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6051409 |
Method for achieving integration of exogenous DNA delivered by non-biological means to plant cells
The present invention provides an improved method for achieving stable integration of an exogenous DNA fragment in intact form into the genome of a eukaryotic cell, particularly a plant cell. The...
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6051556 |
Hybrid pesticidal toxins
The invention concerns novel hybrid pesticidal toxins. These toxins are expressed as the fusion protein of a chimeric gene. Specifically exemplified is a novel B.t. hybrid toxin. These novel toxins...
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6051753 |
Figwort mosaic virus promoter and uses
This invention relates to a novel plant promoter derived from the figwort mosaic virus and methods of use of same.
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6051404 |
Recombinant vaccine against Marek's disease
The invention is related to a nucleic acid sequence encoding a MD06 Marek's Disease Virus protein. Such a protein can be used for the immunization of poultry against MDV infection or disease. The...
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6046384 |
Papaya ringspot virus NIa protease gene
NIa protease genes of papaya ringspot virus strains FLA83 and USA P-type (HA-attenuated strain) are provided.
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6040496 |
Use of translationally altered RNA to confer resistance to maize dwarf mosaic virus and other monocotyledonous plant viruses
The present invention provides methods and compositions for inhibiting virus infection in susceptible monocotyledonous plants. The methods and compositions involve the production of translationally...
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6040177 |
High efficiency transduction of T lymphocytes using rapid expansion methods ("REM")
The present invention provides a rapid expansion method (termed "REM"), for quickly generating large numbers of T lymphocytes, including cytolytic and helper T lymphocytes. REM involves culturing...
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6037150 |
Insect sequences for improving the efficiency of secretion of non-secreted proteins in eukaryotic cells
An expression cassette useful for the secretion of a heterologous protein from eukaryotic cells comprising a DNA sequence encoding a promoter functionally linked to a DNA sequence coding for the...
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6033669 |
Methods for generating cytotoxic T cells and treatment of diseases thereby
The present invention relates a novel class of biologically active compounds, to processes for their production and to their use in therapy. More particularly the invention provides immunogenic...
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6033845 |
Specific diagnostic for feline infectious peritonitis antibodies
The present invention is based on the discovery of an antigenic site in the unique 7B polypeptide sequence of Feline Infectious Peritonitis Virus. Specific and sensitive methods for detecting cats...
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6033898 |
Enhanced yeast expression using regulatory control sequences from yeast sorbitol dehydrogenase gene
An isolated DNA segment is disclosed which is derived from a Saccharomyces cerevisiae sorbitol dehydrogenase gene and which functions to increase expression of an associated foreign polypeptide...
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6030954 |
Targeted delivery of poly- or oligonucleotides to cells
Molecular complexes for targeting oligonucleotides, such as antisense oligonucleotides or ribozymes, to a specific cell to block expression of a gene or genes in the cell are described. The...
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6025193 |
Methods and compositions for diagnosis and treatment of pathological conditions related to abnormal dopamine receptor expression
Methods and compositions are provided for diagnosing and treating pathological conditions related to a dopamine receptor abnormality. The methods comprise administering to a patient having such a...
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6022726 |
Genetically engineered attenuated viruses
The present invention relates to engineering attenuated viruses by altering a non-coding region or the coding sequence of a viral gene. Alterations of the non-coding regions which regulate...
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6020171 |
Method of preparing plasmid having both expressing ability of retroviral gene and processing ability after translation, and resultant plasmid and expression products thereof
The present invention provides a method of preparing a plasmid having both the ability of expressing retroviral genes and the ability of effecting the after-translational processing of the encoded...
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6017542 |
Nucleotide and amino acid sequences of canine herpesvirus GD and uses therefor
Disclosed and claimed are nucleotides for genes encoding the canine herpesvirus (CHV) gB, gC and gD homologues. These genes encode polypeptides of 879, 459 and 345 amino acids, respectively, which...
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6017734 |
Unique nucleotide and amino acid sequence and uses thereof
Provided are hydrophobic targeting sequences, which may serve to target heterologous proteins to a variety of cellular membranes. In particular, the structural components of the nuclear envelope,...
