants
The subject invention pertains to materials and methods for producing plants that are resistant to infection by geminiviruses and other related viruses. Methods of the invention comprise...
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7291452 |
Erythrovirus and its applications
The invention concerns nucleic acids derived from human V9 erythrovirus, fragments thereof, encoded polypeptides, and applications as diagnostic reagents and as immunogenic agents.
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7291455 |
Assessment of human papilloma virus-related disease
This invention provides novel methods for assessing HPV infection. Gene expression levels are used to assess the progression of HPV infection from benign to malignant growth. Also provided are kits...
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7291723 |
GB virus C and methods of treating viral infections
The present application provides GB virus C sequences (GBV-C or hepatitis G virus) and methods of using the sequences.
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7288258 |
Polyepitopic protein fragments of the E6 and E7 proteins of HPV, their production and their use particularly in vaccination
Polyepitopic peptides of E6 and E7 proteins of Human Papillomavirus, their production, and methods of treating pathologies in which a polyepitopic peptide of the E6 and E7 protein of Human...
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7282364 |
Polynucleotides encoding antigenic HIV type B polypeptides, polypeptides and uses thereof
The present invention relates to polynucleotides encoding immunogenic HIV polypeptides. Uses of the polynucleotides in applications including immunization, generation of packaging cell lines, and...
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7279335 |
Nucleic acids encoding lettuce big-vein viral proteins and utilization thereof
The coat protein of lettuce big-vein virus (LBVV) was purified from highly purified LBVV, and its partial amino acid sequences were determined. An RNA encoding the coat protein of LBVV was cloned...
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7279167 |
Infectious Salmon Anaemia virus vaccine
This invention relates to Infectious Salmon Anaemia Virus (ISAV) antigenic polypeptides and nucleic acid molecules encoding them, as well as vaccines, transformed cells and transgenic fish. The...
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7279168 |
Recombinant virus expressing foreign DNA encoding feline CD86 and uses thereof
The present invention involves a recombinant virus which comprises at least one foreign nucleic acid inserted within a non-essential region of the viral genome of a virus, wherein each such foreign...
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7279166 |
Chimeric infectious DNA clones, chimeric porcine circoviruses and uses thereof
The present invention relates to infectious DNA clones, infectious chimeric DNA clones of porcine circovirus (PCV), vaccines and means of protecting pigs against viral infection or postweaning...
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