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6017535 |
cDNA sequence of Dengue virus serotype 1 (Singapore strain)
DENI-S275/90 (ECACC V92042111) is a new strain of Dengue virus serotype 1. The complete cDNA sequence of this virus has been cloned and protein-coding fragments thereof have been used in the...
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6017761 |
Method for obtaining retroviral packaging cell lines producing high transducing efficiency retroviral supernatant
This invention provides a method for obtaining a recombinant retroviral packaging cell capable of producing retroviral vectors as well as the recombinant packaging cell obtained by the method. Also...
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6015663 |
Restriction enzyme screen for differentiating porcine reproductive and respiratory syndrome virus strains
A test based on restriction enzyme analysis identifies and differentiates strains of porcine reproductive and respiratory syndrome virus (PRRSV). Amplified cDNA from the ORF 5 region of the viral...
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6015694 |
Method for stimulating an immune response utilizing recombinant alphavirus particles
The present invention provides compositions and methods for utilizing recombinant alphavirus vectors. Also disclosed are compositions and methods for making and utilizing eukaryotic layered vector...
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6015795 |
Bovine viral diarrhea virus II vaccine and method of immunization
This invention relates to the identification of Bovine Viral Diarrhea Virus group II (BVDV-II) nucleic acid sequences (e.g., gp53 sequences), to methods of using the nucleic acid sequences for...
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6015566 |
Peptide composition generating an immune response against herpes virus
A composition is disclosed for generating an immune response against a herpes virus in an animal subject susceptible thereto, wherein the vaccine comprises a compound of the Formula: TBL Val Asn...
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6013864 |
Plants resistant to infection by luteoviruses
An isolated DNA sequence which codes for a luteo replicase gene is disclosed herein. A method for providing resistance to infection by a virus by expressing a replicase gene in plants is also...
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6013258 |
Immunogenic peptides from the HPV E7 protein
The invention provides immunogenic peptides from the HPV type 16 E7 protein that comprise overlapping class I restricted T cell epitopes. Also disclosed are methods of administering DNA molecules...
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6013262 |
Recombinant papilloma virus L1
This invention relates to a recombinant papilloma virus L1 protein which can elicit an immune response which recognises papilloma virus VLP including L1 protein and can form extracellularly a...
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6013261 |
Recombinant Marek's disease virus (MDV) and vaccine
A recombinant herpes virus is provided which efficiently expresses an exogenous protein of interest in an inoculated animal host to thereby endow the host with excellent immunization. A recombinant...
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6004557 |
Variants of human papillomavirus antigens
Variants of human papilloma virus (HPV) E6 and E7 able to elicit a humoral or cellular immune response against HPV in a host animal but not being cell-transforming in the host animal are disclosed,...
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6005166 |
Papaya ringspot virus replicase gene
NIb replicase gene of papaya ringspot virus replicase strain FLA.83 W is provided.
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6002072 |
Coat protein gene for the FLA83 W strain of papaya ringspot virus
The present invention relates to a coat protein gene of papaya ringspot virus strain FLA83 W. This coat protein gene can be used to prepare plants which are resistant to papaya ringspot virus.
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5998601 |
VR-2332 viral nucleotide sequence and methods of use
A nucleotide sequence is provided for the VR-2332 virus, which is capable of causing Porcine Reproductive and Respiratory Syndrome. The nucleotide sequence includes protein coding regions that are...
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5998699 |
Potyvirus coat protein genes and plants transformed therewith
The present invention relates to the coat protein genes of Papaya Ringspot Virus Strain papaya ringspot (PRV-p), Watermelon Mosaic Virus II (WMVII), and Zucchini Yellow Mosaic Virus (ZYMV); to...
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5998598 |
Immunoadhesins and methods of production and use thereof
The invention is directed toward a compound comprising a recombinant nucleic acid encoding an immunoadhesin inserted within an adenoviral nucleic acid, wherein the recombinant nucleic acid can be...
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5998174 |
Multigene vectors
The present invention provides a method for preparing HSV vectors. The method comprises co-transfecting a source vector and a mutating cassette together into a population of appropriate host cells,...
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5993821 |
Modified papilloma virus L2 protein and VLPs formed therefrom
The invention, in one aspect, is directed to a modified papilloma virus L2 protein which does not bind DNA or which has a substantially impaired ability to bind DNA compared to wild-type papilloma...
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5994516 |
Mutated proteins encoded by a lentivirus mutated env gene, peptide fragments and expression vectors
Mutated proteins coded by a mutated env gene of a lentivirus, particularly FIV, HIV or CAEV, peptide fragments contained in said mutated proteins and expression vectors expressing said mutaded...
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5989561 |
Recombinant poxvirus-calicivirus rabbit hemorrhagic disease virus (RHDV) compositions and uses
Attenuated recombinant viruses containing DNA encoding a calicivirus antigen such as a RHDV antigen, e.g., a capsid gene, as well as methods and compositions employing the viruses, expression...
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5989548 |
Peptide-based composition against papillomavirus infection
Pharmaceutical compositions comprising an antigenic amount of peptides derived from the L1 and L2 OFR's of human papillomavirus type 16 coupled to a carrier or in multimer form.
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5985283 |
Adenovirus E1A-Associated protein BS69, inhibitor of E1A-transactivation
The present invention relates to a transcription inhibiting factor, designated BS69. The factor can bind to both the 243R and 289R E1A adenovirus proteins, inhibiting the transactivating activity...
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5985609 |
Process for preparing hepatitis C virus envelope glycoproteins
The present invention relates to a novel process for preparing hepatitis C virus (HCV) envelope glycoproteins employing Chinese Hamster Ovary (CHO) cells transformed with recombinant expression...
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5986175 |
Virus resistant plants
An isolated DNA sequence which codes for a potyvirus replicase gene is disclosed herein. A method for providing resistance to infection by a virus by expressing a replicase gene in plants is also...
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5981224 |
Bovine heat shock promoter and uses thereof
A novel expression system using the heat-inducible bovine hsp70A promoter and associated cis-acting elements is disclosed. The system provides for the continuous production of a highly pure,...
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5981173 |
Genital human papillomavirus type 68a (HPV-68a), related to the potentially oncogenic HPV-39
The genomes of two novel human papillomavirus (HPV) types, HPV68 and HPV70, were cloned from a low grade cervical intraepithelial neoplasia and a vulvar papilloma, respectively, and sequenced. Both...
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5981225 |
Gene transfer vector, recombinant adenovirus particles containing the same, method for producing the same and method of use of the same
A gene transfer vector comprising adenovirus inverted terminal repeats, at least one adenovirus packaging signal, and an adenoviral VAI gene and/or VAII gene; recombinant adenovirus particles...
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5973135 |
DNA comprising plum pox virus and tomato spotted wilt virus cDNAS for disease resistance
The present invention relates to novel, recombinant deoxyribonucleic acids (DNA), to vectors and host organisms which contain them, and to transgenic plants which contain the recombinant DNA and...
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5972596 |
Nucleic acid constructs containing HIV genes with mutated inhibitory/instability regions and methods of using same
A method of locating an inhibitory/instability sequence or sequences within the coding region of an mRNA and modifying the gene encoding that mRNA to remove these inhibitory/instability sequences...
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5968828 |
Virus-resistant transgenic plants comprising cells transformed with a polynucleotide encoding a potyviridae P1 protein or P1 protein fragment
Provided are transgenic plants with resistance to viral infection polynucleotides and methods for conferring such resistance, and methods for producing the transgenic plants. Plants transformed...
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5965139 |
Chicken infectious anemia virus vaccine
Novel sequences in the genome of a wild type isolate of chicken infectious anemia virus are described, The amino acid sequence of a polypeptide, VP1, encoded by a novel sequence is also disclosed....
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5965134 |
Immunogenic composition against Classical Swine Fever Virus (CSFV)
This application is concerned with immunogenic polypeptides of pestiviruses, specifically Classical Swine Fever Virus (CVFV), specifically the nonstructural protein p10, more specifically T-cell...
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5965140 |
Hybrid particle immunogens
Novel immunogenic compositions are provided involving viral particles composed at least in part of hybrid proteins of at least a portion of a particle forming protein and one or more polypeptides...
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